Combining induced pluripotent stem cells, tissue engineering, optogenetic and chemogenetic concepts for the study and treatment of atrial fibrillation

Project Information

iPS-ChOp-AF

Grant agreement ID: 773181

DOI

10.3030/773181

Project closed

EC signature date 18 February 2018

Start date 1 March 2018

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 988 750,00

EU contribution

€ 1 988 750,00

Coordinated by

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes

Author(s): Idit Goldfracht, Stephanie Protze, Assad Shiti, Noga Setter, Amit Gruber, Naim Shaheen, Yulia Nartiss, Gordon Keller, Lior Gepstein
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13868-x

Cardiac optogenetics: the next frontier

Author(s): Amit Gruber, Oded Edri, Lior Gepstein
Published in: Europace, 2018, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/eux371

Single-Cell Mechanical Analysis of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Testing and Pathophysiological Studies

Author(s): Nimer Ballan, Naim Shaheen, Gordon M. Keller, Lior Gepstein
Published in: Stem Cell Reports, Issue 15/3, 2020, Page(s) 587-596, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.07.006

Chemogenetics for Gene Therapy Based Targeted Cardiac Electrophysiological Modulation

Author(s): Yehuda Wexler, Matteo Ghiringhelli, Naim Shaheen, Shany Glatstein, Irit Huber, Oded Edri, Yousef Abboud, Michal Landesberg, Daniel Shiff, Gil Arbel, Lior Gepstein
Published in: Circulation Research, 2023, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.322041

Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes

Author(s): Lili Wang, Yuko Wada, Nimer Ballan, Jeffrey Schmeckpeper, Jijun Huang, Christoph Daniel Rau, Yibin Wang, Lior Gepstein, Bjorn C. Knollmann
Published in: Journal of Molecular and Cellular Cardiology, 2021, ISSN 0022-2828
Publisher: Academic Press
DOI: 10.1016/j.yjmcc.2021.08.005

Reply to ‘Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?’

Author(s): Assad Shiti, Idit Goldfracht, Naim Shaheen, Stephanie Protze, Lior Gepstein
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21950-6

Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Author(s): Federica Giannetti, Miriam Barbieri, Assad Shiti, Simona Casini, Philip T. Sager, Saumya Das, Sabindra Pradhananga, Dinesh Srinivasan, Saranda Nimani, Nicolò Alerni, Julien Louradour, Manuela Mura, Massimiliano Gnecchi, Paul Brink, Manfred Zehender, Gideon Koren, Antonio Zaza, Lia Crotti, Arthur A.M. Wilde, Peter J. Schwartz, Carol Ann Remme, Lior Gepstein, Luca Sala, Katja E. Odening
Published in: Europace, 2023, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euad094

Optogenetic modulation of cardiac action potential properties may prevent arrhythmogenesis in short and long QT syndromes

Author(s): Amit Gruber, Oded Edri, Irit Huber, Gil Arbel, Amira Gepstein, Assad Shiti, Naim Shaheen, Snizhana Chorna, Michal Landesberg, Lior Gepstein
Published in: JCI Insight, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.147470

Human Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets Expressing Genetically Encoded Voltage Indicator for Pharmacological and Arrhythmia Studies

Author(s): Naim Shaheen, Assad Shiti, Irit Huber, Rami Shinnawi, Gil Arbel, Amira Gepstein, Noga Setter, Idit Goldfracht, Amit Gruber, Snizhanna V. Chorna, Lior Gepstein
Published in: Stem Cell Reports, Issue 10/6, 2018, Page(s) 1879-1894, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2018.04.006

Utilizing human induced pluripotent stem cells to study cardiac electroporation pulsed-field ablation

Author(s): Leonid Maizels, Eyal Heller, Michal Landesberg, Shany Glatstein, Irit Huber, Gil Arbel, Amira Gepstein, Doron Aronson, Shirley Sharabi, Roy Beinart, Amit Segev, Elad Maor, Lior Gepstein
Published in: Circulation Arrhythmia and Electrophysiology, 2024, ISSN 1941-3149
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circep.123.012278

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

Author(s): Idit Goldfracht, Yael Efraim, Rami Shinnawi, Ekaterina Kovalev, Irit Huber, Amira Gepstein, Gil Arbel, Naim Shaheen, Malte Tiburcy, Wolfram H. Zimmermann, Marcelle Machluf, Lior Gepstein
Published in: Acta Biomaterialia, Issue 92, 2019, Page(s) 145-159, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.05.016

Utilizing human induced pluripotent stem cells to study atrial arrhythmias in the short QT syndrome

Author(s): Assad Shiti, Gil Arbel G, Naim Shaheen, Irit Huber, Noga Setter, Lior Gepstein
Published in: Journal of Molecular and Cellular Cardiology, 2023, ISSN 0022-2828
Publisher: Academic Press
DOI: 10.1016/j.yjmcc.2023.08.003

Modeling Reentry in the Short QT Syndrome With Human-Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets

Author(s): Rami Shinnawi; Naim Shaheen; Irit Huber; Assad Shiti; Gil Arbel; Amira Gepstein; Noga Setter; Anke Tijsen; Martin Borggrefe; Lior Gepstein
Published in: Journal of American College of Cardiology, Issue 1, 2019, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2019.02.055

Synthetic cells with self-activating optogenetic proteins communicate with natural cells

Author(s): Omer Adir, Mia R. Albalak, Ravit Abel, Lucien E. Weiss, Gal Chen, Amit Gruber, Oskar Staufer, Yaniv Kurman, Ido Kaminer, Jeny Shklover, Janna Shainsky-Roitman, Ilia Platzman, Lior Gepstein, Yoav Shechtman, Benjamin A. Horwitz, Avi Schroeder.
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29871-8

Extracellular Vesicles From Epicardial Fat Facilitate Atrial Fibrillation

Author(s): Olga Shaihov-Teper, Eilon Ram, Nimer Ballan, Rafael Y. Brzezinski, Nili Naftali-Shani, Rula Masoud, Tamar Ziv, Nir Lewis, Yeshai Schary, La-Paz Levin-Kotler, David Volvovitch, Elchanan M. Zuroff, Sergei Amunts, Neta Regev-Rudzki, Leonid Sternik, Ehud Raanani, Lior Gepstein, Jonathan Leor
Published in: Circulation, 2021, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.052009

Optogenetic Control of Human Induced Pluripotent Stem Cell-Derived Cardiac Tissue Models

Author(s): Amit Gruber, Oded Edri, Shany Glatstein, Idit Goldfracht, Irit Huber, Gil Arbel, Amira Gepstein, Snizhanna Chorna, Lior Gepstein
Published in: Journal of the American Heart Association, 2022, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.121.021615