The Mitochondrial Unfolded Protein Response

Información del proyecto

UPRmt

Identificador del acuerdo de subvención: 787702

DOI

10.3030/787702

Proyecto cerrado

Fecha de la firma de la CE 14 Junio 2018

Fecha de inicio 1 Noviembre 2018

Fecha de finalización 31 Marzo 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

Create and submit Data Management Plan

Publicaciones

Peer reviewed articles (31)

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Autores: Terytty Yang Li; Arwen W. Gao; Xiaoxu Li; Hao Li; Yasmine J. Liu; Amelia Lalou; Nagammal Neelagandan; Felix Naef; Kristina Schoonjans; Johan Auwerx
Publicado en: Journal Cell Biology, Edición 222, 2023, Página(s) e202205045, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202205045

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

Autores: Ji Sun Moon, Ludger J. E. Goeminne, Jung Tae Kim, Jing Wen Tian, Seok‐Hwan Kim, Ha Thi Nga, Seul Gi Kang, Baeki E. Kang, Jin‐Seok Byun, Young‐Sun Lee, Jae‐Han Jeon, Minho Shong, Johan Auwerx, Dongryeol Ryu, Hyon‐Seung Yi
Publicado en: Aging Cell, Edición 19/8, 2020, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.13195

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Autores: H. Li, A. Perino, Q. Huang, G.V.G. Von Alvensleben, A. Banaei-Esfahani, L.A. Velazquez-Villegas, K. Gariani, M. Korbelius, M. Bou Sleiman, J. Imbach, Y. Sun, X. Li, A. Bachmann, L.J.E. Goeminne, H. Gallart-Ayala, E.G. Williams, J. Ivanisevic, J. Auwerx, K. Schoonjans
Publicado en: cell metabolism, 2022, Página(s) Volume 34, Edición 10, 4 October 2022, Pages 1594-1610.e4, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2022.08.015

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Autores: Giorgia Benegiamo; Maroun Bou Sleiman; Martin Wohlwend; Sandra Rodríguez-López; Ludger J. E. Goeminne; Pirkka-Pekka Laurila; Marie Klevjer; Minna K. Salonen; Jari Lahti; Pooja Jha; Sara Cogliati; José Antonio Enriquez; Ben M. Brumpton; Anja Bye; Johan G. Eriksson; Johan Auwerx
Publicado en: Nature Metabolism, Edición 1, 2022, Página(s) 1336–1351, ISSN 2522-5812
Editor: Springer Nature
DOI: 10.1038/s42255-022-00655-0

NAD+ homeostasis in health and disease

Autores: Elena Katsyuba, Mario Romani, Dina Hofer, Johan Auwerx
Publicado en: Nature Metabolism, Edición 2/1, 2020, Página(s) 9-31, ISSN 2522-5812
Editor: Elsevier Nature Metabolism
DOI: 10.1038/s42255-019-0161-5

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

Autores: Maria Elisa Perez-Munoz, Autumn M. McKnite, Evan G. Williams, Johan Auwerx, Robert W. Williams, Daniel A. Peterson, Daniel C. Ciobanu
Publicado en: PLOS ONE, Edición 14/10, 2019, Página(s) e0224100, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0224100

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression.

Autores: Gregory C. Addicks; Hongbo Zhang; Dongryeol Ryu; Goutham Vasam; Alexander E. Green; Philip L. Marshall; Sonia Patel; Baeki E. Kang; Doyoun Kim; Elena Katsyuba; Evan G. Williams; Jean-Marc Renaud; Johan Auwerx; Keir J. Menzies
Publicado en: Journal Cell Biology, Edición 221, 2022, Página(s) e202104022, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202104022

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

Autores: Naho Kitamura; Shiyang Zhang; Jean‐David Morel; Utana Nagano; Tanon Taworntawat; Shotaro Hosoda; Anna Nakamura; Yoko Ogawa; Giorgia Benegiamo; Johan Auwerx; Kazuo Tsubota; Yoko Yokoyama; Mitsuhiro Watanabe
Publicado en: Obesity, Edición 31, 2023, Página(s) 1038-1049, ISSN 1930-7381
Editor: Wiley-Blackwell
DOI: 10.1002/oby.23705

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Autores: Arwen W. Gao; G. El Alam; A. Lalou; Terytty Yang Li; Marte Molenaars; Yunyun Zhu; Katherine A. Overmyer; Katherine A. Overmyer; Evgenia Shishkova; Kevin S Hof; M. S. Bou Sleiman; Riekelt H. Houtkooper; Joshua J. Coon; Johan Auwerx
Publicado en: iScience, Edición 1, 2022, Página(s) Volume 25, Edición 2, 18 February 2022, 103734, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2022.103734

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

Autores: H. B. Atakan, K. S. Hof, M. Cornaglia, J. Auwerx, M. A. M. Gijs
Publicado en: Scientific Reports, Edición 9/1, 2019, Página(s) 19315, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-55979-x

Niacin: an old lipid drug in a new NAD+ dress

Autores: Mario Romani, Dina Carina Hofer, Elena Katsyuba, Johan Auwerx
Publicado en: Journal of Lipid Research, Edición 60/4, 2019, Página(s) 741-746, ISSN 0022-2275
Editor: Lipid Research, Inc.
DOI: 10.1194/jlr.s092007

Genetic background and sex control the outcome of high-fat diet feeding in mice.

Autores: Alexis Maximilien Bachmann; Jean-David Morel; Gaby El Alam; Sandra Rodríguez-López; Tanes Imamura de lima; Ludger J.E. Goeminne; Giorgia Benegiamo; Sylvain Loric; Marc Conti; Maroun Bou Sleiman; Johan Auwerx
Publicado en: i-Science, Edición 25, 2022, Página(s) 104468, ISSN 0000-0000
Editor: Elsevier
DOI: 10.1016/j.isci.2022.104468

Mitocellular communication: Shaping health and disease

Autores: Adrienne Mottis, Sébastien Herzig, Johan Auwerx
Publicado en: Science, Edición 366/6467, 2019, Página(s) 827-832, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aax3768

Mouse Systems Genetics as a Prelude to Precision Medicine

Autores: Hao Li, Johan Auwerx
Publicado en: Trends in Genetics, Edición 36/4, 2020, Página(s) 259-272, ISSN 0168-9525
Editor: Elsevier BV
DOI: 10.1016/j.tig.2020.01.004

A platform for experimental precision medicine: The extended BXD mouse family.

Autores: Ashbrook, David; Arends, Danny; Prins, P; Mulligan, Megan; Roy, S; Williams, Evan G; Lutz, CM; Valenzuela, Abel; Bohl, CG; Ingels, JS; McCarty, MS; Centena, AG; Hager, Reinmar; Auwerx, Johan; Lu, L; Williams, Robert W.
Publicado en: Cell Syst, Edición 3, 2021, Página(s) Volume 12, Edición 3, 17 March 2021, Pages 235-247.e9, ISSN 2405-4712
Editor: Elsevier
DOI: 10.1016/j.cels.2020.12.002

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Autores: Giorgia Benegiamo; Giacomo V.G. von Alvensleben; Sandra Rodríguez-López; Ludger J.E. Goeminne; Alexis M. Bachmann; Jean-David Morel; Ellen Broeckx; Jing Ying Ma; Vinicius Carreira; Sameh A. Youssef; Nabil Azhar; Dermot F. Reilly; Katharine D’Aquino; Shannon Mullican; Maroun Bou-Sleiman; Johan Auwerx
Publicado en: Journal of Experimental Medicine, Edición 220, 2023, Página(s) e20221738, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20221738

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

Autores: Adrienne Mottis; Terytty Y. Li; Gaby El Alam; Alexis Rapin; Elena Katsyuba; David Liaskos; Davide D’Amico; Nicola L. Harris; Mark C. Grier; Laurent Mouchiroud; Mark L. Nelson; Johan Auwerx
Publicado en: Journal of Clinical Investigation, Edición 132, 2022, Página(s) e151540, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci151540

Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models

Autores: Alessia De Masi, Nadège Zanou, Keno Strotjohann, Dohyun Lee, Tanes I. Lima, Xiaoxu Li, Jongsu Jeon, Nicolas Place, Hoe-Yune Jung, and Johan Auwerx
Publicado en: Advanced Science, 2024, Página(s) Adv. Sci. 2024, 2305927, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.202305927

Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population

Autores: Xiaoxu Li; Jean-David Morel; Giorgia Benegiamo; Johanne Poisson; Alexis Bachmann; Alexis Rapin; Jonathan Sulc; Evan Williams; Alessia Perino; Kristina Schoonjans; Maroun Bou Sleiman; Johan Auwerx
Publicado en: eLife, Vol 12 (2023), Edición 1, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.1101/2023.03.22.533818

Identifying gene function and module connections by the integration of multispecies expression compendia

Autores: Hao Li, Daria Rukina, Fabrice P.A. David, Terytty Yang Li, Chang-Myung Oh, Arwen W. Gao, Elena Katsyuba, Maroun Bou Sleiman, Andrea Komljenovic, Qingyao Huang, Robert W. Williams, Marc Robinson-Rechavi, Kristina Schoonjans, Stephan Morgenthaler, Johan Auwerx
Publicado en: Genome Research, Edición 29/12, 2019, Página(s) 2034-2045, ISSN 1088-9051
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.251983.119

Inhibition of<i>CERS1</i>in skeletal muscle exacerbates age-related muscle dysfunction

Autores: Martin Wohlwend; Pirkka-Pekka Laurila; Ludger JE Goeminne; Tanes Lima; Ioanna Daskalaki; Xiaoxu Li; Giacomo von Alvensleben; Barbara Crisol; Renata Mangione; Hector Gallart-Ayala; Olivier Burri; Stephen Butler; Jonathan Morris; Nigel Turner; Julijana Ivanisevic; Johan Auwerx
Publicado en: eLife, Edición 1, 2024, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.1101/2023.08.05.552113

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Autores: Kim, Yuna; Jung, Kwan-Young; Kim, Yun Hak; Xu, Pan; Kang, Baeki E; Jo, Yunju; Pandit, Navin; Kwon, Jeongho; Gariani, Karim; Gariani, Joanna; Lee, Junguee; Verbeek, Jef; Nam, Seungyoon; Bae, Sung-Jin; Ha, Ki-Tae; Yi, Hyon-Seung; Shong, Minho; Kim, Kyun-Hwan; Kim, Doyoun; Jung, Hee Jung; Lee, Chang-Woo; Kim, Kwang Rok; Schoonjans, Kristina; Auwerx, Johan; Ryu, Dongryeol
Publicado en: Drug Resistance Updates - Elsevier, Edición 1, 2024, Página(s) vol. 73 (2024), ISSN 1368-7646
Editor: Churchill Livingstone
DOI: 10.1016/j.drup.2024.101054

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Autores: Laurila, Pirkka-Pekka; Luan, Peiling; Wohlwend, Martin; Zanou, Nadège; Crisol, Barbara; Imamura de Lima, Tanes; Goeminne, Ludger J. E.; Gallart-Ayala, Hector; Shong, Minho; Ivanisevic, Julijana; Place, Nicolas; Auwerx, Johan
Publicado en: Science advances, vol. 8, no. 4, pp. eabh4423, Edición 1, 2022, Página(s) eabh4423, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.abh4423

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Autores: Maroun Bou Sleiman , Suheeta Roy, Arwen W Gao, Marie C Sadler, Giacomo V G von Alvensleben, Hao Li , Saunak Sen, David E Harrison, James F Nelson, Randy Strong, Richard A Miller, Zoltán Kutalik, Robert W Williams, Johan Auwerx
Publicado en: Science, Edición 377, 2022, Página(s) eabo3191, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abo3191

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

Autores: Anna Nakamura, Yoko Yokoyama, Kazuki Tanaka, Giorgia Benegiamo, Akiyoshi Hirayama, Qi Zhu, Naho Kitamura, Taichi Sugizaki, Kohkichi Morimoto, Hiroshi Itoh, Shinji Fukuda, Johan Auwerx, Kazuo Tsubota, Mitsuhiro Watanabe
Publicado en: iScience, Edición 23/9, 2020, Página(s) 101522, ISSN 2589-0042
Editor: ELSEVIER science direct https://www.sciencedirect.com/
DOI: 10.1016/j.isci.2020.101522

Cyclo(his-Pro): a further step in the management of steatohepatitis

Autores: A. De Masi, X. Li, D. Lee, J. Jeon, Q. Wang, S. Baek, O. Park, A. Mottis, K. Strotjohann, A. Rapin, H.Y. Jung HY, J. Auwerx
Publicado en: J Hep reports, 2023, Página(s) Volume 5, Edición 9, September 2023, 100815, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2023.100815

Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population

Autores: Jean-David Morel, Maroun Bou Sleiman, Terytty Yang Li, Giacomo von Alvensleben, Alexis M Bachmann, Dina Hofer, Ellen Broeckx, Jing Ying Ma, Vinicius Carreira, Tao Chen, Nabil Azhar, Romer A Gonzalez-Villalobos, Matthew Breyer, Dermot Reilly, Shannon Mullican, Johan Auwerx
Publicado en: JCI Insight, Edición 8, 2023, Página(s) e164626, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.164626

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Autores: Li TY, Wang Q, Gao AW, Li X, Sun Y, Mottis A, Shong M, Auwerx J.
Publicado en: cell discovery, 2023, Página(s) 9, Article number: 92 (2023), ISSN 2056-5968
Editor: Elsevier
DOI: 10.1038/s41421-023-00589-1

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Autores: Mario Romani, Vincenzo Sorrentino, Chang-Myung Oh, Hao Li, Tanes Imamura de Lima, Hongbo Zhang, Minho Shong, Johan Auwerx
Publicado en: Cell Reports, Edición 34/3, 2021, Página(s) 108660, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108660

The mouse metallomic landscape of aging and metabolism

Autores: Jean-David Morel; Lucie Sauzéat; Ludger J. E. Goeminne; Pooja Jha; Evan Williams; Riekelt H. Houtkooper; Ruedi Aebersold; Johan Auwerx; Vincent Balter
Publicado en: Nature communications, Edición 13, 2022, Página(s) 607, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-28060-x

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Autores: Maroun Bou Sleiman, Pooja Jha, Riekelt Houtkooper, Robert W. Williams, Xu Wang, Johan Auwerx
Publicado en: Cell Reports, Edición 32/13, 2020, Página(s) 108203, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108203

Other (3)

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mice

Autores: Alexis Maximilien Bachmann; Jean-David Morel; Gaby El Alam; Sandra Rodríguez-López; Tanes Imamura de lima; Ludger J.E. Goeminne; Giorgia Benegiamo; Maroun Bou Sleiman; Johan Auwerx
Publicado en: bioRxiv, Edición 1, 2021
Editor: bioRxiv
DOI: 10.1101/2021.09.02.458729

Induction of mitophagy reverts age-associated decline of the hematopoietic and immune systems

Autores: Mukul Girotra; Yi-Hsuan Chiang; Melanie Charmoy; Pierpaolo Ginefra; Frederica Schyrr; Fabien Franco; Ping-Chih Ho; Olaia Naveiras; Johan Auwerx; Werner Held; Nicola Vannini
Publicado en: bioRxiv, 2023
Editor: bioRxiv
DOI: 10.1101/2023.03.30.534925

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

Autores: Yuna Kim; Kwan-Young Jung; Yun Hak Kim; Pan Xu; Yunju Jo; Baeki E. Kang; Navin Pandit; Jeongho Kwon; Karim Gariani; Joanna Gariani; Junguee Lee; Jef Verbeek; Seungyoon Nam; Sung-Jin Bae; Ki-Tae Ha; Hyon-Seung Yi; Minho Shong; Kyun-Hwan Kim; Doyoun Kim; Chang-Woo Lee; Hee Jung Jung; Kwang Rok Kim; Kristina Schoonjans; Dongryeol Ryu; Johan Auwerx
Publicado en: biorxiv, Edición 1, 2023
Editor: biorxiv
DOI: 10.1101/2023.03.13.531998