Promoting Osteogenesis through Vascular Endothelial Cells

Project Information

PROVEC

Grant agreement ID: 786672

DOI

10.3030/786672

Project closed

EC signature date 23 August 2018

Start date 1 February 2019

End date 31 January 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 205 875,00

EU contribution

€ 2 205 875,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease

Author(s): Andras Piffko, Thomas Broggini, Christoph Harms, Ralf Heinrich Adams, Peter Vajkoczy, Marcus Czabanka
Published in: International Journal of Molecular Sciences, Issue 22:8028, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22158028

Loss of Notch signaling in skeletal stem cells enhances bone formation with aging

Author(s): Lindsey H Remark, Kevin Leclerc, Malissa Ramsukh, Ziyan Lin, Sooyeon Lee, Backialakshmi Dharmalingam, Lauren Gillinov, Vasudev V Nayak, Paulo El Parente, Margaux Sambon, Pablo J Atria, Mohamed A E Ali, Lukasz Witek, Alesha B Castillo, Christopher Y Park, Ralf H Adams, Aristotelis Tsirigos, Sophie M Morgani, Philipp Leucht
Published in: Bone Research, Issue 11(1):50, 2023, ISSN 2095-6231
Publisher: Nature Publishing Group
DOI: 10.1038/s41413-023-00283-8

A specialized bone marrow microenvironment for fetal haematopoiesis

Author(s): Yang Liu, Qi Chen, Hyun-Woo Jeong, Bong Ihn Koh, Emma C. Watson, Cong Xu, Martin Stehling, Bin Zhou,Ralf H. Adams
Published in: Nature Communications, Issue 13, Article number: 1327, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28775-x

YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells

Author(s): Kishor K Sivaraj, Backialakshmi Dharmalingam, Vishal Mohanakrishnan, Hyun-Woo Jeong, Katsuhiro Kato, Silke Schröder, Susanne Adams, Gou Young Koh, Ralf H Adams
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.50770

The bone marrow microenvironment at single-cell resolution

Author(s): Anastasia N. Tikhonova, Igor Dolgalev, Hai Hu, Kishor K. Sivaraj, Edlira Hoxha, Álvaro Cuesta-Domínguez, Sandra Pinho, Ilseyar Akhmetzyanova, Jie Gao, Matthew Witkowski, Maria Guillamot, Michael C. Gutkin, Yutong Zhang, Christian Marier, Catherine Diefenbach, Stavroula Kousteni, Adriana Heguy, Hua Zhong, David R. Fooksman, Jason M. Butler, Aris Economides, Paul S. Frenette, Ralf H. Adams, Rahul
Published in: Nature, Issue 569/7755, 2019, Page(s) 222-228, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1104-8

Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury

Author(s): Qi Chen, Yang Liu, Hyun-Woo Jeong, Martin Stehling, Van Vuong Dinh, Bin Zhou, Ralf H. Adams
Published in: Cell Stem Cell, Issue 25/6, 2019, Page(s) 768-783.e6, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2019.10.006

Dopamine signaling regulates hematopoietic stem and progenitor cell function

Author(s): Yang Liu, Qi Chen, Hyun-Woo Jeong, Dong Han, Jörg Fabian, Hannes C A Drexler, Martin Stehling, Hans R Schöler, Ralf H Adams
Published in: Blood, Issue 138, 2021, Page(s) 2051-2065, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020010419

Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing

Author(s): Kishor K. Sivaraj, Paul-Georg Majev, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Silke Schröder, M. Gabriele Bixel, Melanie Timmen, Richard Stange, and Ralf H. Adams
Published in: Nature Communications, Issue 13:571, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28142-w

Induction of osteogenesis by bone-targeted Notch activation

Author(s): Cong Xu, Van Vuong Dinh, Kai Kruse, Hyun-Woo Jeong, Emma C Watson, Susanne Adams, Frank Berkenfeld, Martin Stehling, Seyed Javad Rasouli, Rui Fan, Rui Chen, Ivan Bedzhov, Qi Chen, Katsuhiro Kato, Mara Elena Pitulescu, Ralf H Adams
Published in: Elife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60183

Regional specialization and fate specification of bone stromal cells in skeletal development

Author(s): Kishor K. Sivaraj, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Susanne Adams, Michael Potente, Ralf H. Adams
Published in: Cell Reports, Issue 36/2, 2021, Page(s) 109352, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109352

Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease

Author(s): David Rohde, Katrien Vandoorne, I-Hsiu Lee, Jana Grune, Shuang Zhang, Cameron S. McAlpine, Maximilian J. Schloss, Ribhu Nayar, Gabriel Courties, Vanessa Frodermann, Gregory Wojtkiewicz, Lisa Honold, Qi Chen, Stephen Schmidt, Yoshiko Iwamoto, Yuan Sun, Sebastian Cremer, Friedrich F. Hoyer, Oriol Iborra-Egea, Christian Muñoz-Guijosa, Fei Ji, Bin Zhou, Ralf H. Adams, Joshua D. Wythe, Juan Hidalgo,
Published in: Nature Cardiovascular Research, Issue 1(1): 28–44, 2022, ISSN 2731-0590
Publisher: Nature Publishing Group
DOI: 10.1038/s44161-021-00002-8

The endothelium–bone axis in development, homeostasis and bone and joint disease

Author(s): Jan Tuckermann, Ralf H Adams
Published in: Nature Reviews Rheumatology, Issue 17, 2021, Page(s) pages 608–620, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-021-00682-3

Antipsychotic drugs induce vascular defects in hematopoietic organs

Author(s): Zhao‐hua Deng; Jing Zhong; Hai‐lin Jiang; Hyun‐Woo Jeong; Jian‐wei Chen; Ya‐hai Shu; Ming Tan; Ralf H. Adams; Ke‐ping Xie; Qi Chen; Yang Liu
Published in: FASEB Journal, Issue 36(10):e22538, 2022, ISSN 1530-6860
Publisher: The Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202200862r