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CANITEST: Proof-Of-Concept of a PCR test designed to identify the dogs carrying the more virulent strains of Capnocytophaga canimorsus

Objective

The idea to be taken as proof of concept is drawn from the ERC Advanced grant N°293605-CAPCAN (2012-2016). This grant aimed at understanding the molecular and genetic bases of the dramatic human infections caused by Capnocytophaga canimorsus. One of the questions that we addressed in the frame of CAPCAN is why are there so few cases of human infections while so many dogs carry C. canimorsus? In other words, are all C. canimorsus strains equally dangerous and, if not, could we prevent the disease by detecting the dogs carrying the more dangerous strains? During CAPCAN, among others, we showed that C. canimorsus is endowed with a capsular polysaccharide (CPS) and its assembly pathway was characterized [1]. We also showed that the CPS of 25/25 strains isolated from human infections present a limited variability, with 3 dominant capsular serovars. In contrast, only 4 out of 52 C. canimorsus isolated from dog mouths did belong to these three serovars [2]. This implies that a small minority of dog-hosted C. canimorsus strains are virulent for humans than most strains and that these strains can be identified by capsular serotyping. We also set up a PCR test to achieve this capsular serotyping [2]. The proposal to be taken to proof of concept is to market the PCR test designed to identify the dogs carrying the more virulent strains of C. canimorsus.

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-POC - Proof of Concept Grant

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2017-PoC

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Host institution

UNIVERSITE DE NAMUR
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 150 000,00
Address
RUE DE BRUXELLES 61
5000 NAMUR
Belgium

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Region
Région wallonne Prov. Namur Arr. Namur
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 150 000,00

Beneficiaries (1)

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