Mechanisms of vascular maturation and quiescence during development, homeostasis and aging

Informazioni relative al progetto

AngioMature

ID dell’accordo di sovvenzione: 787181

DOI

10.3030/787181

Progetto chiuso

Data della firma CE 10 Luglio 2018

Data di avvio 1 Agosto 2018

Data di completamento 31 Ottobre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 338 918,00

Contributo UE

€ 2 338 918,00

Coordinato da

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan (DMP)

Pubblicazioni

Peer reviewed articles (19)

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Autori: Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli-Matti Leppänen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari Vaahtomeri, Pipsa Saharinen, Taija Mäkinen, Kari Alitalo
Pubblicato in: Journal of Clinical Investigation, Numero 132, 2023, ISSN 1558-8238
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci155478

The spatial zonation of the murine placental vasculature is specified by epigenetic mechanisms

Autori: Stephanie Gehrs, Moritz Jakab, Ewgenija Gutjahr, Zuguang Gu, Dieter Weichenhan, Jan-Philipp Mallm, Carolin Mogler, Matthias Schlesner, Christoph Plass, Katharina Schlereth, Hellmut G. Augustin
Pubblicato in: Developmental Cell, 2025, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2024.12.037

Tie2 Receptor in Tumor-Infiltrating Macrophages Is Dispensable for Tumor Angiogenesis and Tumor Relapse after Chemotherapy

Autori: Moritz Jakab, Till Rostalski, Ki Hong Lee, Carolin Mogler, Hellmut G. Augustin
Pubblicato in: Cancer Research, Numero 82, 2022, Pagina/e 1353-1364, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-21-3181

A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

Autori: Donato Inverso, Jingjing Shi, Ki Hong Lee, Moritz Jakab, Shani Ben-Moshe, Shubhada R. Kulkarni, Martin Schneider, Guanxiong Wang, Marziyeh Komeili, Paula Argos Vélez, Maria Riedel, Carleen Spegg, Thomas Ruppert, Christine Schaeffer-Reiss, Dominic Helm, Indrabahadur Singh, Michael Boutros, Sudhakar Chintharlapalli, Mathias Heikenwalder, Shalev Itzkovitz, Hellmut G. Augustin
Pubblicato in: Developmental Cell, Numero 56/11, 2021, Pagina/e 1677-1693.e10, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2021.05.001

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Autori: Mahak Singhal, Nicolas Gengenbacher, Ashik Ahmed Abdul Pari, Miki Kamiyama, Ling Hai, Bianca J. Kuhn, David M. Kallenberg, Shubhada R. Kulkarni, Carlotta Camilli, Stephanie F. Preuß, Barbara Leuchs, Carolin Mogler, Elisa Espinet, Eva Besemfelder, Danijela Heide, Mathias Heikenwalder, Martin R. Sprick, Andreas Trumpp, Jeroen Krijgsveld, Matthias Schlesner, Junhao Hu, Stephen E. Moss, John Greenwoo
Pubblicato in: Science Translational Medicine, Numero 13, 2024, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abe6805

Angiodiversity and organotypic functions of sinusoidal endothelial cells

Autori: Philipp-Sebastian Koch, Ki Hong Lee, Sergij Goerdt, Hellmut G. Augustin
Pubblicato in: Angiogenesis, Numero 24/2, 2021, Pagina/e 289-310, ISSN 0969-6970
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10456-021-09780-y

Systemic Reprogramming of Endothelial Cell Signaling in Metastasis and Cachexia

Autori: Stephanie F. Preuss, Denise Grieshober, Hellmut G. Augustin
Pubblicato in: Physiology, Numero 38, 2023, Pagina/e 189-202, ISSN 1548-9213
Editore: American Physiological Society
DOI: 10.1152/physiol.00001.2023

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Autori: Atsushi Sugimoto, Yoshinobu Saito, Guanxiong Wang, Qiuyan Sun, Chuan Yin, Ki Hong Lee, Yana Geng, Presha Rajbhandari, Celine Hernandez, Marcella Steffani, Jingran Qie, Thomas Savage, Dhruv M. Goyal, Kevin C. Ray, Taruna V. Neelakantan, Deqi Yin, Johannes Melms, Brandon M. Lehrich, Tyler M. Yasaka, Silvia Liu, Michael Oertel, Tian Lan, Adrien Guillot, Moritz Peiseler, Aveline Filliol, Hiroaki Kanza
Pubblicato in: Nature, Numero 640, 2025, Pagina/e 752-761, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-025-08677-w

LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency

Autori: Marie N. O’Connor, David M. Kallenberg, Carlotta Camilli, Camilla Pilotti, Athina Dritsoula, Rene Jackstadt, Chantelle E. Bowers, H. Angharad Watson, Markella Alatsatianos, Julia Ohme, Laura Dowsett, Jestin George, Jack W.D. Blackburn, Xiaomeng Wang, Mahak Singhal, Hellmut G. Augustin, Ann Ager, Owen J. Sansom, Stephen E. Moss, John Greenwood
Pubblicato in: Med, Numero 2, 2022, Pagina/e 1231-1252.e10, ISSN 2666-6340
Editore: Elsevier BV
DOI: 10.1016/j.medj.2021.10.002

Endothelial cell fitness dictates the source of regenerating liver vasculature

Autori: Mahak Singhal, Xiaoting Liu, Donato Inverso, Kai Jiang, Jianing Dai, Hao He, Susanne Bartels, Weiping Li, Ashik Ahmed Abdul Pari, Nicolas Gengenbacher, Eva Besemfelder, Lijian Hui, Hellmut G. Augustin, Junhao Hu
Pubblicato in: Journal of Experimental Medicine, Numero 215/10, 2018, Pagina/e 2497-2508, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20180008

Tumor Cell–Derived Angiopoietin-2 Promotes Metastasis in Melanoma

Autori: Ashik Ahmed Abdul Pari, Mahak Singhal, Corinne Hübers, Carolin Mogler, Benjamin Schieb, Anja Gampp, Nicolas Gengenbacher, Louise E. Reynolds, Dorothee Terhardt, Cyrill Géraud, Jochen Utikal, Markus Thomas, Sergij Goerdt, Kairbaan M. Hodivala-Dilke, Hellmut G. Augustin, Moritz Felcht
Pubblicato in: Cancer Research, Numero 80/12, 2020, Pagina/e 2586-2598, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-2660

Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk

Autori: Isidora Paredes, José Ricardo Vieira, Bhavin Shah, Carla F. Ramunno, Julia Dyckow, Heike Adler, Melanie Richter, Geza Schermann, Evangelia Giannakouri, Lucas Schirmer, Hellmut G. Augustin, Carmen Ruiz de Almodóvar
Pubblicato in: Nature Neuroscience, Numero 24, 2023, Pagina/e 478-488, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-020-00788-z

Preclinical validation of a novel metastasis‐inhibiting Tie1 function‐blocking antibody

Autori: Mahak Singhal, Nicolas Gengenbacher, Silvia La Porta, Stephanie Gehrs, Jingjing Shi, Miki Kamiyama, Diane M Bodenmiller, Anthony Fischl, Benjamin Schieb, Eva Besemfelder, Sudhakar Chintharlapalli, Hellmut G Augustin
Pubblicato in: EMBO Molecular Medicine, Numero 12/6, 2020, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911164

A systems view of the vascular endothelium in health and disease

Autori: Hellmut G. Augustin, Gou Young Koh
Pubblicato in: Cell, Numero 187, 2024, Pagina/e 4833-4858, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2024.07.012

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Autori: Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D. Nguyen, Sinem Karaman, Emilia A. Korhonen, Ralf H. Adams, Hellmut G. Augustin, Katariina Öörni, Oliver Soehnlein, Minna U. Kaikkonen, Kari Alitalo
Pubblicato in: Nature Cardiovascular Research, Numero 2, 2023, Pagina/e 307-321, ISSN 2731-0590
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44161-023-00224-y

Timed Ang2-Targeted Therapy Identifies the Angiopoietin–Tie Pathway as Key Regulator of Fatal Lymphogenous Metastasis

Autori: Nicolas Gengenbacher, Mahak Singhal, Carolin Mogler, Ling Hai, Laura Milde, Ashik Ahmed Abdul Pari, Eva Besemfelder, Claudine Fricke, Daniel Baumann, Stephanie Gehrs, Jochen Utikal, Moritz Felcht, Junhao Hu, Matthias Schlesner, Rienk Offringa, Sudhakar R. Chintharlapalli, Hellmut G. Augustin
Pubblicato in: Cancer Discovery, Numero 11, 2022, Pagina/e 424-445, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0122

Lung endothelium exploits susceptible tumor cell states to instruct metastatic latency

Autori: Moritz Jakab, Ki Hong Lee, Alexey Uvarovskii, Svetlana Ovchinnikova, Shubhada R. Kulkarni, Sevinç Jakab, Till Rostalski, Carleen Spegg, Simon Anders, Hellmut G. Augustin
Pubblicato in: Nature Cancer, Numero 5, 2024, Pagina/e 716-730, ISSN 2662-1347
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s43018-023-00716-7

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

Autori: Corinne Hübers, Ashik Ahmed Abdul Pari, Denise Grieshober, Martin Petkov, Alexander Schmidt, Tatjana Messmer, Christian Moritz Heyer, Sebastian Schölch, Stephanie S. Kapel, Nicolas Gengenbacher, Mahak Singhal, Benjamin Schieb, Claudine Fricke, Rainer Will, Kim Remans, Jochen Sven Utikal, Christoph Reissfelder, Matthias Schlesner, Kairbaan M. Hodivala-Dilke, Sander Kersten, Sergij Goerdt, Hellmut
Pubblicato in: Journal of Experimental Medicine, Numero 220, 2022, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20202595

The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner

Autori: Robert Luck, Andromachi Karakatsani, Bhavin Shah, Geza Schermann, Heike Adler, Janina Kupke, Nathalie Tisch, Hyun-Woo Jeong, Michaela Kerstin Back, Florian Hetsch, Anna D’Errico, Michele De Palma, Ellen Wiedtke, Dirk Grimm, Amparo Acker-Palmer, Jakob von Engelhardt, Ralf H. Adams, Hellmut G. Augustin, Carmen Ruiz de Almodóvar
Pubblicato in: Cell Reports, Numero 36, 2021, Pagina/e 109522, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109522