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An in silico-based approach to improve the efficacy and precision of drug REPurpOsing TRIALs for a mechanism-based patient cohort with predominant cerebro-cardiovascular phenotypes

Objective

Our programme will develop an innovative in-silico based approach to improve the efficacy and precision of drug repurposing trials. We have chosen drug repurposing as it has the shortest time for clinical validation and translation. Validation of all putatively de novo discovered drug repositionings within the time-frame of this programme would be unrealistic. To improve efficacy and precision, and to adopt our computer simulation parameters and models, we choose a systems medicine based in-silico approach that identifies mechanistically related disease phenotypes and, as a result, a virtual patient cohort. We then validate this in-silico drug repurposing via high precision clinical trials in patients with cerebro-cardiovascular phenotypes stratified using an exclusive mechanistic biomarker panel. We thus innovate two biomedical product classes, drugs and diagnostics. With this we will establish generally applicable in silico trials for other mechanistically related or defined disease phenotypes, for which size, duration, and risks will be reduced and precision increased. This generates rapid patient benefit, reduces drug development costs as well as risks, and enhances industrial competitiveness. Scientifically, we will contribute to reducing the uncertainty and vagueness of many of our current disease definitions that describe a symptom or apparent phenotype in an organ rather than defining diseases mechanistically as disturbance of self-regulation equilibria of biomolecular processes. Finally, we will reduce animal experimentation and animal numbers in general by applying a preclinical randomised confirmatory trial (pRCTs) concept and preclinical systematic reviews and meta-analyses facilitated by our open access pre-clinicaltrials.org platform, a pendant to clinicaltrials.gov.

Call for proposal

H2020-SC1-2017-CNECT-2
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Funding Scheme

RIA - Research and Innovation action
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Coordinator

UNIVERSITEIT MAASTRICHT
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 270 089,50

Participants (10)

SYDDANSK UNIVERSITET

Participation ended

Denmark
EU contribution
€ 0
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 844 728
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 597 565
Address
Hufelandstrasse 55
45147 Essen
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 550 722
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 550 722
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
BIOCRATES LIFE SCIENCES AG
Austria
EU contribution
€ 157 789
Address
Eduard Bodem Gasse 8 1 Stock
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SOMALOGIC LIMITED
United Kingdom
EU contribution
€ 342 964
Address
4 Studley Court Guildford Road
GU24 8EB Chobham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MUCKE HERMANN
Austria
EU contribution
€ 125 122
Address
Enenkelstr. 28/32
1160 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Concentris Research Management GmbH
Germany
EU contribution
€ 355 026
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 742 045
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments