New Selenium-based Targeted Nanocapsules to treat Breast Cancer

Project Information

NEOSETAC

Grant agreement ID: 778325

DOI 10.3030/778325

Project closed

EC signature date 2 October 2017

Start date 1 January 2018

End date 31 October 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 504 000,00

EU contribution € 504 000,00

Coordinated by

UNIVERSITAT AUTONOMA DE BARCELONA
Spain

Deliverables

Documents, reports (3)

Report of in vitro tests results and Se speciation of targeted nanosystems

Report of in vitro tests results and Se speciation of targeted nanosystems: The in vitro cytotoxicity of will be examined on breast cancer cell lines and control cell lines: Se cocktail; Naked NPs; Se cocktail loaded naked NPs; NPs with targeting antibody; Se cocktail loaded NPs with targeting antibody. Speciation of selenium before (after loading targeted nanosystems, drug release, stability) and after cell uptake (UAB).

Dissemination and Communication Strategy defined including promotional kit

By M6. Document that will include a compilation of the purposes of the Dissemination and Communication Strategy and the employed tools and guarantee that dissemination activities are highly targeted (in content and method) to have the highest possible impact. The promotional kit includes the website, brochure, project logo, newsletter, presentation of the project indicating partnership, project outputs and research aims. The promotional material will be produced mainly in electronic form as well as hard copies when needed in English and Spanish, downloadable from the NEOSETAC website.

Monitoring report derived from D&C indicators of the outreach activities

Report compiling information concerning some outreach activities indicators such as i the number of accesses to the website ii the number of conferencesworkshops attended iii the number of newsletters downloaded iv the number of flyers leaflets brochures distributed v the produced posters vi the attendance at the kick off meeting and the final conference vii the number of press releases circulated and press conferences organized

Publications

Thesis and dissertations (1)

Development of targeted nanocapsules against breast cancer cells

Author(s): Camila Cazorla Ares
Published in: 2023
Publisher: Universitat Autònoma de Barcelona

Conference proceedings (1)

New Selenium-based nanocapsules to treat Breast Cancer: NEOSETAC

Author(s): MARÍA-JESUS SANCHEZ-MARTIN, YING ZHAO, WENYI ZHENG, MOUSTAPHA HASSAN MANUEL VALIENTE
Published in: ONCO EMERGENCE FORUM BARCELONA, 2018
Publisher: Onco emergence Forum

Peer reviewed articles (2)

Extracellular Albumin Covalently Sequesters Selenocompounds and Determines Cytotoxicity

Author(s): Wenyi Zheng, Roberto Boada, Rui He, Tingting Xiao, Fei Ye, Laura Simonelli, Manuel Valiente, Ying Zhao, Moustapha Hassan
Published in: International Journal of Molecular Sciences, Issue 20/19, 2019, Page(s) 4734, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20194734

A general covalent binding model between cytotoxic selenocompounds and albumin revealed by mass spectrometry and X-ray absorption spectroscopy

Author(s): Wenyi Zheng; Rui He; Rui He; Roberto Boada; Maria Angels Subirana; Tobias Ginman; Håkan Ottosson; Manuel Valiente; Ying Zhao; Ying Zhao; Moustapha Hassan; Moustapha Hassan
Published in: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020), Issue 20452322, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-57983-y