Studying Secondary Nucleation for the Intensification of Continuous Crystallization

Project Information

SNICC

Grant agreement ID: 788607

DOI

10.3030/788607

Project closed

EC signature date 30 May 2018

Start date 1 July 2018

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (26)

Model-based design of pressure-driven product removal from stirred suspensions

Author(s): Ramona Achermann, Viktoria Wiedmeyer, Mercedeh Sadat Hosseinalipour, Selin Güngör, Marco Mazzotti
Published in: Chemical Engineering Research and Design, Issue 174, 2021, Page(s) 57-70, ISSN 0263-8762
Publisher: Institute of Chemical Engineers
DOI: 10.1016/j.cherd.2021.07.001

Secondary Nucleation by Interparticle Energies. II. Kinetics

Author(s): Byeongho Ahn; Luca Bosetti; Marco Mazzotti
Published in: Crystal Growth & Design, 22 (22), Issue 22 (22), 2022, Page(s) 74–86, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000519706

On Solute Recovery and Productivity in Chiral Resolution through Solid-State Deracemization by Temperature Cycling

Author(s): Hosseinalipour, Mercedeh Sadat; id_orcid0000-0001-5524-0050; Deck, Leif-Thore; id_orcid0000-0002-0955-6801; Mazzotti, Marco
Published in: Crystal Growth & Design, 24 (9), Issue 2024, 24, 9, 3925–3932, 2024, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.1021/acs.cgd.4c00233

Characterization of a small-scale crystallizer using CFD simulations and X-ray CT measurements

Author(s): Achermann, Ramona; id_orcid0000-0001-7537-4531; Adams, Robert; Prasser, Horst-Michael; Mazzotti, Marco
Published in: Chemical Engineering Science, Issue 2022, 256, 2022, Page(s) 117697, ISSN 0009-2509
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ces.2022.117697

Conceptual Validation of Stochastic and Deterministic Methods To Estimate Crystal Nucleation Rates

Author(s): Marco Mazzotti; Leif-Thore Deck
Published in: Crystal Growth & Design, 23 (2), Issue 2023, 23, 2, 2023, Page(s) 899–914, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000594916

Comparative assessment and possible applications of three models of Taylor slug flows

Author(s): Achermann, Ramona; Antunes Morgado, Nicolas; Corti, Andrea Lucas; Mazzotti, Marco
Published in: Computers & Chemical Engineering, Issue 2022, 161, 2022, Page(s) 107773, ISSN 0098-1354
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2022.107773

Secondary Nucleation by Interparticle Energies. III. Nucleation Rate Model

Author(s): Marco Mazzotti; Luca Bosetti; Byeongho Ahn
Published in: Crystal Growth & Design, 22 (22), Issue 22 (22), 2022, Page(s) 3625–3636, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000546500

HPLC method development for the quantification of a mixture of reacting species: The case of lactose

Author(s): Trespi, Silvio; Mazzotti, Marco
Published in: Journal of Chromatography A, 1715, Issue 2024, 1715, 464553, 2024, ISSN 0021-9673
Publisher: Elsevier BV
DOI: 10.1016/j.chroma.2023.464553

Solid-State Deracemization via Temperature Cycles in Continuous Operation: Model-Based Process Design

Author(s): Marco Mazzotti; Brigitta Bodák
Published in: Crystal Growth & Design, Issue 2022, 22, 3, 2022, Page(s) 1846–1856, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000539219

Population balance modelling of magnesium hydroxide precipitation: Full validation on different reactor configurations

Author(s): Antonello Raponi; Ramona Achermann; Salvatore Romano; Silvio Trespi; Marco Mazzotti; Andrea Cipollina; Antonio Buffo; Marco Vanni; Daniele Marchisio
Published in: Chemical Engineering Journal, 477, Issue 2023, 477, 146540, 2023, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2023.146540

Process Performance and Operational Challenges in Continuous Crystallization: A Study of the Polymorphs of <scp>L</scp>-Glutamic Acid

Author(s): Ramona Achermann; Andraž Košir; Brigitta Bodák; Luca Bosetti; Marco Mazzotti
Published in: Crystal Growth & Design, Issue 2023 (23), 2023, Page(s) 2485−2503, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.1021/acs.cgd.2c01424

Exact and Ubiquitous Condition for Solid-State Deracemization in Vitro and in Nature

Author(s): Deck, Leif-Thore; id_orcid0000-0002-0955-6801; Hosseinalipour, Mercedeh Sadat; id_orcid0000-0001-5524-0050; Mazzotti, Marco
Published in: Journal of the American Chemical Society, 146 (6), Issue 2024, 146, 6, 3872–3882, 2024, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c11332

Study of Secondary Nucleation by Attrition of Potassium Alum Crystals Suspended in Different Solvents

Author(s): Luca Bosetti, Marco Mazzotti
Published in: Crystal Growth & Design, Issue 20/4, 2020, Page(s) 2570-2577, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.1021/acs.cgd.9b01700

Population Balance Modeling of Growth and Secondary Nucleation by Attrition and Ripening

Author(s): Luca Bosetti, Marco Mazzotti
Published in: Crystal Growth & Design, Issue 20/1, 2019, Page(s) 307-319, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.1021/acs.cgd.9b01240

Statistical Analysis and Nucleation Parameter Estimation from Nucleation Experiments in Flowing Microdroplets

Author(s): Elena Cândida dos Santos, Giovanni Maria Maggioni, Marco Mazzotti
Published in: Crystal Growth & Design, Issue 19/11, 2019, Page(s) 6159-6174, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.1021/acs.cgd.9b00562

Modeling of Mixing‐Precipitation Processes: Agglomeration

Author(s): Pawel M. Orlewski, Marco Mazzotti
Published in: Chemical Engineering & Technology, 2020, ISSN 0930-7516
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/ceat.201900551

Tuning the Particle Sizes in Spherical Agglomeration

Author(s): Pawel M. Orlewski, Byeongho Ahn, Marco Mazzotti
Published in: Crystal Growth & Design, Issue 18/10, 2018, Page(s) 6257-6265, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.1021/acs.cgd.8b01134

Online Monitoring of the Concentrations of Amorphous and Crystalline Mesoscopic Species Present in Solution

Author(s): Marco Mazzotti; Michele Chen; Byeongho Ahn
Published in: Crystal Growth & Design 22 (22), Issue 22, 2022, Page(s) 5071−5080, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000560961

Kinetics and Thermodynamics of Lactose Mutarotation through Chromatography

Author(s): Silvio Trespi; Marco Mazzotti
Published in: Industrial & Engineering Chemistry Research, 63 (12), Issue 2024, 63, 12, 5028–5038, 2024, ISSN 0888-5885
Publisher: American Chemical Society
DOI: 10.1021/acs.iecr.3c04110

Secondary Nucleation by Interparticle Energies. I. Thermodynamics

Author(s): Luca Bosetti; Byeongho Ahn; Marco Mazzotti
Published in: Crystal Growth & Design, 22 (1), Issue 22 (1), 2021, Page(s) 87–97, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000523208

General stability analysis of the steady states in the continuous mixed-suspension crystallizer

Author(s): Leif-Thore Deck; Marco Mazzotti
Published in: Chemical Engineering Journal, 483, Issue 2024, 483, 148721, 2024, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2024.148721

The Role of Operating Conditions in the Precipitation of Magnesium Hydroxide Hexagonal Platelets Using NaOH Solutions

Author(s): Salvatore Romano; Silvio Trespi; Ramona Achermann; Giuseppe Battaglia; Antonello Raponi; Daniele Marchisio; Marco Mazzotti; Giorgio Micale; Andrea Cipollina
Published in: Crystal Growth & Design, 23 (9), Issue 2023, 23, 9, 6491–6505, 2023, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.1021/acs.cgd.3c00462

Crystallization-Induced Deracemization: Experiments and Modeling

Author(s): Marco Mazzotti; Brigitta Bodák; Francesca Breveglieri
Published in: Crystal Growth & Design, Issue 2022, 22 (2), 2022, Page(s) 1427–1436, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.1021/acs.cgd.1c01374

Deracemization via Periodic and Non-periodic Temperature Cycles: Rationalization and Experimental Validation of a Simplified Process Design Approach.

Author(s): Francesca Breveglieri; Brigitta Bodák; Marco Mazzotti
Published in: Organic Process Research & Development, Issue 2021, 25, 11, 2021, Page(s) 2551–2565, ISSN 1083-6160
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000518898

Accounting for the Presence of Molecular Clusters in Modeling and Interpreting Nucleation and Growth

Author(s): Marco Mazzotti; Luca Bosetti; Byeongho Ahn
Published in: Crystal Growth & Design, 22 (1), Issue 22 (1), 2022, Page(s) 661–672, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000519719

On the model-based design and comparison of crystallization-based deracemization techniques

Author(s): Brigitta Bodák; Francesca Breveglieri; Marco Mazzotti
Published in: Chemical Engineering Science, Issue 2022, 2022, Page(s) 117595, ISSN 0009-2509
Publisher: Pergamon Press Ltd.
DOI: 10.3929/ethz-b-000541843

Thesis and dissertations (5)

Modeling of crystallization-based deracemization processes

Author(s): Brigitta Bodak
Published in: 2022
Publisher: ETH Zürich
DOI: 10.3929/ethz-b-000543520

Deracemization via batch temperature cycles - Combining racemization and crystallization for chiral resolution

Author(s): Breveglieri, Francesca
Published in: Issue 5, 2021
Publisher: ETH Zürich
DOI: 10.3929/ethz-b-000528254

Characterizing Mesoscopic Species Present in Solution and Modeling Their Roles in Crystallization Processes

Author(s): Ahn, Byeongho; id_orcid0000-0002-4405-5041
Published in: Issue 1, 2022
Publisher: ETH Zürich
DOI: 10.3929/ethz-b-000574827

Design, Operational Challenges and Opportunities for the Intensification of Continuous Crystallization

Author(s): Ramona Achermann
Published in: 2023
Publisher: ETH Zürich
DOI: 10.3929/ethz-b-000606968

Mechanisms and models of secondary nucleation

Author(s): Luca Bosetti
Published in: 2021
Publisher: ETH Zürich
DOI: 10.3929/ethz-b-000528059