Mechanisms of vascular maturation and quiescence during development, homeostasis and aging

Project Information

AngioMature

Grant agreement ID: 787181

DOI

10.3030/787181

Project closed

EC signature date 10 July 2018

Start date 1 August 2018

End date 31 October 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 338 918,00

EU contribution

€ 2 338 918,00

Coordinated by

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan (DMP)

Publications

Peer reviewed articles (19)

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Author(s): Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli-Matti Leppänen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari Vaahtomeri, Pipsa Saharinen, Taija Mäkinen, Kari Alitalo
Published in: Journal of Clinical Investigation, Issue 132, 2023, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci155478

The spatial zonation of the murine placental vasculature is specified by epigenetic mechanisms

Author(s): Stephanie Gehrs, Moritz Jakab, Ewgenija Gutjahr, Zuguang Gu, Dieter Weichenhan, Jan-Philipp Mallm, Carolin Mogler, Matthias Schlesner, Christoph Plass, Katharina Schlereth, Hellmut G. Augustin
Published in: Developmental Cell, 2025, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2024.12.037

Tie2 Receptor in Tumor-Infiltrating Macrophages Is Dispensable for Tumor Angiogenesis and Tumor Relapse after Chemotherapy

Author(s): Moritz Jakab, Till Rostalski, Ki Hong Lee, Carolin Mogler, Hellmut G. Augustin
Published in: Cancer Research, Issue 82, 2022, Page(s) 1353-1364, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-21-3181

A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

Author(s): Donato Inverso, Jingjing Shi, Ki Hong Lee, Moritz Jakab, Shani Ben-Moshe, Shubhada R. Kulkarni, Martin Schneider, Guanxiong Wang, Marziyeh Komeili, Paula Argos Vélez, Maria Riedel, Carleen Spegg, Thomas Ruppert, Christine Schaeffer-Reiss, Dominic Helm, Indrabahadur Singh, Michael Boutros, Sudhakar Chintharlapalli, Mathias Heikenwalder, Shalev Itzkovitz, Hellmut G. Augustin
Published in: Developmental Cell, Issue 56/11, 2021, Page(s) 1677-1693.e10, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.05.001

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Author(s): Mahak Singhal, Nicolas Gengenbacher, Ashik Ahmed Abdul Pari, Miki Kamiyama, Ling Hai, Bianca J. Kuhn, David M. Kallenberg, Shubhada R. Kulkarni, Carlotta Camilli, Stephanie F. Preuß, Barbara Leuchs, Carolin Mogler, Elisa Espinet, Eva Besemfelder, Danijela Heide, Mathias Heikenwalder, Martin R. Sprick, Andreas Trumpp, Jeroen Krijgsveld, Matthias Schlesner, Junhao Hu, Stephen E. Moss, John Greenwoo
Published in: Science Translational Medicine, Issue 13, 2024, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abe6805

Angiodiversity and organotypic functions of sinusoidal endothelial cells

Author(s): Philipp-Sebastian Koch, Ki Hong Lee, Sergij Goerdt, Hellmut G. Augustin
Published in: Angiogenesis, Issue 24/2, 2021, Page(s) 289-310, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-021-09780-y

Systemic Reprogramming of Endothelial Cell Signaling in Metastasis and Cachexia

Author(s): Stephanie F. Preuss, Denise Grieshober, Hellmut G. Augustin
Published in: Physiology, Issue 38, 2023, Page(s) 189-202, ISSN 1548-9213
Publisher: American Physiological Society
DOI: 10.1152/physiol.00001.2023

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Author(s): Atsushi Sugimoto, Yoshinobu Saito, Guanxiong Wang, Qiuyan Sun, Chuan Yin, Ki Hong Lee, Yana Geng, Presha Rajbhandari, Celine Hernandez, Marcella Steffani, Jingran Qie, Thomas Savage, Dhruv M. Goyal, Kevin C. Ray, Taruna V. Neelakantan, Deqi Yin, Johannes Melms, Brandon M. Lehrich, Tyler M. Yasaka, Silvia Liu, Michael Oertel, Tian Lan, Adrien Guillot, Moritz Peiseler, Aveline Filliol, Hiroaki Kanza
Published in: Nature, Issue 640, 2025, Page(s) 752-761, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-08677-w

LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency

Author(s): Marie N. O’Connor, David M. Kallenberg, Carlotta Camilli, Camilla Pilotti, Athina Dritsoula, Rene Jackstadt, Chantelle E. Bowers, H. Angharad Watson, Markella Alatsatianos, Julia Ohme, Laura Dowsett, Jestin George, Jack W.D. Blackburn, Xiaomeng Wang, Mahak Singhal, Hellmut G. Augustin, Ann Ager, Owen J. Sansom, Stephen E. Moss, John Greenwood
Published in: Med, Issue 2, 2022, Page(s) 1231-1252.e10, ISSN 2666-6340
Publisher: Elsevier BV
DOI: 10.1016/j.medj.2021.10.002

Endothelial cell fitness dictates the source of regenerating liver vasculature

Author(s): Mahak Singhal, Xiaoting Liu, Donato Inverso, Kai Jiang, Jianing Dai, Hao He, Susanne Bartels, Weiping Li, Ashik Ahmed Abdul Pari, Nicolas Gengenbacher, Eva Besemfelder, Lijian Hui, Hellmut G. Augustin, Junhao Hu
Published in: Journal of Experimental Medicine, Issue 215/10, 2018, Page(s) 2497-2508, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20180008

Tumor Cell–Derived Angiopoietin-2 Promotes Metastasis in Melanoma

Author(s): Ashik Ahmed Abdul Pari, Mahak Singhal, Corinne Hübers, Carolin Mogler, Benjamin Schieb, Anja Gampp, Nicolas Gengenbacher, Louise E. Reynolds, Dorothee Terhardt, Cyrill Géraud, Jochen Utikal, Markus Thomas, Sergij Goerdt, Kairbaan M. Hodivala-Dilke, Hellmut G. Augustin, Moritz Felcht
Published in: Cancer Research, Issue 80/12, 2020, Page(s) 2586-2598, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-2660

Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk

Author(s): Isidora Paredes, José Ricardo Vieira, Bhavin Shah, Carla F. Ramunno, Julia Dyckow, Heike Adler, Melanie Richter, Geza Schermann, Evangelia Giannakouri, Lucas Schirmer, Hellmut G. Augustin, Carmen Ruiz de Almodóvar
Published in: Nature Neuroscience, Issue 24, 2023, Page(s) 478-488, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-00788-z

Preclinical validation of a novel metastasis‐inhibiting Tie1 function‐blocking antibody

Author(s): Mahak Singhal, Nicolas Gengenbacher, Silvia La Porta, Stephanie Gehrs, Jingjing Shi, Miki Kamiyama, Diane M Bodenmiller, Anthony Fischl, Benjamin Schieb, Eva Besemfelder, Sudhakar Chintharlapalli, Hellmut G Augustin
Published in: EMBO Molecular Medicine, Issue 12/6, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911164

A systems view of the vascular endothelium in health and disease

Author(s): Hellmut G. Augustin, Gou Young Koh
Published in: Cell, Issue 187, 2024, Page(s) 4833-4858, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.07.012

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Author(s): Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D. Nguyen, Sinem Karaman, Emilia A. Korhonen, Ralf H. Adams, Hellmut G. Augustin, Katariina Öörni, Oliver Soehnlein, Minna U. Kaikkonen, Kari Alitalo
Published in: Nature Cardiovascular Research, Issue 2, 2023, Page(s) 307-321, ISSN 2731-0590
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44161-023-00224-y

Timed Ang2-Targeted Therapy Identifies the Angiopoietin–Tie Pathway as Key Regulator of Fatal Lymphogenous Metastasis

Author(s): Nicolas Gengenbacher, Mahak Singhal, Carolin Mogler, Ling Hai, Laura Milde, Ashik Ahmed Abdul Pari, Eva Besemfelder, Claudine Fricke, Daniel Baumann, Stephanie Gehrs, Jochen Utikal, Moritz Felcht, Junhao Hu, Matthias Schlesner, Rienk Offringa, Sudhakar R. Chintharlapalli, Hellmut G. Augustin
Published in: Cancer Discovery, Issue 11, 2022, Page(s) 424-445, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0122

Lung endothelium exploits susceptible tumor cell states to instruct metastatic latency

Author(s): Moritz Jakab, Ki Hong Lee, Alexey Uvarovskii, Svetlana Ovchinnikova, Shubhada R. Kulkarni, Sevinç Jakab, Till Rostalski, Carleen Spegg, Simon Anders, Hellmut G. Augustin
Published in: Nature Cancer, Issue 5, 2024, Page(s) 716-730, ISSN 2662-1347
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43018-023-00716-7

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

Author(s): Corinne Hübers, Ashik Ahmed Abdul Pari, Denise Grieshober, Martin Petkov, Alexander Schmidt, Tatjana Messmer, Christian Moritz Heyer, Sebastian Schölch, Stephanie S. Kapel, Nicolas Gengenbacher, Mahak Singhal, Benjamin Schieb, Claudine Fricke, Rainer Will, Kim Remans, Jochen Sven Utikal, Christoph Reissfelder, Matthias Schlesner, Kairbaan M. Hodivala-Dilke, Sander Kersten, Sergij Goerdt, Hellmut
Published in: Journal of Experimental Medicine, Issue 220, 2022, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20202595

The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner

Author(s): Robert Luck, Andromachi Karakatsani, Bhavin Shah, Geza Schermann, Heike Adler, Janina Kupke, Nathalie Tisch, Hyun-Woo Jeong, Michaela Kerstin Back, Florian Hetsch, Anna D’Errico, Michele De Palma, Ellen Wiedtke, Dirk Grimm, Amparo Acker-Palmer, Jakob von Engelhardt, Ralf H. Adams, Hellmut G. Augustin, Carmen Ruiz de Almodóvar
Published in: Cell Reports, Issue 36, 2021, Page(s) 109522, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109522