Survival of the Fittest: On how to enhance recovery from critical illness through learning from evolutionary conserved catabolic pathways

Información del proyecto

FitteR-CATABOLIC

Identificador del acuerdo de subvención: 785809

DOI

10.3030/785809

Proyecto cerrado

Fecha de la firma de la CE 22 Agosto 2018

Fecha de inicio 1 Octubre 2018

Fecha de finalización 31 Marzo 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (37)

Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU

Autores: Gunst, Jan; Debaveye, Yves; Güiza, Fabian; Dubois, Jasperina; De Bruyn, Astrid; Dauwe, Dieter; De Troy, Erwin; Casaer, Michael P; De Vlieger, Greet; Haghedooren, Renata; Jacobs, Bart; Meyfroidt, Geert; Ingels, Catherine; Muller, Jan; Vlasselaers, Dirk; Desmet, Lars; Mebis, Liese; Wouters, Pieter J; Stessel, Björn; Geebelen, Laurien; Vandenbrande, Jeroen; Brands, Michiel; Gruyters, Ine; Geerts, E
Publicado en: The New England Journal of Medicine, Edición 389 (13), 2023, Página(s) 1180-1190, ISSN 0028-4793
Editor: Massachusetts Medical Society
DOI: 10.1056/nejmoa2304855

Weakness in the ICU: the right weight on the right scale

Autores: Nathalie Van Aerde, Greet Van den Berghe, Greet Hermans
Publicado en: Intensive Care Medicine, Edición 47/1, 2021, Página(s) 137-138, ISSN 0342-4642
Editor: Springer Verlag
DOI: 10.1007/s00134-020-06274-1

Effect of withholding early parenteral nutrition in PICU on ketogenesis as potential mediator of its outcome benefit

Autores: Astrid De Bruyn, Jan Gunst, Chloë Goossens, Sarah Vander Perre, Gonzalo G. Guerra, Sascha Verbruggen, Koen Joosten, Lies Langouche, Greet Van den Berghe
Publicado en: Critical Care, Edición 24/1, 2020, ISSN 1364-8535
Editor: Biomed Central
DOI: 10.1186/s13054-020-03256-z

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients

Autores: Jan Gunst, Astrid De Bruyn, Michael P. Casaer, Sarah Vander Perre, Lies Langouche, Greet Van den Berghe
Publicado en: Critical Care, Edición 25/1, 2021, ISSN 1364-8535
Editor: Biomed Central
DOI: 10.1186/s13054-021-03772-6

Long-term developmental effect of withholding parenteral nutrition in paediatric intensive care units: a 4-year follow-up of the PEPaNIC randomised controlled trial

Autores: An Jacobs, Karolijn Dulfer, Renate D Eveleens, José Hordijk, Hanna Van Cleemput, Ines Verlinden, Pieter J Wouters, Liese Mebis, Gonzalo Garcia Guerra, Koen Joosten, Sascha C Verbruggen, Fabian Güiza, Ilse Vanhorebeek, Greet Van den Berghe
Publicado en: The Lancet Child & Adolescent Health, Edición 4/7, 2020, Página(s) 503-514, ISSN 2352-4642
Editor: Elsevier
DOI: 10.1016/s2352-4642(20)30104-8

Role of ketones, ketogenic diets and intermittent fasting in ICU.

Autores: Jan Gunst; Michael P Casaer; Lies Langouche; Greet Van den Berghe
Publicado en: Curr Opin Crit Care, Edición 27(4), 2021, Página(s) 385-389, ISSN 1070-5295
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mcc.0000000000000841

Toward nutrition improving outcome of critically ill patients: How to interpret recent feeding RCTs?

Autores: Jan Gunst; Michael P. Casaer; Jean-Charles Preiser; Jean Reignier; Greet Van den Berghe
Publicado en: Critical Care, Edición 27, 2023, ISSN 1466-609X
Editor: BioMed Central
DOI: 10.1186/s13054-023-04317-9

Efficacy and safety of ketone ester infusion to prevent muscle weakness in a mouse model of sepsis-induced critical illness

Autores: Ruben Weckx; Chloë Goossens; Sarah Derde; Lies Pauwels; Sarah Vander Perre; Greet Van den Berghe; Lies Langouche
Publicado en: Scientific Reports, Edición 1, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-14961-w

Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate.

Autores: Chloë Goossens; Ruben Weckx; Sarah Derde; Sarah Vander Perre; Inge Derese; Paul P. Van Veldhoven; Bart Ghesquière; Greet Van den Berghe; Lies Langouche
Publicado en: Critical Care, Edición Vol 25, Iss 1, 2021, Página(s) Pp 1-12, ISSN 1466-609X
Editor: BioMed Central
DOI: 10.1186/s13054-021-03688-1

Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU

Autores: Ines Verlinden, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen Joosten, Sascha C. Verbruggen, Greet Van den Berghe, Ilse Vanhorebeek
Publicado en: Clinical Epigenetics, Edición 12/1, 2020, ISSN 1868-7075
Editor: Springer Verlag
DOI: 10.1186/s13148-020-00947-w

Aerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up study.

Autores: Nathalie Van Aerde; Philippe Meersseman; Yves Debaveye; Alexander Wilmer; Michael P Casaer; Jan Gunst; Joost Wauters; Pieter Wouters; Kaatje Goetschalckx; Rik Gosselink; Greet Van den Berghe; Greet Hermans
Publicado en: Intensive Care Medicine, Edición 47/12), 2021, Página(s) 1462-1471, ISSN 0342-4642
Editor: Springer Verlag
DOI: 10.1007/s00134-021-06541-9

Impact of prolonged sepsis on neural and muscular components of muscle contractions in a mouse model

Autores: Chloë Goossens, Ruben Weckx, Sarah Derde, Lawrence Van Helleputte, Dominik Schneidereit, Michael Haug, Barbara Reischl, Oliver Friedrich, Ludo Van Den Bosch, Greet Van den Berghe, Lies Langouche
Publicado en: Journal of Cachexia, Sarcopenia and Muscle, 2021, ISSN 2190-5991
Editor: Springer Verlag
DOI: 10.1002/jcsm.12668

The GH Axis in Relation to Accepting an Early Macronutrient Deficit and Outcome of Critically Ill Patients

Autores: Lisa Van Dyck, Inge Derese, Sarah Vander Perre, Pieter J Wouters, Michaël P Casaer, Greet Hermans, Greet Van den Berghe, Ilse Vanhorebeek
Publicado en: The Journal of Clinical Endocrinology & Metabolism, Edición 104/11, 2019, Página(s) 5507-5518, ISSN 0021-972X
Editor: The Endocrine Society
DOI: 10.1210/jc.2019-00842

Role of ketones, ketogenic diets and intermittent fasting in ICU

Autores: Jan Gunst, Michael P. Casaer, Lies Langouche, Greet Van den Berghe
Publicado en: Current Opinion in Critical Care, Edición 27/4, 2021, Página(s) 385-389, ISSN 1070-5295
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mcc.0000000000000841

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients.

Autores: Jan Gunst; Astrid De Bruyn; Michael P Casaer; Sarah Vander Perre; Lies Langouche; Greet Van den Berghe
Publicado en: Critical Care, Edición Vol 25, Iss 1, 2021, Página(s) Pp 1-8, ISSN 1466-609X
Editor: BioMed Central
DOI: 10.1186/s13054-021-03772-6

Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate

Autores: Chloë Goossens, Ruben Weckx, Sarah Derde, Sarah Vander Perre, Inge Derese, Paul P. Van Veldhoven, Bart Ghesquière, Greet Van den Berghe, Lies Langouche
Publicado en: Critical Care, Edición 25/1, 2021, ISSN 1364-8535
Editor: Biomed Central
DOI: 10.1186/s13054-021-03688-1

Early Supplemental Parenteral Nutrition in Critically Ill Children: An Update

Autores: An Jacobs, Ines Verlinden, Ilse Vanhorebeek, Greet Van den Berghe
Publicado en: Journal of Clinical Medicine, Edición 8/6, 2019, Página(s) 830, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8060830

"The clinical potential of GDF15 as a ""ready-to-feed indicator"" for critically ill adults"

Autores: Lisa Van Dyck, Jan Gunst, Michael P Casaer, Bram Peeters, Inge Derese, Pieter J Wouters, Francis de Zegher, Ilse Vanhorebeek, Greet Van den Berghe
Publicado en: Critical Care, 2020, ISSN 1466-609X
Editor: BioMed Central
DOI: 10.1186/s13054-020-03254-1

Hyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different?

Autores: Greet Van den Berghe; Jan Gunst; Lies Langouche
Publicado en: Critical Care, Edición Vol 25, Iss 1, 2021, Página(s) Pp 1-3, ISSN 1466-609X
Editor: BioMed Central
DOI: 10.1186/s13054-021-03861-6

Effect of late versus early initiation of parenteral nutrition on weight deterioration during PICU stay: Secondary analysis of the PEPaNIC randomised controlled trial

Autores: E. van Puffelen, J.M. Hulst, I. Vanhorebeek, K. Dulfer, G. Van den Berghe, K.F.M. Joosten, S.C.A.T. Verbruggen
Publicado en: Clinical Nutrition, 2019, ISSN 0261-5614
Editor: Churchill Livingstone
DOI: 10.1016/j.clnu.2019.02.014

Outcomes of Delaying Parenteral Nutrition for 1 Week vs Initiation Within 24 Hours Among Undernourished Children in Pediatric Intensive Care

Autores: Esther van Puffelen, Jessie M. Hulst, Ilse Vanhorebeek, Karolijn Dulfer, Greet Van den Berghe, Sascha C. A. T. Verbruggen, Koen F. M. Joosten
Publicado en: JAMA Network Open, Edición 1/5, 2018, Página(s) e182668, ISSN 2574-3805
Editor: American Medical Association
DOI: 10.1001/jamanetworkopen.2018.2668

Glucose control in the ICU

Autores: Jan Gunst, Astrid De Bruyn, Greet Van den Berghe
Publicado en: Current Opinion in Anaesthesiology, Edición 32/2, 2019, Página(s) 156-162, ISSN 0952-7907
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ACO.0000000000000706

Paediatric critical care survival: how to avoid bias

Autores: Greet Van den Berghe
Publicado en: The Lancet Respiratory Medicine, Edición 7/2, 2019, Página(s) e2, ISSN 2213-2600
Editor: Elsevier Limited
DOI: 10.1016/S2213-2600(18)30408-9

Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones

Autores: Chloë Goossens, Ruben Weckx, Sarah Derde, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Steven E. Thiessen, Paul P. Van Veldhoven, Greet Van den Berghe, Lies Langouche
Publicado en: Critical Care, Edición 23/1, 2019, Página(s) 236, ISSN 1364-8535
Editor: Springer Nature
DOI: 10.1186/s13054-019-2506-6

Hepatic PPARα is critical in the metabolic adaptation to sepsis

Autores: Réjane Paumelle, Joel T. Haas, Nathalie Hennuyer, Eric Baugé, Yann Deleye, Dieter Mesotten, Lies Langouche, Jonathan Vanhoutte, Céline Cudejko, Kristiaan Wouters, Sarah Anissa Hannou, Vanessa Legry, Steve Lancel, Fanny Lalloyer, Arnaud Polizzi, Sarra Smati, Pierre Gourdy, Emmanuelle Vallez, Emmanuel Bouchaert, Bruno Derudas, Hélène Dehondt, Céline Gheeraert, Sébastien Fleury, Anne Tailleux,
Publicado en: Journal of Hepatology, Edición 70/5, 2019, Página(s) 963-973, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2018.12.037

Effect of early parenteral nutrition during paediatric critical illness on DNA methylation as a potential mediator of impaired neurocognitive development: a pre-planned secondary analysis of the PEPaNIC international randomised controlled trial

Autores: Fabian Güiza, Ilse Vanhorebeek, Sören Verstraete, Ines Verlinden, Inge Derese, Catherine Ingels, Karolijn Dulfer, Sascha C Verbruggen, Gonzalo Garcia Guerra, Koen F Joosten, Pieter J Wouters, Greet Van den Berghe
Publicado en: The Lancet Respiratory Medicine, Edición 8/3, 2020, Página(s) 288-303, ISSN 2213-2600
Editor: Elsevier Limited
DOI: 10.1016/S2213-2600(20)30046-1

Five-year impact of ICU-acquired neuromuscular complications: a prospective, observational study

Autores: Nathalie Van Aerde, Philippe Meersseman, Yves Debaveye, Alexander Wilmer, Jan Gunst, Michael P. Casaer, Frans Bruyninckx, Pieter J. Wouters, Rik Gosselink, Greet Van den Berghe, Greet Hermans
Publicado en: Intensive Care Medicine, 2020, ISSN 0342-4642
Editor: Springer Verlag
DOI: 10.1007/s00134-020-05927-5

ICU-acquired weakness

Autores: Ilse Vanhorebeek, Nicola Latronico, Greet Van den Berghe
Publicado en: Intensive Care Medicine, Edición 46/4, 2020, Página(s) 637-653, ISSN 0342-4642
Editor: Springer Verlag
DOI: 10.1007/s00134-020-05944-4

Intermittent Fasting

Autores: Jan Gunst, Greet Van den Berghe, Michael P. Casaer
Publicado en: Chest, Edición 158/6, 2020, Página(s) 2707, ISSN 0012-3692
Editor: American College of Chest Physicians
DOI: 10.1016/j.chest.2020.07.071

Five-year outcome of respiratory muscle weakness at intensive care unit discharge: secondary analysis of a prospective cohort study

Autores: Nathalie Van Aerde, Philippe Meersseman, Yves Debaveye, Alexander Wilmer, Jan Gunst, Michael P Casaer, Joost Wauters, Pieter J Wouters, Rik Gosselink, Greet Van den Berghe, Greet Hermans
Publicado en: Thorax, 2021, Página(s) thoraxjnl-2020-216720, ISSN 0040-6376
Editor: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2020-216720

Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study

Autores: Lisa Van Dyck, Ilse Vanhorebeek, Alexander Wilmer, An Schrijvers, Inge Derese, Liese Mebis, Pieter J. Wouters, Greet Van den Berghe, Jan Gunst, Michaël P. Casaer
Publicado en: Critical Care, Edición 24/1, 2020, ISSN 1364-8535
Editor: Critical Care
DOI: 10.1186/s13054-020-02987-3

C-reactive protein rise in response to macronutrient deficit early in critical illness: sign of inflammation or mediator of infection prevention and recovery.

Autores: Catherine Ingels; Lies Langouche; Jasperina Dubois; Inge Derese; Sarah Vander Perre; Pieter Wouters; Jan Gunst; Michael P Casaer; Fabian Güiza; Ilse Vanhorebeek; Greet Van den Berghe
Publicado en: Intensive Care Medicine, Edición 48(1), 2022, Página(s) 25-35, ISSN 0342-4642
Editor: Springer Verlag
DOI: 10.1007/s00134-021-06565-1

Five-year mortality and morbidity impact of prolonged versus brief ICU stay: a propensity score matched cohort study

Autores: Greet Hermans, Nathalie Van Aerde, Philippe Meersseman, Helena Van Mechelen, Yves Debaveye, Alexander Wilmer, Jan Gunst, Michael Paul Casaer, Jasperina Dubois, Pieter Wouters, Rik Gosselink, Greet Van den Berghe
Publicado en: Thorax, Edición 74/11, 2019, Página(s) 1037-1045, ISSN 0040-6376
Editor: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2018-213020

Impact of withholding early parenteral nutrition in adult critically ill patients on ketogenesis in relation to outcome

Autores: Astrid De Bruyn, Lies Langouche, Sarah Vander Perre, Jan Gunst, Greet Van den Berghe
Publicado en: Critical Care, Edición 25/1, 2021, ISSN 1364-8535
Editor: Biomed Central
DOI: 10.1186/s13054-021-03519-3

Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice.

Autores: Ruben Weckx; Chloë Goossens; Sarah Derde; Lies Pauwels; Sarah Vander Perre; Greet Van den Bergh; Lies Langouche
Publicado en: BMC Pharmacology and Toxicology, Edición Vol 22, Iss 1, 2021, Página(s) Pp 1-13, ISSN 2050-6511
Editor: BioMed Central
DOI: 10.1186/s40360-021-00517-7

Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin.

Autores: Wouter Vankrunkelsven; Sarah Derde; Jan Gunst; Sarah Vander Perre; Emiel Declerck; Lies Pauwels; Inge Derese; Greet Van den Berghe; Lies Langouche
Publicado en: Journal of Cachexia, Sarcopenia and Muscle, Edición Vol 13, Iss 1, 2022, Página(s) 418-433, ISSN 2190-5991
Editor: Springer Verlag
DOI: 10.1002/jcsm.12904

Intensive Care Nutrition and Post–Intensive Care Recovery

Autores: Jan Gunst, Greet Van den Berghe
Publicado en: Critical Care Clinics, Edición 34/4, 2018, Página(s) 573-583, ISSN 0749-0704
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ccc.2018.06.004