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Driving the functional characterization of intrinsically disordered proteins

Objective

Intrinsically disordered proteins (IDPs), characterized by high conformational variability and interaction promiscuity, defy the classic protein structure-function paradigm. IDPs cover almost half of the residues in Eukaryotic proteomes. Growing evidence suggests that IDPs, interacting with multiple partners, are major players in cellular regulation and involved in numerous human diseases. Computational methods have contributed to the identification of IDPs from sequence and recently published curated IDP databases provide a starting point. However, functional knowledge for IDPs remains very limited.
IDPfun is an international consortium aiming to extend our knowledge on the functions of IDPs. Starting from available state of the art computational tools and databases, which have been mostly developed by IDPfun participants, it aims drive a new level of IDP characterization leverage the complementary expertise of 5 EU MS and 3 TC institutions in Argentina, the latter providing useful complementary expertises. IDPfun will create a collaborative environment for research on novel ways to detect and characterize different IDP phenomena in their evolutionary context. It will develop an ontology and classification facilitating the comprehension of IDP complexity and aims to understand IDP functional mechanisms. The gained knowledge will be translated into major international protein databases for the benefit of the wider scientific community. Periodic meetings and symposia will generate a continuous knowledge exchange to be disseminated by open training schools and conferences. IDPfun will foster particularly young researchers, through dedicated activities and by ensuring adherence to the highest quality, ethics and gender balance standards. It is expected that IDPfun will strengthen overseas collaborations, focusing and coordinating research, leading to the creation of a sustainable international IDP community, driving knowledge and infrastructure in bioinformatics.

Field of science

  • /natural sciences/computer and information sciences/databases
  • /humanities/philosophy, ethics and religion/philosophy/metaphysics/ontology
  • /humanities/philosophy, ethics and religion/ethics
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

H2020-MSCA-RISE-2017
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA
Address
Via 8 Febbraio 2
35122 Padova
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 423 000

Participants (4)

EOTVOS LORAND TUDOMANYEGYETEM
Hungary
EU contribution
€ 207 000
Address
Egyetem Ter 1-3
1053 Budapest
Activity type
Higher or Secondary Education Establishments
VRIJE UNIVERSITEIT BRUSSEL
Belgium
EU contribution
€ 234 000
Address
Pleinlaan 2
1050 Brussel
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 193 500
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 234 000
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations

Partners (3)

UNIVERSIDAD NACIONAL DE QUILMES
Argentina
Address
Roque Saenz Pena 352
B1876BXD Bernal
Activity type
Higher or Secondary Education Establishments
FUNDACION INSTITUTO LELOIR
Argentina
Address
Av. Patricias Argentinas 435
1405 Buenos Aires
Activity type
Research Organisations
UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN
Argentina
Address
Martin De Irigoyen 3100
1650 San Martin Buenos Aires
Activity type
Higher or Secondary Education Establishments