Rezultaty
We will report for the onsite training provided and usage of the online system
Evaluation of neuroprotective abilities of candidate genes in an in vitro model.We will assess gene expression profile and identify candidate causal MRs and shared molecular pathways between NDs.
3D models generated from 4 different sourcesPatient specific minibrain and spinal cordorganoids generated from iPSCs of ALS SMA FTD and PD will be characterized
Pre-clinical protocols for AAV gene deliveryWe will establish protocols to over-express or knock-down genes of interest by using adeno-associated virus (AAV).
Identification of neuropathological markersWe will identify genes responsible for selective cell death and potential targets to modify ND disease progression
Publikacje
Autorzy:
*S. CORTI1, I. FARAVELLI1, P. RINCHETTI1, S. MANCINELLI2, L. MAPELLI3, G. FOROTTI4, M. RIZZUTI4, C. CORDIGLIERI5, L. CALANDRIELLO4, S. TAMANINI1, N. BRESOLIN1, G. P. COMI1, S. LODATO2, M. NIZZARDO1
Opublikowane w:
2019
Wydawca:
SFN
Autorzy:
Forotti G1, Nizzardo M1, Bucchia M2, Ramirez A2, Trombetta E3, Gatti S4, Bresolin N5, Comi GP5, Corti S6.
Opublikowane w:
Experimental Neurology, 2019, ISSN 0014-4886
Wydawca:
Academic Press
DOI:
10.1016/j.expneurol.2019.113041
Autorzy:
Gianluca Costamagna, Luca Andreoli, Stefania Corti, Irene Faravelli
Opublikowane w:
Cells, Numer 8/11, 2019, Strona(/y) 1438, ISSN 2073-4409
Wydawca:
Multidisciplinary Digital Publishing Institute
DOI:
10.3390/cells8111438
Autorzy:
Kordelia Barbullushi, Elena Abati, Federica Rizzo, Nereo Bresolin, Giacomo P. Comi, Stefania Corti
Opublikowane w:
Molecular Neurobiology, Numer 56/9, 2019, Strona(/y) 6460-6471, ISSN 0893-7648
Wydawca:
Humana Press, Inc.
DOI:
10.1007/s12035-019-1533-2
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