Magnetically Assisted Tissue Engineering Technologies for Tendon Regeneration

Project Information

MagTendon

Grant agreement ID: 772817

DOI 10.3030/772817

EC signature date 17 April 2018

Start date 1 May 2018

End date 31 October 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 854,00

EU contribution € 1 999 854,00

Coordinated by

UNIVERSIDADE DO MINHO
Portugal

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Publications

Book chapters (6)

Multiscale Multifactorial Approaches for Engineering Tendon Substitutes

Author(s): Ana I. Gonçalves, Márcia T. Rodrigues, Ana M. Matos, Helena Almeida, Manuel Gómez-Florit, Rui M. A. Domingues, Manuela E. Gomes
Published in: Organ Tissue Engineering, 2020, Page(s) 1-24, ISBN 978-3-030-18512-1
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-18512-1_8-1

Bioinspired materials and tissue engineering approaches applied to the regeneration of musculoskeletal tissues

Author(s): Márcia T. Rodrigues, Ana I. Gonçalves, Pedro S. Babo, Manuel Gomez-Florit, Rui L. Reis, Manuela E. Gomes
Published in: Engineering Strategies for Regenerative Medicine, 2020, Page(s) 73-105, ISBN 9780128162217
Publisher: Elsevier
DOI: 10.1016/b978-0-12-816221-7.00003-3

Future Directions: What the Future Holds for TERM

Author(s): Márcia T. Rodrigues, Rui M.A. Domingues, Rui L. Reis, Manuela E. Gomes
Published in: Reference Module in Biomedical Sciences, 2019, ISBN 9780128012383
Publisher: Elsevier
DOI: 10.1016/b978-0-12-801238-3.11287-5

Natural Materials

Author(s): Manuel Gómez-Florit, Rui M.A. Domingues, Syeda Mahwish Bakht, Bárbara B. Mendes, Rui L. Reis, Manuela E. Gomes
Published in: Biomaterials Science, 2020, Page(s) 361-375, ISBN 9780128161371
Publisher: Elsevier
DOI: 10.1016/b978-0-12-816137-1.00026-x

Cellular Complexity at the Interface: Challenges in Enthesis Tissue Engineering

Author(s): Isabel Calejo, Raquel Costa-Almeida, Manuela E. Gomes
Published in: Cell Biology and Translational Medicine, Volume 5 - Stem Cells: Translational Science to Therapy, Issue 1144, 2019, Page(s) 71-90, ISBN 978-3-030-17588-7
Publisher: Springer International Publishing
DOI: 10.1007/5584_2018_307

Exploring Stem Cells and Inflammation in Tendon Repair and Regeneration

Author(s): A. Vinhas, M. T. Rodrigues, M. E. Gomes
Published in: Cell Biology and Translational Medicine, Volume 2 - Approaches for Diverse Diseases and Conditions, Issue 1089, 2018, Page(s) 37-46, ISBN 978-3-030-04169-4
Publisher: Springer International Publishing
DOI: 10.1007/5584_2018_258

Peer reviewed articles (38)

Magnetic Stimulation Drives Macrophage Polarization in Cell to–Cell Communication with IL-1β Primed Tendon Cells

Author(s): Adriana Vinhas, Ana F. Almeida, Ana I. Gonçalves, Márcia T. Rodrigues, Manuela E. Gomes
Published in: International Journal of Molecular Sciences, Issue 21/15, 2020, Page(s) 5441, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21155441

Remote triggering of TGF-β/Smad2/3 signaling in human adipose stem cells laden on magnetic scaffolds synergistically promotes tenogenic commitment

Author(s): Ana M. Matos, Ana I. Gonçalves, Márcia T. Rodrigues, Margarida S. Miranda, Alicia J. El Haj, Rui L. Reis, Manuela E. Gomes
Published in: Acta Biomaterialia, Issue 113, 2020, Page(s) 488-500, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.07.009

Epitope‐Imprinted Nanoparticles as Transforming Growth Factor‐β3 Sequestering Ligands to Modulate Stem Cell Fate

Author(s): Simão P. B. Teixeira, Rui M. A. Domingues, Pedro S. Babo, Dominika Berdecka, Margarida S. Miranda, Manuela E. Gomes, Nicholas A. Peppas, Rui L. Reis
Published in: Advanced Functional Materials, 2020, Page(s) 2003934, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202003934

Therapeutic Effects of Platelet-Derived Extracellular Vesicles in a Bioengineered Tendon Disease Model

Author(s): Rui Domingues; Isabel Calejo; Ana Graça; Manuela Gomes; Manuel Gomez-Florit
Published in: International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 2948, Issue 14220067, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23062948

Epitope-imprinted polymers: design principles of synthetic binding partners for natural biomacromolecules

Author(s): Teixeira, Simão P. B.,Reis, R. L.,Peppas, Nicholas A.,Gomes, Manuela E.
Published in: Science Advances, Issue 23752548, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abi9884

Controlling the fate of regenerative cells with engineered platelet-derived extracellular vesicles

Author(s): Ana L. Graça; Manuel Gómez-Florit; Hugo Osório; Márcia T. Rodrigues; Rui M. A. Domingues; Rui L. Reis; Manuela E. Gomes
Published in: Nanoscale, Issue 20403372, 2022, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr08108j

Bioengineered 3D living fibers as in vitro human tissue models of tendon physiology and pathology

Author(s): Isabel Calejo; Claudia J. Labrador‐Rached; Manuel Gomez‐Florit; Denitsa Docheva; Rui L. Reis; Rui M. A. Domingues; Manuela E. Gomes
Published in: Advanced Healthcare Materials, Issue 21922659, 2022, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202102863

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction

Author(s): Ana M. Matos, Ana I. Gonçalves, Alicia J. El Haj, Manuela E. Gomes
Published in: Nanoscale Advances, Issue 2/1, 2020, Page(s) 140-148, ISSN 2516-0230
Publisher: The Royal Society of Chemistry
DOI: 10.1039/c9na00615j

Engineering next-generation bioinks with nanoparticles: moving from reinforcement fillers to multifunctional nanoelements.

Author(s): Syeda Mahwish Bakht; Alberto Pardo; Alberto Pardo; Manuel Gómez-Florit; Rui L. Reis; Rui M. A. Domingues; Manuela E. Gomes
Published in: Journal of Materials Chemistry B, Issue 20507518, 2021, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1tb00717c

The impact of cryopreservation in signature markers and immunomodulatory profile of tendon and ligament derived cells

Author(s): Ana I. Gonçalves; Adriana Vinhas; Márcia T. Rodrigues; Manuela E. Gomes
Published in: Journal of Cellular Physiology, Issue 10974652, 2021, ISSN 1097-4652
Publisher: Wiley
DOI: 10.1002/jcp.30540

Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

Author(s): Simão P. B. Teixeira, Rui M. A. Domingues, Mariya Shevchuk, Manuela E. Gomes, Nicholas A. Peppas, Rui L. Reis
Published in: Advanced Functional Materials, Issue 30/44, 2020, Page(s) 1909011, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201909011

Magnetic responsive materials modulate the inflammatory profile of IL-1β conditioned tendon cells

Author(s): A. Vinhas, M.T. Rodrigues, A.I. Gonçalves, R.L. Reis, M.E. Gomes
Published in: Acta Biomaterialia, Issue 117, 2020, Page(s) 235-245, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.09.028

Injectable and Magnetic Responsive Hydrogels with Bioinspired Ordered Structures

Author(s): Sandra Araújo-Custódio, Manuel Gomez-Florit, Ana R. Tomás, Bárbara B. Mendes, Pedro S. Babo, Suzanne M. Mithieux, Anthony Weiss, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Published in: ACS Biomaterials Science & Engineering, Issue 5/3, 2019, Page(s) 1392-1404, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.8b01179

Tropoelastin-Coated Tendon Biomimetic Scaffolds Promote Stem Cell Tenogenic Commitment and Deposition of Elastin-Rich Matrix

Author(s): Helena Almeida, Rui M. A. Domingues, Suzanne M. Mithieux, Ricardo A. Pires, Ana I. Gonçalves, Manuel Gómez-Florit, Rui L. Reis, Anthony S. Weiss, Manuela E. Gomes
Published in: ACS Applied Materials & Interfaces, Issue 11/22, 2019, Page(s) 19830-19840, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.9b04616

Biphasic Hydrogels Integrating Mineralized and Anisotropic Features for Interfacial Tissue Engineering

Author(s): Mari Carmen Echave, Rui M. A. Domingues, Manuel Gómez-Florit, José Luis Pedraz, Rui L. Reis, Gorka Orive, Manuela E. Gomes
Published in: ACS Applied Materials & Interfaces, Issue 11/51, 2019, Page(s) 47771-47784, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.9b17826

Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications

Author(s): Bárbara B. Mendes, Andrew C. Daly, Rui L. Reis, Rui M.A. Domingues, Manuela E. Gomes, Jason A. Burdick
Published in: Acta Biomaterialia, Issue 119, 2021, Page(s) 101-113, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.10.040

Intrinsically Bioactive Cryogels Based on Platelet Lysate Nanocomposites for Hemostasis Applications

Author(s): Bárbara B. Mendes, Manuel Gómez-Florit, Ana C. Araújo, Justina Prada, Pedro S. Babo, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Published in: Biomacromolecules, Issue 21/9, 2020, Page(s) 3678-3692, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.0c00787

3D bioprinting of miniaturized tissues embedded in self-assembled nanoparticle-based fibrillar platforms

Author(s): Syeda Mahwish Bakht; Manuel Gómez-Florit; Tara Helena Lamers; Rui L. Reis; Rui M. A. Domingues; Manuela E. Gomes
Published in: Advanced Functional Materials, Issue 1, 2021, ISSN 1616-3028
Publisher: Wiley
DOI: 10.1002/adfm.202104245

Magneto-mechanical actuation of magnetic responsive fibrous scaffolds boosts tenogenesis of human adipose stem cells

Author(s): Ana R. Tomás, Ana I. Gonçalves, Elvira Paz, Paulo Freitas, Rui M. A. Domingues, Manuela E. Gomes
Published in: Nanoscale, Issue 11/39, 2019, Page(s) 18255-18271, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr04355a

Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells

Author(s): Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Published in: Journal of Tissue Engineering and Regenerative Medicine, Issue 13/12, 2019, Page(s) 2204-2217, ISSN 1932-6254
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/term.2967

Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structures

Author(s): Bárbara B Mendes, Manuel Gómez-Florit, Alex G Hamilton, Michael S Detamore, Rui M A Domingues, Rui L Reis, Manuela E Gomes
Published in: Biofabrication, Issue 12/1, 2020, Page(s) 015012, ISSN 1758-5090
Publisher: IOP Publishing
DOI: 10.1088/1758-5090/ab33e8

A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds

Author(s): Isabel Calejo, Raquel Costa‐Almeida, Rui L. Reis, Manuela E. Gomes
Published in: Advanced Healthcare Materials, Issue 8/15, 2019, Page(s) 1900200, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201900200

Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies

Author(s): Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes
Published in: International Journal of Molecular Sciences, Issue 20/12, 2019, Page(s) 3002, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20123002

A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering

Author(s): Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
Published in: Trends in Biotechnology, Issue 38/1, 2020, Page(s) 83-98, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2019.06.003

Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair

Author(s): Raquel Costa-Almeida, Isabel Calejo, Roberta Altieri, Rui M A Domingues, Emanuele Giordano, Rui L Reis, Manuela E Gomes
Published in: Biomedical Materials, Issue 14/3, 2019, Page(s) 034104, ISSN 1748-605X
Publisher: IOP Publishing
DOI: 10.1088/1748-605x/ab0de6

Enthesis Tissue Engineering: Biological Requirements Meet at the Interface

Author(s): Isabel Calejo, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
Published in: Tissue Engineering Part B: Reviews, Issue 25/4, 2019, Page(s) 330-356, ISSN 1937-3368
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.teb.2018.0383

Texturing Hierarchical Tissues by Gradient Assembling of Microengineered Platelet‐Lysates Activated Fibers

Author(s): Isabel Calejo; Rui L. Reis; Rui M. A. Domingues; Manuela E. Gomes
Published in: Advanced Healthcare Materials, Issue 21922659, 2021, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202102076

Magnetic Micellar Nanovehicles: Prospects of Multifunctional Hybrid Systems for Precision Theranostics

Author(s): Margarida S. Miranda, Ana F. Almeida, Manuela E. Gomes, and Márcia T. Rodrigues
Published in: International Journal of Molecular Sciences, Issue 14220067, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911793

Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response

Author(s): Bárbara B. Mendes, Manuel Gómez-Florit, Hugo Osório, Adriana Vilaça, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Published in: Chemical Communications, Issue 56/50, 2020, Page(s) 6882-6885, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/D0CC01850C

Magnetically-assisted 3D bioprinting of anisotropic tissue-mimetic constructs

Author(s): Pardo A., Bakht S. M., Gomez-Florit M., Rial R., Monteiro R., Teixeira S. P. B., Taboada P., Reis R. L., Domingues R. M. A., Gomes M. E.
Published in: Advanced Functional Materials, 2022, ISSN 1616-3028
Publisher: Wiley
DOI: 10.1002/adfm.202208940

Platelet-rich Blood Derivatives for Tendon Regeneration.

Author(s): Raquel Costa-Almeida; Pedro S. Babo; Rui L. Reis; Manuela E. Gomes
Published in: Journal of the American Academy of Orthopaedic Surgeons, Issue 19405480, 2020, ISSN 1940-5480
Publisher: Lippincott, Williams & Wilkins
DOI: 10.5435/jaaos-d-18-00638

Magnetic Nanocomposite Hydrogels for Tissue Engineering: Design Concepts and Remote Actuation Strategies to Control Cell Fate

Author(s): Alberto Pardo; Manuel Gómez-Florit; Silvia Barbosa; Pablo Taboada; Rui M. A. Domingues; Manuela E. Gomes
Published in: ACS Nano, Issue 1936086X, 2021, ISSN 1936-086X
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c08253

Pulsed Electromagnetic Field Modulates Tendon Cells Response in IL‐1β‐Conditioned Environment

Author(s): Adriana Vinhas, Márcia T. Rodrigues, Ana I. Gonçalves, Rui L. Reis, Manuela E. Gomes
Published in: Journal of Orthopaedic Research, Issue 38/1, 2019, Page(s) 160-172, ISSN 0736-0266
Publisher: Elsevier BV
DOI: 10.1002/jor.24538

Human tendon-derived cell sheets created by magnetic force-based tissue engineering hold tenogenic and immunomodulatory potential

Author(s): AdrianaVinhas, Ana I.Gonçalves, Márcia T.Rodrigues, Manuela E.Gomes
Published in: Acta Biomaterialia, Issue 18787568, 2021, ISSN 1878-7568
Publisher: Elsevier
DOI: 10.1016/j.actbio.2021.06.036

Magnetic triggers in biomedical applications - prospects for contact free cell sensing and guidance.

Author(s): Ana Filipa Martins Almeida; Adriana Vinhas; Ana I. Gonçalves; Margarida S. Miranda; Márcia T. Rodrigues; Manuela E. Gomes
Published in: Journal of Materials Chemistry B, Issue 20507518, 2021, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0tb02474k

Natural-Based Hydrogels for Tissue Engineering Applications

Author(s): Gómez-Florit M., Pardo A., Domingues R. M. A., Graça A. L., Babo P. S., Reis R. L., Gomes M. E.
Published in: Molecules, 2020, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25245858

In vitro temporal HIF‐mediated deposition of osteochondrogenic matrix governed by hypoxia and osteogenic factors synergy

Author(s): Isabel Calejo, Raquel Costa‐Almeida, Rui L. Reis, Manuela E. Gomes
Published in: Journal of Cellular Physiology, 2020, ISSN 0021-9541
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jcp.30138

Xeno-free bioengineered human skeletal muscle tissue using human platelet lysate-based hydrogels

Author(s): Juan M. Fernandez-Costa; Rui Domingues; Javier Ramon; Xiomara Fernández-Garibay; Manuela Gomes; Manuel Gomez-Florit
Published in: Biofabrication, Issue 17585090, 2022, ISSN 1758-5090
Publisher: IOP Publishing
DOI: 10.1088/1758-5090/ac8dc8