Skip to main content

IN-Silico trials for treatment of acute Ischemic STroke

Objective

Stroke is the number one cause of disability in the Western world and the 3rd most common cause of death. Despite new treatment options with intra-arterial thrombectomy, still 2 out of 3 patients still have a poor outcome. The main goal of INSIST is to advance treatments of ischemic stroke and its introduction in clinical practice by realizing in silico clinical stroke trials in which stroke and treatment are modeled. We will generate virtual populations of stroke patients, generate and validate in silico models for intra-arterial thrombectomy, thrombosis and thrombolysis, and microvascular perfusion and neurological deterioration after stroke, and integrate the in silico models to realize an in silico clinical stroke trial. We are uniquely positioned by the availability of a large pool of clinical, imaging, histopathological, and outcome data from multiple recently finalized stroke trials, a large registry (totaling 4500 patients), and new trials that will start later this year (totaling 2500 patients). We will build a population model that takes this input to generate virtual populations of stroke patients addressing the wide variety of patient characteristics. We will build on existing and emerging in silico models to validate reusable models for stroke and stroke treatment with a strong interaction with experimenting modeling in laboratories. The in silico models and virtual populations will be combined to simulate clinical trials and validated by simulating and comparing finalized and currently running trials. The in silico models will be used to simulate clinical trials to evaluate effectiveness and safety of novel devices and medication, both for the device as well as the pharmacological industry. For the device industry, we will evaluate the optimal configuration of thrombectomy stents for reduction of thrombus fragmentation. From the perspective of the pharmacy industry, we will simulate the effect of increased TAFIa on the effectiveness of alteplase.

Field of science

  • /medical and health sciences/basic medicine/neurology/stroke
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug
  • /medical and health sciences/basic medicine/pharmacology and pharmacy

Call for proposal

H2020-SC1-2017-CNECT-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 908 085

Participants (10)

UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 545 750
Address
Spui 21
1012WX Amsterdam
Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 717 500
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 568 125
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
NEURAVI LIMITED
Ireland
EU contribution
€ 416 275
Address
Block 3 Ballybrit Business Park
H91 K5YD Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 425 365
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 462 500
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
POLITECNICO DI MILANO
Italy
EU contribution
€ 349 600
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 771 975
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
France
EU contribution
€ 85 500
Address
Rue Carnot 50
92284 Suresnes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
M.V. LOMONOSOV MOSCOW STATE UNIVERSITY
Russia
EU contribution
€ 0
Address
Leninskie Gory
119992 Moscow
Activity type
Higher or Secondary Education Establishments