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Manufacturing and testing of an allogeneic gamma delta T cell therapy for the treatment of cancer

Objective

Europe is experiencing an unprecedented cancer epidemic, driven by our ageing population. Traditional cancer treatments such as surgery, chemotherapy and radiation therapy have demonstrated very limited efficacy for patients with late-stage disease and often cause considerable side effects.
Cell therapies are the next breakthrough in oncology, but autologous cells must be harvested from each patient, expanded for several weeks in vitro and re-administered to the same patient while hospitalized.
TCB, a Scottish SME, brings the first allogeneic gamma delta T cell therapy (OmnImmune) where T cells harvested from healthy donors are used to treat multiple recipients.
OmnImmune represents a truly disruptive, step-changing approach to the treatment of a wide variety of cancers. It has the potential to be manufactured for large market segments at a lower cost than competitors and provide valuable increases to the quality of life of life.
OmnImmune will provide next generation cancer treatment at 20% of the cost of any other cell therapy, saving €24Bn per year for 60,000 patients treated.
OmnImmune’s unique characteristics make it a truly disruptive treatment solution for patients and clinicians:
Multifunctional treatment solution: available to all cancer patients, regardless of their disease grade or immune status
Predicted high safety profile: minimal side-effects based on clinical data from trials of autologous GDT cells (to be confirmed in dose-escalation clinical trial)
Ease of use and lower cost: frozen dose-ready units available for immediate patient administration.
The SME Instrument funding will accelerate the development of the OmnImmune therapy and reduce its time to market from 10 years to 6 years. This will allow OmnImmune to reach the market by 2024.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /medical and health sciences/clinical medicine/surgery
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology

Call for proposal

H2020-SMEINST-2-2016-2017
See other projects for this call

Funding Scheme

SME-2 - SME instrument phase 2

Coordinator

TC BIOPHARM LIMITED
Address
Maxim 1 Parklands Way 2 Holytown Motherwell Lanarkshire
ML14WQ Holytown
United Kingdom
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 3 957 000