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Hybrid Nanostructured Oligonucleotide Platforms for Biomedical Applications

Objective

Nanotechnology has received widespread attention in the last several decades due to the technological breakthroughs it has enabled across sectors from electronics to medicine. Towards the great challenges that nanotechnology arise, Nano-OligoMed has the ambition to establish and support a network of international collaboration, enabling a collaborative scientific team to effectively use a diversity of approaches and strategies to generate and test hybrid nanomaterials for the efficient and safe systemic delivery of oligonucleotide-based therapeutic agents. To this end, we have set-up a joint multidisciplinary scientific collaborative programme that through exchange, international mobility, and strongly collaborative transfer of knowledge and training activities between 4 European and 3 extra-European countries, will bring together leading experts under the field of “nanomaterials in biomedicine”. The scientific aim of Nano-OligoMed is the creation of degradable hybrid structures that combine the rigid, inert silica with the delicate programmable oligonucleotides or artificial oligonucleotide-mimics. The possibility to develop novel oligonucleotide-based materials will enable a) the degradation of the drug carrier at the presence of a specific input as a function of the intrinsic bio-responsive feature of oligonucleotides, b) the activation of a therapeutic function as a result of the bio-molecular interaction between the oligonucleotide-based material and the molecular target (i.e. miRNAs) and c) the delivery of the chemical payload (DNA and/or artificial mimics, even in combination with cancer drugs) upon cell internalization. The international academic networking, the broadening of the research skills, the educational activities, will provide to young (PhD students) and senior scientists, specific competences in the field of materials sciences, nanotechnology, molecular biology and molecular medicine.

Coordinator

UNIVERSITA DEGLI STUDI DI MILANO
Net EU contribution
€ 67 500,00
Address
Via Festa Del Perdono 7
20122 Milano
Italy

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (4)

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
Net EU contribution
€ 162 000,00
Address
Via Cracovia 50
00133 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI PARMA
Italy
Net EU contribution
€ 121 500,00
Address
Via Universita 12
43100 Parma

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Region
Nord-Est Emilia-Romagna Parma
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NANOMOL TECHNOLOGIES SL
Spain
Net EU contribution
€ 126 000,00
Address
Lg Edifici Eureka Campus Uab Bellaterra
08193 Cerdanyola Del Valles

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITE DE STRASBOURG

Participation ended

France
Net EU contribution
€ 121 500,00
Address
Rue Blaise Pascal 4
67081 Strasbourg

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Region
Grand Est Alsace Bas-Rhin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (3)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY
Canada
Net EU contribution
€ 0,00
Address
845 Sherbrooke Street West
H3A0G4 Montreal

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD DE LA HABANA
Cuba
Net EU contribution
€ 0,00
Address
Colina Universitaria San Lazaro Y L
10400 Plaza

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 94 500,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Net EU contribution
€ 0,00
Address
Franklin Street 1111 12 Floor
94607 Oakland Ca

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00