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The Mitochondrial Unfolded Protein Response


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Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

Author(s): Ji Sun Moon, Ludger J. E. Goeminne, Jung Tae Kim, Jing Wen Tian, Seok‐Hwan Kim, Ha Thi Nga, Seul Gi Kang, Baeki E. Kang, Jin‐Seok Byun, Young‐Sun Lee, Jae‐Han Jeon, Minho Shong, Johan Auwerx, Dongryeol Ryu, Hyon‐Seung Yi
Published in: Aging Cell, 19/8, 2020, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13195

NAD+ homeostasis in health and disease

Author(s): Elena Katsyuba, Mario Romani, Dina Hofer, Johan Auwerx
Published in: Nature Metabolism, 2/1, 2020, Page(s) 9-31, ISSN 2522-5812
Publisher: Elsevier Nature Metabolism
DOI: 10.1038/s42255-019-0161-5

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

Author(s): Maria Elisa Perez-Munoz, Autumn M. McKnite, Evan G. Williams, Johan Auwerx, Robert W. Williams, Daniel A. Peterson, Daniel C. Ciobanu
Published in: PLOS ONE, 14/10, 2019, Page(s) e0224100, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0224100

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

Author(s): H. B. Atakan, K. S. Hof, M. Cornaglia, J. Auwerx, M. A. M. Gijs
Published in: Scientific Reports, 9/1, 2019, Page(s) 19315, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-55979-x

Niacin: an old lipid drug in a new NAD+ dress

Author(s): Mario Romani, Dina Carina Hofer, Elena Katsyuba, Johan Auwerx
Published in: Journal of Lipid Research, 60/4, 2019, Page(s) 741-746, ISSN 0022-2275
Publisher: Lipid Research, Inc.
DOI: 10.1194/jlr.s092007

Mitocellular communication: Shaping health and disease

Author(s): Adrienne Mottis, Sébastien Herzig, Johan Auwerx
Published in: Science, 366/6467, 2019, Page(s) 827-832, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax3768

Mouse Systems Genetics as a Prelude to Precision Medicine

Author(s): Hao Li, Johan Auwerx
Published in: Trends in Genetics, 36/4, 2020, Page(s) 259-272, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2020.01.004

Identifying gene function and module connections by the integration of multispecies expression compendia

Author(s): Hao Li, Daria Rukina, Fabrice P.A. David, Terytty Yang Li, Chang-Myung Oh, Arwen W. Gao, Elena Katsyuba, Maroun Bou Sleiman, Andrea Komljenovic, Qingyao Huang, Robert W. Williams, Marc Robinson-Rechavi, Kristina Schoonjans, Stephan Morgenthaler, Johan Auwerx
Published in: Genome Research, 29/12, 2019, Page(s) 2034-2045, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.251983.119

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

Author(s): Anna Nakamura, Yoko Yokoyama, Kazuki Tanaka, Giorgia Benegiamo, Akiyoshi Hirayama, Qi Zhu, Naho Kitamura, Taichi Sugizaki, Kohkichi Morimoto, Hiroshi Itoh, Shinji Fukuda, Johan Auwerx, Kazuo Tsubota, Mitsuhiro Watanabe
Published in: iScience, 23/9, 2020, Page(s) 101522, ISSN 2589-0042
Publisher: ELSEVIER science direct
DOI: 10.1016/j.isci.2020.101522

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Author(s): Mario Romani, Vincenzo Sorrentino, Chang-Myung Oh, Hao Li, Tanes Imamura de Lima, Hongbo Zhang, Minho Shong, Johan Auwerx
Published in: Cell Reports, 34/3, 2021, Page(s) 108660, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108660

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Author(s): Maroun Bou Sleiman, Pooja Jha, Riekelt Houtkooper, Robert W. Williams, Xu Wang, Johan Auwerx
Published in: Cell Reports, 32/13, 2020, Page(s) 108203, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108203