How intraflagellar transport shapes the cilium: a single-molecule systems study

Project Information

HITSCIL

Grant agreement ID: 788363

DOI

10.3030/788363

Project closed

EC signature date 8 June 2018

Start date 1 September 2018

End date 31 May 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 580,00

EU contribution

€ 2 499 580,00

Coordinated by

STICHTING VU
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Microfluidics and fluorescence microscopy protocol to study the response of C. elegans to chemosensory stimuli

Author(s): Christine W, Bruggeman; Guus H, Haasnoot; Erwin J G, Peterman
Published in: STAR Protocols, Issue VOLUME 4;ISSUE 1;, 2023, Page(s) 1-11, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2023.102121

A local interplay between diffusion and intraflagellar transport distributes TRPV-channel OCR-2 along C. elegans chemosensory cilia

Author(s): Jaap van Krugten, Noémie Danné, Erwin J. G. Peterman
Published in: Communications Biology, Issue 5, 2022, ISSN 2399-3642
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-022-03683-4

Differentiated dynamic response in C. elegans chemosensory cilia

Author(s): Christine W. Bruggeman, Guus H. Haasnoot, Noémie Danné, Jaap van Krugten, Erwin J.G. Peterman
Published in: Cell Reports, Issue 41, 2024, Page(s) 111471, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111471

IFT cargo and motors associate sequentially with IFT trains to enter cilia of C. elegans

Author(s): Aniruddha Mitra, Elizaveta Loseva and Erwin J. G. Peterman
Published in: Nature Communications, Issue 15, 3456, 2024, Page(s) 1-14, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47807-2

Direct imaging of intraflagellar-transport turnarounds reveals that motors detach, diffuse, and reattach to opposite-direction trains

Author(s): Zhiqing Zhang, Noémie Danné, Bonno Meddens, Iddo Heller, Erwin J. G. Peterman
Published in: Proceedings of the National Academy of Sciences, Issue 118, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2115089118

Mechanisms of Regulation in Intraflagellar Transport

Author(s): Wouter Mul; Aniruddha Mitra; Erwin J. G. Peterman
Published in: Cells, Issue vol. 11 , no. 17 , 2737, 2022, Page(s) 1-25, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11172737

Imaging adult C. elegans live using light‐sheet microscopy

Author(s): J. VAN KRUGTEN, K.‐K.H. TARIS, ERWIN J.G. PETERMAN
Published in: Journal of Microscopy, Issue 281/3, 2021, Page(s) 214-223, ISSN 0022-2720
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jmi.12964

Cutting off ciliary protein import: Intraflagellar transport after dendritic femtosecond-laser ablation

Author(s): Jona Mijalkovic, Jules Girard, Jaap van Krugten, Jasmijn van Loo, Zhiqing Zhang, Elizaveta Loseva, Felix Oswald, Erwin J.G. Peterman
Published in: Molecular Biology of the Cell, Issue Vol. 31, No. 5 March 01, 2020, 2020, Page(s) mbc.E18-06-0399, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e18-06-0399

A small excitation window allows long-duration single-molecule imaging, with reduced background autofluorescence, in<i>C. elegans</i>neurons

Author(s): Aniruddha Mitra; Elizaveta Loseva; Guus H. Haasnoot; Erwin J.G. Peterman
Published in: Optics Communications, Issue vol. 545 , 129700, 2023, Page(s) 1-11, ISSN 1873-0310
Publisher: Elsevier
DOI: 10.1101/2022.12.20.521330

Other (2)

DYF-5 regulates intraflagellar transport by affecting train turnaround

Author(s): Wouter Mul, Aniruddha Mitra, Bram Prevo, Erwin J.G. Peterman
Published in: 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.11.612404

Sorting at ciliary base and ciliary entry of BBSome, IFT-B and IFT-A

Author(s): Aniruddha Mitra, Evangelos Gioukakis, Wouter Mul, Erwin J.G. Peterman
Published in: 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.03.05.583485

Thesis and dissertations (1)

Sensing CIlia

Author(s): Jaap van Krugten
Published in: 2020, ISBN 978-94-6332-702-2
Publisher: Vrije Universiteit

Book chapters (1)

Single-Molecule Fluorescence Microscopy in Sensory Cilia of Living Caenorhabditis elegans

Author(s): Elizaveta Loseva, Jaap van Krugten, Aniruddha Mitra, Erwin J. G. Peterman
Published in: Methods in Molecular Biology, Single Molecule Analysis, 2023, Page(s) 133-150
Publisher: Springer US
DOI: 10.1007/978-1-0716-3377-9_7