Building the product pipeline for commercial demonstration of Plant Molecular Factories

Livrables

GMP guidance

Guidance on GMP compliance in Plant Molecular Farming

Marketed kit

Recombinant protein kit placed on market

Diagnostic kit for sero-negative RA on the market

Public exhibits for PMF

3 public exhibits

Project website

Public and project website

Social media and PMF website established

Social media strategies and setup of an overarching public website for Plant Molecular Farming (not to be confused with the project website).

Publications

Improving yield of a recombinant biologic in a Brassica hairy root manufacturing process

Auteurs: Noemi Gutierrez-Valdes, Suvi T. Häkkinen, Camille Lemasson, Jonas de Groot, Jean-Pierre Ele-Ekouna, Marina Guillet, Florian Cardon, Anneli Ritala
Publié dans: Biotechnology and Bioengineering, Numéro 00063592, 2022, Page(s) 2831-2841, ISSN 0006-3592
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28178

Identification of N-glycan oligomannoside isomers in the diatom Phaeodactylum tricornutum

Auteurs: Rodolphe Dumontier, Corinne Loutelier-Bourhis, Marie-Laure Walet-Balieu, Carole Burel, Alain Mareck, Carlos Afonso, Patrice Lerouge, Muriel Bardor
Publié dans: Carbohydrate Polymers, Numéro 259, 2021, Page(s) 117660, ISSN 0144-8617
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2021.117660

A simplified techno‐economic model for the molecular pharming of antibodies

Auteurs: Pere Mir‐Artigues, Richard M. Twyman, Derry Alvarez, Pedro Cerda Bennasser, Merce Balcells, Paul Christou, Teresa Capell
Publié dans: Biotechnology and Bioengineering, Numéro 116/10, 2019, Page(s) 2526-2539, ISSN 0006-3592
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27093

N- and O-Glycosylation Pathways in the Microalgae Polyphyletic Group

Auteurs: Elodie Mathieu-Rivet, Narimane Mati-Baouche, Marie-Laure Walet-Balieu, Patrice Lerouge, Muriel Bardor
Publié dans: Frontiers in Plant Science, Numéro 11, 2020, ISSN 1664-462X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fpls.2020.609993

Hairy Root Cultures—A Versatile Tool With Multiple Applications

Auteurs: Noemi Gutierrez-Valdes, Suvi T. Häkkinen, Camille Lemasson, Marina Guillet, Kirsi-Marja Oksman-Caldentey, Anneli Ritala, Florian Cardon
Publié dans: Frontiers in Plant Science, Numéro 11, 2020, ISSN 1664-462X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fpls.2020.00033

The concept of an agroinfiltration kit for recombinant protein production for educational and commercial use—A journey through a forest of regulatory and legal implications

Auteurs: Holger Spiegel, Greta Nölke, Harry Thangaraj and Stefan Schillberg
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 22964185, 2022, ISSN 2296-4185
Éditeur: Frontiers SA
DOI: 10.3389/fbioe.2022.926239

Pilot Production of SARS-CoV-2 Related Proteins in Plants: A Proof of Concept for Rapid Repurposing of Indoor Farms Into Biomanufacturing Facilities

Auteurs: Borja Diego-Martin, Beatriz González, Marta Vazquez-Vilar, Sara Selma, Rubén Mateos-Fernández, Silvia Gianoglio, Asun Fernández-del-Carmen, Diego Orzáez
Publié dans: Frontiers in Plant Science, Numéro 11, 2020, ISSN 1664-462X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fpls.2020.612781

Production and use of encapsidated RNA mimics as positive control reagents for SARS-CoV-2 RT-qPCR diagnostics

Auteurs: Hadrien Peyret, Elisabetta Groppelli, David Clark, Nicholas Eckersley, Tim Planche, Julian Ma, George P. Lomonossoff
Publié dans: Journal of Virological Methods, Numéro 01660934, 2022, ISSN 0166-0934
Éditeur: Elsevier BV
DOI: 10.1016/j.jviromet.2021.114372

Plant Molecular Farming as a Strategy Against COVID-19 - The Italian Perspective

Auteurs: Chiara Lico; Luca Santi; Selene Baschieri; Emanuela Noris; Carla Marusic; Marcello Donini; Emanuela Pedrazzini; Giovanni Maga; Rosella Franconi; Paola Di Bonito; Linda Avesani
Publié dans: Frontiers in plant science 11 (2020). doi:10.3389/fpls.2020.609910, Numéro 2, 2020, ISSN 1664-462X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fpls.2020.609910

Physicochemical characterization of the recombinant lectin scytovirin and microbicidal activity of the SD1 domain produced in rice against HIV‑1

Auteurs: Victoria Armario-Najera, Amaya Blanco-Perera, Shilpa R. Shenoy, Yi Sun, Silvia Marfil, Jordana Muñoz-Basagoiti, Daniel Perez-Zsolt, Julià Blanco, Nuria Izquierdo-Useros, Teresa Capell, Barry R. O’Keefe & Paul Christou
Publié dans: Plant Cell Reports, 2022, Page(s) 1013-1023, ISSN 0721-7714
Éditeur: Springer Verlag
DOI: 10.1007/s00299-022-02834-5

Investigation of a monoclonal antibody against enterotoxigenic Escherichia coli, expressed as secretory IgA1 and IgA2 in plants

Auteurs: Audrey Y-H Teh,Lisa Cavacini,Yue Hu,Ozan S. Kumru,Jian Xiong,David T. BolickORCID Icon,Sangeeta B. Joshi,Clemens Grünwald-Gruber,Friedrich Altmann,Mark Klempner,Richard L. Guerrant,David B. Volkin, Yang Wang and Julian K-C. Ma
Publié dans: Gut Microbes, Numéro volume 13 issue 1, 2021, Page(s) 1-14, ISSN 1949-0984
Éditeur: Taylor Francis online
DOI: 10.1080/19490976.2020.1859813

A Replicating Viral Vector Greatly Enhances Accumulation of Helical Virus-Like Particles in Plants

Auteurs: Eva C. Thuenemann, Matthew J. Byrne, Hadrien Peyret, Keith Saunders, Roger Castells-Graells ,Inmaculada Ferriol, Mattia Santoni, John F. C. Steele, Neil A. Ranson, Linda Avesani, Juan Jose Lopez-Moya and George P. Lomonossoff
Publié dans: Viruses, 2021, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13050885

Plant Virus Nanoparticles for Vaccine Applications

Auteurs: Mattia Santoni, Roberta Zampieri, Linda Avesani
Publié dans: Current Protein & Peptide Science, Numéro 21/4, 2020, Page(s) 344-356, ISSN 1389-2037
Éditeur: Bentham Science Publishers
DOI: 10.2174/1389203721666200212100255

Multiple gene expression in plants using MIDAS-P, a versatile type II restriction-based modular expression vector.

Auteurs: Elizabeth C. Pinneh, Craig J. van Dolleweerd, Kathrin Göritzer, Pascal M. W. Drake, Julian K-C. Ma, Audrey Y-H. Teh
Publié dans: Biotechnology and Bioengineering, 2022, ISSN 0006-3592
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28073

Identification of Transgene-Free CRISPR-Edited Plants of Rice, Tomato, and Arabidopsis by Monitoring DsRED Fluorescence in Dry Seeds

Auteurs: Norma Aliaga-Franco1, Cunjin Zhang2, Silvia Presa1, Anjil K. Srivastava2, Antonio Granell1, David Alabadí1, Ari Sadanandom2, Miguel A. Blázquez1 and Eugenio G. Minguet1*
Publié dans: Fronteirs in Plant Science, 2019, ISSN 1664-462x
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fpls.2019.01150

Contributions of the international plant science community to the fight against human infectious diseases – part 1: epidemic and pandemic diseases

Auteurs: Lobato, Maria; Huang, Xin; Alvarez, Derry; He, Wenshu; Baysal, Can; Zhu, Changfu; Armario-Nájera, Victoria; Blanco Perera, Amaya; Cerda, Pedro; Saba-Mayoral, Andrea; Sobrino-Mengual, Guillermo; Vargheese, Ashwin; Abranches, Rita; Abreu, Isabel Alexandra; Balamurugan, Shanmugaraj; Bock, Ralph; Buyel, Johannes F.; Cunha, Nicolau B. da; Daniell, Henry; Faller, Roland; Folgado, André; Gowtham, Iyapp
Publié dans: Plant Biotechnology Journal, 2021, Page(s) 1901-1920, ISSN 1467-7644
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pbi.13657

Potential Applications of Plant Biotechnology against SARS-CoV-2

Auteurs: Teresa Capell, Richard M. Twyman, Victoria Armario-Najera, Julian K.-C. Ma, Stefan Schillberg, Paul Christou
Publié dans: Trends in Plant Science, Numéro 25/7, 2020, Page(s) 635-643, ISSN 1360-1385
Éditeur: Elsevier BV
DOI: 10.1016/j.tplants.2020.04.009

Investigation of the N-Glycosylation of the SARS-CoV-2 S Protein Contained in VLPs Produced in Nicotiana benthamiana

Auteurs: Juliette Balieu, Jae-Wan Jung, Philippe Chan, George P. Lomonossoff, Patrice Lerouge, and Muriel Bardor
Publié dans: Molecules, Numéro 27, 2022, Page(s) 5119, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27165119

Comparative Proteomic Analysis of the Diatom Phaeodactylum tricornutum Reveals New Insights Into Intra- and Extra-Cellular Protein Contents of Its Oval, Fusiform, and Triradiate Morphotypes

Auteurs: Coralie Chuberre, Philippe Chan, Marie-Laure Walet-Balieu, François Thiébert, Carole Burel, Julie Hardouin, Bruno Gügi and Muriel Bardor
Publié dans: Frontiers in Plant Science, 2022, ISSN 1664-462X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fpls.2022.673113

Plant-based expression and characterization of SARS-CoV-2 virus-like particles presenting a native spike protein

Auteurs: Jae-Wan Jung, Gergana Zahmanova, Ivan Minkov, George P. Lomonossoff
Publié dans: Plant Biotechnology Journal, Numéro 20, 2022, ISSN 1467-7644
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pbi.13813

Towards understanding the extensive diversity of protein N-glycan structures in eukaryotes

Auteurs: Charlotte Toustou, Marie-Laure Walet-Balieu, Marie-Christine Kiefer-Meyer, Marine Houdou, Patrice Lerouge, François Foulquier, Muriel Bardor
Publié dans: Biological Reviews, Numéro 14647931, 2021, Page(s) 732-748, ISSN 1464-7931
Éditeur: Cambridge University Press
DOI: 10.1111/brv.12820

Shotguns vs Lasers: Identifying barriers and facilitators to scaling-up plant molecular farming for high-value health products.

Auteurs: Jonathan Menary; Matthew Hobbs; Sara Mesquita de Albuquerque; Agata Pacho; Pascal M. W. Drake; Alison Prendiville; Julian K-C. Ma; Sebastian S. Fuller
Publié dans: PLos One, Numéro 2, 2020, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.31235/osf.io/gwve2

The Use of a Replicating Virus Vector For in Planta Generation of Tobacco Mosaic Virus Nanorods Suitable For Metallization

Auteurs: Keith Saunders, Eva C. Thuenemann, Sachin N. Shah, Hadrien Peyret, Ruth Kristianingsih, Sergio G. Lopez, Jake Richardson and George P. Lomonossoff
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 22964185, 2022, ISSN 2296-4185
Éditeur: Frontiers SA
DOI: 10.3389/fbioe.2022.877361

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm

Auteurs: Evangelia Vamvaka, Gemma Farré, Luis M. Molinos-Albert, Abbey Evans, Anna Canela-Xandri, Richard M. Twyman, Jorge Carrillo, Raziel A. Ordóñez, Robin J. Shattock, Barry R. O’Keefe, Bonaventura Clotet, Julian Blanco, Gurdev S. Khush, Paul Christou, Teresa Capell
Publié dans: Proceedings of the National Academy of Sciences, Numéro 115/33, 2018, Page(s) E7854-E7862, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1806022115

Optimizing product quality in molecular farming

Auteurs: Andreas Schiermeyer
Publié dans: Current Opinion in Biotechnology, Numéro 61, 2020, Page(s) 15-20, ISSN 0958-1669
Éditeur: Elsevier BV
DOI: 10.1016/j.copbio.2019.08.012

Engineering the interactions between a plant‐produced HIV antibody and human Fc receptors

Auteurs: Szymon Stelter, Mathew J. Paul, Audrey Y.‐H. Teh, Melanie Grandits, Friedrich Altmann, Jessica Vanier, Muriel Bardor, Alexandra Castilho, Rachel Louise Allen, Julian K‐C. Ma
Publié dans: Plant Biotechnology Journal, Numéro 18/2, 2019, Page(s) 402-414, ISSN 1467-7644
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pbi.13207

Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants

Auteurs: Catherine M. Moore, Melanie Grandits, Clemens Grünwald-Gruber, Friedrich Altmann, Maria Kotouckova, Audrey Y.-H. Teh & Julian K.-C. Ma
Publié dans: Retrovirology, Numéro 18, 2021, ISSN 1742-4690
Éditeur: BioMed Central
DOI: 10.21203/rs.3.rs-104508/v1

Molecular Pharming for low and middle income countries

Auteurs: Sheeba Murad, Sebastian Fuller, Jonathan Menary, Cathy Moore, Elizabeth Pinneh, Tim Szeto, Inga Hitzeroth, Marcos Freire, Suthira Taychakhoonavudh, Waranyoo Phoolcharoen, Julian K-C Ma
Publié dans: Current Opinion in Biotechnology, Numéro 61, 2020, Page(s) 53-59, ISSN 0958-1669
Éditeur: Elsevier BV
DOI: 10.1016/j.copbio.2019.10.005

Comparative Structural and Functional Analyses of the Fusiform, Oval, and Triradiate Morphotypes of Phaeodactylum tricornutum Pt3 Strain.

Auteurs: Galas, Ludovic; Burel, Carole; Schapman, Damien; Ropitaux, Marc; Bernard, Sophie; Bénard, Magalie; Bardor, Muriel
Publié dans: Frontiers in Plant Science, Numéro 2, 2021, ISSN 1664-462X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fpls.2021.638181

Contributions of the international plant science community to the fight against infectious diseases in humans-part 2: Affordable drugs in edible plants for endemic and re-emerging diseases.

Auteurs: He, Wenshu; Baysal, Can; Lobato, Maria; Huang, Xin; Alvarez, Derry; Zhu, Changfu; Armario-Nájera, Victoria; Blanco Perera, Amaya; Cerda, Pedro; Saba-Mayoral, Andrea; Sobrino-Mengual, Guillermo; Vargheese, Ashwin; Abranches, Rita; Abreu, Isabel Alexandra; Balamurugan, Shanmugaraj; Bock, Ralph; Buyel, Johannes F.; Cunha, Nicolau B. da; Daniell, Henry; Faller, Roland; Folgado, André; Gowtham, Iyapp
Publié dans: Plant Biotechnology Journal, 2021, Page(s) 1921-1936, ISSN 1467-7644
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pbi.13658

Plant molecular farming for the production of valuable proteins – Critical evaluation of achievements and future challenges

Auteurs: Stefan Schillberg, Ricarda Finnern
Publié dans: Journal of Plant Physiology, Numéro 258-259, 2021, Page(s) 153359, ISSN 0176-1617
Éditeur: Elsevier BV
DOI: 10.1016/j.jplph.2020.153359

Development of Fast and Portable Frequency Magnetic Mixing-Based Serological SARS-CoV-2-Specific Antibody Detection Assay

Auteurs: Jan Pietschmann1*†, Nadja Voepel1†, Leonie Voß1, Stefan Rasche1, Max Schubert1, Michael Kleines2, Hans-Joachim Krause3, Tamlyn M. Shaw4, Holger Spiegel1‡ and Florian Schroeper1‡
Publié dans: Frontiers in Microbiology, 2021, ISSN 1664-302x
Éditeur: Frontiers Media
DOI: 10.3389/fmicb.2021.643275

Critical Analysis of the Commercial Potential of Plants for the Production of Recombinant Proteins

Auteurs: Stefan Schillberg, Nicole Raven, Holger Spiegel, Stefan Rasche, Matthias Buntru
Publié dans: Frontiers in Plant Science, Numéro 10, 2019, ISSN 1664-462X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fpls.2019.00720

Production of Recombinant Proteins by Agrobacterium-Mediated Transient Expression

Auteurs: Holger Spiegel, Stefan Schillberg & Greta Nölke
Publié dans: Methods in Molecular Biology - Recombinant Proteins in Plants, Numéro 10643745, 2022, Page(s) 89-102, ISSN 1064-3745
Éditeur: Humana Press, Inc.
DOI: 10.1007/978-1-0716-2241-4_6

Project proximities: A meta review of how design addresses distance in complex collaborations

Auteurs: Rosie Hornbuckle
Publié dans: Lockton, D., Lenzi, S., Hekkert, P., Oak, A., Sádaba, J., Lloyd, P. (eds.), DRS2022: Bilbao, 25 June - 3 July, Bilbao, Spain, 2022
Éditeur: Design Research Society
DOI: 10.21606/drs.2022.677

Beyond Science Communication: a service design approach to building mutual stakeholder understanding in the development of novel biotechnologies.

Auteurs: Hornbuckle, Rosie and Grimaldi, Silvia and Prendiville, Alison
Publié dans: Proceedings of the 6th conference on Design4Health. 2020 Lab4Living, Sheffield Hallam University, 2020, Page(s) 230-238, ISBN 978-1-8381117-0-0
Éditeur: Sheffield Hallam University
DOI: 10.5281/zenodo.7188867

Pilot production of SARS-CoV-2 related proteins in plants: a proof of concept for rapid repurposing of indoors farms into biomanufacturing facilities

Auteurs: Diego-Martin, Borja; González Beatriz; Vázquez Vilar, Marta; Selma, Sara; Mateos-Fernández, Rubén; Gianoglio, Silvia; Fernández-del-Carmen, Asun; Orzáez, Diego
Publié dans: BioRxiv, 2020, ISSN 2692-8205
Éditeur: cold spring harbor laboratory
DOI: 10.1101/2020.10.13.331306

Droits de propriété intellectuelle

METHODS FOR THE IMPROVED RECOVERY OF SECRETED COMPOUNDS IN A HAIRY ROOTS-BASED EXPRESSION SYSTEM

Numéro de demande/publication: 20 21083070
Date: 2021-11-25

METHOD FOR ESTIMATING THE BIOMASS OF HAIRY ROOTS IN A MULTI-PHASIC CULTURE

Numéro de demande/publication: 20 22067056
Date: 2022-06-22

Product composed of a large-scale bioreactor specifically developed for hairy root growth

Numéro de demande/publication: FR 22 305 436.2
Date: 2022-04-11

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