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Transferring autonomous and non autonomous cell degeneration 3D models between EU and USA for development of effective therapies for neurodegenerative diseases (ND)

Objective

Neurodegenerative diseases (NDs), such as Dementia, Parkinson’s and motor neuron diseases, are a major and continuously growing worldwide health issue, particularly devastating for patients and their families. Yet, no cures are available, largely due to the lack of knowledge of ND pathogenic mechanisms. Strikingly, co-occurrence of several NDs in the same patient or family, and evidence that mutations in the same gene lead to several NDs are indicating that common molecular pathways are involved across NDs. Elucidating these shared mechanisms could have a major impact for the treatment and the prevention of this spectrum of NDs. Leveraging on our expertise in studying autonomous and non-autonomous mechanisms of NDs, we propose an innovative, multinational and multidisciplinary collaborative research project to perform network analyses across NDs and identify key common underlying mechanisms. The CROSS-NEUROD project is focused on: 1) the development of integrative in vitro 3D disease models (mini-brains, mini-spinal cords, and motor unit) to elucidate common cellular and molecular pathways across NDs; 2) the validation in animal models of the therapeutic targets identified. To achieve these aims we will consolidate research partnerships through staff exchanges and networking activities between 3 European research organizations, two of which from Italy, one from Greece, and a partner, USA. The project is based on a 4 years coordinated joint program of exchanges of researchers for short periods. It has been developed from active bilateral cooperation between individual countries and partners and represents the natural progression of our previously funded and successfully completed EU 7PQ IRSES grant “No-MND” (2013 call). Our ongoing research programs are well supported by funding. The RISE scheme provides a unique opportunity to integrate ongoing collaboration activities into a coherent program addressing an issue of high priority for public health both in EU and USA.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /medical and health sciences/basic medicine/neurology/parkinson

Call for proposal

H2020-MSCA-RISE-2017
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

UNIVERSITA DEGLI STUDI DI MILANO
Address
Via Festa Del Perdono 7
20122 Milano
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 306 000

Participants (2)

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
EU contribution
€ 153 000
Address
Soranou Efesiou 4
115 27 Athina
Activity type
Research Organisations
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO
Italy
EU contribution
€ 135 000
Address
Via Francesco Sforza 28
20122 Milano
Activity type
Other

Partners (1)

TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
United States
Address
Amsterdam Avenue 1210 Room
10027 7003 New York
Activity type
Higher or Secondary Education Establishments