Deliverables Documents, reports (25) Periodic reporting period 3 Periodic technical reports and periodic financial and ethical reports for the ECMonth 54 is Period end report is due month 56 Outcome of in silico trials Outcome of in silico trials Final report on all available models with full validation data for thrombosis and thrombolysis including the description of the increased understanding of the pathophysiological aspects of thrombosis and thrombolysis Final report on all available models with full validation data for thrombosis and thrombolysis including the description of the increased understanding of the pathophysiological aspects of thrombosis and thrombolysisThis deliverables is not just a report but will also deliver the associated models as simulation software eg to WP6 Periodic report period 2 Periodic technical reports and periodic financial and ethical reports for the EC Report is due month 38 Validated in silico trial platform Validated in silico trial platform Implementation of full 3D characterized models Implementation of full 3D characterized models Initial integration of all models Initial integration of all models Finite element meshes of patient specific clot and vessel geometries Finite element meshes of patient specific clot and vessel geometries Second report on models for advanced versions thrombosis and thrombolysis and combined model including validation and the formal VVUQ and reports on the experiments carried out during the second 18 months of the project Second report on models for advanced versions thrombosis and thrombolysis and combined model including validation and the formal VVUQ and reports on the experiments carried out during the second 18 months of the project. This deliverables is not just a report, but will also deliver the associated models as simulation software (e.g. to WP6). Implementation of individual models of interaction Implementation of individual models of interaction Quality Assurance Plan Quality Assurance Plan to manage the quality control including a detailed risk analysis and contingency planning In silico model for mechanical performance of thrombectomy devices In silico model for mechanical performance of thrombectomy devices Project Handbook Project Handbook to ensure consistent implementation of the management Implementation of model of microvascular damage Implementation of model of microvascular damage Data Management Plan template Data Management Plan template Validation of models with clinical data Validation of models with clinical data Data base of composition-specific clot mechanical properties and a new constitutive law for clots Data base of composition-specific clot mechanical properties and a new constitutive law for clots Modelling platform for simulation of thrombectomy performance in patient specific models Modelling platform for simulation of thrombectomy performance in patient specific models First public version of a population model to generate virtual populations First public version of a population model to generate virtual populations Initial report on dissemination, exploitation and sustainability plan Initial report on dissemination, exploitation and sustainability plan with a detailed plan and schedule for all dissemination, communication, and exploitation activities. The plan will be delivered in M3, and updated to coincide with reporting period Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6) Periodic reporting Periodic technical reports and periodic financial and ethical reports for the EC. Report is due month 20 Implementation of VVUQ procedures and initial validation exercises on integrated models Implementation of VVUQ procedures and initial validation exercises on integrated models An in silico clinical stroke trial computing environment An in silico clinical stroke trial computing environment First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments. This deliverables is not just a report, but will also deliver the associated models as simulation software (e.g. to WP6). Consortium Agreement Consortium Agreement Websites, patent fillings, videos etc. (3) Second report on dissemination, communication and sustainability Second dissemination, communication and sustainability report. Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6) First report on dissemination, communication and sustainability First dissemination, communication and sustainability report, with a review of events dissemination, communication, and exploitation results including an update of dissemination, communication, and exploitation action plan Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6) Final dissemination, communication and sustainability report Final dissemination communication and sustainability report with a review of the events and dissemination communication and exploitation results and reports on postproject plans for exploitations of INSIST M54Note All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management WP1 and the template for Data Management Plan D16 Other (2) First version of a virtual population of stroke patients (Module I) First version of a virtual population of stroke patients (Module I) Final Statistical model that relates images features of clot to clot characteristics Final statistical model that relates images features of clot to clot characteristics Publications Peer reviewed articles (56) Early recanalization in large-vessel occlusion stroke patients transferred for endovascular treatment Author(s): Nerea Arrarte Terreros, Agnetha A E Bruggeman, Isabella S J Swijnenburg, Laura C C van Meenen, Adrien E Groot, Jonathan M Coutinho, Yvo B W E M Roos, Bart J Emmer, Ludo F M Beenen, Ed van Bavel, Henk A Marquering, Charles B L M Majoie Published in: Journal of NeuroInterventional Surgery, 2021, Page(s) neurintsurg-2021-017441, ISSN 1759-8478 Publisher: BMJ Publishing Group DOI: 10.1136/neurintsurg-2021-017441 A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke Author(s): T. I. Józsa, R. M. Padmos, N. Samuels, W. K. El-Bouri, A. G. Hoekstra, S. J. Payne Published in: Interface Focus, 11/1, 2021, Page(s) 20190127, ISSN 2042-8898 Publisher: Royal Society Publishing DOI: 10.1098/rsfs.2019.0127 Impact of the Internal Carotid Artery Morphology on in silico Stent-Retriever Thrombectomy Outcome Author(s): Sara Bridio, Giulia Luraghi, Jose F. Rodriguez Matas, Gabriele Dubini, Giorgia G. Giassi, Greta Maggio, Julia N. Kawamoto, Kevin M. Moerman, Patrick McGarry, Praneeta R. Konduri, Nerea Arrarte Terreros, Henk A. Marquering, Ed van Bavel, Charles B. L. M. Majoie, Francesco Migliavacca Published in: Frontiers in Medical Technology, 3, 2021, ISSN 2673-3129 Publisher: Frontiers Media SA DOI: 10.3389/fmedt.2021.719909 Blood clot fracture properties are dependent on red blood cell and fibrin content Author(s): B. Fereidoonnezhad; Anushree Dwivedi; Sarah E. Johnson; Ray McCarthy; Patrick McGarry Published in: Acta Biomaterialia, 7, 2021, Page(s) 213-228, ISSN 1742-7061 Publisher: Elsevier BV DOI: 10.1101/2020.10.05.326165 Bifurcation occlusions and endovascular treatment outcome in acute ischemic stroke Author(s): Nerea Arrarte Terreros, Agnetha A E Bruggeman, Henk van Voorst, Praneeta R Konduri, Ivo G H Jansen, Manon Kappelhof, Manon L Tolhuisen, Nikki Boodt, Diederik W J Dippel, Aad van der Lugt, Wim H van Zwam, Robert J van Oostenbrugge, H. Bart van der Worp, Bart J Emmer, Frederick J A Meijer, Yvo B W E M Roos, Ed van Bavel, Henk A Marquering, Charles B L M Majoie MR CLEAN Registry investigators Published in: journal of NeuroInterventional Surgery, 2022, ISSN 1759-8486 Publisher: BMJ DOI: 10.1136/neurintsurg-2021-018560 Redistribution of TPA Fluxes in the Presence of PAI-1 Regulates Spatial Thrombolysis Author(s): Alexey M. Shibeko, Bastien Chopard, Alfons G. Hoekstra, Mikhail A. Panteleev Published in: Biophysical Journal, 119/3, 2020, Page(s) 638-651, ISSN 0006-3495 Publisher: Biophysical Society DOI: 10.1016/j.bpj.2020.06.020 Mechanical Characterization of Thrombi Retrieved With Endovascular Thrombectomy in Patients With Acute Ischemic Stroke Author(s): Nikki Boodt, Philip R.W. Snouckaert van Schauburg, Hajo M. Hund, Behrooz Fereidoonnezhad, J. Patrick McGarry, Ali C. Akyildiz, Adriaan C.G.M. van Es, Simon F. De Meyer, Diederik W.J. Dippel, Hester F. Lingsma, Heleen M.M. van Beusekom, Aad van der Lugt, Frank J.H. Gijsen Published in: Stroke, 52/8, 2021, Page(s) 2510-2517, ISSN 0039-2499 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/strokeaha.120.033527 Red blood cell and platelet diffusivity and margination in the presence of cross-stream gradients in blood flows Author(s): Gábor Závodszky, Britt van Rooij, Ben Czaja, Victor Azizi, David de Kanter, Alfons G. Hoekstra Published in: Physics of Fluids, 31/3, 2019, Page(s) 031903, ISSN 1070-6631 Publisher: American Institute of Physics DOI: 10.1063/1.5085881 Investigating the Mechanical Behavior of Clot Analogues Through Experimental and Computational Analysis Author(s): Sarah Johnson, Ray McCarthy, Michael Gilvarry, Peter E. McHugh, J. Patrick McGarry Published in: Annals of Biomedical Engineering, 49/1, 2021, Page(s) 420-431, ISSN 0090-6964 Publisher: Kluwer Academic Publishers DOI: 10.1007/s10439-020-02570-5 Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance Author(s): Senna Staessens, Frederik Denorme, Olivier Francois, Linda Desender, Tom Dewaele, Peter Vanacker, Hans Deckmyn, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer Published in: Haematologica, 105/2, 2020, Page(s) 498-507, ISSN 0390-6078 Publisher: Ferrata Storti Foundation DOI: 10.3324/haematol.2019.219881 Occult blood flow patterns distal to an occluded artery in acute ischemic stroke Author(s): Nerea Arrarte Terreros; Bettine G. van Willigen; Wera S. Niekolaas; Manon L. Tolhuisen; Josje Brouwer; Jonathan M. Coutinho; Ludo F. M. Beenen; Charles B. L. Majoie; Ed van Bavel; Henk A. Marquering Published in: J Cereb Blood Flow Metab., 42, 2022, Page(s) 292-302, ISSN 0271-678X Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1177/0271678x211044941 Applicability analysis to evaluate credibility of an in silico thrombectomy procedure Author(s): Giulia Luraghi, Sara Bridio, Claire Miller, Alfons Hoekstra, Jose Felix Rodriguez Matas, Francesco Migliavacca Published in: Journal of Biomechanics, 126, 2021, Page(s) 110631, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110631 Modelling the leptomeningeal collateral circulation during acute ischaemic stroke Author(s): Raymond M. Padmos, Nerea Arrarte Terreros, Tamás I. Józsa, Gábor Závodszky, Henk A. Marquering, Charles B.L.M. Majoie, Alfons G. Hoekstra Published in: Medical Engineering & Physics, 91, 2021, Page(s) 1-11, ISSN 1350-4533 Publisher: Elsevier BV DOI: 10.1016/j.medengphy.2021.03.003 The Ageing Brain: Investigating the Role of Age in Changes to the Human Cerebral Microvasculature With an in silico Model Author(s): Barnaby J. Graff; Stephen J. Payne; Wahbi K. El-Bouri; Wahbi K. El-Bouri; Wahbi K. El-Bouri Published in: Frontiers in Aging Neuroscience, 8, 2021, ISSN 1663-4365 Publisher: Frontiers Research Foundation DOI: 10.3389/fnagi.2021.632521 The first virtual patient-specific thrombectomy procedure Author(s): Giulia Luraghi, Sara Bridio, Jose Felix Rodriguez Matas, Gabriele Dubini, Nikki Boodt, Frank J.H. Gijsen, Aad van der Lugt, Behrooz Fereidoonnezhad, Kevin M. Moerman, Patrick McGarry, Praneeta R. Konduri, Nerea Arrarte Terreros, Henk A. Marquering, Charles B.L.M. Majoie, Francesco Migliavacca Published in: Journal of Biomechanics, 126, 2021, Page(s) 110622, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110622 In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke Author(s): Giulia Luraghi, Rachel M.E. Cahalane, Emma van de Ven, Serena C.M. Overschie, Frank J.H. Gijsen, Ali C. Akyildiz Published in: Journal of Biomechanics, 127, 2021, Page(s) 110693, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110693 A new constitutive model for permanent deformation of blood clots with application to simulation of aspiration thrombectomy Author(s): Behrooz Fereidoonnezhad, Patrick McGarry Published in: Journal of Biomechanics, 130, 2022, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110865 Is modeling stents still an important issue? Author(s): Francesco Migliavacca Published in: Procedia Structural Integrity, 15, 2019, Page(s) 46-50, ISSN 2452-3216 Publisher: Elsevier DOI: 10.1016/j.prostr.2019.07.009 A new anisotropic soft tissue model for elimination of unphysical auxetic behaviour Author(s): B. Fereidoonnezhad, C. O’Connor, J.P. McGarry Published in: Journal of Biomechanics, 111, 2020, Page(s) 110006, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2020.110006 A review on the association of thrombus composition with mechanical and radiological imaging characteristics in acute ischemic stroke. Author(s): Rachel Cahalane, Nikki Boodt, Ali Cagdas Akyildiz, Jo-anne Giezen, Manouk Mondeel, Aad van der Lugt, Henk Marquering, Frank Gijsen. Published in: Journal of Biomechanics, 129, 2021, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110816 Recovery of Hypoxic Regions in a Rat Model of Microembolism Author(s): Theodosia Georgakopoulou, Anne-Eva van der Wijk, Erik N.T.P. Bakker, Ed vanBavel Published in: Journal of Stroke and Cerebrovascular Diseases, 30/6, 2021, Page(s) 105739, ISSN 1052-3057 Publisher: W. B. Saunders Co., Ltd. DOI: 10.1016/j.jstrokecerebrovasdis.2021.105739 Reliable Numerical Models of Nickel-Titanium Stents: How to Deduce the Specific Material Properties from Testing Real Devices Author(s): Francesca Berti; Sara Bridio; Giulia Luraghi; Sanjay Pant; Dario Allegretti; Giancarlo Pennati; Lorenza Petrini Published in: Ann Biomed Eng., 00906964, 2022, Page(s) 467-481, ISSN 0090-6964 Publisher: Kluwer Academic Publishers DOI: 10.1007/s10439-022-02932-1 Stroke Etiology and Thrombus Computed Tomography Characteristics in Patients With Acute Ischemic Stroke Author(s): Nikki Boodt, Kars C.J. Compagne, Bruna G. Dutra, Noor Samuels, Manon L. Tolhuisen, Heitor C.B.R. Alves, Manon Kappelhof, Geert J. Lycklama à Nijeholt, Henk. A. Marquering, Charles B.L.M. Majoie, Hester F. Lingsma, Diederik W.J. Dippel, Aad van der Lugt, Yvo Roos, Robert van Oostenbrugge, Wim van Zwam, Jelis Boiten, Jan Albert Vos, Ivo Jansen, Maxim Mulder, Robert-Jan Goldhoorn, Wouter Schonewille Published in: Stroke, 51/6, 2020, Page(s) 1727-1735, ISSN 0039-2499 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/strokeaha.119.027749 Blood Pressure in the First 6 Hours Following Endovascular Treatment for Ischemic Stroke Is Associated With Outcome Author(s): Samuels N, van de Graaf RA, van den Berg CAL, Uniken Venema SM, Bala K, van Doormaal PJ, van der Steen W, Witvoet E, Boiten J, den Hertog H, Schonewille WJ, Hofmeijer J, Schreuder F, Schreuder TAHCML, van der Worp HB, Roos YBWEM, Majoie CBLM, Burke JF, van Es ACGM, van der Lugt A, Roozenbeek B, Lingsma HF, Dippel DWJ; MR CLEAN Registry Investigators. Published in: Stroke., 20479980, 2021, Page(s) 3514-3522, ISSN 2047-9980 Publisher: Wiley-Blackwell DOI: 10.1161/strokeaha.120.033657 Perivascular Clearance of Blood Proteins after Blood-Brain Barrier Disruption in a Rat Model of Micro-Infarcts Author(s): Theodosia Georgakopoulou; Anne-Eva van der Wijk; Ed van Bavel; Erik N.T.P. Bakker Published in: Microvascular research, Volume 148, July 2023, 2023, Page(s) 104515, ISSN 1751-6161 Publisher: Elsevier BV DOI: 10.2139/ssrn.4292893 Automated final lesion segmentation in posterior circulation acute ischemic stroke using deep learning Author(s): Riaan Zoetmulder; Praneeta R Konduri; Iris V Obdeijn; Efstratios Gavves; Ivana Išgum; Charles B. L. M. Majoie; Diederik W.J. Dippel; Yvo B.W.E.M. Roos; Mayank Goyal; Mayank Goyal; Peter Mitchell; Bruce C.V. Campbell; Demetrius K. Lopes; Gernot Reimann; Tudor G Jovin; Jeffrey L. Saver; Keith W. Muir; Phil White; Serge Bracard; Bailiang Chen; Scott Brown; Wouter J. Schonewille; Erik J.R.J. van der Published in: Diagnostics, Sep 4;11(9), 2021, Page(s) 1621, ISSN 2075-4418 Publisher: MDPI DOI: 10.3390/diagnostics11091621 Modelling collateral flow and thrombus permeability during acute ischaemic stroke Author(s): Raymond M. Padmos; Nerea Arrarte Terreros; Tamás I. Józsa; Gábor Závodszky; Henk A. Marquering; Charles B. L. M. Majoie; Stephen J. Payne; Alfons G. Hoekstra Published in: Journal of the Royal Society, Interface, vol. 19 , no. 195, 2022, Page(s) 20220649, ISSN 1742-5662 Publisher: The royal society publishing DOI: 10.1098/rsif.2022.0649 Thrombolysis: Observations and numerical models Author(s): Remy Petkantchin; Raymond Padmos; Karim Zouaoui Boudjeltia; Franck Raynaud; Bastien Chopard Published in: Journal of Biomechanics, 132:110902. Elsevier, 9, 2022, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110902 Studying Stroke Thrombus Composition After Thrombectomy: What Can We Learn? Author(s): Senna Staessens, Olivier François, Waleed Brinjikji, Karen M. Doyle, Peter Vanacker, Tommy Andersson and Simon F. De Meyer Published in: Stroke, 20479980, 2021, Page(s) 3718–3727, ISSN 2047-9980 Publisher: Wiley-Blackwell DOI: 10.1161/strokeaha.121.034289 From perviousness to permeability, modelling and measuring intra-thrombus flow in acute ischemic stroke Author(s): Nerea Arrarte Terreros, Manon L. Tolhuisen, Edwin Bennink, Hugo W.A.M. de Jong, Ludo F.M. Beenen, Charles B.L.M. Majoie, Ed van Bavel, Henk A. Marquering Published in: Journal of Biomechanics, 111, 2020, Page(s) 110001, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2020.110001 Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees Author(s): Yidan Xue; Theodosia Georgakopoulou; Anne-Eva van der Wijk; Tamás I. Józsa; Ed van Bavel; Stephen J. Payne Published in: PLoS Computational Biology, 18, 2022, ISSN 1553-734X Publisher: Public Library of Science DOI: 10.1101/2022.05.06.490869 Measuring the effect of thrombosis, thrombus maturation and thrombolysis on clot mechanical properties in an in-vitro model. Author(s): Anushree Dwivedi; Aoife Glynn; Sarah Johnson; Sarah Johnson; Sharon Duffy; Sharon Duffy; Behrooz Fereidoonnezhad; Patrick McGarry; Michael Gilvarry; Ray McCarthy Published in: Journal of Biomechanics, 129, 2021, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110731 A new compressible hyperelastic model for the multi-axial deformation of blood clot occlusions in vessels Author(s): Behrooz Fereidoonnezhad, Kevin M. Moerman, Sarah Johnson, Ray McCarthy, Patrick J. McGarry Published in: Biomechanics and Modeling in Mechanobiology, 2021, ISSN 1617-7959 Publisher: Springer Verlag DOI: 10.1007/s10237-021-01446-4 Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts Author(s): Anne-Eva van der Wijk, Nadia Lachkar, Judith de Vos, Anita E. Grootemaat, Nicole N. van der Wel, Peter L. Hordijk, Erik N.T.P. Bakker, Ed vanBavel Published in: Stroke, 50/6, 2019, Page(s) 1590-1594, ISSN 0039-2499 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/strokeaha.119.024975 Quantitative 3D analysis of tissue damage in a rat model of microembolization Author(s): Georgakopoulou T, van der Wijk AE, Bakker ENTP, vanBavel E; INSIST investigators. Published in: J Biomech., 128, 2021, Page(s) 110723, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110723 On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation Author(s): T. I. Józsa, R. M. Padmos, W. K. El-Bouri, A. G. Hoekstra, S. J. Payne Published in: Annals of Biomedical Engineering, 2021, ISSN 0090-6964 Publisher: Kluwer Academic Publishers DOI: 10.1007/s10439-021-02808-w Modelling the impact of clot fragmentation on the microcirculation after thrombectomy Author(s): Wahbi K. El-Bouri, Andrew MacGowan, Tamás I. Józsa, Matthew J. Gounis, Stephen J. Payne Published in: PLOS Computational Biology, 17/3, 2021, Page(s) e1008515, ISSN 1553-7358 Publisher: PLOS DOI: 10.1371/journal.pcbi.1008515 In-Silico Trials for Treatment of Acute Ischemic Stroke Author(s): Praneeta R. Konduri, Henk A. Marquering, Ed E. van Bavel, Alfons Hoekstra, Charles B. L. M. Majoie Published in: Frontiers in Neurology, 11, 2020, ISSN 1664-2295 Publisher: Frontiers Research Foundation DOI: 10.3389/fneur.2020.558125 Novel hyperelastic models for large volumetric deformations Author(s): Kevin M. Moerman, Behrooz Fereidoonnezhad, J. Patrick McGarry Published in: International Journal of Solids and Structures, 193-194, 2020, Page(s) 474-491, ISSN 0020-7683 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.ijsolstr.2020.01.019 Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance Author(s): Senna Staessens, Frederik Denorme, Olivier François, Linda Desender, Tom Dewaele, Peter Vanacker, Hans Deckmyn, Karen Vanhoorelbeke, Tommy Andersson, Simon F De Meyer Published in: Haematologica, May 2019;104, 2019, ISSN 0390-6078 Publisher: Ferrata Storti Foundation Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations Author(s): S Staessens, S Fitzgerald, T Andersson, F Clarençon, F Denorme, MJ Gounis, W Hacke, DS Liebeskind, I Szikora, ACGM van Es, W Brinjikji, KM Doyle, SF De Meyer Published in: International Journal of Stroke, 15/5, 2020, Page(s) 467-476, ISSN 1747-4930 Publisher: Blackwell DOI: 10.1177/1747493019884527 Detailed histological analysis of a thrombectomy-resistant ischemic stroke thrombus: a case report Author(s): Senna Staessens, Olivier François, Linda Desender, Peter Vanacker, Tom Dewaele, Raf Sciot, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer Published in: Thrombosis Journal, 19/1, 2021, ISSN 1477-9560 Publisher: BioMed Central DOI: 10.1186/s12959-021-00262-1 Thrombus heterogeneity in ischemic stroke Author(s): Senna Staessens, Simon F. De Meyer Published in: Platelets, 2020, Page(s) 1-9, ISSN 0953-7104 Publisher: Taylor & Francis DOI: 10.1080/09537104.2020.1748586 Quantitative thrombus characteristics on thin-slice computed tomography improve prediction of thrombus histopathology: results of the MR CLEAN Registry. Author(s): Hund H, Boodt N, Arrarte Terreros N, Taha A, Marquering HA, van Es ACGM, Bokkers RPH, Lycklama À Nijeholt GJ, Majoie CBLM, Dippel DWJ, Lingsma HF, van Beusekom HMM, van der Lugt A;MR CLEAN Registry Investigators. Published in: European Radiology, 2022, ISSN 0938-7994 Publisher: Springer Verlag DOI: 10.1007/s00330-022-08762-y The Role of Edema in Subacute Lesion Progression After Treatment of Acute Ischemic Stroke Author(s): Konduri, Praneeta; van Kranendonk, Katinka; Boers, Anna; Treurniet, Kilian; Berkhemer, Olvert; Yoo, Albert J.; van Zwam, Wim; Oostenbrugge, Robert van; van der Lugt, Aad; Dippel, Diederik; Roos, Yvo; Bot, Joost; Majoie, Charles; Marquering, Henk Published in: Frontiers in Neurology, 8, 2021, ISSN 1664-2295 Publisher: Frontiers Research Foundation DOI: 10.3389/fneur.2021.705221 Self-expandable stent for thrombus removal modeling: Solid or beam finite elements? Author(s): Giulia Luraghi; Sara Bridio; Francesco Migliavacca; Jose Felix Rodriguez Matas Published in: Med Eng Phys, 106, 2022, Page(s) 103836, ISSN 1751-6161 Publisher: Elsevier BV DOI: 10.1016/j.medengphy.2022.103836 Investigating the two regimes of fibrin clot lysis: an experimental and computational approach Author(s): Franck Raynaud, Alexandre Rousseau, Daniel Monteyne, David Perez-Morga, Karim Zouaoui Boudjeltia, Bastien Chopard Published in: Biophysical Journal, 120/18, 2021, Page(s) 4091-4106, ISSN 0006-3495 Publisher: Biophysical Society DOI: 10.1016/j.bpj.2021.08.005 A low dimensional surrogate model for a fast estimation of strain in the thrombus during a thrombectomy procedure. Author(s): Sara Bridio; Giulia Luraghi; Francesco Migliavacca; Sanjay Pant; Alberto García-González; Jose F. Rodriguez Matas Published in: Med Eng Phys, 106, 2022, Page(s) 103836, ISSN 1751-6161 Publisher: Elsevier BV DOI: 10.1016/j.jmbbm.2022.105577 Modelling the effects of cerebral microthrombi on tissue oxygenation and cell death Author(s): Yidan Xue, Wahbi K. El-Bouri, Tamás I. Józsa, Stephen J. Payne Published in: Journal of Biomechanics, 127, 2021, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110705 Blood pressure during endovascular treatment under conscious sedation or local anesthesia Author(s): Noor Samuels, Rob A. van de Graaf, Carlijn A.L. van den Berg, Daan Nieboer, Ismail Eralp, Kilian M. Treurniet, Bart J. Emmer, Rogier V. Immink, Charles B.L.M. Majoie, Wim H. van Zwam, Reinoud P.H. Bokkers, Maarten Uyttenboogaart, Boudewijn A.A.M. van Hasselt, Jörg Mühling, James F. Burke, Bob Roozenbeek, Aad van der Lugt, Diederik W.J. Dippel, Hester F. Lingsma, Adriaan C.G.M. van Es Published in: Neurology, 2020, Page(s) 10.1212/WNL.0000000000011006, ISSN 0028-3878 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1212/wnl.0000000000011006 similarities and interdependence Author(s): Terreros, N.A.; Bruggeman, A.A.E.; Kappelhof, M.; Tolhuisen, M.L.; Brouwer, J.; Hoving, J.W.; Konduri, P.R.; Kranendonk, K.R. van; Dutra, B.G.; Alves, H.C.B.R.; Dippel, D.W.J.; Zwam, W.H. van; Beenen, L.F.M.; Yo, L.S.F.; Bavel, E. van; Majoie, C.B.L.M.; Marquering, H.A.; MR CLEAN Registry Investigators Published in: Journal of Neurointerventional Surgery, 6, 2022, ISSN 1759-8478 Publisher: BMJ Publishing Group DOI: 10.1136/jnis-2022-019134 Development of a patient-specific cerebral vasculature fluid–structure-interaction model Author(s): Kevin M. Moerman; Praneeta Konduri; Behrooz Fereidoonnezhad; Henk Marquering; Aad van der Lugt; Giulia Luraghi; Sara Bridio; Francesco Migliavacca; Jose F. Rodriguez Matas; Patrick McGarry Published in: Journal of Biomechanics, 133, 2022, Page(s) 110896, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110896 Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke Author(s): Raymond M. Padmos, Tamás I. Józsa, Wahbi K. El-Bouri, Praneeta R. Konduri, Stephen J. Payne, Alfons G. Hoekstra Published in: Interface Focus, 11/1, 2021, Page(s) 20190125, ISSN 2042-8898 Publisher: Royal Society Publishing DOI: 10.1098/rsfs.2019.0125 In silico trials for treatment of acute ischemic stroke: Design and implementation Author(s): Claire Miller, Raymond M. Padmos, Max van der Kolk, Tamás I. Józsa, Noor Samuels, Yidan Xue, Stephen J. Payne, Alfons G. Hoekstra Published in: Computers in Biology and Medicine, 137, 2021, Page(s) 104802, ISSN 0010-4825 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.compbiomed.2021.104802 Applicability assessment of a stent-retriever thrombectomy finite-element model Author(s): Giulia Luraghi, Jose Felix Rodriguez Matas, Gabriele Dubini, Francesca Berti, Sara Bridio, Sharon Duffy, Anushree Dwivedi, Ray McCarthy, Behrooz Fereidoonnezhad, Patrick McGarry, Charles B. L. M. Majoie, Francesco Migliavacca Published in: Interface Focus, 11/1, 2021, Page(s) 20190123, ISSN 2042-8898 Publisher: Royal Society Publishing DOI: 10.1098/rsfs.2019.0123 Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain Author(s): Anne-Eva van der Wijk, Theodosia Georgakopoulou, Jisca Majolée, Jan S. M. van Bezu, Miesje M. van der Stoel, Bert J. van het Hof, Helga E. de Vries, Stephan Huveneers, Peter L. Hordijk, Erik N. T. P. Bakker, Ed van Bavel Published in: Acta Neuropathologica Communications, 8/1, 2020, ISSN 2051-5960 Publisher: BioMed Central DOI: 10.1186/s40478-020-01071-9 Other (8) sj-pdf-2-wso-10.1177_1747493019884527 - Supplemental material for Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations Author(s): S Staessens; S Fitzgerald; T Andersson; F Clarençon; F Denorme; MJ Gounis; W Hacke; DS Liebeskind; I Szikora; ACGM Van Es; W Brinjikji; KM Doyle; SF De Meyer Published in: International journal of stroke, 11, 2020, ISSN 1747-4930 Publisher: Blackwell DOI: 10.25384/sage.12325865 Novel hyperelastic models for large volumetric deformations Author(s): Kevin M. Moerman; Behrooz Fereidoonnezhad; J. Patrick McGarry Published in: 1, 2019 Publisher: Engxriv DOI: 10.31224/OSF.IO/CFXDR Thrombus mechanics: How can we contribute to improve diagnostics and treatment? Author(s): Migliavacca F, Luraghi G, Akyildiz AC, Gijsen FJH. Published in: J Biomech., 132, 2022, Page(s) 110935, ISSN 0021-9290 Publisher: Elsevier BV DOI: 10.1016/j.jbiomech.2021.110935 sj-pdf-1-wso-10.1177_1747493019884527 - Supplemental material for Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations Author(s): S Staessens; S Fitzgerald; T Andersson; F Clarençon; F Denorme; MJ Gounis; W Hacke; DS Liebeskind; I Szikora; ACGM Van Es; W Brinjikji; KM Doyle; SF De Meyer Published in: International journal of stroke, 4, 2020, ISSN 1747-4930 Publisher: Blackwell DOI: 10.25384/sage.10253195.v2 Additional file 9 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain Author(s): Wijk, Anne-Eva Van Der; Georgakopoulou, Theodosia; Majolée, Jisca; Bezu, Jan S. M. Van; Stoel, Miesje M. Van Der; Hof, Bert J. Van Het; Vries, Helga E. De; Huveneers, Stephan; Hordijk, Peter L.; Bakker, Erik N. T. P.; Bavel, Ed Van Published in: Acta Neuropathologica Communications, 8/1, 2020, ISSN 2051-5960 Publisher: BioMed Central DOI: 10.6084/m9.figshare.13250804.v1 Additional file 4 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain Author(s): Wijk, Anne-Eva Van Der; Georgakopoulou, Theodosia; Majolée, Jisca; Bezu, Jan S. M. Van; Stoel, Miesje M. Van Der; Hof, Bert J. Van Het; Vries, Helga E. De; Huveneers, Stephan; Hordijk, Peter L.; Bakker, Erik N. T. P.; Bavel, Ed Van Published in: Acta Neuropathologica Communications, 8/1, 2020, ISSN 2051-5960 Publisher: BioMed Central DOI: 10.6084/m9.figshare.13250789.v1 Additional file 1 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain Author(s): Wijk, Anne-Eva Van Der; Georgakopoulou, Theodosia; Majolée, Jisca; Bezu, Jan S. M. Van; Stoel, Miesje M. Van Der; Hof, Bert J. Van Het; Vries, Helga E. De; Huveneers, Stephan; Hordijk, Peter L.; Bakker, Erik N. T. P.; Bavel, Ed Van Published in: Acta Neuropathologica Communications, 8/1, 2020, ISSN 2051-5960 Publisher: BioMed Central DOI: 10.6084/m9.figshare.13250780.v1 sj-pdf-2-wso-10.1177_1747493019884527 - Supplemental material for Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations Author(s): S Staessens; S Fitzgerald; T Andersson; F Clarençon; F Denorme; MJ Gounis; W Hacke; DS Liebeskind; I Szikora; ACGM Van Es; W Brinjikji; KM Doyle; SF De Meyer Published in: International jounral of stroke, 10, 2020, ISSN 1747-4930 Publisher: Blackwell publishing DOI: 10.25384/sage.12325865.v1 Book chapters (3) Uncertainty Quantification of Coupled 1D Arterial Blood Flow and 3D Tissue Perfusion Models Using the INSIST Framework Author(s): Claire Miller, Max van der Kolk, Raymond Padmos, Tamás Józsa, Alfons Hoekstra Published in: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part VI, 12747, 2021, Page(s) 691-697, ISBN 978-3-030-77979-5 Publisher: Springer International Publishing DOI: 10.1007/978-3-030-77980-1_52 Two-Way Coupling Between 1D Blood Flow and 3D Tissue Perfusion Models Author(s): Raymond M. Padmos, Tamás I. Józsa, Wahbi K. El-Bouri, Gábor Závodszky, Stephen J. Payne, Alfons G. Hoekstra Published in: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part III, 12744, 2021, Page(s) 670-683, ISBN 978-3-030-77966-5 Publisher: Springer International Publishing DOI: 10.1007/978-3-030-77967-2_56 des-ist: A Simulation Framework to Streamline Event-Based In Silico Trials Author(s): Max van der Kolk, Claire Miller, Raymond Padmos, Victor Azizi, Alfons Hoekstra Published in: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part III, 12744, 2021, Page(s) 648-654, ISBN 978-3-030-77966-5 Publisher: Springer International Publishing DOI: 10.1007/978-3-030-77967-2_53 Conference proceedings (1) INSIST - IN SILICO TRIALS FOR TREATMENT OF ACUTE ISCHEMIC STROKE Author(s): Konduri, Praneeta Published in: 3, 2018 Publisher: Moressier DOI: 10.26226/morressier.5aeac941521e300021137ff8 Searching for OpenAIRE data... 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