Epigenetic and metabolic regulation of endothelial heterogeneity

Publicaciones

Control of endothelial quiescence by FOXO-regulated metabolites

Autores: Jorge Andrade, Chenyue Shi, Ana S. H. Costa, Jeongwoon Choi, Jaeryung Kim, Anuradha Doddaballapur, Toshiya Sugino, Yu Ting Ong, Marco Castro, Barbara Zimmermann, Manuel Kaulich, Stefan Guenther, Kerstin Wilhelm, Yoshiaki Kubota, Thomas Braun, Gou Young Koh, Ana Rita Grosso, Christian Frezza, Michael Potente
Publicado en: Nature Cell Biology, Edición 23/4, 2021, Página(s) 413-423, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-021-00637-6

Post-myocardial infarction heart failure dysregulates the bone vascular niche

Autores: Jedrzej Hoffmann, Guillermo Luxán, Wesley Tyler Abplanalp, Simone-Franziska Glaser, Tina Rasper, Ariane Fischer, Marion Muhly-Reinholz, Michael Potente, Birgit Assmus, David John, Andreas Michael Zeiher & Stefanie Dimmeler
Publicado en: Nature Communications, Edición 12(1), 2021, Página(s) 3964, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24045-4

Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine

Autores: Fan Wu, Xiang Li, Mario Looso, Hang Liu, Dong Ding, Stefan Günther, Carsten Kuenne, Shuya Liu, Norbert Weissmann, Thomas Böttger, Ann Atzberger, Saeed Kolahian, Harald Renz, Stefan Offermanns, Ulrich Gärtner, Michael Potente, Yonggang Zhou, Xuejun Yuan, Thomas Braun
Publicado en: Nature Genetics, 2022, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-022-01252-3

Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state

Autores: Christian SM Helker, Jean Eberlein, Kerstin Wilhelm, Toshiya Sugino, Julian Malchow, Annika Schuermann, Stefan Baumeister, Hyouk-Bum Kwon, Hans-Martin Maischein, Michael Potente, Wiebke Herzog, Didier YR Stainier
Publicado en: eLife, Edición 9, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.55589

Arterialization requires the timely suppression of cell growth

Autores: Wen Luo, Irene Garcia-Gonzalez, Macarena Fernández-Chacón, Verónica Casquero-Garcia, Maria S. Sanchez-Muñoz, Severin Mühleder, Lourdes Garcia-Ortega, Jorge Andrade, Michael Potente, Rui Benedito
Publicado en: Nature, Edición 589/7842, 2021, Página(s) 437-441, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-3018-x

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

Autores: Akihiro Kaneshige, Takayuki Kaji, Lidan Zhang, Hayato Saito, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Kazutake Tsujikawa, Shigeto Seno, Masatoshi Hori, Yasuyuki Saito, Takashi Matozaki, Kazumitsu Maehara, Yasuyuki Ohkawa, Michael Potente, Shuichi Watanabe, Thomas Braun, Akiyoshi Uezumi, So-Ichiro Fukada
Publicado en: Cell Stem Cell, Edición 29(2), 2022, Página(s) 265-280.e6, ISSN 1934-5909
Editor: Cell Press
DOI: 10.1016/j.stem.2021.11.003

Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics

Autores: Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente , Franz Oswald, Tilman Borggrefe
Publicado en: Cell Death & Disease, Edición 13(7), 2022, Página(s) 600, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-022-05052-9

Metabolic modulation regulates cardiac wall morphogenesis in zebrafish

Autores: Ryuichi Fukuda, Alla Aharonov, Yu Ting Ong, Oliver A Stone, Mohamed El-Brolosy, Hans-Martin Maischein, Michael Potente, Eldad Tzahor, Didier YR Stainier
Publicado en: eLife, Edición 8, 2019, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.50161

Deubiquitinase USP10 regulates Notch signaling in the endothelium

Autores: Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M
Publicado en: Science, Edición 364/6436, 2019, Página(s) 364(6436):188-193, ISSN 0036-8075
Editor: American Association for the Advancement of Science

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

Autores: Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-06406-8

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability

Autores: Meghan Riddell, Akiko Nakayama, Takao Hikita, Fatemeh Mirzapourshafiyi, Takuji Kawamura, Ayesha Pasha, Mengnan Li, Mikio Masuzawa, Mario Looso, Tim Steinbacher, Klaus Ebnet, Michael Potente, Tomonori Hirose, Shigeo Ohno, Ingrid Fleming, Stefan Gattenlöhner, Phyu P. Aung, Thuy Phung, Osamu Yamasaki, Teruki Yanagi, Hiroshi Umemura, Masanori Nakayama
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-07739-0

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

Autores: Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S H Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan, Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso, Michael Potente
Publicado en: Nature Metabolism, Edición 4(6), 2022, Página(s) 672-682, ISSN 2522-5812
Editor: Nature Publishing Group
DOI: 10.1038/s42255-022-00584-y

YAP and TAZ protect against white adipocyte cell death during obesity

Autores: Lei Wang, ShengPeng Wang, Yue Shi, Rui Li, Stefan Günther, Yu Ting Ong, Michael Potente, Zuyi Yuan, Enqi Liu, Stefan Offermanns
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-19229-3

Regional specialization and fate specification of bone stromal cells in skeletal development

Autores: Kishor K Sivaraj, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Susanne Adams, Michael Potente, Ralf H Adams
Publicado en: Cell Reports, Edición 36(2), 2021, Página(s) 109352, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109352

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

Autores: Aileen A. Ren, Daniel A. Snellings, Yourong S. Su, Courtney C. Hong, Marco Castro, Alan T. Tang, Matthew R. Detter, Nicholas Hobson, Romuald Girard, Sharbel Romanos, Rhonda Lightle, Thomas Moore, Robert Shenkar, Christian Benavides, M. Makenzie Beaman, Helge Müller-Fielitz, Mei Chen, Patricia Mericko, Jisheng Yang, Derek C. Sung, Michael T. Lawton, J. Michael Ruppert, Markus Schwaninger, Jakob K
Publicado en: Nature, Edición 594(7862), 2021, Página(s) 271-276, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-03562-8

Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses

Autores: Andreas W Heumüller, Alisha N Jones, André Mourão, Marius Klangwart, Chenyue Shi, Ilka Wittig, Ariane Fischer, Marion Muhly-Reinholz, Giulia K Buchmann, Christoph Dieterich, Michael Potente, Thomas Braun, Phillip Grote, Nicolas Jaé, Michael Sattler, Stefanie Dimmeler
Publicado en: Circulation Research, Edición 130(1), 2022, Página(s) 67-79, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.320029

Inhibition of fatty acid oxidation enables heart regeneration in adult mice

Autores: Xiang Li, Fan Wu, Stefan Günther, Mario Looso, Carsten Kuenne, Ting Zhang, Marion Wiesnet, Stephan Klatt, Sven Zukunft, Ingrid Fleming, Gernot Poschet, Astrid Wietelmann, Ann Atzberger, Michael Potente, Xuejun Yuan, Thomas Braun
Publicado en: Nature, Edición 2023 Oct;622(7983), 2023, Página(s) 619-626, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-023-06585-5

Top-NOTCH Regulation of Cardiac Metabolism

Autores: Radiance Lim, Michael Potente
Publicado en: Circulation, Edición 137/24, 2018, Página(s) 2609-2612, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.118.033669

Endothelial metabolism—more complex (III) than previously thought

Autores: Jorge Andrade, Michael Potente
Publicado en: Nature Metabolism, 2019, ISSN 2522-5812
Editor: Springer Nature
DOI: 10.1038/s42255-018-0019-2

Endothelial Cells Don’t Waste: Endothelial-Derived Lactate Boosts Muscle Regeneration

Autores: Marco Castro, Jorge Andrade, Michael Potente
Publicado en: Developmental Cell, Edición 54/2, 2020, Página(s) 137-139, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2020.06.023

The blood-brain barrier-a metabolic ecosystem

Autores: Marco Castro, Michael Potente
Publicado en: EMBO Journal, Edición 41(9), 2022, Página(s) e111189, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2022111189

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