Promoting Osteogenesis through Vascular Endothelial Cells

Informazioni relative al progetto

PROVEC

ID dell’accordo di sovvenzione: 786672

DOI

10.3030/786672

Progetto chiuso

Data della firma CE 23 Agosto 2018

Data di avvio 1 Febbraio 2019

Data di completamento 31 Gennaio 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 205 875,00

Contributo UE

€ 2 205 875,00

Coordinato da

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (13)

Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease

Autori: Andras Piffko, Thomas Broggini, Christoph Harms, Ralf Heinrich Adams, Peter Vajkoczy, Marcus Czabanka
Pubblicato in: International Journal of Molecular Sciences, Numero 22:8028, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22158028

Loss of Notch signaling in skeletal stem cells enhances bone formation with aging

Autori: Lindsey H Remark, Kevin Leclerc, Malissa Ramsukh, Ziyan Lin, Sooyeon Lee, Backialakshmi Dharmalingam, Lauren Gillinov, Vasudev V Nayak, Paulo El Parente, Margaux Sambon, Pablo J Atria, Mohamed A E Ali, Lukasz Witek, Alesha B Castillo, Christopher Y Park, Ralf H Adams, Aristotelis Tsirigos, Sophie M Morgani, Philipp Leucht
Pubblicato in: Bone Research, Numero 11(1):50, 2023, ISSN 2095-6231
Editore: Nature Publishing Group
DOI: 10.1038/s41413-023-00283-8

A specialized bone marrow microenvironment for fetal haematopoiesis

Autori: Yang Liu, Qi Chen, Hyun-Woo Jeong, Bong Ihn Koh, Emma C. Watson, Cong Xu, Martin Stehling, Bin Zhou,Ralf H. Adams
Pubblicato in: Nature Communications, Numero 13, Article number: 1327, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28775-x

YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells

Autori: Kishor K Sivaraj, Backialakshmi Dharmalingam, Vishal Mohanakrishnan, Hyun-Woo Jeong, Katsuhiro Kato, Silke Schröder, Susanne Adams, Gou Young Koh, Ralf H Adams
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.50770

The bone marrow microenvironment at single-cell resolution

Autori: Anastasia N. Tikhonova, Igor Dolgalev, Hai Hu, Kishor K. Sivaraj, Edlira Hoxha, Álvaro Cuesta-Domínguez, Sandra Pinho, Ilseyar Akhmetzyanova, Jie Gao, Matthew Witkowski, Maria Guillamot, Michael C. Gutkin, Yutong Zhang, Christian Marier, Catherine Diefenbach, Stavroula Kousteni, Adriana Heguy, Hua Zhong, David R. Fooksman, Jason M. Butler, Aris Economides, Paul S. Frenette, Ralf H. Adams, Rahul
Pubblicato in: Nature, Numero 569/7755, 2019, Pagina/e 222-228, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1104-8

Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury

Autori: Qi Chen, Yang Liu, Hyun-Woo Jeong, Martin Stehling, Van Vuong Dinh, Bin Zhou, Ralf H. Adams
Pubblicato in: Cell Stem Cell, Numero 25/6, 2019, Pagina/e 768-783.e6, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2019.10.006

Dopamine signaling regulates hematopoietic stem and progenitor cell function

Autori: Yang Liu, Qi Chen, Hyun-Woo Jeong, Dong Han, Jörg Fabian, Hannes C A Drexler, Martin Stehling, Hans R Schöler, Ralf H Adams
Pubblicato in: Blood, Numero 138, 2021, Pagina/e 2051-2065, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2020010419

Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing

Autori: Kishor K. Sivaraj, Paul-Georg Majev, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Silke Schröder, M. Gabriele Bixel, Melanie Timmen, Richard Stange, and Ralf H. Adams
Pubblicato in: Nature Communications, Numero 13:571, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28142-w

Induction of osteogenesis by bone-targeted Notch activation

Autori: Cong Xu, Van Vuong Dinh, Kai Kruse, Hyun-Woo Jeong, Emma C Watson, Susanne Adams, Frank Berkenfeld, Martin Stehling, Seyed Javad Rasouli, Rui Fan, Rui Chen, Ivan Bedzhov, Qi Chen, Katsuhiro Kato, Mara Elena Pitulescu, Ralf H Adams
Pubblicato in: Elife, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.60183

Regional specialization and fate specification of bone stromal cells in skeletal development

Autori: Kishor K. Sivaraj, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Susanne Adams, Michael Potente, Ralf H. Adams
Pubblicato in: Cell Reports, Numero 36/2, 2021, Pagina/e 109352, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109352

Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease

Autori: David Rohde, Katrien Vandoorne, I-Hsiu Lee, Jana Grune, Shuang Zhang, Cameron S. McAlpine, Maximilian J. Schloss, Ribhu Nayar, Gabriel Courties, Vanessa Frodermann, Gregory Wojtkiewicz, Lisa Honold, Qi Chen, Stephen Schmidt, Yoshiko Iwamoto, Yuan Sun, Sebastian Cremer, Friedrich F. Hoyer, Oriol Iborra-Egea, Christian Muñoz-Guijosa, Fei Ji, Bin Zhou, Ralf H. Adams, Joshua D. Wythe, Juan Hidalgo,
Pubblicato in: Nature Cardiovascular Research, Numero 1(1): 28–44, 2022, ISSN 2731-0590
Editore: Nature Publishing Group
DOI: 10.1038/s44161-021-00002-8

The endothelium–bone axis in development, homeostasis and bone and joint disease

Autori: Jan Tuckermann, Ralf H Adams
Pubblicato in: Nature Reviews Rheumatology, Numero 17, 2021, Pagina/e pages 608–620, ISSN 1759-4790
Editore: Nature Publishing Group
DOI: 10.1038/s41584-021-00682-3

Antipsychotic drugs induce vascular defects in hematopoietic organs

Autori: Zhao‐hua Deng; Jing Zhong; Hai‐lin Jiang; Hyun‐Woo Jeong; Jian‐wei Chen; Ya‐hai Shu; Ming Tan; Ralf H. Adams; Ke‐ping Xie; Qi Chen; Yang Liu
Pubblicato in: FASEB Journal, Numero 36(10):e22538, 2022, ISSN 1530-6860
Editore: The Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202200862r