Objective The European Chronic Diseases Alliance has defined cancer as one of the major non-communicable diseases, accountingfor 13% of the deaths worldwide, resulting in 8.2 million deaths annually. In the NEOSETAC project, breast cancer will be thefocus of study being the most common cancers in women. It comprises of 10.4% of all the cancer incidences among women,causing 411 093 deaths per year overall the world. In Europe, there is more than twice of the amount of new breast cancercases annually than new cases of cancer in any other place. The complexity of breast cancer makes it a big challenge forsuccessful treatment. The NEOSETAC project will demonstrate the anti-cancer therapeutic potential of a novel Seleniumbasedtherapy for the management of breast cancer. The clinical application of Selenium (Se) compounds for cancertreatment is until now limited in chemoprevention as dietary supplement. In this proposal, we aim to improve the therapeuticwindow, pharmacokinetic properties and targeting drug delivery via nanoparticles (NPs). By loading Se into biodegradableNPs, drug release is controlled within the narrow therapeutic window of Se. At the same time the uptake and activation of Secompounds at desired location (tumor lesions and metastasis) is achieved. We also propose to functionalize NPs by cancercell / cancer stem cell targeting ligands to further improve the therapeutic efficacy and prevent cancer recurrence afterchemotherapy. These advantages will lead to an enhanced anticancer activity and reduced systemic toxicity. Moreover,targeting via NPs will improve the pharmacokinetic properties and increase the relatively short half-life (~18 hours) of Se. Fields of science medical and health sciencesclinical medicinesurgerynatural sciencesbiological sciencescell biologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologybreast cancernatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopy Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2017 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2017 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator UNIVERSITAT AUTONOMA DE BARCELONA Net EU contribution € 202 500,00 Address Edif a campus de la uab bellaterra cerdanyola v 08193 Cerdanyola del valles Spain See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (8) Sort alphabetically Sort by Net EU contribution Expand all Collapse all KAROLINSKA INSTITUTET Sweden Net EU contribution € 40 635,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ACIB GMBH Austria Net EU contribution € 27 000,00 Address Krenngasse 37/2 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AB BCN SL Participation ended Spain Net EU contribution € 22 500,00 Address Lg bellaterra parc de recerca uab campus uni uab 08193 Cerdanyola del valles See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 QUALIZYME DIAGNOSTICS GMBH & CO KG Participation ended Austria Net EU contribution € 0,00 Address Neue stiftingtalstrasse 2 8010 Graz See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Südösterreich Steiermark Graz Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 REGION STOCKHOLM Sweden Net EU contribution € 94 365,00 Address Hantverkargatan 45 104 22 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ADSI-AUSTRIAN DRUG SCREENING INSTITUTE GMBH Austria Net EU contribution € 27 000,00 Address Innrain 66a 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CLINISCIENCES SL Spain Net EU contribution € 22 500,00 Address Cl alt de gironella 67 08017 Barcelona See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 REDINN - SRL Italy Net EU contribution € 67 500,00 Address Via mar di bering 39b 00040 Pomezia See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Lazio Roma Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
