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Hybrid Nanostructured Oligonucleotide Platforms for Biomedical Applications

Objective

Nanotechnology has received widespread attention in the last several decades due to the technological breakthroughs it has enabled across sectors from electronics to medicine. Towards the great challenges that nanotechnology arise, Nano-OligoMed has the ambition to establish and support a network of international collaboration, enabling a collaborative scientific team to effectively use a diversity of approaches and strategies to generate and test hybrid nanomaterials for the efficient and safe systemic delivery of oligonucleotide-based therapeutic agents. To this end, we have set-up a joint multidisciplinary scientific collaborative programme that through exchange, international mobility, and strongly collaborative transfer of knowledge and training activities between 4 European and 3 extra-European countries, will bring together leading experts under the field of “nanomaterials in biomedicine”. The scientific aim of Nano-OligoMed is the creation of degradable hybrid structures that combine the rigid, inert silica with the delicate programmable oligonucleotides or artificial oligonucleotide-mimics. The possibility to develop novel oligonucleotide-based materials will enable a) the degradation of the drug carrier at the presence of a specific input as a function of the intrinsic bio-responsive feature of oligonucleotides, b) the activation of a therapeutic function as a result of the bio-molecular interaction between the oligonucleotide-based material and the molecular target (i.e. miRNAs) and c) the delivery of the chemical payload (DNA and/or artificial mimics, even in combination with cancer drugs) upon cell internalization. The international academic networking, the broadening of the research skills, the educational activities, will provide to young (PhD students) and senior scientists, specific competences in the field of materials sciences, nanotechnology, molecular biology and molecular medicine.

Call for proposal

H2020-MSCA-RISE-2017
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Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

UNIVERSITE DE STRASBOURG
Address
Rue Blaise Pascal 4
67081 Strasbourg
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 180 000

Participants (3)

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
EU contribution
€ 162 000
Address
Via Cracovia 50
00133 Roma
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PARMA
Italy
EU contribution
€ 130 500
Address
Via Universita 12
43100 Parma
Activity type
Higher or Secondary Education Establishments
NANOMOL TECHNOLOGIES SL
Spain
EU contribution
€ 126 000
Address
Lg Edifici Eureka Campus Uab Bellaterra
08193 Cerdanyola Del Valles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (3)

ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY
Canada
Address
845 Sherbrooke Street West
H3A0G4 Montreal
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE LA HABANA
Cuba
Address
Colina Universitaria San Lazaro Y L
10400 Plaza
Activity type
Higher or Secondary Education Establishments
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments