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New Selenium-based Targeted Nanocapsules to treat Breast Cancer

Objective

The European Chronic Diseases Alliance has defined cancer as one of the major non-communicable diseases, accounting
for 13% of the deaths worldwide, resulting in 8.2 million deaths annually. In the NEOSETAC project, breast cancer will be the
focus of study being the most common cancers in women. It comprises of 10.4% of all the cancer incidences among women,
causing 411 093 deaths per year overall the world. In Europe, there is more than twice of the amount of new breast cancer
cases annually than new cases of cancer in any other place. The complexity of breast cancer makes it a big challenge for
successful treatment. The NEOSETAC project will demonstrate the anti-cancer therapeutic potential of a novel Seleniumbased
therapy for the management of breast cancer. The clinical application of Selenium (Se) compounds for cancer
treatment is until now limited in chemoprevention as dietary supplement. In this proposal, we aim to improve the therapeutic
window, pharmacokinetic properties and targeting drug delivery via nanoparticles (NPs). By loading Se into biodegradable
NPs, drug release is controlled within the narrow therapeutic window of Se. At the same time the uptake and activation of Se
compounds at desired location (tumor lesions and metastasis) is achieved. We also propose to functionalize NPs by cancer
cell / cancer stem cell targeting ligands to further improve the therapeutic efficacy and prevent cancer recurrence after
chemotherapy. These advantages will lead to an enhanced anticancer activity and reduced systemic toxicity. Moreover,
targeting via NPs will improve the pharmacokinetic properties and increase the relatively short half-life (~18 hours) of Se.

Coordinator

UNIVERSIDAD AUTONOMA DE BARCELONA
Net EU contribution
€ 202 500,00
Address
Calle Campus Universitario Sn Cerdanyola V
08290 Cerdanyola Del Valles
Spain

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (8)

KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 40 635,00
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ACIB GMBH
Austria
Net EU contribution
€ 27 000,00
Address
Krenngasse 37/2
8010 Graz

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Region
Südösterreich Steiermark Graz
Activity type
Research Organisations
Non-EU contribution
€ 0,00
AB BCN SL

Participation ended

Spain
Net EU contribution
€ 22 500,00
Address
Lg Bellaterra Parc De Recerca Uab Campus Uni Uab
08193 Cerdanyola Del Valles

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
QUALIZYME DIAGNOSTICS GMBH & CO KG

Participation ended

Austria
Net EU contribution
€ 0,00
Address
Neue Stiftingtalstrasse 2
8010 Graz

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Südösterreich Steiermark Graz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
REGION STOCKHOLM
Sweden
Net EU contribution
€ 94 365,00
Address
Hantverkargatan 45
104 22 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
ADSI-AUSTRIAN DRUG SCREENING INSTITUTE GMBH
Austria
Net EU contribution
€ 27 000,00
Address
Innrain 66a
6020 Innsbruck

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Region
Westösterreich Tirol Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CLINISCIENCES SL
Spain
Net EU contribution
€ 22 500,00
Address
Cl Alt De Gironella 67
08017 Barcelona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
REDINN - SRL
Italy
Net EU contribution
€ 67 500,00
Address
Via Mar Di Bering 39b
00040 Pomezia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Lazio Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00