Combining induced pluripotent stem cells, tissue engineering, optogenetic and chemogenetic concepts for the study and treatment of atrial fibrillation

Informazioni relative al progetto

iPS-ChOp-AF

ID dell’accordo di sovvenzione: 773181

DOI

10.3030/773181

Progetto chiuso

Data della firma CE 18 Febbraio 2018

Data di avvio 1 Marzo 2018

Data di completamento 31 Agosto 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 988 750,00

Contributo UE

€ 1 988 750,00

Coordinato da

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (16)

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes

Autori: Idit Goldfracht, Stephanie Protze, Assad Shiti, Noga Setter, Amit Gruber, Naim Shaheen, Yulia Nartiss, Gordon Keller, Lior Gepstein
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-13868-x

Cardiac optogenetics: the next frontier

Autori: Amit Gruber, Oded Edri, Lior Gepstein
Pubblicato in: Europace, 2018, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/eux371

Single-Cell Mechanical Analysis of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Testing and Pathophysiological Studies

Autori: Nimer Ballan, Naim Shaheen, Gordon M. Keller, Lior Gepstein
Pubblicato in: Stem Cell Reports, Numero 15/3, 2020, Pagina/e 587-596, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2020.07.006

Chemogenetics for Gene Therapy Based Targeted Cardiac Electrophysiological Modulation

Autori: Yehuda Wexler, Matteo Ghiringhelli, Naim Shaheen, Shany Glatstein, Irit Huber, Oded Edri, Yousef Abboud, Michal Landesberg, Daniel Shiff, Gil Arbel, Lior Gepstein
Pubblicato in: Circulation Research, 2023, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.322041

Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes

Autori: Lili Wang, Yuko Wada, Nimer Ballan, Jeffrey Schmeckpeper, Jijun Huang, Christoph Daniel Rau, Yibin Wang, Lior Gepstein, Bjorn C. Knollmann
Pubblicato in: Journal of Molecular and Cellular Cardiology, 2021, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2021.08.005

Reply to ‘Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?’

Autori: Assad Shiti, Idit Goldfracht, Naim Shaheen, Stephanie Protze, Lior Gepstein
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21950-6

Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Autori: Federica Giannetti, Miriam Barbieri, Assad Shiti, Simona Casini, Philip T. Sager, Saumya Das, Sabindra Pradhananga, Dinesh Srinivasan, Saranda Nimani, Nicolò Alerni, Julien Louradour, Manuela Mura, Massimiliano Gnecchi, Paul Brink, Manfred Zehender, Gideon Koren, Antonio Zaza, Lia Crotti, Arthur A.M. Wilde, Peter J. Schwartz, Carol Ann Remme, Lior Gepstein, Luca Sala, Katja E. Odening
Pubblicato in: Europace, 2023, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euad094

Optogenetic modulation of cardiac action potential properties may prevent arrhythmogenesis in short and long QT syndromes

Autori: Amit Gruber, Oded Edri, Irit Huber, Gil Arbel, Amira Gepstein, Assad Shiti, Naim Shaheen, Snizhana Chorna, Michal Landesberg, Lior Gepstein
Pubblicato in: JCI Insight, 2021, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.147470

Human Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets Expressing Genetically Encoded Voltage Indicator for Pharmacological and Arrhythmia Studies

Autori: Naim Shaheen, Assad Shiti, Irit Huber, Rami Shinnawi, Gil Arbel, Amira Gepstein, Noga Setter, Idit Goldfracht, Amit Gruber, Snizhanna V. Chorna, Lior Gepstein
Pubblicato in: Stem Cell Reports, Numero 10/6, 2018, Pagina/e 1879-1894, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2018.04.006

Utilizing human induced pluripotent stem cells to study cardiac electroporation pulsed-field ablation

Autori: Leonid Maizels, Eyal Heller, Michal Landesberg, Shany Glatstein, Irit Huber, Gil Arbel, Amira Gepstein, Doron Aronson, Shirley Sharabi, Roy Beinart, Amit Segev, Elad Maor, Lior Gepstein
Pubblicato in: Circulation Arrhythmia and Electrophysiology, 2024, ISSN 1941-3149
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circep.123.012278

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

Autori: Idit Goldfracht, Yael Efraim, Rami Shinnawi, Ekaterina Kovalev, Irit Huber, Amira Gepstein, Gil Arbel, Naim Shaheen, Malte Tiburcy, Wolfram H. Zimmermann, Marcelle Machluf, Lior Gepstein
Pubblicato in: Acta Biomaterialia, Numero 92, 2019, Pagina/e 145-159, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2019.05.016

Utilizing human induced pluripotent stem cells to study atrial arrhythmias in the short QT syndrome

Autori: Assad Shiti, Gil Arbel G, Naim Shaheen, Irit Huber, Noga Setter, Lior Gepstein
Pubblicato in: Journal of Molecular and Cellular Cardiology, 2023, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2023.08.003

Modeling Reentry in the Short QT Syndrome With Human-Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets

Autori: Rami Shinnawi; Naim Shaheen; Irit Huber; Assad Shiti; Gil Arbel; Amira Gepstein; Noga Setter; Anke Tijsen; Martin Borggrefe; Lior Gepstein
Pubblicato in: Journal of American College of Cardiology, Numero 1, 2019, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2019.02.055

Synthetic cells with self-activating optogenetic proteins communicate with natural cells

Autori: Omer Adir, Mia R. Albalak, Ravit Abel, Lucien E. Weiss, Gal Chen, Amit Gruber, Oskar Staufer, Yaniv Kurman, Ido Kaminer, Jeny Shklover, Janna Shainsky-Roitman, Ilia Platzman, Lior Gepstein, Yoav Shechtman, Benjamin A. Horwitz, Avi Schroeder.
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-29871-8

Extracellular Vesicles From Epicardial Fat Facilitate Atrial Fibrillation

Autori: Olga Shaihov-Teper, Eilon Ram, Nimer Ballan, Rafael Y. Brzezinski, Nili Naftali-Shani, Rula Masoud, Tamar Ziv, Nir Lewis, Yeshai Schary, La-Paz Levin-Kotler, David Volvovitch, Elchanan M. Zuroff, Sergei Amunts, Neta Regev-Rudzki, Leonid Sternik, Ehud Raanani, Lior Gepstein, Jonathan Leor
Pubblicato in: Circulation, 2021, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.052009

Optogenetic Control of Human Induced Pluripotent Stem Cell-Derived Cardiac Tissue Models

Autori: Amit Gruber, Oded Edri, Shany Glatstein, Idit Goldfracht, Irit Huber, Gil Arbel, Amira Gepstein, Snizhanna Chorna, Lior Gepstein
Pubblicato in: Journal of the American Heart Association, 2022, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/jaha.121.021615