Skip to main content

Driving the functional characterization of intrinsically disordered proteins

Objective

Intrinsically disordered proteins (IDPs), characterized by high conformational variability and interaction promiscuity, defy the classic protein structure-function paradigm. IDPs cover almost half of the residues in Eukaryotic proteomes. Growing evidence suggests that IDPs, interacting with multiple partners, are major players in cellular regulation and involved in numerous human diseases. Computational methods have contributed to the identification of IDPs from sequence and recently published curated IDP databases provide a starting point. However, functional knowledge for IDPs remains very limited.
IDPfun is an international consortium aiming to extend our knowledge on the functions of IDPs. Starting from available state of the art computational tools and databases, which have been mostly developed by IDPfun participants, it aims drive a new level of IDP characterization leverage the complementary expertise of 5 EU MS and 3 TC institutions in Argentina, the latter providing useful complementary expertises. IDPfun will create a collaborative environment for research on novel ways to detect and characterize different IDP phenomena in their evolutionary context. It will develop an ontology and classification facilitating the comprehension of IDP complexity and aims to understand IDP functional mechanisms. The gained knowledge will be translated into major international protein databases for the benefit of the wider scientific community. Periodic meetings and symposia will generate a continuous knowledge exchange to be disseminated by open training schools and conferences. IDPfun will foster particularly young researchers, through dedicated activities and by ensuring adherence to the highest quality, ethics and gender balance standards. It is expected that IDPfun will strengthen overseas collaborations, focusing and coordinating research, leading to the creation of a sustainable international IDP community, driving knowledge and infrastructure in bioinformatics.

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA
Net EU contribution
€ 427 500,00
Address
Via 8 Febbraio 2
35122 Padova
Italy

See on map

Region
Nord-Est Veneto Padova
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (4)

EOTVOS LORAND TUDOMANYEGYETEM
Hungary
Net EU contribution
€ 220 500,00
Address
Egyetem Ter 1-3
1053 Budapest

See on map

Region
Közép-Magyarország Budapest Budapest
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
VRIJE UNIVERSITEIT BRUSSEL
Belgium
Net EU contribution
€ 247 500,00
Address
Pleinlaan 2
1050 Brussel

See on map

Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Net EU contribution
€ 162 000,00
Address
Belfield
4 Dublin

See on map

Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Net EU contribution
€ 234 000,00
Address
Meyerhofstrasse 1
69117 Heidelberg

See on map

Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Partners (3)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD NACIONAL DE QUILMES
Argentina
Net EU contribution
€ 0,00
Address
Roque Saenz Pena 352
B1876BXD Bernal

See on map

Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 499 500,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

FUNDACION INSTITUTO LELOIR
Argentina
Net EU contribution
€ 0,00
Address
Av. Patricias Argentinas 435
1405 Buenos Aires

See on map

Activity type
Research Organisations
Non-EU contribution
€ 283 500,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN
Argentina
Net EU contribution
€ 0,00
Address
Martin De Irigoyen 3100
1650 San Martin Buenos Aires

See on map

Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 202 500,00