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The Mitochondrial Unfolded Protein Response

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Publications

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Author(s): Terytty Yang Li; Arwen W. Gao; Xiaoxu Li; Hao Li; Yasmine J. Liu; Amelia Lalou; Nagammal Neelagandan; Felix Naef; Kristina Schoonjans; Johan Auwerx
Published in: Journal Cell Biology, Issue 222, 2023, Page(s) e202205045, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202205045

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

Author(s): Ji Sun Moon, Ludger J. E. Goeminne, Jung Tae Kim, Jing Wen Tian, Seok‐Hwan Kim, Ha Thi Nga, Seul Gi Kang, Baeki E. Kang, Jin‐Seok Byun, Young‐Sun Lee, Jae‐Han Jeon, Minho Shong, Johan Auwerx, Dongryeol Ryu, Hyon‐Seung Yi
Published in: Aging Cell, Issue 19/8, 2020, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13195

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Author(s): Giorgia Benegiamo; Maroun Bou Sleiman; Martin Wohlwend; Sandra Rodríguez-López; Ludger J. E. Goeminne; Pirkka-Pekka Laurila; Marie Klevjer; Minna K. Salonen; Jari Lahti; Pooja Jha; Sara Cogliati; José Antonio Enriquez; Ben M. Brumpton; Anja Bye; Johan G. Eriksson; Johan Auwerx
Published in: Nature Metabolism, Issue 1, 2022, Page(s) 1336–1351, ISSN 2522-5812
Publisher: Springer Nature
DOI: 10.1038/s42255-022-00655-0

NAD+ homeostasis in health and disease

Author(s): Elena Katsyuba, Mario Romani, Dina Hofer, Johan Auwerx
Published in: Nature Metabolism, Issue 2/1, 2020, Page(s) 9-31, ISSN 2522-5812
Publisher: Elsevier Nature Metabolism
DOI: 10.1038/s42255-019-0161-5

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

Author(s): Maria Elisa Perez-Munoz, Autumn M. McKnite, Evan G. Williams, Johan Auwerx, Robert W. Williams, Daniel A. Peterson, Daniel C. Ciobanu
Published in: PLOS ONE, Issue 14/10, 2019, Page(s) e0224100, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0224100

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression.

Author(s): Gregory C. Addicks; Hongbo Zhang; Dongryeol Ryu; Goutham Vasam; Alexander E. Green; Philip L. Marshall; Sonia Patel; Baeki E. Kang; Doyoun Kim; Elena Katsyuba; Evan G. Williams; Jean-Marc Renaud; Johan Auwerx; Keir J. Menzies
Published in: Journal Cell Biology, Issue 221, 2022, Page(s) e202104022, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202104022

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

Author(s): Naho Kitamura; Shiyang Zhang; Jean‐David Morel; Utana Nagano; Tanon Taworntawat; Shotaro Hosoda; Anna Nakamura; Yoko Ogawa; Giorgia Benegiamo; Johan Auwerx; Kazuo Tsubota; Yoko Yokoyama; Mitsuhiro Watanabe
Published in: Obesity, Issue 31, 2023, Page(s) 1038-1049, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.23705

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Author(s): Arwen W. Gao; G. El Alam; A. Lalou; Terytty Yang Li; Marte Molenaars; Yunyun Zhu; Katherine A. Overmyer; Katherine A. Overmyer; Evgenia Shishkova; Kevin S Hof; M. S. Bou Sleiman; Riekelt H. Houtkooper; Joshua J. Coon; Johan Auwerx
Published in: iScience, Issue 1, 2022, Page(s) Volume 25, Issue 2, 18 February 2022, 103734, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2022.103734

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

Author(s): H. B. Atakan, K. S. Hof, M. Cornaglia, J. Auwerx, M. A. M. Gijs
Published in: Scientific Reports, Issue 9/1, 2019, Page(s) 19315, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-55979-x

Niacin: an old lipid drug in a new NAD+ dress

Author(s): Mario Romani, Dina Carina Hofer, Elena Katsyuba, Johan Auwerx
Published in: Journal of Lipid Research, Issue 60/4, 2019, Page(s) 741-746, ISSN 0022-2275
Publisher: Lipid Research, Inc.
DOI: 10.1194/jlr.s092007

Genetic background and sex control the outcome of high-fat diet feeding in mice.

Author(s): Alexis Maximilien Bachmann; Jean-David Morel; Gaby El Alam; Sandra Rodríguez-López; Tanes Imamura de lima; Ludger J.E. Goeminne; Giorgia Benegiamo; Sylvain Loric; Marc Conti; Maroun Bou Sleiman; Johan Auwerx
Published in: i-Science, Issue 25, 2022, Page(s) 104468, ISSN 0000-0000
Publisher: Elsevier
DOI: 10.1016/j.isci.2022.104468

Mitocellular communication: Shaping health and disease

Author(s): Adrienne Mottis, Sébastien Herzig, Johan Auwerx
Published in: Science, Issue 366/6467, 2019, Page(s) 827-832, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax3768

Mouse Systems Genetics as a Prelude to Precision Medicine

Author(s): Hao Li, Johan Auwerx
Published in: Trends in Genetics, Issue 36/4, 2020, Page(s) 259-272, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2020.01.004

A platform for experimental precision medicine: The extended BXD mouse family.

Author(s): Ashbrook, David; Arends, Danny; Prins, P; Mulligan, Megan; Roy, S; Williams, Evan G; Lutz, CM; Valenzuela, Abel; Bohl, CG; Ingels, JS; McCarty, MS; Centena, AG; Hager, Reinmar; Auwerx, Johan; Lu, L; Williams, Robert W.
Published in: Cell Syst, Issue 3, 2021, Page(s) Volume 12, Issue 3, 17 March 2021, Pages 235-247.e9, ISSN 2405-4712
Publisher: Elsevier
DOI: 10.1016/j.cels.2020.12.002

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Author(s): Giorgia Benegiamo; Giacomo V.G. von Alvensleben; Sandra Rodríguez-López; Ludger J.E. Goeminne; Alexis M. Bachmann; Jean-David Morel; Ellen Broeckx; Jing Ying Ma; Vinicius Carreira; Sameh A. Youssef; Nabil Azhar; Dermot F. Reilly; Katharine D’Aquino; Shannon Mullican; Maroun Bou-Sleiman; Johan Auwerx
Published in: Journal of Experimental Medicine, Issue 220, 2023, Page(s) e20221738, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20221738

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

Author(s): Adrienne Mottis; Terytty Y. Li; Gaby El Alam; Alexis Rapin; Elena Katsyuba; David Liaskos; Davide D’Amico; Nicola L. Harris; Mark C. Grier; Laurent Mouchiroud; Mark L. Nelson; Johan Auwerx
Published in: Journal of Clinical Investigation, Issue 132, 2022, Page(s) e151540, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci151540

Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population

Author(s): Xiaoxu Li; Jean-David Morel; Giorgia Benegiamo; Johanne Poisson; Alexis Bachmann; Alexis Rapin; Jonathan Sulc; Evan Williams; Alessia Perino; Kristina Schoonjans; Maroun Bou Sleiman; Johan Auwerx
Published in: eLife, Vol 12 (2023), Issue 1, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2023.03.22.533818

Identifying gene function and module connections by the integration of multispecies expression compendia

Author(s): Hao Li, Daria Rukina, Fabrice P.A. David, Terytty Yang Li, Chang-Myung Oh, Arwen W. Gao, Elena Katsyuba, Maroun Bou Sleiman, Andrea Komljenovic, Qingyao Huang, Robert W. Williams, Marc Robinson-Rechavi, Kristina Schoonjans, Stephan Morgenthaler, Johan Auwerx
Published in: Genome Research, Issue 29/12, 2019, Page(s) 2034-2045, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.251983.119

Inhibition of<i>CERS1</i>in skeletal muscle exacerbates age-related muscle dysfunction

Author(s): Martin Wohlwend; Pirkka-Pekka Laurila; Ludger JE Goeminne; Tanes Lima; Ioanna Daskalaki; Xiaoxu Li; Giacomo von Alvensleben; Barbara Crisol; Renata Mangione; Hector Gallart-Ayala; Olivier Burri; Stephen Butler; Jonathan Morris; Nigel Turner; Julijana Ivanisevic; Johan Auwerx
Published in: eLife, Issue 1, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2023.08.05.552113

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Author(s): Kim, Yuna; Jung, Kwan-Young; Kim, Yun Hak; Xu, Pan; Kang, Baeki E; Jo, Yunju; Pandit, Navin; Kwon, Jeongho; Gariani, Karim; Gariani, Joanna; Lee, Junguee; Verbeek, Jef; Nam, Seungyoon; Bae, Sung-Jin; Ha, Ki-Tae; Yi, Hyon-Seung; Shong, Minho; Kim, Kyun-Hwan; Kim, Doyoun; Jung, Hee Jung; Lee, Chang-Woo; Kim, Kwang Rok; Schoonjans, Kristina; Auwerx, Johan; Ryu, Dongryeol
Published in: Drug Resistance Updates - Elsevier, Issue 1, 2024, Page(s) vol. 73 (2024), ISSN 1368-7646
Publisher: Churchill Livingstone
DOI: 10.1016/j.drup.2024.101054

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Author(s): Laurila, Pirkka-Pekka; Luan, Peiling; Wohlwend, Martin; Zanou, Nadège; Crisol, Barbara; Imamura de Lima, Tanes; Goeminne, Ludger J. E.; Gallart-Ayala, Hector; Shong, Minho; Ivanisevic, Julijana; Place, Nicolas; Auwerx, Johan
Published in: Science advances, vol. 8, no. 4, pp. eabh4423, Issue 1, 2022, Page(s) eabh4423, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abh4423

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Author(s): Maroun Bou Sleiman , Suheeta Roy, Arwen W Gao, Marie C Sadler, Giacomo V G von Alvensleben, Hao Li , Saunak Sen, David E Harrison, James F Nelson, Randy Strong, Richard A Miller, Zoltán Kutalik, Robert W Williams, Johan Auwerx
Published in: Science, Issue 377, 2022, Page(s) eabo3191, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abo3191

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

Author(s): Anna Nakamura, Yoko Yokoyama, Kazuki Tanaka, Giorgia Benegiamo, Akiyoshi Hirayama, Qi Zhu, Naho Kitamura, Taichi Sugizaki, Kohkichi Morimoto, Hiroshi Itoh, Shinji Fukuda, Johan Auwerx, Kazuo Tsubota, Mitsuhiro Watanabe
Published in: iScience, Issue 23/9, 2020, Page(s) 101522, ISSN 2589-0042
Publisher: ELSEVIER science direct https://www.sciencedirect.com/
DOI: 10.1016/j.isci.2020.101522

Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population

Author(s): Jean-David Morel, Maroun Bou Sleiman, Terytty Yang Li, Giacomo von Alvensleben, Alexis M Bachmann, Dina Hofer, Ellen Broeckx, Jing Ying Ma, Vinicius Carreira, Tao Chen, Nabil Azhar, Romer A Gonzalez-Villalobos, Matthew Breyer, Dermot Reilly, Shannon Mullican, Johan Auwerx
Published in: JCI Insight, Issue 8, 2023, Page(s) e164626, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.164626

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Author(s): Mario Romani, Vincenzo Sorrentino, Chang-Myung Oh, Hao Li, Tanes Imamura de Lima, Hongbo Zhang, Minho Shong, Johan Auwerx
Published in: Cell Reports, Issue 34/3, 2021, Page(s) 108660, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108660

The mouse metallomic landscape of aging and metabolism

Author(s): Jean-David Morel; Lucie Sauzéat; Ludger J. E. Goeminne; Pooja Jha; Evan Williams; Riekelt H. Houtkooper; Ruedi Aebersold; Johan Auwerx; Vincent Balter
Published in: Nature communications, Issue 13, 2022, Page(s) 607, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28060-x

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Author(s): Maroun Bou Sleiman, Pooja Jha, Riekelt Houtkooper, Robert W. Williams, Xu Wang, Johan Auwerx
Published in: Cell Reports, Issue 32/13, 2020, Page(s) 108203, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108203

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mice

Author(s): Alexis Maximilien Bachmann; Jean-David Morel; Gaby El Alam; Sandra Rodríguez-López; Tanes Imamura de lima; Ludger J.E. Goeminne; Giorgia Benegiamo; Maroun Bou Sleiman; Johan Auwerx
Published in: bioRxiv, Issue 1, 2021
Publisher: bioRxiv
DOI: 10.1101/2021.09.02.458729

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

Author(s): Yuna Kim; Kwan-Young Jung; Yun Hak Kim; Pan Xu; Yunju Jo; Baeki E. Kang; Navin Pandit; Jeongho Kwon; Karim Gariani; Joanna Gariani; Junguee Lee; Jef Verbeek; Seungyoon Nam; Sung-Jin Bae; Ki-Tae Ha; Hyon-Seung Yi; Minho Shong; Kyun-Hwan Kim; Doyoun Kim; Chang-Woo Lee; Hee Jung Jung; Kwang Rok Kim; Kristina Schoonjans; Dongryeol Ryu; Johan Auwerx
Published in: biorxiv, Issue 1, 2023
Publisher: biorxiv
DOI: 10.1101/2023.03.13.531998

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