Harnessing tumor metabolism to overcome immunosupression

Project Information

ImmunoFit

Grant agreement ID: 773208

DOI

10.3030/773208

Project closed

EC signature date 12 February 2018

Start date 1 July 2018

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 721,00

EU contribution

€ 1 999 721,00

Coordinated by

VIB VZW
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages

Author(s): Alessio Menga, Marina Serra, Simona Todisco, Carla Riera‐Domingo, Ummi Ammarah, Manuel Ehling, Erika M Palmieri, Maria Antonietta Di Noia, Rosanna Gissi, Maria Favia, Ciro L Pierri, Paolo E Porporato, Alessandra Castegna, Massimiliano Mazzone
Published in: EMBO Molecular Medicine, Issue 12/10, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911210

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix

Author(s): Emily J. Kay; Karla Paterson; Carla Riera-Domingo; David Sumpton; J. Henry M. Däbritz; Saverio Tardito; Claudia Boldrini; Juan R. Hernandez-Fernaud; Dimitris Athineos; Sandeep Dhayade; Ekaterina Stepanova; Enio Gjerga; Lisa J. Neilson; Sergio Lilla; Ann Hedley; Grigorios Koulouras; Grace McGregor; Craig Jamieson; Radia Marie Johnson; Morag Park; Kristina Kirschner; Crispin Miller; Jurre J. Kampho
Published in: 2522-5812, Issue 6, 2022, ISSN 2522-5812
Publisher: nature
DOI: 10.1038/s42255-022-00582-0

Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis

Author(s): Massimiliano Mazzone, Gabriele Bergers
Published in: Annual Review of Physiology, Issue 81/1, 2019, Page(s) 535-560, ISSN 0066-4278
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-physiol-020518-114721

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

Author(s): Patricia Altea-Manzano; Ginevra Doglioni; Yawen Liu; Alejandro M. Cuadros; Emma Nolan; Juan Fernández-García; Qi Wu; Mélanie Planque; Kathrin Julia Laue; Florencia Cidre-Aranaz; Xiao-Zheng Liu; Oskar Marin-Bejar; Joke Van Elsen; Ines Vermeire; Dorien Broekaert; Sofie Demeyer; Xander Spotbeen; Jakub Idkowiak; Aurélie Montagne; Margherita Demicco; H. Furkan Alkan; Nick Rabas; Carla Riera-Domingo
Published in: Nature Cancer, Issue 7, 2023, Page(s) 344+, ISSN 2662-1347
Publisher: Nature
DOI: 10.1038/s43018-023-00513-2

Macrophage-derived glutamine boosts satellite cells and muscle regeneration

Author(s): Min Shang, Federica Cappellesso, Ricardo Amorim, Jens Serneels, Federico Virga, Guy Eelen, Stefania Carobbio, Melvin Y. Rincon, Pierre Maechler, Katrien De Bock, Ping-Chih Ho, Marco Sandri, Bart Ghesquière, Peter Carmeliet, Mario Di Matteo, Emanuele Berardi, Massimiliano Mazzone
Published in: Nature, Issue 587/7835, 2020, Page(s) 626-631, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2857-9

MicroRNA-Mediated Metabolic Shaping of the Tumor Microenvironment

Author(s): Federico Virga, Lorena Quirico, Stefania Cucinelli, Massimiliano Mazzone, Daniela Taverna, Francesca Orso
Published in: Cancers, Issue 13/1, 2021, Page(s) 127, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13010127

The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer

Author(s): Rindert Missiaen, Massimiliano Mazzone, Gabriele Bergers
Published in: Seminars in Cancer Biology, Issue 52, 2018, Page(s) 107-116, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2018.06.002

Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding

Author(s): Carla Riera-Domingo; Eduarda Leite-Gomes; Iris Charatsidou; Peihua Zhao; Giovanna Carrá; Federica Cappellesso; Larissa Mourao; Maxim De Schepper; Dana Liu; Jens Serneels; Mohamad-Gabriel Alameh; Vladimir V. Shuvaev; Tatjana Geukens; Edoardo Isnaldi; Hans Prenen; Drew Weissman; Vladimir R. Muzykantov; Stefaan Soenen; Christine Desmedt; Colinda L. G. J. Scheele; Anna Sablina; Mario Di Matteo; Ros
Published in: Science Advances, Issue 3, 2023, ISSN 2375-2548
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.add5028

Stroma-derived miR-214 coordinates tumor dissemination

Author(s): Orso, Francesca; Virga, Federico; Dettori, Daniela; Dalmasso, Alberto; Paradzik, Mladen; Savino, Aurora; Pomatto, Margherita A C; Quirico, Lorena; Cucinelli, Stefania; Coco, Martina; Mareschi, Katia; Fagioli, Franca; Salmena, Leonardo; Camussi, Giovanni; Provero, Paolo; Poli, Valeria; Mazzone, Massimiliano; Pandolfi, Pier Paolo; Taverna, Daniela
Published in: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-23 (2023), Issue 5, 2023, ISSN 1756-9966
Publisher: BMC
DOI: 10.1186/s13046-022-02553-5

Editorial: Macrophage Metabolism and Immune Responses

Author(s): Héctor Rodríguez, Rafael Prados-Rosales, José Luis Lavín3, Massimiliano Mazzone and Juan Anguita
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.01078

N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages.

Author(s): Alessio Menga; Alessio Menga; Maria Favia; Maria Favia; Iolanda Spera; Maria C Vegliante; Rosanna Gissi; Anna De Grassi; Luna Laera; Annalisa Campanella; Andrea Gerbino; Giovanna Carrà; Marcella Canton; Vera Loizzi; Ciro Leonardo Pierri; Gennaro Cormio; Massimiliano Mazzone; Massimiliano Mazzone; Alessandra Castegna
Published in: EMBO Reports, Issue 3, 2021, ISSN 1469-3178
Publisher: Wiley
DOI: 10.15252/embr.202051981

Blood Vessel Proximity Shapes Cancer Cell Metabolism

Author(s): Federico Virga, Manuel Ehling, Massimiliano Mazzone
Published in: Cell Metabolism, Issue 30/1, 2019, Page(s) 16-18, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.06.011

Isolation and separation of murine tumor-associated macrophages (TAMs) subpopulations from orthotopic 4T1 breast tumors

Author(s): Pawel Bieniasz-Krzywiec, Rosa Martín-Pérez, Carla Riera-Domingo, Massimiliano Mazzone
Published in: STAR Protocols, Issue 2/2, 2021, Page(s) 100481, ISSN 2666-1667
Publisher: ScienceDirect
DOI: 10.1016/j.xpro.2021.100481

Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

Author(s): Carla Riera-Domingo, Annette Audigé, Sara Granja, Wan-Chen Cheng, Ping-Chih Ho, Fátima Baltazar, Christian Stockmann, Massimiliano Mazzone
Published in: Physiological Reviews, Issue 100/1, 2020, Page(s) 1-102, ISSN 0031-9333
Publisher: American Physiological Society
DOI: 10.1152/physrev.00018.2019

Impact of Immunometabolism on Cancer Metastasis: A Focus on T Cells and Macrophages

Author(s): Nina C. Flerin, Sotiria Pinioti, Alessio Menga, Alessandra Castegna, Massimiliano Mazzone
Published in: Cold Spring Harbor Perspectives in Medicine, Issue 15Oct2019, 2019, Page(s) a037044, ISSN 2157-1422
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a037044

Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development

Author(s): Marina Serra; Mario Di Matteo; Jens Serneels; Rajesh Pal; Sarah Trusso Cafarello; Martina Lanza; Carlos Sanchez-Martin; Matthias Evert; Alessandra Castegna; Diego Francesco Calvisi; Massimiliano Mazzone; Amedeo Columbano
Published in: Cellular and Molecular Gastroenterology and Hepatolog, Issue 3, 2022, Page(s) 609-624, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.06.003

Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation

Author(s): Federico Virga, Federica Cappellesso, Benoit Stijlemans, Anne-Theres Henze, Rosa Trotta, Jonas Van Audenaerde, Ananda S. Mirchandani, Manuel A. Sanchez-Garcia, Jolien Vandewalle, Francesca Orso, Carla Riera-Domingo, Alberto Griffa, Cristina Ivan, Evelien Smits, Damya Laoui, Fabio Martelli, Lies Langouche, Greet Van den Berghe, Olivier Feron, Bart Ghesquière, Hans Prenen, Claude Libert, Sarah R. W
Published in: Science Advances, Issue 7/19, 2021, Page(s) eabf0466, ISSN 2375-2548
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abf0466

Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer

Author(s): Paweł Bieniasz-Krzywiec, Rosa Martín-Pérez, Manuel Ehling, Melissa García-Caballero, Sotiria Pinioti, Samantha Pretto, Roel Kroes, Chiara Aldeni, Mario Di Matteo, Hans Prenen, María Virginia Tribulatti, Oscar Campetella, Ann Smeets, Agnes Noel, Giuseppe Floris, Jo A. Van Ginderachter, Massimiliano Mazzone
Published in: Cell Metabolism, Issue 30/5, 2019, Page(s) 917-936.e10, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.07.015

Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer : PlexinA4 reguleert cytotoxische T-cel migratie en proliferatie bij kanker

Author(s): Celus, Ward; Oliveira, Ana; Rivis, Silvia; Van Acker, Heleen H; Landeloos, Ewout; Serneels, Jens; Cafarello, Sarah Trusso; Van Herck, Yannick; Mastrantonio, Roberta; Koehler, Arnaud; Garg, Abhishek D; Flamand, Veronique; Tamagnone, Luca; Marine, Jean-Christophe; Di Matteo, Mario; Costa, Bruno M; Bechter, Oliver; Mazzone, Massimiliano
Published in: Cancer Immunology Research, Issue 2, 2022, Page(s) 126-141, ISSN 2326-6066
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-21-0061

B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling

Author(s): Manuel Ehling, Ward Celus, Rosa Martín-Pérez, Roser Alba-Rovira, Sander Willox, Donatella Ponti, Maria C. Cid, Elizabeth A.V. Jones, Giusy Di Conza, Massimiliano Mazzone
Published in: Circulation Research, Issue 127/6, 2020, Page(s) 707-723, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.316071

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer

Author(s): Marina Bacci, Nicla Lorito, Luigi Ippolito, Matteo Ramazzotti, Simone Luti, Simone Romagnoli, Matteo Parri, Francesca Bianchini, Federica Cappellesso, Federico Virga, Qiong Gao, Bruno M. Simões, Elisabetta Marangoni, Lesley-Ann Martin, Giuseppina Comito, Manuela Ferracin, Elisa Giannoni, Massimiliano Mazzone, Paola Chiarugi, Andrea Morandi
Published in: Cell Reports, Issue 28/1, 2019, Page(s) 104-118.e8, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.06.010

Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

Author(s): Federica Cappellesso; Marie-Pauline Orban; Niranjan Shirgaonkar; Emanuele Berardi; Jens Serneels; Marie-Aline Neveu; Daria Di Molfetta; Francesca Piccapane; Rosa Caroppo; Lucantonio Debellis; Tessa Ostyn; Nicolas Joudiou; Lionel Mignion; Elena Richiardone; Bénédicte F. Jordan; Bernard Gallez; Cyril Corbet; Tania Roskams; Ramanuj DasGupta; Sabine Tejpar; Mario Di Matteo; Daniela Taverna; Stephan
Published in: Nature Cancer, Issue 2, 2022, Page(s) 1464-1483, ISSN 2662-1347
Publisher: Nature
DOI: 10.1038/s43018-022-00470-2

Metabolic traits ruling the specificity of the immune response in different cancer types

Author(s): Nina C Flerin, Federica Cappellesso, Samantha Pretto, Massimiliano Mazzone
Published in: Current Opinion in Biotechnology, Issue 68, 2021, Page(s) 124-143, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2020.10.011

Intellectual Property Rights

Other (1)

Combination of P2RY6 inhibitors and immune checkpoint inhibitors

Application/Publication number: GB 2015082.7
Date: 2020-09-24
Applicant(s): VIB VZW

Patent (7)

CD8+ T-CELLS LACKING PLEXINS AND THEIR APPLICATION IN CANCER TREATMENT

Application/Publication number: 20 20064884
Date: 2020-05-28
Applicant(s): VIB VZW

INHIBITION OF SLC4A4 IN THE TREATMENT OF CANCER

Application/Publication number: 22 706595
Date: 2022-02-17
Applicant(s): VIB VZW

PODOPLANIN POSITIVE MACROPHAGES

Application/Publication number: 18 789445
Date: 2018-10-26
Applicant(s): VIB VZW

GLUTAMINE DEHYDROGENASE INHIBITORS FOR USE IN MUSCLE REGENERATION

Application/Publication number: 18 728408
Date: 2018-06-08
Applicant(s): VIB VZW

CANCER TREATMENT BY TARGETING PLEXINS IN THE IMMUNE COMPARTMENT

Application/Publication number: 20 728498
Date: 2020-05-28
Applicant(s): VIB VZW

CD8+ T-CELLS LACKING PLEXINS AND THEIR APPLICATION IN CANCER TREATMENT

Application/Publication number: 20 727681
Date: 2020-05-28
Applicant(s): VIB VZW

BIOMARKER FOR ANTI-TUMOR THERAPY

Application/Publication number: 20 21076314
Date: 2021-09-24
Applicant(s): VIB VZW