The Mitochondrial Unfolded Protein Response

Informazioni relative al progetto

UPRmt

ID dell’accordo di sovvenzione: 787702

DOI

10.3030/787702

Progetto chiuso

Data della firma CE 14 Giugno 2018

Data di avvio 1 Novembre 2018

Data di completamento 31 Marzo 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 500 000,00

Contributo UE

€ 2 500 000,00

Coordinato da

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Create and submit Data Management Plan

Pubblicazioni

Peer reviewed articles (31)

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Autori: Terytty Yang Li; Arwen W. Gao; Xiaoxu Li; Hao Li; Yasmine J. Liu; Amelia Lalou; Nagammal Neelagandan; Felix Naef; Kristina Schoonjans; Johan Auwerx
Pubblicato in: Journal Cell Biology, Numero 222, 2023, Pagina/e e202205045, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202205045

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

Autori: Ji Sun Moon, Ludger J. E. Goeminne, Jung Tae Kim, Jing Wen Tian, Seok‐Hwan Kim, Ha Thi Nga, Seul Gi Kang, Baeki E. Kang, Jin‐Seok Byun, Young‐Sun Lee, Jae‐Han Jeon, Minho Shong, Johan Auwerx, Dongryeol Ryu, Hyon‐Seung Yi
Pubblicato in: Aging Cell, Numero 19/8, 2020, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.13195

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Autori: H. Li, A. Perino, Q. Huang, G.V.G. Von Alvensleben, A. Banaei-Esfahani, L.A. Velazquez-Villegas, K. Gariani, M. Korbelius, M. Bou Sleiman, J. Imbach, Y. Sun, X. Li, A. Bachmann, L.J.E. Goeminne, H. Gallart-Ayala, E.G. Williams, J. Ivanisevic, J. Auwerx, K. Schoonjans
Pubblicato in: cell metabolism, 2022, Pagina/e Volume 34, Numero 10, 4 October 2022, Pages 1594-1610.e4, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2022.08.015

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Autori: Giorgia Benegiamo; Maroun Bou Sleiman; Martin Wohlwend; Sandra Rodríguez-López; Ludger J. E. Goeminne; Pirkka-Pekka Laurila; Marie Klevjer; Minna K. Salonen; Jari Lahti; Pooja Jha; Sara Cogliati; José Antonio Enriquez; Ben M. Brumpton; Anja Bye; Johan G. Eriksson; Johan Auwerx
Pubblicato in: Nature Metabolism, Numero 1, 2022, Pagina/e 1336–1351, ISSN 2522-5812
Editore: Springer Nature
DOI: 10.1038/s42255-022-00655-0

NAD+ homeostasis in health and disease

Autori: Elena Katsyuba, Mario Romani, Dina Hofer, Johan Auwerx
Pubblicato in: Nature Metabolism, Numero 2/1, 2020, Pagina/e 9-31, ISSN 2522-5812
Editore: Elsevier Nature Metabolism
DOI: 10.1038/s42255-019-0161-5

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

Autori: Maria Elisa Perez-Munoz, Autumn M. McKnite, Evan G. Williams, Johan Auwerx, Robert W. Williams, Daniel A. Peterson, Daniel C. Ciobanu
Pubblicato in: PLOS ONE, Numero 14/10, 2019, Pagina/e e0224100, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0224100

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression.

Autori: Gregory C. Addicks; Hongbo Zhang; Dongryeol Ryu; Goutham Vasam; Alexander E. Green; Philip L. Marshall; Sonia Patel; Baeki E. Kang; Doyoun Kim; Elena Katsyuba; Evan G. Williams; Jean-Marc Renaud; Johan Auwerx; Keir J. Menzies
Pubblicato in: Journal Cell Biology, Numero 221, 2022, Pagina/e e202104022, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202104022

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

Autori: Naho Kitamura; Shiyang Zhang; Jean‐David Morel; Utana Nagano; Tanon Taworntawat; Shotaro Hosoda; Anna Nakamura; Yoko Ogawa; Giorgia Benegiamo; Johan Auwerx; Kazuo Tsubota; Yoko Yokoyama; Mitsuhiro Watanabe
Pubblicato in: Obesity, Numero 31, 2023, Pagina/e 1038-1049, ISSN 1930-7381
Editore: Wiley-Blackwell
DOI: 10.1002/oby.23705

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Autori: Arwen W. Gao; G. El Alam; A. Lalou; Terytty Yang Li; Marte Molenaars; Yunyun Zhu; Katherine A. Overmyer; Katherine A. Overmyer; Evgenia Shishkova; Kevin S Hof; M. S. Bou Sleiman; Riekelt H. Houtkooper; Joshua J. Coon; Johan Auwerx
Pubblicato in: iScience, Numero 1, 2022, Pagina/e Volume 25, Numero 2, 18 February 2022, 103734, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2022.103734

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

Autori: H. B. Atakan, K. S. Hof, M. Cornaglia, J. Auwerx, M. A. M. Gijs
Pubblicato in: Scientific Reports, Numero 9/1, 2019, Pagina/e 19315, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-55979-x

Niacin: an old lipid drug in a new NAD+ dress

Autori: Mario Romani, Dina Carina Hofer, Elena Katsyuba, Johan Auwerx
Pubblicato in: Journal of Lipid Research, Numero 60/4, 2019, Pagina/e 741-746, ISSN 0022-2275
Editore: Lipid Research, Inc.
DOI: 10.1194/jlr.s092007

Genetic background and sex control the outcome of high-fat diet feeding in mice.

Autori: Alexis Maximilien Bachmann; Jean-David Morel; Gaby El Alam; Sandra Rodríguez-López; Tanes Imamura de lima; Ludger J.E. Goeminne; Giorgia Benegiamo; Sylvain Loric; Marc Conti; Maroun Bou Sleiman; Johan Auwerx
Pubblicato in: i-Science, Numero 25, 2022, Pagina/e 104468, ISSN 0000-0000
Editore: Elsevier
DOI: 10.1016/j.isci.2022.104468

Mitocellular communication: Shaping health and disease

Autori: Adrienne Mottis, Sébastien Herzig, Johan Auwerx
Pubblicato in: Science, Numero 366/6467, 2019, Pagina/e 827-832, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aax3768

Mouse Systems Genetics as a Prelude to Precision Medicine

Autori: Hao Li, Johan Auwerx
Pubblicato in: Trends in Genetics, Numero 36/4, 2020, Pagina/e 259-272, ISSN 0168-9525
Editore: Elsevier BV
DOI: 10.1016/j.tig.2020.01.004

A platform for experimental precision medicine: The extended BXD mouse family.

Autori: Ashbrook, David; Arends, Danny; Prins, P; Mulligan, Megan; Roy, S; Williams, Evan G; Lutz, CM; Valenzuela, Abel; Bohl, CG; Ingels, JS; McCarty, MS; Centena, AG; Hager, Reinmar; Auwerx, Johan; Lu, L; Williams, Robert W.
Pubblicato in: Cell Syst, Numero 3, 2021, Pagina/e Volume 12, Numero 3, 17 March 2021, Pages 235-247.e9, ISSN 2405-4712
Editore: Elsevier
DOI: 10.1016/j.cels.2020.12.002

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Autori: Giorgia Benegiamo; Giacomo V.G. von Alvensleben; Sandra Rodríguez-López; Ludger J.E. Goeminne; Alexis M. Bachmann; Jean-David Morel; Ellen Broeckx; Jing Ying Ma; Vinicius Carreira; Sameh A. Youssef; Nabil Azhar; Dermot F. Reilly; Katharine D’Aquino; Shannon Mullican; Maroun Bou-Sleiman; Johan Auwerx
Pubblicato in: Journal of Experimental Medicine, Numero 220, 2023, Pagina/e e20221738, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20221738

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

Autori: Adrienne Mottis; Terytty Y. Li; Gaby El Alam; Alexis Rapin; Elena Katsyuba; David Liaskos; Davide D’Amico; Nicola L. Harris; Mark C. Grier; Laurent Mouchiroud; Mark L. Nelson; Johan Auwerx
Pubblicato in: Journal of Clinical Investigation, Numero 132, 2022, Pagina/e e151540, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci151540

Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models

Autori: Alessia De Masi, Nadège Zanou, Keno Strotjohann, Dohyun Lee, Tanes I. Lima, Xiaoxu Li, Jongsu Jeon, Nicolas Place, Hoe-Yune Jung, and Johan Auwerx
Pubblicato in: Advanced Science, 2024, Pagina/e Adv. Sci. 2024, 2305927, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202305927

Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population

Autori: Xiaoxu Li; Jean-David Morel; Giorgia Benegiamo; Johanne Poisson; Alexis Bachmann; Alexis Rapin; Jonathan Sulc; Evan Williams; Alessia Perino; Kristina Schoonjans; Maroun Bou Sleiman; Johan Auwerx
Pubblicato in: eLife, Vol 12 (2023), Numero 1, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.1101/2023.03.22.533818

Identifying gene function and module connections by the integration of multispecies expression compendia

Autori: Hao Li, Daria Rukina, Fabrice P.A. David, Terytty Yang Li, Chang-Myung Oh, Arwen W. Gao, Elena Katsyuba, Maroun Bou Sleiman, Andrea Komljenovic, Qingyao Huang, Robert W. Williams, Marc Robinson-Rechavi, Kristina Schoonjans, Stephan Morgenthaler, Johan Auwerx
Pubblicato in: Genome Research, Numero 29/12, 2019, Pagina/e 2034-2045, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.251983.119

Inhibition of<i>CERS1</i>in skeletal muscle exacerbates age-related muscle dysfunction

Autori: Martin Wohlwend; Pirkka-Pekka Laurila; Ludger JE Goeminne; Tanes Lima; Ioanna Daskalaki; Xiaoxu Li; Giacomo von Alvensleben; Barbara Crisol; Renata Mangione; Hector Gallart-Ayala; Olivier Burri; Stephen Butler; Jonathan Morris; Nigel Turner; Julijana Ivanisevic; Johan Auwerx
Pubblicato in: eLife, Numero 1, 2024, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.1101/2023.08.05.552113

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Autori: Kim, Yuna; Jung, Kwan-Young; Kim, Yun Hak; Xu, Pan; Kang, Baeki E; Jo, Yunju; Pandit, Navin; Kwon, Jeongho; Gariani, Karim; Gariani, Joanna; Lee, Junguee; Verbeek, Jef; Nam, Seungyoon; Bae, Sung-Jin; Ha, Ki-Tae; Yi, Hyon-Seung; Shong, Minho; Kim, Kyun-Hwan; Kim, Doyoun; Jung, Hee Jung; Lee, Chang-Woo; Kim, Kwang Rok; Schoonjans, Kristina; Auwerx, Johan; Ryu, Dongryeol
Pubblicato in: Drug Resistance Updates - Elsevier, Numero 1, 2024, Pagina/e vol. 73 (2024), ISSN 1368-7646
Editore: Churchill Livingstone
DOI: 10.1016/j.drup.2024.101054

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Autori: Laurila, Pirkka-Pekka; Luan, Peiling; Wohlwend, Martin; Zanou, Nadège; Crisol, Barbara; Imamura de Lima, Tanes; Goeminne, Ludger J. E.; Gallart-Ayala, Hector; Shong, Minho; Ivanisevic, Julijana; Place, Nicolas; Auwerx, Johan
Pubblicato in: Science advances, vol. 8, no. 4, pp. eabh4423, Numero 1, 2022, Pagina/e eabh4423, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.abh4423

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Autori: Maroun Bou Sleiman , Suheeta Roy, Arwen W Gao, Marie C Sadler, Giacomo V G von Alvensleben, Hao Li , Saunak Sen, David E Harrison, James F Nelson, Randy Strong, Richard A Miller, Zoltán Kutalik, Robert W Williams, Johan Auwerx
Pubblicato in: Science, Numero 377, 2022, Pagina/e eabo3191, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abo3191

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

Autori: Anna Nakamura, Yoko Yokoyama, Kazuki Tanaka, Giorgia Benegiamo, Akiyoshi Hirayama, Qi Zhu, Naho Kitamura, Taichi Sugizaki, Kohkichi Morimoto, Hiroshi Itoh, Shinji Fukuda, Johan Auwerx, Kazuo Tsubota, Mitsuhiro Watanabe
Pubblicato in: iScience, Numero 23/9, 2020, Pagina/e 101522, ISSN 2589-0042
Editore: ELSEVIER science direct https://www.sciencedirect.com/
DOI: 10.1016/j.isci.2020.101522

Cyclo(his-Pro): a further step in the management of steatohepatitis

Autori: A. De Masi, X. Li, D. Lee, J. Jeon, Q. Wang, S. Baek, O. Park, A. Mottis, K. Strotjohann, A. Rapin, H.Y. Jung HY, J. Auwerx
Pubblicato in: J Hep reports, 2023, Pagina/e Volume 5, Numero 9, September 2023, 100815, ISSN 2589-5559
Editore: Elsevier
DOI: 10.1016/j.jhepr.2023.100815

Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population

Autori: Jean-David Morel, Maroun Bou Sleiman, Terytty Yang Li, Giacomo von Alvensleben, Alexis M Bachmann, Dina Hofer, Ellen Broeckx, Jing Ying Ma, Vinicius Carreira, Tao Chen, Nabil Azhar, Romer A Gonzalez-Villalobos, Matthew Breyer, Dermot Reilly, Shannon Mullican, Johan Auwerx
Pubblicato in: JCI Insight, Numero 8, 2023, Pagina/e e164626, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.164626

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Autori: Li TY, Wang Q, Gao AW, Li X, Sun Y, Mottis A, Shong M, Auwerx J.
Pubblicato in: cell discovery, 2023, Pagina/e 9, Article number: 92 (2023), ISSN 2056-5968
Editore: Elsevier
DOI: 10.1038/s41421-023-00589-1

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Autori: Mario Romani, Vincenzo Sorrentino, Chang-Myung Oh, Hao Li, Tanes Imamura de Lima, Hongbo Zhang, Minho Shong, Johan Auwerx
Pubblicato in: Cell Reports, Numero 34/3, 2021, Pagina/e 108660, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108660

The mouse metallomic landscape of aging and metabolism

Autori: Jean-David Morel; Lucie Sauzéat; Ludger J. E. Goeminne; Pooja Jha; Evan Williams; Riekelt H. Houtkooper; Ruedi Aebersold; Johan Auwerx; Vincent Balter
Pubblicato in: Nature communications, Numero 13, 2022, Pagina/e 607, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28060-x

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Autori: Maroun Bou Sleiman, Pooja Jha, Riekelt Houtkooper, Robert W. Williams, Xu Wang, Johan Auwerx
Pubblicato in: Cell Reports, Numero 32/13, 2020, Pagina/e 108203, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108203

Other (3)

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mice

Autori: Alexis Maximilien Bachmann; Jean-David Morel; Gaby El Alam; Sandra Rodríguez-López; Tanes Imamura de lima; Ludger J.E. Goeminne; Giorgia Benegiamo; Maroun Bou Sleiman; Johan Auwerx
Pubblicato in: bioRxiv, Numero 1, 2021
Editore: bioRxiv
DOI: 10.1101/2021.09.02.458729

Induction of mitophagy reverts age-associated decline of the hematopoietic and immune systems

Autori: Mukul Girotra; Yi-Hsuan Chiang; Melanie Charmoy; Pierpaolo Ginefra; Frederica Schyrr; Fabien Franco; Ping-Chih Ho; Olaia Naveiras; Johan Auwerx; Werner Held; Nicola Vannini
Pubblicato in: bioRxiv, 2023
Editore: bioRxiv
DOI: 10.1101/2023.03.30.534925

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

Autori: Yuna Kim; Kwan-Young Jung; Yun Hak Kim; Pan Xu; Yunju Jo; Baeki E. Kang; Navin Pandit; Jeongho Kwon; Karim Gariani; Joanna Gariani; Junguee Lee; Jef Verbeek; Seungyoon Nam; Sung-Jin Bae; Ki-Tae Ha; Hyon-Seung Yi; Minho Shong; Kyun-Hwan Kim; Doyoun Kim; Chang-Woo Lee; Hee Jung Jung; Kwang Rok Kim; Kristina Schoonjans; Dongryeol Ryu; Johan Auwerx
Pubblicato in: biorxiv, Numero 1, 2023
Editore: biorxiv
DOI: 10.1101/2023.03.13.531998