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Studying Secondary Nucleation for the Intensification of Continuous Crystallization

Objective

Many products in the chemical, food and pharmaceutical industry are produced as powders through a crystallization process. Continuous crystallization has been for decades the process of choice for large-scale production, for instance of sugar, table salt, adipic acid, and has become more recently a key component of the new paradigm, i.e. the continuous
manufacturing of active pharmaceutical ingredients.
All product crystals of continuous crystallization processes are formed through secondary nucleation, which is both ubiquitous and elusive. Research has left several key questions unanswered, such as about where and how secondary nuclei are formed, either from the parent crystal due to collisions or from the solution layer around it due to fluid shear; or
about the rate at which secondary nuclei are generated, with which properties, and under which conditions; or, also, about the coupling between the parent crystal microscale and the collective behavior of the ensemble of crystals suspended in a specific continuous crystallizer.
The project SNICC intends to unveil the microscale mechanisms of secondary nucleation, and to bring its scientific understanding to a level where it can be exploited to model, design, operate, optimize and control continuous crystallization processes at any desired scale. It aims at creating a comprehensive knowledge about secondary nucleation at the microscale, applicable to any type of compound, and at establishing guidelines for the intensification of continuous crystallization, based on the use of newly developed full models of different types of continuous crystallizers. This will have a major impact on both the science of crystallization and the related industrial processes. Building on the recognized experimental and theoretical expertise on crystallization at all relevant scales of the PI and his lab, a team consisting of 4 PhD students and 2 postdocs will work for five years on this challenging, interdisciplinary project.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-ADG - Advanced Grant

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2017-ADG

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Host institution

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 500 000,00
Address
Raemistrasse 101
8092 Zuerich
Switzerland

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 500 000,00

Beneficiaries (1)

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