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Chromatin-localized central metabolism regulating gene expression and cell identity

Publikacje

Acute BAF perturbation causes immediate changes in chromatin accessibility

Autorzy: Sandra Schick, Sarah Grosche, Katharina Eva Kohl, Danica Drpic, Martin G. Jaeger, Nara C. Marella, Hana Imrichova, Jung-Ming G. Lin, Gerald Hofstätter, Michael Schuster, André F. Rendeiro, Anna Koren, Mark Petronczki, Christoph Bock, André C. Müller, Georg E. Winter, Stefan Kubicek
Opublikowane w: Nature Genetics, Issue 53/3, 2021, Page(s) 269-278, ISSN 1061-4036
DOI: 10.1038/s41588-021-00777-3

Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

Autorzy: Brenda Marquina-Sanchez, Nikolaus Fortelny, Matthias Farlik, Andhira Vieira, Patrick Collombat, Christoph Bock, Stefan Kubicek
Opublikowane w: Genome Biology, Issue 21(1), 2020, Page(s) 106, ISSN 1474-760X
DOI: 10.1186/s13059-020-02006-2

Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states

Autorzy: Kai-Chun Li, Enrico Girardi, Felix Kartnig, Sarah Grosche, Tea Pemovska, Johannes W. Bigenzahn, Ulrich Goldmann, Vitaly Sedlyarov, Ariel Bensimon, Sandra Schick, Jung-Ming G. Lin, Bettina Gürtl, Daniela Reil, Kristaps Klavins, Stefan Kubicek, Sara Sdelci, Giulio Superti-Furga
Opublikowane w: Nature Metabolism, Issue 3/5, 2021, Page(s) 651-664, ISSN 2522-5812
DOI: 10.1038/s42255-021-00386-8

Therapeutic targeting of chromatin: Status and opportunities

Autorzy: Marton Siklos, Stefan Kubicek
Opublikowane w: The FEBS Journal, 2021, ISSN 1742-464X
DOI: 10.1111/febs.15966

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

Autorzy: Sara Sdelci, André F. Rendeiro, Philipp Rathert, Wanhui You, Jung-Ming G. Lin, Anna Ringler, Gerald Hofstätter, Herwig P. Moll, Bettina Gürtl, Matthias Farlik, Sandra Schick, Freya Klepsch, Matthew Oldach, Pisanu Buphamalai, Fiorella Schischlik, Peter Májek, Katja Parapatics, Christian Schmidl, Michael Schuster, Thomas Penz, Dennis L. Buckley, Otto Hudecz, Richard Imre, Shuang-Yan Wang, Hans M
Opublikowane w: Nature Genetics, Issue 51/6, 2019, Page(s) 990-998, ISSN 1061-4036
DOI: 10.1038/s41588-019-0413-z

Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers

Autorzy: Sandra Schick, André F. Rendeiro, Kathrin Runggatscher, Anna Ringler, Bernd Boidol, Melanie Hinkel, Peter Májek, Loan Vulliard, Thomas Penz, Katja Parapatics, Christian Schmidl, Jörg Menche, Guido Boehmelt, Mark Petronczki, André C. Müller, Christoph Bock, Stefan Kubicek
Opublikowane w: Nature Genetics, Issue 51/9, 2019, Page(s) 1399-1410, ISSN 1061-4036
DOI: 10.1038/s41588-019-0477-9

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

Autorzy: Enrico Girardi, Adrián César-Razquin, Sabrina Lindinger, Konstantinos Papakostas, Justyna Konecka, Jennifer Hemmerich, Stefanie Kickinger, Felix Kartnig, Bettina Gürtl, Kristaps Klavins, Vitaly Sedlyarov, Alvaro Ingles-Prieto, Giuseppe Fiume, Anna Koren, Charles-Hugues Lardeau, Richard Kumaran Kandasamy, Stefan Kubicek, Gerhard F. Ecker, Giulio Superti-Furga
Opublikowane w: Nature Chemical Biology, Issue 16/4, 2020, Page(s) 469-478, ISSN 1552-4450
DOI: 10.1038/s41589-020-0483-3

Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time

Autorzy: Andreas Reicher, Anna Koren, Stefan Kubicek
Opublikowane w: Genome Research, Issue 30, 2020, Page(s) 1846-1855, ISSN 1088-9051
DOI: 10.1101/gr.261503.120