Objective Intrinsically disordered proteins (IDPs), characterized by high conformational variability and interaction promiscuity, defy the classic protein structure-function paradigm. IDPs cover almost half of the residues in Eukaryotic proteomes. Growing evidence suggests that IDPs, interacting with multiple partners, are major players in cellular regulation and involved in numerous human diseases. Computational methods have contributed to the identification of IDPs from sequence and recently published curated IDP databases provide a starting point. However, functional knowledge for IDPs remains very limited.IDPfun is an international consortium aiming to extend our knowledge on the functions of IDPs. Starting from available state of the art computational tools and databases, which have been mostly developed by IDPfun participants, it aims drive a new level of IDP characterization leverage the complementary expertise of 5 EU MS and 3 TC institutions in Argentina, the latter providing useful complementary expertises. IDPfun will create a collaborative environment for research on novel ways to detect and characterize different IDP phenomena in their evolutionary context. It will develop an ontology and classification facilitating the comprehension of IDP complexity and aims to understand IDP functional mechanisms. The gained knowledge will be translated into major international protein databases for the benefit of the wider scientific community. Periodic meetings and symposia will generate a continuous knowledge exchange to be disseminated by open training schools and conferences. IDPfun will foster particularly young researchers, through dedicated activities and by ensuring adherence to the highest quality, ethics and gender balance standards. It is expected that IDPfun will strengthen overseas collaborations, focusing and coordinating research, leading to the creation of a sustainable international IDP community, driving knowledge and infrastructure in bioinformatics. Fields of science natural sciencescomputer and information sciencesknowledge engineeringontologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencescomputer and information sciencesdatabasesnatural sciencescomputer and information sciencescomputational science Keywords intrinsic disorder in proteins databases prediction ontology protein structure Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2017 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2017 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator UNIVERSITA DEGLI STUDI DI PADOVA Net EU contribution € 427 500,00 Address Via 8 febbraio 2 35122 Padova Italy See on map Region Nord-Est Veneto Padova Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all EOTVOS LORAND TUDOMANYEGYETEM Hungary Net EU contribution € 220 500,00 Address Egyetem ter 1-3 1053 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 VRIJE UNIVERSITEIT BRUSSEL Belgium Net EU contribution € 247 500,00 Address Pleinlaan 2 1050 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland Net EU contribution € 162 000,00 Address Belfield 4 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany Net EU contribution € 234 000,00 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (3) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSIDAD NACIONAL DE QUILMES Argentina Net EU contribution € 0,00 Address Roque saenz pena 352 B1876BXD Bernal See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 499 500,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. FUNDACION INSTITUTO LELOIR Argentina Net EU contribution € 0,00 Address Av. patricias argentinas 435 1405 Buenos aires See on map Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 283 500,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN Argentina Net EU contribution € 0,00 Address Martin de irigoyen 3100 1650 San martin buenos aires See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 202 500,00
