Resultado final
We will report for the onsite training provided and usage of the online system
Evaluation of neuroprotective abilities of candidate genes in an in vitro model.We will assess gene expression profile and identify candidate causal MRs and shared molecular pathways between NDs.
3D models generated from 4 different sourcesPatient specific minibrain and spinal cordorganoids generated from iPSCs of ALS SMA FTD and PD will be characterized
Pre-clinical protocols for AAV gene deliveryWe will establish protocols to over-express or knock-down genes of interest by using adeno-associated virus (AAV).
Identification of neuropathological markersWe will identify genes responsible for selective cell death and potential targets to modify ND disease progression
Publicaciones
Autores:
*S. CORTI1, I. FARAVELLI1, P. RINCHETTI1, S. MANCINELLI2, L. MAPELLI3, G. FOROTTI4, M. RIZZUTI4, C. CORDIGLIERI5, L. CALANDRIELLO4, S. TAMANINI1, N. BRESOLIN1, G. P. COMI1, S. LODATO2, M. NIZZARDO1
Publicado en:
2019
Editor:
SFN
Autores:
Forotti G1, Nizzardo M1, Bucchia M2, Ramirez A2, Trombetta E3, Gatti S4, Bresolin N5, Comi GP5, Corti S6.
Publicado en:
Experimental Neurology, 2019, ISSN 0014-4886
Editor:
Academic Press
DOI:
10.1016/j.expneurol.2019.113041
Autores:
Gianluca Costamagna, Luca Andreoli, Stefania Corti, Irene Faravelli
Publicado en:
Cells, Edición 8/11, 2019, Página(s) 1438, ISSN 2073-4409
Editor:
Multidisciplinary Digital Publishing Institute
DOI:
10.3390/cells8111438
Autores:
Kordelia Barbullushi, Elena Abati, Federica Rizzo, Nereo Bresolin, Giacomo P. Comi, Stefania Corti
Publicado en:
Molecular Neurobiology, Edición 56/9, 2019, Página(s) 6460-6471, ISSN 0893-7648
Editor:
Humana Press, Inc.
DOI:
10.1007/s12035-019-1533-2
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