New Selenium-based Targeted Nanocapsules to treat Breast Cancer

Livrables

Report of in vitro tests results and Se speciation of targeted nanosystems

Report of in vitro tests results and Se speciation of targeted nanosystems: The in vitro cytotoxicity of will be examined on breast cancer cell lines and control cell lines: Se cocktail; Naked NPs; Se cocktail loaded naked NPs; NPs with targeting antibody; Se cocktail loaded NPs with targeting antibody. Speciation of selenium before (after loading targeted nanosystems, drug release, stability) and after cell uptake (UAB).

Dissemination and Communication Strategy defined including promotional kit

By M6. Document that will include a compilation of the purposes of the Dissemination and Communication Strategy and the employed tools and guarantee that dissemination activities are highly targeted (in content and method) to have the highest possible impact. The promotional kit includes the website, brochure, project logo, newsletter, presentation of the project indicating partnership, project outputs and research aims. The promotional material will be produced mainly in electronic form as well as hard copies when needed in English and Spanish, downloadable from the NEOSETAC website.

Monitoring report derived from D&C indicators of the outreach activities

Report compiling information concerning some outreach activities indicators such as i the number of accesses to the website ii the number of conferencesworkshops attended iii the number of newsletters downloaded iv the number of flyers leaflets brochures distributed v the produced posters vi the attendance at the kick off meeting and the final conference vii the number of press releases circulated and press conferences organized

Publications

Development of targeted nanocapsules against breast cancer cells

Auteurs: Camila Cazorla Ares
Publié dans: 2023
Éditeur: Universitat Autònoma de Barcelona

New Selenium-based nanocapsules to treat Breast Cancer: NEOSETAC

Auteurs: MARÍA-JESUS SANCHEZ-MARTIN, YING ZHAO, WENYI ZHENG, MOUSTAPHA HASSAN MANUEL VALIENTE
Publié dans: ONCO EMERGENCE FORUM BARCELONA, 2018
Éditeur: Onco emergence Forum

Extracellular Albumin Covalently Sequesters Selenocompounds and Determines Cytotoxicity

Auteurs: Wenyi Zheng, Roberto Boada, Rui He, Tingting Xiao, Fei Ye, Laura Simonelli, Manuel Valiente, Ying Zhao, Moustapha Hassan
Publié dans: International Journal of Molecular Sciences, Numéro 20/19, 2019, Page(s) 4734, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20194734

A general covalent binding model between cytotoxic selenocompounds and albumin revealed by mass spectrometry and X-ray absorption spectroscopy

Auteurs: Wenyi Zheng; Rui He; Rui He; Roberto Boada; Maria Angels Subirana; Tobias Ginman; Håkan Ottosson; Manuel Valiente; Ying Zhao; Ying Zhao; Moustapha Hassan; Moustapha Hassan
Publié dans: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020), Numéro 20452322, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-57983-y

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