Objective Neurodegenerative diseases (NDs), such as Dementia, Parkinson’s and motor neuron diseases, are a major and continuously growing worldwide health issue, particularly devastating for patients and their families. Yet, no cures are available, largely due to the lack of knowledge of ND pathogenic mechanisms. Strikingly, co-occurrence of several NDs in the same patient or family, and evidence that mutations in the same gene lead to several NDs are indicating that common molecular pathways are involved across NDs. Elucidating these shared mechanisms could have a major impact for the treatment and the prevention of this spectrum of NDs. Leveraging on our expertise in studying autonomous and non-autonomous mechanisms of NDs, we propose an innovative, multinational and multidisciplinary collaborative research project to perform network analyses across NDs and identify key common underlying mechanisms. The CROSS-NEUROD project is focused on: 1) the development of integrative in vitro 3D disease models (mini-brains, mini-spinal cords, and motor unit) to elucidate common cellular and molecular pathways across NDs; 2) the validation in animal models of the therapeutic targets identified. To achieve these aims we will consolidate research partnerships through staff exchanges and networking activities between 3 European research organizations, two of which from Italy, one from Greece, and a partner, USA. The project is based on a 4 years coordinated joint program of exchanges of researchers for short periods. It has been developed from active bilateral cooperation between individual countries and partners and represents the natural progression of our previously funded and successfully completed EU 7PQ IRSES grant “No-MND” (2013 call). Our ongoing research programs are well supported by funding. The RISE scheme provides a unique opportunity to integrate ongoing collaboration activities into a coherent program addressing an issue of high priority for public health both in EU and USA. Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesbasic medicineneurologydementianatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesbasic medicineneurologyparkinson Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2017 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2017 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator UNIVERSITA DEGLI STUDI DI MILANO Net EU contribution € 306 000,00 Address Via festa del perdono 7 20122 Milano Italy See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 49 500,00 Participants (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Greece Net EU contribution € 153 000,00 Address Soranou efesiou 4 115 27 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 27 000,00 FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO Italy Net EU contribution € 135 000,00 Address Via francesco sforza 28 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 22 500,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK United States Net EU contribution € 0,00 Address Amsterdam avenue 1210 room 10027 7003 New york See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 99 000,00
