Rheuma Tolerance for Cure

Resultado final

Update on key risk predictors for the transition from the at-risk status to clinical arthritis

Update on key risk predictors for the transition from the atrisk status to clinical arthritis

ARIAA Report on status of posting results

Clinical trial ARIAA Report on status of posting results UKER BMS

Report on progress of the prospective at-risk RTCure cohort

Establish an RTCure prospective cohort of atrisk individualsWhile the analysis of already existing cohorts will allow us to obtain valuable information on the potential parameters which predict progression to RA the establishment of a new prospective cohort of atrisk individuals with contribution from all partners and with a harmonized mode of data acquisition will be an important step further which will allow i study of larger sample size of atrisk individuals with ii a higher possibility to better compare data based on standardized protocols of data acquisition and iii to provide a basis for future clinical trials see also WP6 For establishing this cohort the use of methods such as Multiple Randomised Controlled Trial MRCT design will be considered The plan is that each academic partner contributes at least 50 atrisk individuals to this joint RTCure cohort allowing a total number of at least 600 atrisk individuals with identical data collection to be studied by the RTCure consortium Immunomonitoring techniques applied and developed in WP3 and WP4 will also feed into this cohort

Identification of auto-antigens associated with pathogenesis of RA

Report on the identification of auto-antigens associated with pathogenesis of RA

Standard operating procedures for the application of immune profiling

D43 Standard operating procedures for the application of immune profiling Type R Dissemination level PU Delivery Date Month 42 Responsible partner KCL and DRFZ

Final review of Data and knowledge management plan
Report on immune profiling across the disease spectrum, including the enumeration of autoantigenic peptide specific T and B cells defined at different stages of the disease

Report on immune profiling across the disease spectrum including the enumeration of autoantigenic peptide specific T and B cells defined at different stages of the disease

Report on the validation of immune tolerance signatures in relevant experimental medicine studies

Report on the validation of immune tolerance signatures in relevant experimental medicine studies Type R Dissemination level PU Delivery Date Month 60 Responsible partners KCL LUMC KI

Suitable strategy for testing of multiple tolerogenic therapies

Agreement on a suitable strategy for testing of multiple tolerogenic therapies (UNEW, UCB)

Report on the core data set for characterisation of individuals at-risk for developing RA

Report on the core data set for characterisation of individuals at-risk for developing rheumatoid arthritis. In this part of WP2 the existing cohorts of individuals at-risk for development of RA from the RTCure partners will be analyzed and compared for their type of data acquisition in order to define an essential core data set for describing the “at-risk” state. This approach will comprise clinical parameters (such for instance the documentation of inflammatory arthralgia), laboratory parameters (such as ultrasensitive C-reactive protein and autoantibody titers against various autoantigens and peptides thereof, citrullinated proteins and other relevant antigenic protein modifications), and other relevant biomarkers (such as autoantibody profiles, protein biomarkers, RNA expression profiles, epigenetic profiles) as well as imaging parameters (such as subclinical synovitis, osteitis or tenosynovitis). Core parameters will be identified, which allow a comprehensive but also feasible description of the nature of the at-risk state in these individuals. In addition, novel more experimental parameters, in particular approaches coming from the immune-phenotyping of T and B cell populations done in WP3 and WP4 will be added to this parameter set, if shown to be relevant for a better characterization of the at-risk state. Importantly, the agreed key parameters will allow for harmonization of patient criteria that can be applied across clinical sites so as to ensure data comparability.

Characterisation of pathogenic T- and B- cell receptors and antibodies

Report on the characterisation of pathogenic T cell receptors B cell receptors and antibodies

Comparison of serologic features of at-risk individuals and recent onset arthritis patients

Compare at-risk individuals with recent-onset/early arthritis patients RTCure partners have already established well characterized cohorts of recent onset/early arthritis patients such as the TACERA, the Leiden Early Arthritis and the Scottish Early RA (SERA) cohorts, which provide an excellent possibility to compare the clinical, serologic and cellular features of patients who have recently moved into the inflammatory phase of the disease with those of imminent risk of developing the disease. Additional biobanks of recent onset/early arthritis patients from other RTCure partners (MUW, KI) provide valuable information of the serologic features of recent onset/early arthritis patients.

Development of at least 3 mechanistically oriented clinical studies of different tolerising therapies.

Development of at least 3 mechanistically oriented clinical studies of different tolerising therapies In terms of deliverables development implies all stages up to but excluding first patient first visit Whether the studies can be initiated or indeed completed during this IMI will depend on several factors including validation of the specific technology with a GMP process and regulatory documentation availability of funding approval of a protocol by partners ethical approvals and a trial sponsor

Screening and analysis of biological and clinical datasets

Screening and analysis of biological and clinical datasets generated within the project. Responsible partners LUMC and Pfizer.

Algorithm for predicting the development of arthritis

Establishment of an algorithm for predicting the development of arthritis. The aim of this part is to develop a risk prediction model for development of RA, which is based on the parameters collected in the at-risk cohorts of the RTCure partners. Many of these cohorts contain longitudinal follow-ups, which allow to evaluate which of the at-risk individuals developed RA and which one remained in the at-risk stage. A particular focus will be drawn on parameters which predict progression to RA in several different cohorts. In addition, additive risk prediction by using several different parameters such as combination of clinical, laboratory and imaging parameters will be addressed.

ARIAA Midterm recruitment report

Clinical trial ARIAA Midterm recruitment report (UKER, BMS)

Report on the link between immune signatures and clinical outcomes

D46 Report on the link between immune signatures and clinical outcomes including those associated with immune tolerance and deep remission

Key risk predictors for the transition from the at-risk status to clinical arthritis

Establishment of key risk predictors for the transition from the at-risk status to clinical arthritis (UA or RA). Core data sets extracted from existing cohorts in the first part of WP2 will be evaluated for their role in predicting the risk to progress from the at-risk state to the clinical state of arthritis (either undifferentiated arthritis or rheumatoid arthritis).

Regulatory briefing doc

Regulatory briefing doc to be used in interactions with regulatory agencies

Bioinformatic plan

Bioinformatic plan for data generated and collected in RTCure

Report on the development of strategies for the depletion of pathogenic cells refractory to tolerance induction
Report on the outcome of experimental and therapeutic tolerance induction in pre-clinical animal models

Report on the outcome of experimental and therapeutic tolerance induction in preclinical animal models This includes information on cellularautoimmune biological pathways in animal models and a prioritizing strategy of the best candidates for clinical development

Optimal participant population(s) for clinical studies of tolerogenic interventions

Definition of the optimal participant population(s) for clinical studies of tolerogenic interventions (UKER and UQ). The target population is critical for testing tolerogenic therapies and will be a topic for ongoing debate among WP6 members, with input from WPs 1 and 2 in particular.

Status on ongoing clinical trials in RTCure

Status on ongoing clinical trials in RTCure. Including: First study subject approvals package (ASCARA, ICosRA, APPIPRA), All approval package (ICosRA and APIPPRA), Midterm recruitment report (ICosRA, APIPPRA)

Compendium on current researches for inducing clinical therapeutic tolerance (4 papers published in Lancet Rheumatology)

Compendium on current researches for inducing clinical therapeutic tolerancea previous and current attempts to induce clinical therapeutic tolerance with a focus on RA but including other autoimmune allergic and transplant settingsb postulated autoantigens and supporting data in RA c information on the preRA state including data on B and T cell epitope spreading involving key autoantigens illustrating how tolerance is lost over timed potential biomarkers of the tolerant stateThis will be published reviews in a per reviewed journal

Set up internal and external website with a RTCure logo

Set up external website with a RTCure logo and an internal communication platform where partners can store and share data and information and communicate about publications.

Build a multidisciplinary task force

Build a multidisciplinary task force with expertise on biology, statistics, database management, including clinicians and ethicists.

Tools and long term solutions for RTCure data

Design a tool(s) and also a long-term solution that allow access to and analysis of RTcure clinical, genetic, transcriptional, cytometry data (pre-existing and new). (KI, Pfizer, LUMC)

Arrange thematic workshops in collaboration with the other WPs

Arrange thematic workshops in collaboration with the other WPs. Approximately one every year.

Publicaciones

Autoreactive B cells in rheumatoid arthritis consist of activated CXCR3+ memory B cells and plasmablasts

Autores: Sanne Reijm, Joanneke C. Kwekkeboom, Nienke J. Blomberg, Jolien Suurmond, Diane van der Woude, Rene E.M. Toes, Hans U. Scherer
Publicado en: JCI insight, 2023, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.172006

IgG Fab Glycans Hinder FcRn-Mediated Placental Transport

Autores: Volkov, Mikhail; Brinkhaus, Maximilian; van Schie, Karin A; Bondt, Albert; Kissel, Theresa; van der Kooi, Elvera J; Bentlage, Arthur E H; Koeleman, Carolien A M; de Taeye, Steven W; Derksen, Ninotska I; Dolhain, Radboud J E M; Braig-Scherer, Ute; Huizinga, Tom W J; Wuhrer, Manfred; Toes, René E M; Vidarsson, Gestur; van der Woude, Diane; Sub Biomol.Mass Spectrometry & Proteom.; Afd Biomol.Mass Sp
Publicado en: Journal of Immunology, 210(2), 158. American Association of Immunologists, Edición 8, 2023, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.2200438

Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis

Autores: Kroos, S., Kampstra, A.S.B., Toes, R.E.M. et al
Publicado en: Arthritis Res Ther, 2022, ISSN 1478-6362
Editor: BioMed Central
DOI: 10.1186/s13075-022-02919-2

Designing custom CRISPR libraries for hypothesis-driven drug target discovery

Autores: Vaishnavi Srinivasan Iyer, Long Jiang, Yunbing Shen, Sanjaykumar V. Boddul, Sudeepta Kumar Panda, Zsolt Kasza, Bernhard Schmierer, Fredrik Wermeling
Publicado en: Computational and Structural Biotechnology Journal, Edición 18, 2020, Página(s) 2237-2246, ISSN 2001-0370
Editor: Elsevier
DOI: 10.1016/j.csbj.2020.08.009

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype

Autores: Chikashi Terao, Boel Brynedal, Zuomei Chen, Xia Jiang, Helga Westerlind, Monika Hansson, Per-Johan Jakobsson, Karin Lundberg, Karl Skriner, Guy Serre, Johan Rönnelid, Linda Mathsson-Alm, Mikael Brink, Solbritt Rantapää Dahlqvist, Leonid Padyukov, Peter K. Gregersen, Anne Barton, Lars Alfredsson, Lars Klareskog, Soumya Raychaudhuri
Publicado en: The American Journal of Human Genetics, Edición 105/4, 2019, Página(s) 880, ISSN 0002-9297
Editor: University of Chicago Press
DOI: 10.1016/j.ajhg.2019.09.018

Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation—Lessons From Rheumatoid Arthritis

Autores: Karine Chemin, Christina Gerstner, Vivianne Malmström
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2019.00353

Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings

Autores: Maria V. Sokolova, Georg Schett, Ulrike Steffen
Publicado en: Clinical Reviews in Allergy & Immunology, 2021, ISSN 1080-0549
Editor: Humana Press, Inc.
DOI: 10.1007/s12016-021-08890-1

Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial

Autores: Andrew P Cope, Marianna Jasenecova, Joana C Vasconcelos, Andrew Filer, Karim Raza, Sumera Qureshi, Maria Antonietta D’Agostino, Iain B McInnes, John D Isaacs, Arthur G Pratt, Benjamin A Fisher, Christopher D Buckley, Paul Emery, Pauline Ho, Maya H Buch, Coziana Ciurtin, Dirkjan van Schaardenburg, Thomas Huizinga, René Toes, Evangelos Georgiou, Joanna Kelly, Caroline Murphy, A Toby Prevost, on b
Publicado en: The Lancet, 2024, ISSN 0140-6736
Editor: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(23)02649-1

Patient and public involvement in an international rheumatology translational research project – an evaluation.

Autores: Savia de Souza, Eva C Johansson, Susanne Karlfeldt, Karim Raza, Ruth Williams
Publicado en: BMC Rheumatology, 2022, ISSN 2520-1026
Editor: BioMed Central
DOI: 10.1186/s41927-022-00311-w

Rheumatoid Arthritis-Specific Autoimmunity in the Lung Before and at the Onset of Disease.

Autores: Joshua V, Loberg Haarhaus M, Hensvold A, Wähämaa H, Gerstner C, Hansson M, Israelsson L, Stålesen R, Sköld M, Grunewald J, Klareskog L, Grönwall C, Réthi B, Catrina A, Malmström V.
Publicado en: Arthritis Rheumatol., 2023, ISSN 2326-5205
Editor: Wiley, Hoboken
DOI: 10.1002/art.42549

Rheumatoid Factor and Anti-Modified Protein Antibody Reactivities Converge on IgG Epitopes

Autores: Aisha M Mergaert, Zihao Zheng, Michael F Denny, Maya F Amjadi, S Janna Bashar, Michael A Newton, Vivianne Malmström, Caroline Grönwall, Sara S McCoy, Miriam A Shelef
Publicado en: Arthritis & rheumatology, 2022, ISSN 2326-5191
Editor: Malden, MA : Wiley, [2014]-
DOI: 10.1002/art.42064

Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases

Autores: S. Reijm,T. Kissel,R.E.M. Toes
Publicado en: European Journal of Immunology, Edición Volume 50, issue 12, 2020, Página(s) 1885-1894, ISSN 1521-4141
Editor: Wiley
DOI: 10.1002/eji.202048820

Autoantibodies targeting malondialdehyde-modifications in rheumatoid arthritis regulate osteoclasts via inducing glycolysis and lipid biosynthesis

Autores: Sakuraba K, Krishnamurthy A, Sun J, Zheng X, Xu C, Peng B, Engström M, Jakobsson PJ, Wermeling F, Catrina S, Grönwall C, Catrina AI, Réthi B.
Publicado en: Journal of autoimmunity, 2022, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2022.102903

Prospective Studies on the Risk of Rheumatoid Arthritis: The European Risk RA Registry

Autores: Paul Studenic, Aase Hensvold, Arnd Kleyer, Annette van der Helm-van Mil, Arthur G. Pratt, Daniela Sieghart, Gerhard Krönke, Ruth Williams, Savia de Souza, Susanne Karlfeldt, Martina Johannesson, Niels Steen Krogh, Lars Klareskog and Anca I. Catrina
Publicado en: Frontiers in Medicine, Edición 2296858X, 2022, ISSN 2296-858X
Editor: Frontiers Media S.A
DOI: 10.3389/fmed.2022.824501

Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis

Autores: Jule Taubmann, Brenda Krishnacoumar, Christina Böhm, Maria Faas, Dorothea I. H. Müller, Susanne Adam, Cornelia Stoll, Martin Böttcher, Dimitrios Mougiakakos, Uwe Sonnewald, Jörg Hofmann, Georg Schett, Gerhard Krönke, Carina Scholtysek
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-77892-4

Antigen‐driven PD‐1 + TOX + BHLHE40 + and PD‐1 + TOX + EOMES + T lymphocytes regulate juvenile idiopathic arthritis in situ

Autores: Patrick Maschmeyer, Gitta Anne Heinz, Christopher Mark Skopnik, Lisanne Lutter, Alessio Mazzoni, Frederik Heinrich, Sae Lim Stuckrad, Lorenz Elias Wirth, Cam Loan Tran, René Riedel, Katrin Lehmann, Imme Sakwa, Rolando Cimaz, Francesco Giudici, Marcus Alexander Mall, Philipp Enghard, Bas Vastert, Hyun‐Dong Chang, Pawel Durek, Francesco Annunziato, Femke Wijk, Andreas Radbruch, Tilmann Kallinich,
Publicado en: European Journal of Immunology, Edición 51/4, 2021, Página(s) 915-929, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048797

Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis.

Autores: Vugar Azizov, Katharina Dietel, Franziska Steffen, Kerstin Dürholz, Julia Meidenbauer, Sébastien Lucas, Michael Frech, Yasunori Omata, Narges Tajik, Lisa Knipfer, Anne Kolenbrander, Silvia Seubert, Dennis Lapuente, Maria V. Sokolova, Jörg Hofmann, Matthias Tenbusch, Andreas Ramming, Ulrike Steffen, Falk Nimmerjahn, Ralf Linker, Stefan Wirtz, Martin Herrmann, Vladimir Temchura, Kerstin Sarter, G
Publicado en: Nature communications, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-15855-z

IgG Anti-Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ~1,500 Samples.

Autores: Theresa Kissel,Lise Hafkenscheid,Tineke J. Wesemael,Mami Tamai,Shin-ya Kawashiri,Atsushi Kawakami,Hani S. El-Gabalawy,Dirkjan van Schaardenburg,Solbritt Rantapää-Dahlqvist,Manfred Wuhrer,Annette H. M. van der Helm-van Mil,Cornelia F. Allaart,Diane van der Woude,Hans U. Scherer,Rene E. M. Toes,Tom W. J. Huizinga
Publicado en: Arthritis & Rheumatology (Hoboken, N.J.), 2022, ISSN 2326-5205
Editor: Wiley
DOI: 10.1002/art.42098

Combination of two monoclonal ACPAs induced tenosynovitis, pain and bone loss in mice in a Peptidyl Arginine Deiminase-4 dependent manner

Autores: Krishnamurthy A, Circiumaru A, Sun J, Kisten Y, Damberg P, Sakuraba K, Sandor K, Jarvoll P, Zhou T, Malmström V, Svensson CI, Hensvold A, Catrina AI, Klareskog L, Réthi B.
Publicado en: Arthritis & rheumatology, 2022, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.42320

Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis.

Autores: Göschl L, Preglej T, Boucheron N, Saferding V, Müller L, Platzer A, Hirahara K, Shih HY, Backlund J, Matthias P, Niederreiter B, Hladik A, Kugler M, Gualdoni GA, Scheinecker C, Knapp S, Seiser C, Holmdahl R, Tillmann K, Plasenzotti R, Podesser B, Aletaha D, Smolen JS, Karonitsch T, Steiner G, Ellmeier W, Bonelli M.
Publicado en: J Autoimmun, 2020, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2019.102379

The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients.

Autores: Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina, Johan Rönnelid, Günter Steiner & Karl Skriner
Publicado en: Arthritis Research & Therapy, Edición 23, Article number: 239 (2021), 2021, ISSN 1478-6354
Editor: BioMed Central
DOI: 10.1186/s13075-021-02603-x

Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization

Autores: Jurczak A, Delay L, Barbier J, Simon N, Krock E, Sandor K, Agalave NM, Rudjito R, Wigerblad G, Rogóż K, Briat A, Miot-Noirault E, Martinez-Martinez A, Brömme D, Grönwall C, Malmström V, Klareskog L, Khoury S, Ferreira T, Labrum B, Deval E, Jiménez-Andrade JM, Marchand F, Svensson CI.
Publicado en: Pain, 2022, ISSN 0304-3959
Editor: Elsevier BV
DOI: 10.1097/j.pain.0000000000002543

Brief Report: Humoral and cellular immune responses to SARS‐CoV‐2 infection and vaccination in B cell depleted autoimmune patients

Autores: David Simon, Koray Tascilar, Katja Schmidt, Bernhard Manger, Leonie Weckwerth, Maria Sokolova, Laura Bucci, Filippo Fagni, Karin Manger, Florian Schuch, Monika Ronneberger, Axel Hueber, Ulrike Steffen, Dirk Mielenz, Martin Herrmann, Thomas Harrer, Arnd Kleyer, Gerhard Krönke, Georg Schett
Publicado en: Arthritis & Rheumatology, 2021, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.41914

Tolerance-inducing medicines in autoimmunity: rheumatology and beyond

Autores: James A Stanway, John D Isaacs
Publicado en: The Lancet Rheumatology, Edición 2/9, 2020, Página(s) e565-e575, ISSN 2665-9913
Editor: Elsevier
DOI: 10.1016/s2665-9913(20)30100-4

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

Autores: HENDY KRISTYANTO HTTPS://ORCID.ORG/0000-0002-8022-6637NIENKE J. BLOMBERGLINDA M. SLOTELLEN I. H. VAN DER VOORTPRISCILLA F. KERKMAN HTTPS://ORCID.ORG/0000-0002-6212-002XALEIDA BAKKERLEONIE E. BURGERSROBIN M. TEN BRINCK HTTPS://ORCID.ORG/0000-0002-6128-6888ANNETTE H. M. VAN DER HELM-VAN MILHERGEN SPITS HTTPS://ORCID.ORG/0000-0003-3269-8338DOMINIQUE L. BAETENTOM W. J. HUIZINGA HTTPS://ORCID.ORG/0000-
Publicado en: SCIENCE TRANSLATIONAL MEDICINE, Edición VOL. 12, NO. 570, 2020, Página(s) 570, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaz5327

Data-Driven Mathematical Model of Apoptosis Regulation in Memory Plasma Cells

Autores: Burt P, Cornelis R, Geißler G, Hahne S, Radbruch A, Chang HD, Thurley K
Publicado en: Cells, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11091547

Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry-based peptide-MHC class-II tetramer staining

Autores: Patel S, Ramnoruth N, Wehr P, Rossjohn J, Reid HH, Campbell K, Nel HJ, Thomas R.
Publicado en: Clin Exp Immunol, Edición 2022 Jan 28;207(1), 2022, Página(s) 72-83, ISSN 0009-9104
Editor: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxab008

Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapy

Autores: Hendrik J Nel, Vivianne Malmström, David C Wraith, Ranjeny Thomas
Publicado en: The Lancet Rheumatology, Edición 2/11, 2020, Página(s) e712-e723, ISSN 2665-9913
Editor: Elsevier
DOI: 10.1016/s2665-9913(20)30344-1

Deep Phenotyping of Urinary Leukocytes by Mass Cytometry Reveals a Leukocyte Signature for Early and Non-Invasive Prediction of Response to Treatment in Active Lupus Nephritis

Autores: Martina Bertolo, Sabine Baumgart, Pawel Durek, Anette Peddinghaus, Henrik Mei, Thomas Rose, Philipp Enghard, Andreas Grützkau
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2020.00256

Genetic predisposition (HLA-SE) is associated with ACPA-IgG variable domain glycosylation in the predisease phase of RA

Autores: "Theresa Kissel # 1, Tineke J van Wesemael # 2, Anders Lundquist 3, Heidi Kokkonen 4, Atsushi Kawakami 5, Mami Tamai 6, Dirkjan van Schaardenburg 7 8, Manfred Wuhrer 9, Tom Wj Huizinga 2, Hans Ulrich Scherer 2, Diane van der Woude 2, Solbritt Rantapää-Dahlqvist 4, René E M Toes 2"
Publicado en: Ann Rheum Dis ., Edición Jan;81(1), 2021, Página(s) 141-143, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220841

Benchmarking computational methods for B-cell receptor reconstruction from single cell RNA-seq data

Autores: Andreani T, Slot LM, Gabillard S, Strübing C, Reimertz C, Yaligara V, Bakker AM, Olfati-Saber R, Toes REM, Scherer HU , Augé F, Šimaitė D
Publicado en: NAR Genomics and Bioinformatics, 2022, ISSN 2631-9268
Editor: Oxford University Press
DOI: 10.1093/nargab/lqac049

Why remission is not enough: underlying disease mechanisms in RA that prevent cure

Autores: Georg Schett, Yoshiya Tanaka, John D. Isaacs
Publicado en: Nature Reviews Rheumatology, Edición 17/3, 2021, Página(s) 135-144, ISSN 1759-4790
Editor: Nature Publishing Group
DOI: 10.1038/s41584-020-00543-5

Functional Analysis of Autoantibody Signatures in Rheumatoid Arthritis.

Autores: Milchram L, Fischer A, Huber J, Soldo R, Sieghart D, Vierlinger K, Blüml S, Steiner G, Weinhäusel A.
Publicado en: Molecules, Edición 14203049, 2022, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27041452

Disruptive innovation in rheumatology: new networks of global public-private partnerships are needed to take advantage of scientific progress.

Autores: Tom Wj Huizinga,* V Michael Holers,* Jennifer Anolik, Michael B Brenner, Christopher Dominic Buckley, Vivian Bykerk, Sean E Connolly, Kevin D Deane, Jianping Guo, Martin Hodge, Steve Hoffmann, Frank Nestle, Costantino Pitzalis, Soumya Raychaudhuri, Kazuhiko Yamamoto, Zhanguo Li,and Lars Klareskog
Publicado en: Annals of the Rheumatic Diseases, 2020, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-216846

Rheumatic?-A Digital Diagnostic Decision Support Tool for Individuals Suspecting Rheumatic Diseases: A Multicenter Pilot Validation Study

Autores: Rachel Knevel, Johannes Knitza, Aase Hensvold, Alexandra Circiumaru, Tor Bruce, Sebastian Evans, Tjardo Maarseveen, Marc Maurits, Liesbeth Beaart-van de Voorde, David Simon, Arnd Kleyer, Martina Johannesson, Georg Schett, Tom Huizinga, Sofia Svanteson, Alexandra Lindfors, Lars Klareskog, Anca Catrina
Publicado en: Frontiers in Medicine, 2022, ISSN 2296-858X
Editor: Frontiers Media S.A.
DOI: 10.3389/fmed.2022.774945

Characterisation of age-associated B cells in early drug-naïve rheumatoid arthritis patients

Autores: Vidal-Pedrola, Gemma; Naamane, Najib; Cameron, James A.; Pratt, Arthur G.; Mellor, Andrew; Isaacs, John; Scheel-Toellner, D; Anderson, Amy E.
Publicado en: Immunology, 2022, ISSN 1365-2567
Editor: Wiley
DOI: 10.1111/imm.13598

IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients

Autores: Léonie A. N. Staats, Hella Pfeiffer, Jasmin Knopf, Aylin Lindemann, Julia Fürst, Andreas E. Kremer, Holger Hackstein, Markus F. Neurath, Luis E. Muñoz, Susanne Achenbach, Moritz Leppkes, Martin Herrmann, Georg Schett, Ulrike Steffen
Publicado en: Cells, Edición 9/12, 2020, Página(s) 2676, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9122676

Divergent and dominant anti-inflammatory effects of patient-derived anticitrullinated protein antibodies (ACPA) in arthritis development

Autores: Bruno Raposo, Marcelo Afonso, Lena Israelsson, Heidi Wähämaa, Ragnhild Stålesen, Fredrik Wermeling, Aase Hensvold, Caroline Grönwall, Bence Rethi, Lars Klareskog and Vivianne Malmström
Publicado en: Annals of the Rheumatic Diseases, 2023, ISSN 1468-2060
Editor: BMJ publishing group
DOI: 10.1136/ard-2022-223417

Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission

Autores: Kenneth F. Baker, Ben Thompson, Dennis W. Lendrem, Adam Scadeng, Arthur G. Pratt, John D. Isaacs
Publicado en: Therapeutic Advances in Musculoskeletal Disease, Edición 12, 2020, Página(s) 1759720X2091532, ISSN 1759-720X
Editor: SAGE Publications Inc.
DOI: 10.1177/1759720x20915322

Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance

Autores: Yan Wang, Katy A. Lloyd, Ioannis Melas, Diana Zhou, Radha Thyagarajan, Joakim Lindqvist, Monika Hansson, Anna Svärd, Linda Mathsson-Alm, Alf Kastbom, Karin Lundberg, Lars Klareskog, Anca I. Catrina, Stephen Rapecki, Vivianne Malmström, Caroline Grönwall
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-56279-0

Autores: Anna‐Maria Liphardt, Eva Manger, Sonja Liehr, Lisa Bieniek, Arnd Kleyer, David Simon, Koray Tascilar, Michael Sticherling, Jürgen Rech, Georg Schett, Axel J. Hueber
Publicado en: ACR Open Rheumatology, Edición 2/12, 2020, Página(s) 734-740, ISSN 2578-5745
Editor: Wiley
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Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis

Autores: Vijay Joshua, Aase Haj Hensvold, Gudrun Reynisdottir, Monica Hansson, Martin Cornillet, Leonor Nogueira, Guy Serre, Sven Nyren, Reza Karimi, Anders Eklund, Magnus Sköld, Johan Grunewald, Katerina Chatzidionysiou, Anca Catrina
Publicado en: RMD Open, Edición 6/2, 2020, Página(s) e001278, ISSN 2056-5933
Editor: BMJ Publishing Group
DOI: 10.1136/rmdopen-2020-001278

Neutrophil-specific Syk expression is crucial for skin disease in experimental epidermolysis bullosa acquisita.

Autores: Németh T, Balogh L, Káposztás E, Szilveszter KP and Mócsai A
Publicado en: Journal of Investigative Dermatology, 2023, ISSN 0022-202X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2022.12.016

MiR-146a controls age related bone loss

Autores: Victoria Saferding; Melanie Hofmann; Julia S. Brunner; Birgit Niederreiter; Melanie Timmen; Nathaniel Magilnick; Silvia Hayer; Gerwin Heller; Guenter Steiner; Richard Stange; Mark Boldin; Gernot Schabbauer; Moritz Weigl; Matthias Hackl; Johannes Grillari; Josef S Smolen; S Blueml
Publicado en: Aging Cell, Edición 18, 2020, ISSN 1474-9726
Editor: Wiley
DOI: 10.1101/2020.03.20.000174

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications.

Autores: Kissel T, Reijm S, Slot LM, Cavallari M, Wortel CM, Vergroesen RD, Stoeken-Rijsbergen G, Kwekkeboom JC, Kampstra A, Levarht E, Drijfhout JW, Bang H, Bonger KM, Janssen G, van Veelen PA, Huizinga T, Scherer HU, Reth M, Toes R.
Publicado en: Annals of the rheumatic disease, Edición Volume 79, Edición 4, 2020, Página(s) 472-480, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-216499

Key opinion leaders — a critical perspective

Autores: Jose U. Scher, Georg Schett
Publicado en: Nature Reviews Rheumatology, Edición 17/2, 2021, Página(s) 119-124, ISSN 1759-4790
Editor: Nature Publishing Group
DOI: 10.1038/s41584-020-00539-1

Fluorine labelling of therapeutic human tolerogenic dendritic cells for 19F-magnetic resonance imaging

Autores: Cooke F, Neal M , Wood MJ , de Vries IJM, Anderson AE, Diboll J, Pratt AG, Stanway J, Nicorescu I, Moyse N, Hiles D, Caulfield D, Dickinson AM, Blamire AM, Thelwall P, Isaacs JD, Hilkens CMU
Publicado en: Frontiers in Immunology,, 2022, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2022.988667

Biomarkers of tolerance in immune-mediated inflammatory diseases: a new era in clinical management?

Autores: Kenneth F Baker, Jasmine P X Sim, John D Isaacs
Publicado en: The Lancet Rheumatology, Edición 3/5, 2021, Página(s) e371-e382, ISSN 2665-9913
Editor: Elsevier
DOI: 10.1016/s2665-9913(21)00069-2

The human bone marrow plasma cell compartment in rheumatoid arthritis - Clonal relationships and anti-citrulline autoantibody producing cells.

Autores: Hensvold A, Horuluoglu B, Sahlström P, Thyagarajan R, Diaz Boada JS, Hansson M, Mathsson-Alm L, Gerstner C, Sippl N, Israelsson L, Wedin R, Steen J, Klareskog L, Réthi B, Catrina AI, Diaz-Gallo LM, Malmström V, Grönwall C
Publicado en: Journal of Autoimmunity, 2023, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2023.103022

Randomized phase-1 trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis.

Autores: Sonigra A*, Nel H*, Wehr P*, Ramnoruth N, Patel S, van Schie K, Bladen M, Mehdi AM, Tesiram J, Talekar M, Rossjohn J, Reid H, Stuurman FE, Roberts H, Vecchio P, Gourley I, Rigby M, Becart S, Toes REM, Scherer HU, Le Cao KA, Campbell K and R Thomas.
Publicado en: JCI Insight, 2022, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.160964

Preclinical models of arthritis for studying immunotherapy and immune tolerance

Autores: Gavin R Meehan, Ranjeny Thomas, Shaima Al Khabouri, Pascale Wehr, Catharien MU Hilkens, David C Wraith, Daniela Sieghart, Michael Bonelli, György Nagy, Paul Garside, David F Tough, Huw D Lewis, James M Brewer
Publicado en: Annals of the Rheumatic Diseases, Edición 80/10, 2021, Página(s) 1268-1277, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220043

Single cell sequencing identifies clonally expanded synovial CD4+ TPH cells expressing GPR56 in rheumatoid arthritis

Autores: Argyriou A, Wadsworth MH 2nd, Lendvai A, Christensen SM, Hensvold AH, Gerstner C, van Vollenhoven A, Kravarik K, Winkler A, Malmström V, Chemin K.
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-31519-6

Immunological memory in rheumatic inflammation — a roadblock to tolerance induction

Autores: Patrick Maschmeyer, Hyun-Dong Chang, Qingyu Cheng, Mir-Farzin Mashreghi, Falk Hiepe, Tobias Alexander, Andreas Radbruch
Publicado en: Nature Reviews Rheumatology, Edición 17/5, 2021, Página(s) 291-305, ISSN 1759-4790
Editor: Nature Publishing Group
DOI: 10.1038/s41584-021-00601-6

Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models.

Autores: Futosi K, Németh T, Horváth ÁI, Abram CL, Tusnády S, Lowell CA, Helyes Z and Mócsai A
Publicado en: Journal of Experimental Medicine, 2023, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20221010

COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses

Autores: Filippo Fagni, David Simon, Koray Tascilar, Verena Schoenau, Michael Sticherling, Markus F Neurath, Georg Schett
Publicado en: The Lancet Rheumatology, Edición 3/10, 2021, Página(s) e724-e736, ISSN 2665-9913
Editor: Elsevier
DOI: 10.1016/s2665-9913(21)00247-2

I Would Never Take Preventive Medication! Perspectives and Information Needs of People Who Underwent Predictive Tests for Rheumatoid Arthritis

Autores: Erika Mosor, Michaela Stoffer‐Marx, Günter Steiner, Karim Raza, Rebecca J. Stack, Gwenda Simons, Marie Falahee, Diana Skingle, Mircia Dobrin, Georg Schett, Matthias Englbrecht, Josef S. Smolen, Ingvild Kjeken, Axel J. Hueber, Tanja A. Stamm
Publicado en: Arthritis Care & Research, Edición 72/3, 2020, Página(s) 360-368, ISSN 2151-464X
Editor: John Wiley & Sons Inc.
DOI: 10.1002/acr.23841

Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis

Autores: Sharma RK, Boddul SV, Yoosuf N, Turcinov S, Dubnovitsky A, Kozhukh G, Wermeling F, Kwok WW, Klareskog L, Malmström V
Publicado en: Scientific Reports, Edición 31 Dec 2021, 11(1):24512, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-04291-8

A Virtual Reality–Based App to Educate Health Care Professionals and Medical Students About Inflammatory Arthritis: Feasibility Study

Autores: Philipp Klemm, Arnd Kleyer, Koray Tascilar, Louis Schuster, Timo Meinderink, Florian Steiger, Uwe Lange, Ulf Müller-Ladner, Johannes Knitza, Philipp Sewerin, Johanna Mucke, Alexander Pfeil, Georg Schett, Fabian Hartmann, Axel J Hueber, David Simon
Publicado en: JMIR Serious Games, Edición 9/2, 2021, Página(s) e23835, ISSN 2291-9279
Editor: JMIR Publications
DOI: 10.2196/23835

IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints

Autores: Sudeepta Kumar Panda, Gustaf Wigerblad, Long Jiang, Yanek Jiménez-Andrade, Vaishnavi Srinivasan Iyer, Yunbing Shen, Sanjaykumar V. Boddul, André Ortlieb Guerreiro-Cacais, Bruno Raposo, Zsolt Kasza, Fredrik Wermeling
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/6, 2020, Página(s) 3103-3113, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1914186117

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

Autores: Sanne Reijm, Theresa Kissel, Gerrie Stoeken-Rijsbergen, Linda M. Slot, Corrie M. Wortel, Hugo J. van Dooren, Nivine E. W. Levarht, Arieke S. B. Kampstra, Veerle F. A. M. Derksen, Pleuni Ooijevaar-de Heer, Holger Bang, Jan W. Drijfhout, Leendert A. Trouw, Tom W. J. Huizinga, Theo Rispens, Hans U. Scherer & René E. M. Toes
Publicado en: Arthritis Research & Therapy, Edición Arthritis Research & Therapy volume 23, Article number: 230 (2021), 2021, ISSN 1478-6354
Editor: BioMed Central
DOI: 10.1186/s13075-021-02609-5

A Detailed Analysis of the Association between Urate Deposition and Erosions and Osteophytes in Gout

Autores: Caroline Pecherstorfer, David Simon, Sara Unbehend, Hanna Ellmann, Matthias Englbrecht, Fabian Hartmann, Camille Figueiredo, Axel Hueber, Judith Haschka, Roland Kocijan, Arnd Kleyer, Georg Schett, Jürgen Rech, Sara Bayat
Publicado en: ACR Open Rheumatology, Edición 2/10, 2020, Página(s) 565-572, ISSN 2578-5745
Editor: Wiley
DOI: 10.1002/acr2.11172

Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activity

Autores: Evan Reed, Anna Karin Hedström, Monika Hansson, Linda Mathsson-Alm, Boel Brynedal, Saedis Saevarsdottir, Martin Cornillet, Per-Johan Jakobsson, Rikard Holmdahl, Karl Skriner, Guy Serre, Lars Alfredsson, Johan Rönnelid, Karin Lundberg
Publicado en: Arthritis Research & Therapy, Edición 22/1, 2020, ISSN 1478-6362
Editor: BMC
DOI: 10.1186/s13075-020-02191-2

In vitro and ex vitro functional characterization of human HLA-DRB1∗04 restricted T cell receptors

Autores: Sanjaykumar V. Boddul, Ravi Kumar Sharma, Anatoly Dubnovitsky, Bruno Raposo, Christina Gerstner, Yunbing Shen, Vaishnavi Srinivasan Iyer, Zsolt Kasza, William W. Kwok, Aaron R. Winkler, Lars Klareskog, Vivianne Malmström, Maria Bettini, Fredrik Wermeling
Publicado en: Journal of Translational Autoimmunity, Edición 4, 2021, Página(s) 100087, ISSN 2589-9090
Editor: Elsevier
DOI: 10.1016/j.jtauto.2021.100087

Neutrophils as emerging therapeutic targets

Autores: Tamás Németh, Markus Sperandio, Attila Mócsai
Publicado en: Nature Reviews Drug Discovery, Edición 19/4, 2020, Página(s) 253-275, ISSN 1474-1776
Editor: Nature Publishing Group
DOI: 10.1038/s41573-019-0054-z

Osmium-Labeled Microspheres for Bead-Based Assays in Mass Cytometry

Autores: Lisa Budzinski, Axel R. Schulz, Sabine Baumgart, Tyler Burns, Thomas Rose, Heike Hirseland, Henrik E. Mei
Publicado en: The Journal of Immunology, Edición 202/10, 2019, Página(s) 3103-3112, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1801640

The Role of B Cells in Adult and Paediatric Liver Injury

Autores: Patel AM, Liu YS, Davies SP, Brown RM, Kelly DA, Scheel-Toellner D, Reynolds GM, Stamataki Z
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.729143

Neutralizing monoclonal antibodies against SARS-CoV-2 for COVID-19 pneumonia in a rituximab treated patient with systemic sclerosis-A case report and literature review

Autores: Melek Yalcin Mutlu, Jule Taubmann, Jochen Wacker, Koray Tascilar, Filippo Fagni, Maximilian Gerner, Daniel Klett, Georg Schett, Bernhard Manger, David Simon
Publicado en: Frontiers in medicine, 2022, ISSN 2296-858X
Editor: Frontiers Media S.A
DOI: 10.3389/fmed.2022.934169

Impact of autoimmune serology test results on RA classification and diagnosis

Autores: Van Hoovels L, Studenic P, Sieghart D, Steiner G, Bossuyt X, Rönnelid J.
Publicado en: Journal of translational autoimmunity, Edición 25899090, 2022, ISSN 2589-9090
Editor: Elsevier B.V.
DOI: 10.1016/j.jtauto.2022.100142

Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS–CoV-2 in an Unvaccinated Cohort

Autores: David Simon, Koray Tascilar, Arnd Kleyer, Filippo Fagni, Gerhard Krönke, Christine Meder, Peter Dietrich, Till Orlemann, Thorsten Kliem, Johanna Mößner, Anna-Maria Liphardt, Verena Schönau, Daniela Bohr, Louis Schuster, Fabian Hartmann, Moritz Leppkes, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J. Hueber, Karin Manger, Bernhard Manger, Raja Atr
Publicado en: Arthritis and Rheumatology, 2022, ISSN 2326-5205
Editor: Wiley
DOI: 10.1002/art.42035

The autoimmune response as a potential target for tolerance induction before the development of rheumatoid arthritis

Autores: Rene EM Toes, Karim Raza
Publicado en: The Lancet Rheumatology, Edición 3/3, 2021, Página(s) e214-e223, ISSN 2665-9913
Editor: Elsevier
DOI: 10.1016/s2665-9913(20)30445-8

Multifunctional, Multivalent PIC Polymer Scaffolds for Targeting Antigen-Specific, Autoreactive B Cells.

Autores: Kristyanto H, Holborough-Kerkvliet MD, Lelieveldt L, Bartels Y, Hammink R, van Schie KAJ, Toes REM, Bonger KM, Scherer HU
Publicado en: ACS Biomater Sci Eng, Edición 23739878, 2022, ISSN 2373-9878
Editor: American Chemical Society
DOI: 10.1021/acsbiomaterials.1c01395

Insights into FcγR involvement in pain-like behavior induced by an RA-derived anti-modified protein autoantibody

Autores: Jurczak A, Sandor K, Bersellini Farinotti A, Krock E, Hunt MA, Agalave NM, Barbier J, Simon N, Wang Z, Rudjito R, Vazquez-Mora JA, Martinez-Martinez A, Raoof R, Eijkelkamp N, Grönwall C, Klareskog L, Jimenéz-Andrade JM, Marchand F, Svensson CI.
Publicado en: Brain, Behavior, and Immunity, 2023, ISSN 1090-2139
Editor: Elsevier
DOI: 10.1016/j.bbi.2023.07.001

Autoreactive B cells against malondialdehyde-induced protein cross-links are present in the joint, lung, and bone marrow of rheumatoid arthritis patients.

Autores: Sahlström P, Joshua V, Valkovskaia V, Biese C, Stålesen R, Israelsson L, Végvári Á, Scheel-Toellner D, Klareskog L, Hansson M, Hensvold A, Malmström V, Grönwall C.
Publicado en: Journal of Biological Chemistry, 2023, ISSN 1083-351X
Editor: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology
DOI: 10.1016/j.jbc.2023.105320

A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis

Autores: Caroline Grönwall, Lisa Liljefors, Holger Bang, Aase H. Hensvold, Monika Hansson, Linda Mathsson-Alm, Lena Israelsson, Vijay Joshua, Anna Svärd, Ragnhild Stålesen, Philip J. Titcombe, Johanna Steen, Luca Piccoli, Natalia Sherina, Cyril Clavel, Elisabet Svenungsson, Iva Gunnarsson, Saedis Saevarsdottir, Alf Kastbom, Guy Serre, Lars Alfredsson, Vivianne Malmström, Johan Rönnelid, Anca I. Catrin
Publicado en: Frontiers in Immunology, Edición 12, 2021, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2021.627986

IgA subclasses have different effector functions associated with distinct glycosylation profiles

Autores: Ulrike Steffen, Carolien A. Koeleman, Maria V. Sokolova, Holger Bang, Arnd Kleyer, Jürgen Rech, Harald Unterweger, Martin Schicht, Fabian Garreis, Jonas Hahn, Fabian T. Andes, Fabian Hartmann, Madelaine Hahn, Aparna Mahajan, Friedrich Paulsen, Markus Hoffmann, Günter Lochnit, Luis E. Muñoz, Manfred Wuhrer, David Falck, Martin Herrmann, Georg Schett
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-13992-8

Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women

Autores: Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U. Scherer, Helena Forsblad-d’Elia, Georg Schett
Publicado en: Arthritis Research & Therapy, Edición 20/1, 2018, ISSN 1478-6362
Editor: Springer Nature
DOI: 10.1186/s13075-018-1586-z

Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures

Autores: Fabian Stemmler, David Simon, Anna-Maria Liphardt, Matthias Englbrecht, Juergen Rech, Axel J Hueber, Klaus Engelke, Georg Schett, Arnd Kleyer
Publicado en: Annals of the Rheumatic Diseases, Edición 77/7, 2018, Página(s) 973-980, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212404

Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner

Autores: Aline Bozec, Yubin Luo, Cecilia Engdahl, Camille Figueiredo, Holger Bang, Georg Schett
Publicado en: Arthritis Research & Therapy, Edición 20/1, 2018, ISSN 1478-6362
Editor: Springer Nature
DOI: 10.1186/s13075-018-1527-x

Determination of Autoantibody Isotypes Increases the Sensitivity of Serodiagnostics in Rheumatoid Arthritis

Autores: Daniela Sieghart, Alexander Platzer, Paul Studenic, Farideh Alasti, Maresa Grundhuber, Sascha Swiniarski, Thomas Horn, Helmuth Haslacher, Stephan Blüml, Josef Smolen, Günter Steiner
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers in immunology
DOI: 10.3389/fimmu.2018.00876

Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors

Autores: Tobias Alexander, Qingyu Cheng, Jens Klotsche, Laleh Khodadadi, Aderajew Waka, Robert Biesen, Bimba F. Hoyer, Gerd R. Burmester, Andreas Radbruch, Falk Hiepe
Publicado en: European Journal of Immunology, Edición 48/9, 2018, Página(s) 1573-1579, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201847492

Emerging therapies for pre-RA

Autores: Andrew P. Cope
Publicado en: Best Practice & Research Clinical Rheumatology, Edición 31/1, 2017, Página(s) 99-111, ISSN 1521-6942
Editor: Bailliere Tindall And Cassell
DOI: 10.1016/j.berh.2017.08.005

PU.1 controls fibroblast polarization and tissue fibrosis

Autores: Thomas Wohlfahrt, Simon Rauber, Steffen Uebe, Markus Luber, Alina Soare, Arif Ekici, Stefanie Weber, Alexandru-Emil Matei, Chih-Wei Chen, Christiane Maier, Emmanuel Karouzakis, Hans P. Kiener, Elena Pachera, Clara Dees, Christian Beyer, Christoph Daniel, Kolja Gelse, Andreas E. Kremer, Elisabeth Naschberger, Michael Stürzl, Falk Butter, Michael Sticherling, Susetta Finotto, Alexander Kreuter, Mar
Publicado en: Nature, Edición 566/7744, 2019, Página(s) 344-349, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-0896-x

Regulation of Fatty Acid Oxidation by Twist 1 in the Metabolic Adaptation of T Helper Lymphocytes to Chronic Inflammation

Autores: Kristyna Hradilkova, Patrick Maschmeyer, Kerstin Westendorf, Heidi Schliemann, Olena Husak, Anne Sae Lim Stuckrad, Tilmann Kallinich, Kirsten Minden, Pawel Durek, Joachim R. Grün, Hyun‐Dong Chang, Andreas Radbruch
Publicado en: Arthritis & Rheumatology, 2019, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.40939

Generation and Analysis of Human and Murine Osteoclasts

Autores: Ulrike Steffen, Fabian T. Andes, Georg Schett
Publicado en: Current Protocols in Immunology, Edición 125/1, 2019, Página(s) e74, ISSN 1934-3671
Editor: Greene Pub. Associates
DOI: 10.1002/cpim.74

Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells

Autores: Lianne P. W. M. Lelieveldt, Hendy Kristyanto, Ger J. M. Pruijn, Hans Ulrich Scherer, René E. M. Toes, Kimberly M. Bonger
Publicado en: Molecular Pharmaceutics, Edición 15/12, 2018, Página(s) 5565-5573, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b00741

Simultaneous quantification of bone erosions and enthesiophytes in the joints of patients with psoriasis or psoriatic arthritis - effects of age and disease duration

Autores: David Simon, Arnd Kleyer, Francesca Faustini, Matthias Englbrecht, Judith Haschka, Andreas Berlin, Sebastian Kraus, Axel J. Hueber, Roland Kocijan, Michael Sticherling, Juergen Rech, Georg Schett
Publicado en: Arthritis Research & Therapy, Edición 20/1, 2018, ISSN 1478-6362
Editor: Springer Nature
DOI: 10.1186/s13075-018-1691-z

Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammation—data from the prospective IVEPSA study

Autores: Eleni Kampylafka, David Simon, Isabelle d’Oliveira, Christina Linz, Veronika Lerchen, Matthias Englbrecht, Juergen Rech, Arnd Kleyer, Michael Sticherling, Georg Schett, Axel J. Hueber
Publicado en: Arthritis Research & Therapy, Edición 21/1, 2019, ISSN 1478-6362
Editor: Springer Nature
DOI: 10.1186/s13075-019-1957-0

Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis

Autores: Anna Neumann, Judith Haschka, Arnd Kleyer, Louis Schuster, Matthias Englbrecht, Andreas Berlin, Camille P. Figueiredo, David Simon, Christian Muschitz, Roland Kocijan, Heinrich Resch, Jürgen Rech, Georg Schett
Publicado en: Arthritis Research & Therapy, Edición 20/1, 2018, ISSN 1478-6362
Editor: Springer Nature
DOI: 10.1186/s13075-018-1620-1

Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients

Autores: David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett, Axel J. Hueber
Publicado en: Arthritis Research & Therapy, Edición 21/1, 2019, ISSN 1478-6362
Editor: Springer Nature
DOI: 10.1186/s13075-019-1938-3

Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification

Autores: Arieke Suzanna Berendina Kampstra, Jacqueline Stephanie Dekkers, Mikhail Volkov, Annemarie L Dorjée, Lise Hafkenscheid, Ayla C Kempers, Myrthe van Delft, Theresa Kissel, Sanne Reijm, George M C Janssen, Peter A van Veelen, Holger Bang, Tom W J Huizinga, Leendert A Trouw, Diane van der Woude, René E M Toes
Publicado en: Annals of the Rheumatic Diseases, Edición 78/7, 2019, Página(s) 908-916, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214950

On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis

Autores: Theresa Kissel, Karin Anna van Schie, Lise Hafkenscheid, Anders Lundquist, Heidi Kokkonen, Manfred Wuhrer, Tom WJ Huizinga, Hans Ulrich Scherer, René Toes, Solbritt Rantapää-Dahlqvist
Publicado en: Annals of the Rheumatic Diseases, 2019, Página(s) annrheumdis-2019-215698, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-215698

N ‐Linked Glycans in the Variable Domain of IgG Anti–Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis

Autores: Lise Hafkenscheid, Emma Moel, Irene Smolik, Stacey Tanner, Xiaobo Meng, Bas C. Jansen, Albert Bondt, Manfred Wuhrer, Tom W. J. Huizinga, Rene E. M. Toes, Hani El‐Gabalawy, Hans U. Scherer
Publicado en: Arthritis & Rheumatology, Edición 71/10, 2019, Página(s) 1626-1633, ISSN 2326-5191
Editor: Springer nature
DOI: 10.1002/art.40920

The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells

Autores: Esperanza Perucha, Rossella Melchiotti, Jack A Bibby, Wing Wu, Klaus Stensgaard Frederiksen, Ceri A. Roberts, Zoe Hall, Gaelle LeFriec, Kevin A. Robertson, Paul Lavender, Jens Gammeltoft Gerwien, Leonie S. Taams, Julian L. Griffin, Emanuele de Rinaldis, Lisa G. M. van Baarsen, Claudia Kemper, Peter Ghazal, Andrew P. Cope
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-08332-9

The involvement of Toll‐like receptor 9 in the pathogenesis of erosive autoimmune arthritis

Autores: Anita Fischer, Shahla Abdollahi‐Roodsaz, Christina Böhm, Birgit Niederreiter, Brigitte Meyer, Anthony C. Y. Yau, Erik Lönnblom, Leo A. B. Joosten, Marije Koenders, Christian H. K. Lehmann, Diana Dudziak, Gerhard Krönke, Rikard Holmdahl, Günter Steiner
Publicado en: Journal of Cellular and Molecular Medicine, Edición 22/9, 2018, Página(s) 4399-4409, ISSN 1582-1838
Editor: Wiley-Blackwell
DOI: 10.1111/jcmm.13735

MicroRNA-155 Controls T Helper Cell Activation During Viral Infection

Autores: Eliana Goncalves-Alves, Victoria Saferding, Christopher Schliehe, Robert Benson, Mariola Kurowska-Stolarska, Julia Stefanie Brunner, Antonia Puchner, Bruno K. Podesser, Josef S. Smolen, Kurt Redlich, Michael Bonelli, James Brewer, Andreas Bergthaler, Günter Steiner, Stephan Blüml
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2019.01367

Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form

Autores: Janka Zsófia Csepregi, Anita Orosz, Erik Zajta, Orsolya Kása, Tamás Németh, Edina Simon, Szabina Fodor, Katalin Csonka, Balázs L. Barátki, Dorottya Kövesdi, You-Wen He, Attila Gácser, Attila Mócsai
Publicado en: The Journal of Immunology, Edición 201/12, 2018, Página(s) 3793-3803, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1701803

N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development

Autores: Rochelle D. Vergroesen, Linda M. Slot, Barbera D. C. van Schaik, Marvyn T. Koning, Theo Rispens, Antoine H. C. van Kampen, René E. M. Toes, Hans U. Scherer
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2019.02092

IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes

Autores: Michael Bonelli, Karolina Dalwigk, Alexander Platzer, Isabel Olmos Calvo, Silvia Hayer, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Thomas Pap, Günter Steiner, Giulio Superti-Furga, Josef S. Smolen, Hans P. Kiener, Thomas Karonitsch
Publicado en: Experimental & Molecular Medicine, Edición 51/7, 2019, ISSN 1226-3613
Editor: Korean Society of Medical Biochemistry and Molecular Biology
DOI: 10.1038/s12276-019-0267-6

Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis

Autores: Tamás Németh, Krisztina Futosi, Marcell Szabó, Petra Aradi, Takashi Saito, Attila Mócsai, Zoltán Jakus
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: frontiers
DOI: 10.3389/fimmu.2019.00252

Dendritic cells, T cells and their interaction in rheumatoid arthritis

Autores: P. Wehr, H. Purvis, S.‐C. Law, R. Thomas
Publicado en: Clinical & Experimental Immunology, Edición 196/1, 2019, Página(s) 12-27, ISSN 0009-9104
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cei.13256

Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts

Autores: Meng Sun, Bence Rethi, Akilan Krishnamurthy, Vijay Joshua, Alexandra Circiumaru, Aase Haj Hensvold, Elena Ossipova, Caroline Grönwall, Yanying Liu, Marianne Engstrom, Sergiu Bogdan Catrina, Johanna Steen, Vivianne Malmstrom, Lars Klareskog, Camilla Svensson, Caroline Ospelt, Heidi Wähämaa, Anca Irinel Catrina
Publicado en: Annals of the Rheumatic Diseases, 2019, Página(s) annrheumdis-2018-214967, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214967

Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis

Autores: Kaja Eriksson, Guozhong Fei, Anna Lundmark, Daniel Benchimol, Linkiat Lee, Yue O. O. Hu, Anna Kats, Saedis Saevarsdottir, Anca Irinel Catrina, Björn Klinge, Anders F. Andersson, Lars Klareskog, Karin Lundberg, Leif Jansson, Tülay Yucel-Lindberg
Publicado en: Journal of Clinical Medicine, Edición 8/5, 2019, Página(s) 630, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8050630

Secretory anti-citrullinated protein antibodies in serum associate with lung involvement in early rheumatoid arthritis

Autores: Karin Roos Ljungberg, Vijay Joshua, Thomas Skogh, Anders Eklund, C Magnus Sköld, Reza Karimi, Sven Nyrén, Anna Svärd, Anca I Catrina, Alf Kastbom
Publicado en: Rheumatology, 2019, ISSN 1462-0324
Editor: Oxford University Press
DOI: 10.1093/rheumatology/kez377

Considerations for Optimal Trial Design for Rheumatoid Arthritis Prevention Studies

Autores: Andrew P. Cope
Publicado en: Clinical Therapeutics, Edición 41/7, 2019, Página(s) 1299-1311, ISSN 0149-2918
Editor: Excerpta Medica, Inc.
DOI: 10.1016/j.clinthera.2019.04.014

Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis

Autores: Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere, Catharien M. U. Hilkens
Publicado en: Journal of Translational Medicine, Edición 17/1, 2019, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1186/s12967-019-2128-4

IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes

Autores: Anna-Katharina Gimpel, Antonio Maccataio, Harald Unterweger, Maria V Sokolova, Georg Schett, Ulrike Steffen
Publicado en: Frontiers in immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.761816

Different hierarchies of anti‐modified protein autoantibody reactivities in rheumatoid arthritis

Autores: Peter Sahlström, Monika Hansson, Johanna Steen, Khaled Amara, Philip J Titcombe, Björn Forsström, Ragnhild Stålesen, Lena Israelsson, Luca Piccoli, Karin Lundberg, Lars Klareskog, Daniel L. Mueller, Anca I Catrina, Karl Skriner, Vivianne Malmström, Caroline Grönwall
Publicado en: Arthritis & Rheumatology, Edición 72/10, 2020, Página(s) 1643-1657, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.41385

BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study

Autores: Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. Pratt, Jonathan Prichard, Karim Raza, Stefan Siebert, Deborah Stocken, M. Dawn Teare, Stephen Young, John D. Isaacs
Publicado en: BMC Rheumatology, Edición 5/1, 2021, ISSN 2520-1026
Editor: BioMed Central Springer nature
DOI: 10.1186/s41927-021-00194-3

Mobile Health Usage, Preferences, Barriers, and eHealth Literacy in Rheumatology: Patient Survey Study

Autores: Johannes Knitza, David Simon, Antonia Lambrecht, Christina Raab, Koray Tascilar, Melanie Hagen, Arnd Kleyer, Sara Bayat, Adrian Derungs, Oliver Amft, Georg Schett, Axel J Hueber
Publicado en: JMIR mHealth and uHealth, Edición 8/8, 2020, Página(s) e19661, ISSN 2291-5222
Editor: JMIR Publications
DOI: 10.2196/19661

Diversity and Clonality of T Cell Receptor Repertoire and Antigen Specificities in Small Joints of Early Rheumatoid Arthritis

Autores: Turcinov S, Af Klint E, Van Schoubroeck B, Kouwenhoven A, Mia S, Chemin K, Wils H, Van Hove C, De Bondt A, Keustermans K, Van Houdt J, Reumers J, Felix N, Rao NL, Peeters P, Stevenaert F, Klareskog L, McKinnon M, Baker D, Suri A, Malmström V.
Publicado en: Arthritis & Rheumatology, 2023, ISSN 2326-5205
Editor: Wiley Periodicals LLC on behalf of American College of Rheumatology.
DOI: 10.1002/art.42407

Biomechanical stress in the context of competitive sports training triggers enthesitis

Autores: David Simon, Arnd Kleyer, Sara Bayat, Johannes Knitza, Larissa Valor-Mendez, Marina Schweiger, Georg Schett, Koray Tascilar, Axel J. Hueber
Publicado en: Arthritis Research & Therapy, Edición 23/1, 2021, ISSN 1478-6362
Editor: Biomed Central
DOI: 10.1186/s13075-021-02530-x

SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases

Autores: David Simon, Koray Tascilar, Filippo Fagni, Gerhard Krönke, Arnd Kleyer, Christine Meder, Raja Atreya, Moritz Leppkes, Andreas E Kremer, Andreas Ramming, Milena L Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J Hueber, Karin Manger, Bernhard Manger, Carola Berking, Michael Sticherling, Markus F Neurath, Georg Schett
Publicado en: Annals of the Rheumatic Diseases, Edición 80/10, 2021, Página(s) 1312-1316, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220461

Rheumatology tolerance for cure (RTCure) – an IMI project aimed at prevention and cure of RA

Autores: Lars Klareskog on behalf of RTCure
Publicado en: Seminars in Arthritis and Rheumatism, 2023, ISSN 0049-0172
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semarthrit.2023.152322

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Autores: Jasna Friščić, Martin Böttcher, Christiane Reinwald, Heiko Bruns, Benjamin Wirth, Samantha-Josefine Popp, Kellie Irene Walker, Jochen A. Ackermann, Xi Chen, Jason Turner, Honglin Zhu, Lisa Seyler, Maximilien Euler, Philipp Kirchner, René Krüger, Arif B. Ekici, Triin Major, Oliver Aust, Daniela Weidner, Anita Fischer, Fabian T. Andes, Zeljka Stanojevic, Vladimir Trajkovic, Martin Herrmann, Ad
Publicado en: Immunity, Edición 54/5, 2021, Página(s) 1002-1021.e10, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2021.03.003

Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk

Autores: Sokolova MV, Hartmann F, Sieghart D, et al
Publicado en: RMD Open, 2023, ISSN 2056-5933
Editor: BMJ Publishing Group Ltd
DOI: 10.1136/rmdopen-2022-002705

IgM antibodies against acetylated proteins as a possible starting point of the anti-modified protein antibody response in rheumatoid arthritis.

Autores: van Wesemael TJ, Reijm S, Kawakami A, et al
Publicado en: Annals of the Rheumatic Diseases, 2023, ISSN 0003-4967
Editor: BMJ Publishing Group

CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

Autores: Dimitrios Mougiakakos, Gerhard Krönke, Simon Völkl, Sascha Kretschmann, Michael Aigner, Soraya Kharboutli, Sebastian Böltz, Bernhard Manger, Andreas Mackensen, Georg Schett
Publicado en: New England Journal of Medicine, Edición 385/6, 2021, Página(s) 567-569, ISSN 0028-4793
Editor: Massachusetts Medical Society
DOI: 10.1056/nejmc2107725

Performance of a Handheld Ultrasound Device to Assess Articular and Periarticular Pathologies in Patients with Inflammatory Arthritis

Autores: Giulia Corte, Sara Bayat, Koray Tascilar, Larissa Valor-Mendez, Louis Schuster, Johannes Knitza, Filippo Fagni, Georg Schett, Arnd Kleyer, David Simon
Publicado en: Diagnostics, Edición 11/7, 2021, Página(s) 1139, ISSN 2075-4418
Editor: MDPI Journals
DOI: 10.3390/diagnostics11071139

Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study

Autores: David Simon, Koray Tascilar, Filippo Fagni, Arnd Kleyer, Gerhard Krönke, Christine Meder, Peter Dietrich, Till Orlemann, Johanna Mößner, Jule Taubmann, Melek Yalcin Mutlu, Johannes Knitza, Stephan Kemenes, Anna-Maria Liphardt, Verena Schönau, Daniela Bohr, Louis Schuster, Fabian Hartmann, Ioanna Minopoulou, Moritz Leppkes, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger,
Publicado en: The Lancet. Rheumatology, 2022, ISSN 2665-9913
Editor: Elsevier
DOI: 10.1016/s2665-9913(22)00191-6

Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications

Autores: M. Volkov; A. S. B. Kampstra; K. A. van Schie; A. Kawakami; M. Tamai; S. Kawashiri; T. Maeda; T. W. J. Huizinga; R. E. M. Toes; D. van der Woude
Publicado en: Arthritis Research & Therapy, 2021, ISSN 1478-6362
Editor: BioMed Central
DOI: 10.1186/s13075-021-02687-5

Secukinumab leads to shifts from stage-based towards response-based disease clusters—comparative data from very early and established psoriatic arthritis

Autores: Eleni Kampylafka, Koray Tascilar, Veronika Lerchen, Christina Linz, Maria Sokolova, Ana Zekovic, Arnd Kleyer, David Simon, Jürgen Rech, Michael Sticherling, Georg Schett, Axel J. Hueber
Publicado en: Arthritis Research & Therapy, Edición 22/1, 2020, ISSN 1478-6362
Editor: Springer Nature
DOI: 10.1186/s13075-020-02268-y

Impact of Medium-Sized Extracellular Vesicles on the Transduction Efficiency of Adeno-Associated Viruses in Neuronal and Primary Astrocyte Cell Cultures.

Autores: Orsolya Tünde Kovács; Eszter Soltész-Katona; Nikolett Marton; Eszter Baricza; László Hunyady; Gábor Turu; György Nagy
Publicado en: International Journal of Molecular Sciences, Edición 3, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084221

Light chain skewing in autoantibodies and B-cell receptors of the citrullinated antigen-binding B-cell response in rheumatoid arthritis

Autores: Linda M. Slot ,Rochelle D. Vergroesen ,Priscilla F. Kerkman,Ellen Staudinger,Sanne Reijm,Hugo J. van Dooren,Ellen I. H. van der Voort,Tom W. J. Huizinga,René E. M. Toes,Hans U. Scherer
Publicado en: PLoS One, Edición Mar 30;16(3):e0247847, 2021, ISSN 1544-9173
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0247847

Phospholipase Cγ2 is essential for experimental models of epidermolysis bullosa acquisita

Autores: Kata P. Szilveszter, Simon Vikár, Ádám I. Horváth, Zsuzsanna Helyes, Miklós Sárdy, Attila Mócsai
Publicado en: Journal of Investigative Dermatology, 2021, ISSN 0022-202X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2021.09.019

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis

Autores: Christina Gerstner, Sara Turcinov, Aase H. Hensvold, Karine Chemin, Hannes Uchtenhagen, Tamara H. Ramwadhdoebe, Anatoly Dubnovitsky, Genadiy Kozhukh, Lars Rönnblom, William W. Kwok, Adnane Achour, Anca I. Catrina, Lisa G. M. van Baarsen, Vivianne Malmström
Publicado en: BMC Immunology, Edición 21/1, 2020, ISSN 1471-2172
Editor: BioMed Central
DOI: 10.1186/s12865-020-00357-w

Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology.

Autores: Sherina N, de Vries C, Kharlamova N, Sippl N, Jiang X, Brynedal B, Kindstedt E, Hansson M, Mathsson-Alm L, Israelsson L, Stålesen R, Saevarsdottir S, Holmdahl R, Hensvold A, Johannsen G, Eriksson K, Sallusto F, Catrina AI, Rönnelid J, Grönwall C, Yucel-Lindberg T, Alfredsson L, Klareskog L, Piccoli L, Malmström V, Amara K, Lundberg K.
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.804822

The diagnostic and prognostic value of IgG and IgA anti-citrullinated protein antibodies in patients with early rheumatoid arthritis

Autores: Sieghart D, Konrad C, Swiniarski S, Haslacher H, Aletaha D, Steiner G.
Publicado en: Frontiers in Immunology, 2023, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.1096866

Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming

Autores: Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE, Thalayasingam N, Diboll J, Bondet V, Duffy D, Barnes MR, Smith GR, Ng S, Watson D, Henkin R, Cope AP, Reynard LN, Pratt AG
Publicado en: Ann Rheum Dis, Edición 00034967, 2022, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2022-222370

Current view on the pathogenic role of anti-citrullinated protein antibodies in rheumatoid arthritis

Autores: Anca Catrina, Akilan Krishnamurthy, Bence Rethi
Publicado en: RMD Open, Edición 7/1, 2021, Página(s) e001228, ISSN 2056-5933
Editor: BMJ Publishing group
DOI: 10.1136/rmdopen-2020-001228

Towards prevention of autoimmune diseases: The example of rheumatoid arthritis

Autores: Aase Hensvold, Lars Klareskog
Publicado en: European Journal of Immunology, Edición 51/8, 2021, Página(s) 1921-1933, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048952

Anti-Citrullinated Protein Antibody Reactivity towards Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual Variation.

Autores: Cîrciumaru A, Afonso MG, Wähämaa H, Krishnamurthy A, Hansson M, Mathsson-Alm L, Keszei M, Stålesen R, Ottosson L, de Vries C, Shelef MA, Malmström V, Klareskog L, Catrina AI, Grönwall C, Hensvold A, Réthi B.
Publicado en: Biomolecules, 2023, ISSN 2218-273X
Editor: MDPI AG
DOI: 10.3390/biom13040630

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

Autores: Jack A. Bibby, Harriet A. Purvis, Thomas Hayday, Anita Chandra, Klaus Okkenhaug, Sofia Rosenzweig, Ivona Aksentijevich, Michael Wood, Helen J. Lachmann, Claudia Kemper, Andrew P. Cope, Esperanza Perucha
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-17179-4

Immune tolerance therapies for autoimmune diseases: Shifting the goalpost to cure

Autores: Ranjeny Thomas; Patrick Sharkey
Publicado en: Curr Opin Pharmacol, Edición 14714892, 2022, ISSN 1471-4892
Editor: Elsevier BV
DOI: 10.1016/j.coph.2022.102242

Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis

Autores: Kugler M, Dellinger M, Kartnig F, et al
Publicado en: Annals of the Rheumatic Diseases, 2023, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/ard-2022-223396

Associations between rheumatoid arthritis clinical factors with synovial cell types and states

Autores: Dana Weisenfeld, Fan Zhang, Laura D, Anna Helena Jonsson, William Apruzzese, Debbie Campbell; Accelerating Medicines Partnership Program: RA/SLE Network; Deepak A Rao, Kevin Wei, V Michael Holers, Ellen Gravallese, Larry Moreland, Susan Goodman, Michael Brenner, Soumya Raychaudhuri, Andrew Filer, Jennifer Anolik, Vivian Bykerk, Katherine P Liao
Publicado en: Arthritis Rheumatol, 2023, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.42726

Does methotrexate influence COVID-19 infection? Case series and mechanistic data

Autores: Fabian Schälter, Kerstin Dürholz, Laura Bucci, Gerd Burmester, Roberto Caporali, Camille Figuereido, Jaime Fogagnolo Cobra, Bernhard Manger, Mario M. Zaiss, Georg Schett
Publicado en: Arthritis Research & Therapy, Edición 23/1, 2021, ISSN 1478-6362
Editor: Biomed Central
DOI: 10.1186/s13075-021-02464-4

Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells

Autores: Rebecca Cornelis, Stefanie Hahne, Adriano Taddeo, Georg Petkau, Darya Malko, Pawel Durek, Manja Thiem, Lukas Heiberger, Lena Peter, Elodie Mohr, Cora Klaeden, Koji Tokoyoda, Francesco Siracusa, Bimba Franziska Hoyer, Falk Hiepe, Mir-Farzin Mashreghi, Fritz Melchers, Hyun-Dong Chang, Andreas Radbruch
Publicado en: Cell Reports, Edición 32/5, 2020, Página(s) 107982, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.107982

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

Autores: Narges Tajik, Michael Frech, Oscar Schulz, Fabian Schälter, Sébastien Lucas, Vugar Azizov, Kerstin Dürholz, Franziska Steffen, Yasunori Omata, Andreas Rings, Marko Bertog, Aroldo Rizzo, Aida Iljazovic, Marijana Basic, Arnd Kleyer, Stephan Culemann, Gerhard Krönke, Yubin Luo, Klaus Überla, Udo S. Gaipl, Benjamin Frey, Till Strowig, Kerstin Sarter, Stephan C. Bischoff, Stefan Wirtz, Juan D. Ca
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-15831-7

Stabilizing Antibody Cocktails for Mass Cytometry

Autores: Axel R. Schulz, Sabine Baumgart, Julia Schulze, Marie Urbicht, Andreas Grützkau, Henrik E. Mei
Publicado en: Cytometry Part A, 2019, ISSN 1552-4922
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.23781

IgA anti-citrullinated protein antibodies are associated with flares during DMARD tapering in rheumatoid arthritis

Autores: Maria V Sokolova, Melanie Hagen, Holger Bang, Georg Schett, Juergen Rech, Ulrike Steffen
Publicado en: Rheumatology, 2021, ISSN 1462-0324
Editor: Oxford University Press
DOI: 10.1093/rheumatology/keab585

Dysregulated CD38 Expression on Peripheral Blood Immune Cell Subsets in SLE

Autores: Marie Burns, Lennard Ostendorf, Robert Biesen, Andreas Grützkau, Falk Hiepe, Henrik E. Mei, Tobias Alexander
Publicado en: International Journal of Molecular Sciences, Edición 22/5, 2021, Página(s) 2424, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052424

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Autores: Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam‐Klages, William W. Agace, Nima Aghaeepour, Mübeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi, Graham Anderson, Immanuel Andrä, Francesco Annunziato, Achille Anselmo, Petra Bacher, Cosima T. Baldari, Sudipto Bari, Vincenzo Barnaba, Joana Barros‐Martins, Luca Battistini, Wolfgan
Publicado en: European Journal of Immunology, Edición 49/10, 2019, Página(s) 1457-1973, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201970107

Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs

Autores: Asmir Vodencarevic, Koray Tascilar, Fabian Hartmann, Michaela Reiser, Axel J. Hueber, Judith Haschka, Sara Bayat, Timo Meinderink, Johannes Knitza, Larissa Mendez, Melanie Hagen, Gerhard Krönke, Jürgen Rech, Bernhard Manger, Arnd Kleyer, Marcus Zimmermann-Rittereiser, Georg Schett, David Simon
Publicado en: Arthritis Research & Therapy, Edición 23/1, 2021, ISSN 1478-6362
Editor: BioMed Central
DOI: 10.1186/s13075-021-02439-5

OP0074 DISTINCT CIRCULATING LYMPHOCYTE SUBSETS DISTINGUISH FLARE FROM DRUG-FREE REMISSION IN RHEUMATOID ARTHRITIS

Autores: KF Baker, F Rayner, H Lemos, D McDonald, G Hulme, R. Hussain, J. Coxhead, A. Pratt, A. E. Anderson, A. Filby, J. Isaacs
Publicado en: Annals of the Rheumatic Diseases, 2022
Editor: BMJ

GENETIC SUSCEPTIBILITY VARIANTS FOR RHEUMATOID ARTHRITIS ARE NOT ASSOCIATED WITH EARLY REMISSION; A MULTI-COHORT STUDY

Autores: Zapata SJ, Maurits M, Abraham Y, Van den Akker E, Barton A, Brown P, Cope A, González-Álvaro I, Goodyear C, van der Helm-van Mil A, Hu X
Publicado en: Annals of the Rheumatic Diseases, Edición 2021;80, 2021, Página(s) 403-404, ISSN 0003-4967
Editor: BMJ Publishing group

POS0534 TRAJECTORY ANALYSIS OF RHEUMATOID ARTHRITIS PROGRESSION USING CLINICAL DATA

Autores: D Van der Bijl, T Maarseveen, A Cope, A Yann, R Knevel
Publicado en: Annals of the Rheumatic Diseases, Scientific Abstracts, 2022, Página(s) POSTERS onlyRheumatoid arthritis - prognosis, predictors and outcome
Editor: BMJ

OP0016 Abatacept To Silence Anti-Citrullinated Protein Antibody-Expressing B Cells In Rheumatoid Arthritis:

Autores: Blomberg N, Kwekkeboom J, Böhringer S, et al
Publicado en: Annals of the Rheumatic Diseases, 2023
Editor: BMJ

POS0531 ABATACEPT DELAYS THE DEVELOPMENT OF RA– CLINICAL RESULTS AFTER 18 MONTHS FROM THE RANDOMIZED, PLACEBO-CONTROLLED ARIAA STUDY IN RA-AT RISK PATIENTS

Autores: Rech J, Kleyer A, Østergaard M, et al
Publicado en: Annals of the Rheumatic Diseases, 2022, ISSN 0003-4967
Editor: BMJ group

OP0075 FIBROBLAST/MACROPHAGE CROSSTALK VIA LACTATE: NEW THERAPEUTIC TARGET IN RHEUMATOID ARTHRITIS

Autores: V Pucino, M Nefla, V Gauthier, SA Clayton, A Filer, A. R. Clark, K. Raza, C. D. Buckley
Publicado en: Annals of the Rheumatic Diseases, 2022
Editor: BMJ

OP0190 COMPREHENSIVE GENETIC AND FUNCTIONAL ANALYSES OF Fc GAMMA RECEPTORS EXPLAIN RESPONSE TO RITUXIMAB THERAPY FOR AUTOIMMUNE RHEUMATIC DISEASES

Autores: MYMD Yusof, J Robinson, V Davies, D Wild, M Morgan et al.
Publicado en: Annals of the Rheumatic Diseases, 2022
Editor: BMJ

GWAS Identified New Genes in Synovial Fibroblasts Linked to Early Remission in RA

Autores: Maurits M, Abasolo Alcazar l, van den Akker E, Askling J, Barton A, Blüml S, Böhringer S, Cope A, Emery P, Eyre S, Gaddi P, Gonzalez I, Goodyear C, van der Helm-van Mil A, Hu X, Huizinga T, Isaacs J, Jelinsky S, Johannesson M, Jurado Zapata S, Ke C, Klareskog L, Lendrem D, Lewis M, Liu M, Martin P, McInnes I, Micheroli R, Morgan A, Morton F, Naamane N, Orozco G, Ospelt C, Padyukov L, Paterson C,
Publicado en: Arthritis & Rheumatology (Hoboken, N.J.), 2022, ISSN 2326-5191
Editor: Wiley

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