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An in silico-based approach to improve the efficacy and precision of drug REPurpOsing TRIALs for a mechanism-based patient cohort with predominant cerebro-cardiovascular phenotypes

Objective

Our programme will develop an innovative in-silico based approach to improve the efficacy and precision of drug repurposing trials. We have chosen drug repurposing as it has the shortest time for clinical validation and translation. Validation of all putatively de novo discovered drug repositionings within the time-frame of this programme would be unrealistic. To improve efficacy and precision, and to adopt our computer simulation parameters and models, we choose a systems medicine based in-silico approach that identifies mechanistically related disease phenotypes and, as a result, a virtual patient cohort. We then validate this in-silico drug repurposing via high precision clinical trials in patients with cerebro-cardiovascular phenotypes stratified using an exclusive mechanistic biomarker panel. We thus innovate two biomedical product classes, drugs and diagnostics. With this we will establish generally applicable in silico trials for other mechanistically related or defined disease phenotypes, for which size, duration, and risks will be reduced and precision increased. This generates rapid patient benefit, reduces drug development costs as well as risks, and enhances industrial competitiveness. Scientifically, we will contribute to reducing the uncertainty and vagueness of many of our current disease definitions that describe a symptom or apparent phenotype in an organ rather than defining diseases mechanistically as disturbance of self-regulation equilibria of biomolecular processes. Finally, we will reduce animal experimentation and animal numbers in general by applying a preclinical randomised confirmatory trial (pRCTs) concept and preclinical systematic reviews and meta-analyses facilitated by our open access pre-clinicaltrials.org platform, a pendant to clinicaltrials.gov.

Call for proposal

H2020-SC1-2016-2017

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Sub call

H2020-SC1-2017-CNECT-2

Coordinator

UNIVERSITEIT MAASTRICHT
Net EU contribution
€ 1 638 470,24
Address
Minderbroedersberg 4
6200 MD Maastricht
Netherlands

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Region
Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (12)

SYDDANSK UNIVERSITET

Participation ended

Denmark
Net EU contribution
€ 0,00
Address
Campusvej 55
5230 Odense M

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Region
Danmark Syddanmark Fyn
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Net EU contribution
€ 854 103,00
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne

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Region
North East (England) Northumberland and Tyne and Wear Tyneside
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAETSKLINIKUM ESSEN
Germany
Net EU contribution
€ 752 911,50
Address
Hufelandstrasse 55
45147 Essen

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Region
Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
Net EU contribution
€ 267 492,90
Address
Carl-neuberg-strasse 1
30625 Hannover

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Region
Niedersachsen Hannover Region Hannover
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Participation ended

Netherlands
Net EU contribution
€ 66 702,30
Address
Heidelberglaan 100
3584 CX Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
BIOCRATES LIFE SCIENCES AG
Austria
Net EU contribution
€ 149 914,00
Address
Eduard Bodem Gasse 8 1 Stock
6020 Innsbruck

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Region
Westösterreich Tirol Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
SOMALOGIC LIMITED

Participation ended

United Kingdom
Net EU contribution
€ 0,00
Address
4 Studley Court Guildford Road
GU24 8EB Chobham

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Region
South East (England) Surrey, East and West Sussex West Surrey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MUCKE HERMANN
Austria
Net EU contribution
€ 168 628,45
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CONCENTRIS RESEARCH MANAGEMENT GMBH
Germany
Net EU contribution
€ 382 026,00
Address
Ludwigstr. 4
82256 Furstenfeldbruck

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 3,14
TECHNISCHE UNIVERSITAET MUENCHEN

Participation ended

Germany
Net EU contribution
€ 395 077,29
Address
Arcisstrasse 21
80333 Muenchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG
Germany
Net EU contribution
€ 514 479,11
Address
Universitatsplatz 10
6108 Halle

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAET HAMBURG
Germany
Net EU contribution
€ 346 967,71
Address
Mittelweg 177
20148 Hamburg

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Region
Hamburg Hamburg Hamburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00