Survival of the Fittest: On how to enhance recovery from critical illness through learning from evolutionary conserved catabolic pathways

Publications

Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU

Auteurs: Gunst, Jan; Debaveye, Yves; Güiza, Fabian; Dubois, Jasperina; De Bruyn, Astrid; Dauwe, Dieter; De Troy, Erwin; Casaer, Michael P; De Vlieger, Greet; Haghedooren, Renata; Jacobs, Bart; Meyfroidt, Geert; Ingels, Catherine; Muller, Jan; Vlasselaers, Dirk; Desmet, Lars; Mebis, Liese; Wouters, Pieter J; Stessel, Björn; Geebelen, Laurien; Vandenbrande, Jeroen; Brands, Michiel; Gruyters, Ine; Geerts, E
Publié dans: The New England Journal of Medicine, Numéro 389 (13), 2023, Page(s) 1180-1190, ISSN 0028-4793
Éditeur: Massachusetts Medical Society
DOI: 10.1056/nejmoa2304855

Weakness in the ICU: the right weight on the right scale

Auteurs: Nathalie Van Aerde, Greet Van den Berghe, Greet Hermans
Publié dans: Intensive Care Medicine, Numéro 47/1, 2021, Page(s) 137-138, ISSN 0342-4642
Éditeur: Springer Verlag
DOI: 10.1007/s00134-020-06274-1

Effect of withholding early parenteral nutrition in PICU on ketogenesis as potential mediator of its outcome benefit

Auteurs: Astrid De Bruyn, Jan Gunst, Chloë Goossens, Sarah Vander Perre, Gonzalo G. Guerra, Sascha Verbruggen, Koen Joosten, Lies Langouche, Greet Van den Berghe
Publié dans: Critical Care, Numéro 24/1, 2020, ISSN 1364-8535
Éditeur: Biomed Central
DOI: 10.1186/s13054-020-03256-z

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients

Auteurs: Jan Gunst, Astrid De Bruyn, Michael P. Casaer, Sarah Vander Perre, Lies Langouche, Greet Van den Berghe
Publié dans: Critical Care, Numéro 25/1, 2021, ISSN 1364-8535
Éditeur: Biomed Central
DOI: 10.1186/s13054-021-03772-6

Long-term developmental effect of withholding parenteral nutrition in paediatric intensive care units: a 4-year follow-up of the PEPaNIC randomised controlled trial

Auteurs: An Jacobs, Karolijn Dulfer, Renate D Eveleens, José Hordijk, Hanna Van Cleemput, Ines Verlinden, Pieter J Wouters, Liese Mebis, Gonzalo Garcia Guerra, Koen Joosten, Sascha C Verbruggen, Fabian Güiza, Ilse Vanhorebeek, Greet Van den Berghe
Publié dans: The Lancet Child & Adolescent Health, Numéro 4/7, 2020, Page(s) 503-514, ISSN 2352-4642
Éditeur: Elsevier
DOI: 10.1016/s2352-4642(20)30104-8

Role of ketones, ketogenic diets and intermittent fasting in ICU.

Auteurs: Jan Gunst; Michael P Casaer; Lies Langouche; Greet Van den Berghe
Publié dans: Curr Opin Crit Care, Numéro 27(4), 2021, Page(s) 385-389, ISSN 1070-5295
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mcc.0000000000000841

Toward nutrition improving outcome of critically ill patients: How to interpret recent feeding RCTs?

Auteurs: Jan Gunst; Michael P. Casaer; Jean-Charles Preiser; Jean Reignier; Greet Van den Berghe
Publié dans: Critical Care, Numéro 27, 2023, ISSN 1466-609X
Éditeur: BioMed Central
DOI: 10.1186/s13054-023-04317-9

Efficacy and safety of ketone ester infusion to prevent muscle weakness in a mouse model of sepsis-induced critical illness

Auteurs: Ruben Weckx; Chloë Goossens; Sarah Derde; Lies Pauwels; Sarah Vander Perre; Greet Van den Berghe; Lies Langouche
Publié dans: Scientific Reports, Numéro 1, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-14961-w

Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate.

Auteurs: Chloë Goossens; Ruben Weckx; Sarah Derde; Sarah Vander Perre; Inge Derese; Paul P. Van Veldhoven; Bart Ghesquière; Greet Van den Berghe; Lies Langouche
Publié dans: Critical Care, Numéro Vol 25, Iss 1, 2021, Page(s) Pp 1-12, ISSN 1466-609X
Éditeur: BioMed Central
DOI: 10.1186/s13054-021-03688-1

Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU

Auteurs: Ines Verlinden, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen Joosten, Sascha C. Verbruggen, Greet Van den Berghe, Ilse Vanhorebeek
Publié dans: Clinical Epigenetics, Numéro 12/1, 2020, ISSN 1868-7075
Éditeur: Springer Verlag
DOI: 10.1186/s13148-020-00947-w

Aerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up study.

Auteurs: Nathalie Van Aerde; Philippe Meersseman; Yves Debaveye; Alexander Wilmer; Michael P Casaer; Jan Gunst; Joost Wauters; Pieter Wouters; Kaatje Goetschalckx; Rik Gosselink; Greet Van den Berghe; Greet Hermans
Publié dans: Intensive Care Medicine, Numéro 47/12), 2021, Page(s) 1462-1471, ISSN 0342-4642
Éditeur: Springer Verlag
DOI: 10.1007/s00134-021-06541-9

Impact of prolonged sepsis on neural and muscular components of muscle contractions in a mouse model

Auteurs: Chloë Goossens, Ruben Weckx, Sarah Derde, Lawrence Van Helleputte, Dominik Schneidereit, Michael Haug, Barbara Reischl, Oliver Friedrich, Ludo Van Den Bosch, Greet Van den Berghe, Lies Langouche
Publié dans: Journal of Cachexia, Sarcopenia and Muscle, 2021, ISSN 2190-5991
Éditeur: Springer Verlag
DOI: 10.1002/jcsm.12668

The GH Axis in Relation to Accepting an Early Macronutrient Deficit and Outcome of Critically Ill Patients

Auteurs: Lisa Van Dyck, Inge Derese, Sarah Vander Perre, Pieter J Wouters, Michaël P Casaer, Greet Hermans, Greet Van den Berghe, Ilse Vanhorebeek
Publié dans: The Journal of Clinical Endocrinology & Metabolism, Numéro 104/11, 2019, Page(s) 5507-5518, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/jc.2019-00842

Role of ketones, ketogenic diets and intermittent fasting in ICU

Auteurs: Jan Gunst, Michael P. Casaer, Lies Langouche, Greet Van den Berghe
Publié dans: Current Opinion in Critical Care, Numéro 27/4, 2021, Page(s) 385-389, ISSN 1070-5295
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mcc.0000000000000841

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients.

Auteurs: Jan Gunst; Astrid De Bruyn; Michael P Casaer; Sarah Vander Perre; Lies Langouche; Greet Van den Berghe
Publié dans: Critical Care, Numéro Vol 25, Iss 1, 2021, Page(s) Pp 1-8, ISSN 1466-609X
Éditeur: BioMed Central
DOI: 10.1186/s13054-021-03772-6

Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate

Auteurs: Chloë Goossens, Ruben Weckx, Sarah Derde, Sarah Vander Perre, Inge Derese, Paul P. Van Veldhoven, Bart Ghesquière, Greet Van den Berghe, Lies Langouche
Publié dans: Critical Care, Numéro 25/1, 2021, ISSN 1364-8535
Éditeur: Biomed Central
DOI: 10.1186/s13054-021-03688-1

Early Supplemental Parenteral Nutrition in Critically Ill Children: An Update

Auteurs: An Jacobs, Ines Verlinden, Ilse Vanhorebeek, Greet Van den Berghe
Publié dans: Journal of Clinical Medicine, Numéro 8/6, 2019, Page(s) 830, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8060830

"The clinical potential of GDF15 as a ""ready-to-feed indicator"" for critically ill adults"

Auteurs: Lisa Van Dyck, Jan Gunst, Michael P Casaer, Bram Peeters, Inge Derese, Pieter J Wouters, Francis de Zegher, Ilse Vanhorebeek, Greet Van den Berghe
Publié dans: Critical Care, 2020, ISSN 1466-609X
Éditeur: BioMed Central
DOI: 10.1186/s13054-020-03254-1

Hyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different?

Auteurs: Greet Van den Berghe; Jan Gunst; Lies Langouche
Publié dans: Critical Care, Numéro Vol 25, Iss 1, 2021, Page(s) Pp 1-3, ISSN 1466-609X
Éditeur: BioMed Central
DOI: 10.1186/s13054-021-03861-6

Effect of late versus early initiation of parenteral nutrition on weight deterioration during PICU stay: Secondary analysis of the PEPaNIC randomised controlled trial

Auteurs: E. van Puffelen, J.M. Hulst, I. Vanhorebeek, K. Dulfer, G. Van den Berghe, K.F.M. Joosten, S.C.A.T. Verbruggen
Publié dans: Clinical Nutrition, 2019, ISSN 0261-5614
Éditeur: Churchill Livingstone
DOI: 10.1016/j.clnu.2019.02.014

Outcomes of Delaying Parenteral Nutrition for 1 Week vs Initiation Within 24 Hours Among Undernourished Children in Pediatric Intensive Care

Auteurs: Esther van Puffelen, Jessie M. Hulst, Ilse Vanhorebeek, Karolijn Dulfer, Greet Van den Berghe, Sascha C. A. T. Verbruggen, Koen F. M. Joosten
Publié dans: JAMA Network Open, Numéro 1/5, 2018, Page(s) e182668, ISSN 2574-3805
Éditeur: American Medical Association
DOI: 10.1001/jamanetworkopen.2018.2668

Glucose control in the ICU

Auteurs: Jan Gunst, Astrid De Bruyn, Greet Van den Berghe
Publié dans: Current Opinion in Anaesthesiology, Numéro 32/2, 2019, Page(s) 156-162, ISSN 0952-7907
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ACO.0000000000000706

Paediatric critical care survival: how to avoid bias

Auteurs: Greet Van den Berghe
Publié dans: The Lancet Respiratory Medicine, Numéro 7/2, 2019, Page(s) e2, ISSN 2213-2600
Éditeur: Elsevier Limited
DOI: 10.1016/S2213-2600(18)30408-9

Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones

Auteurs: Chloë Goossens, Ruben Weckx, Sarah Derde, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Steven E. Thiessen, Paul P. Van Veldhoven, Greet Van den Berghe, Lies Langouche
Publié dans: Critical Care, Numéro 23/1, 2019, Page(s) 236, ISSN 1364-8535
Éditeur: Springer Nature
DOI: 10.1186/s13054-019-2506-6

Hepatic PPARα is critical in the metabolic adaptation to sepsis

Auteurs: Réjane Paumelle, Joel T. Haas, Nathalie Hennuyer, Eric Baugé, Yann Deleye, Dieter Mesotten, Lies Langouche, Jonathan Vanhoutte, Céline Cudejko, Kristiaan Wouters, Sarah Anissa Hannou, Vanessa Legry, Steve Lancel, Fanny Lalloyer, Arnaud Polizzi, Sarra Smati, Pierre Gourdy, Emmanuelle Vallez, Emmanuel Bouchaert, Bruno Derudas, Hélène Dehondt, Céline Gheeraert, Sébastien Fleury, Anne Tailleux,
Publié dans: Journal of Hepatology, Numéro 70/5, 2019, Page(s) 963-973, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2018.12.037

Effect of early parenteral nutrition during paediatric critical illness on DNA methylation as a potential mediator of impaired neurocognitive development: a pre-planned secondary analysis of the PEPaNIC international randomised controlled trial

Auteurs: Fabian Güiza, Ilse Vanhorebeek, Sören Verstraete, Ines Verlinden, Inge Derese, Catherine Ingels, Karolijn Dulfer, Sascha C Verbruggen, Gonzalo Garcia Guerra, Koen F Joosten, Pieter J Wouters, Greet Van den Berghe
Publié dans: The Lancet Respiratory Medicine, Numéro 8/3, 2020, Page(s) 288-303, ISSN 2213-2600
Éditeur: Elsevier Limited
DOI: 10.1016/S2213-2600(20)30046-1

Five-year impact of ICU-acquired neuromuscular complications: a prospective, observational study

Auteurs: Nathalie Van Aerde, Philippe Meersseman, Yves Debaveye, Alexander Wilmer, Jan Gunst, Michael P. Casaer, Frans Bruyninckx, Pieter J. Wouters, Rik Gosselink, Greet Van den Berghe, Greet Hermans
Publié dans: Intensive Care Medicine, 2020, ISSN 0342-4642
Éditeur: Springer Verlag
DOI: 10.1007/s00134-020-05927-5

ICU-acquired weakness

Auteurs: Ilse Vanhorebeek, Nicola Latronico, Greet Van den Berghe
Publié dans: Intensive Care Medicine, Numéro 46/4, 2020, Page(s) 637-653, ISSN 0342-4642
Éditeur: Springer Verlag
DOI: 10.1007/s00134-020-05944-4

Intermittent Fasting

Auteurs: Jan Gunst, Greet Van den Berghe, Michael P. Casaer
Publié dans: Chest, Numéro 158/6, 2020, Page(s) 2707, ISSN 0012-3692
Éditeur: American College of Chest Physicians
DOI: 10.1016/j.chest.2020.07.071

Five-year outcome of respiratory muscle weakness at intensive care unit discharge: secondary analysis of a prospective cohort study

Auteurs: Nathalie Van Aerde, Philippe Meersseman, Yves Debaveye, Alexander Wilmer, Jan Gunst, Michael P Casaer, Joost Wauters, Pieter J Wouters, Rik Gosselink, Greet Van den Berghe, Greet Hermans
Publié dans: Thorax, 2021, Page(s) thoraxjnl-2020-216720, ISSN 0040-6376
Éditeur: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2020-216720

Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study

Auteurs: Lisa Van Dyck, Ilse Vanhorebeek, Alexander Wilmer, An Schrijvers, Inge Derese, Liese Mebis, Pieter J. Wouters, Greet Van den Berghe, Jan Gunst, Michaël P. Casaer
Publié dans: Critical Care, Numéro 24/1, 2020, ISSN 1364-8535
Éditeur: Critical Care
DOI: 10.1186/s13054-020-02987-3

C-reactive protein rise in response to macronutrient deficit early in critical illness: sign of inflammation or mediator of infection prevention and recovery.

Auteurs: Catherine Ingels; Lies Langouche; Jasperina Dubois; Inge Derese; Sarah Vander Perre; Pieter Wouters; Jan Gunst; Michael P Casaer; Fabian Güiza; Ilse Vanhorebeek; Greet Van den Berghe
Publié dans: Intensive Care Medicine, Numéro 48(1), 2022, Page(s) 25-35, ISSN 0342-4642
Éditeur: Springer Verlag
DOI: 10.1007/s00134-021-06565-1

Five-year mortality and morbidity impact of prolonged versus brief ICU stay: a propensity score matched cohort study

Auteurs: Greet Hermans, Nathalie Van Aerde, Philippe Meersseman, Helena Van Mechelen, Yves Debaveye, Alexander Wilmer, Jan Gunst, Michael Paul Casaer, Jasperina Dubois, Pieter Wouters, Rik Gosselink, Greet Van den Berghe
Publié dans: Thorax, Numéro 74/11, 2019, Page(s) 1037-1045, ISSN 0040-6376
Éditeur: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2018-213020

Impact of withholding early parenteral nutrition in adult critically ill patients on ketogenesis in relation to outcome

Auteurs: Astrid De Bruyn, Lies Langouche, Sarah Vander Perre, Jan Gunst, Greet Van den Berghe
Publié dans: Critical Care, Numéro 25/1, 2021, ISSN 1364-8535
Éditeur: Biomed Central
DOI: 10.1186/s13054-021-03519-3

Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice.

Auteurs: Ruben Weckx; Chloë Goossens; Sarah Derde; Lies Pauwels; Sarah Vander Perre; Greet Van den Bergh; Lies Langouche
Publié dans: BMC Pharmacology and Toxicology, Numéro Vol 22, Iss 1, 2021, Page(s) Pp 1-13, ISSN 2050-6511
Éditeur: BioMed Central
DOI: 10.1186/s40360-021-00517-7

Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin.

Auteurs: Wouter Vankrunkelsven; Sarah Derde; Jan Gunst; Sarah Vander Perre; Emiel Declerck; Lies Pauwels; Inge Derese; Greet Van den Berghe; Lies Langouche
Publié dans: Journal of Cachexia, Sarcopenia and Muscle, Numéro Vol 13, Iss 1, 2022, Page(s) 418-433, ISSN 2190-5991
Éditeur: Springer Verlag
DOI: 10.1002/jcsm.12904

Intensive Care Nutrition and Post–Intensive Care Recovery

Auteurs: Jan Gunst, Greet Van den Berghe
Publié dans: Critical Care Clinics, Numéro 34/4, 2018, Page(s) 573-583, ISSN 0749-0704
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ccc.2018.06.004

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