High-Throughput Cryogenic Spectroscopy for Glycan Analysis

Project Information

GLYCANAL

Grant agreement ID: 788697

DOI

10.3030/788697

Project closed

EC signature date 19 April 2018

Start date 1 September 2018

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 801,00

EU contribution

€ 2 499 801,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (20)

A New Strategy Coupling Ion-Mobility-Selective CID and Cryogenic IR Spectroscopy to Identify Glycan Anomers

Author(s): Robert P. Pellegrinelli; Lei Yue; Eduardo Carrascosa; Ahmed Ben Faleh; Stephan Warnke; Priyanka Bansal; Thomas R. Rizzo
Published in: Journal of the American Society of Mass Spectrometry, Issue 33, 2022, Page(s) 859-864, ISSN 1044-0305
Publisher: Elsevier BV
DOI: 10.1021/jasms.2c00043

Identification of Mobility-Resolved <i>N</i>-Glycan Isomers

Author(s): Ahmed Ben Faleh; Stephan Warnke; Priyanka Bansal; Robert P. Pellegrinelli; Irina Dyukova; Thomas R. Rizzo
Published in: Analytical Chemistry, Issue 94, 2022, Page(s) 10101-10108, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.2c01181

Using Hadamard Transform Multiplexed IR Spectroscopy Together with a Segmented Ion Trap for the Identification of Mobility-Selected Isomers

Author(s): Yatsyna, Vasyl; Abikhodr, Ali H.; Ben Faleh, Ahmed; Warnke, Stephan; Rizzo, Thomas R.
Published in: Analytical Chemistry, Issue 95, 2023, Page(s) 9623-9629, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.3c01340

Cryogenic Infrared Action Spectroscopy Fingerprints the Hydrogen Bonding Network in Gas-Phase Coumarin Cations

Author(s): Eduardo Carrascosa; Robert P. Pellegrinelli; Thomas R. Rizzo; Mark A. Muyskens
Published in: Journal of Physical Chemistry A, Issue 124, 2020, Page(s) 9942-9950, ISSN 1089-5639
Publisher: American Chemical Society
DOI: 10.1021/acs.jpca.0c06430

High-Throughput Multiplexed Infrared Spectroscopy of Ion Mobility-Separated Species Using Hadamard Transform.

Author(s): Ali Abikhodr; Vasyl Yatsyna; Stephan Warnke; Thomas Rizzo; Ahmed Ben Faleh
Published in: Analytical Chemistry, Issue 94, 2022, Page(s) 2912–2917, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.1c04843

Identifying Mixtures of Isomeric Human Milk Oligosaccharides by the Decomposition of IR Spectral Fingerprints

Author(s): Ali H. Abikhodr, Vasyl Yatsyna, Ahmed Ben Faleh, Stephan Warnke, and Thomas R. Rizzo
Published in: Analytical Chemistry, Issue 93, 2021, Page(s) 14730-14736, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.1c03190

A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

Author(s): Irina Dyukova, Ahmed Ben Faleh, Stephan Warnke, Natalia Yalovenko, Vasyl Yatsyna, Priyanka Bansal, Thomas R. Rizzo
Published in: The Analyst, Issue 146/15, 2021, Page(s) 4789-4795, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1an00780g

Analyzing glycans cleaved from a biotherapeutic protein using ultrahigh-resolution ion mobility spectrometry together with cryogenic ion spectroscopy

Author(s): Natalia Yalovenko, Vasyl Yatsyna, Priyanka Bansal, Ali H. AbiKhodr, Thomas R. Rizzo
Published in: The Analyst, Issue 145/20, 2020, Page(s) 6493-6499, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0an01206h

Identification of human milk oligosaccharide positional isomers by combining IMS-CID-IMS and cryogenic IR spectroscopy

Author(s): Ali H. Abikhodr, Ahmed Ben Faleh, Stephan Warnke, Vasyl Yatsyna, and Thomas R. Rizzo
Published in: Analyst, Issue 148, 2023, Page(s) 2277-2282, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3an00407d

New Approach for the Identification of Isobaric and Isomeric Metabolites

Author(s): Ben Faleh, Ahmed; Warnke, Stephan; Van Wieringen, Teun; Abikhodr, Ali H.; Rizzo, Thomas R.
Published in: Analytical Chemistry, Issue 95, 2023, Page(s) 7118-7126, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.2c04962

Multistage Ion Mobility Spectrometry Combined with Infrared Spectroscopy for Glycan Analysis

Author(s): Priyanka Bansal, Ahmed Ben Faleh, Stephan Warnke, Thomas R. Rizzo
Published in: Journal of the American Society for Mass Spectrometry, Issue 34, 2023, Page(s) 695-700, ISSN 1044-0305
Publisher: Elsevier BV
DOI: 10.1021/jasms.2c00361

Combining Ultrahigh-Resolution Ion-Mobility Spectrometry with Cryogenic Infrared Spectroscopy for the Analysis of Glycan Mixtures

Author(s): Ahmed Ben Faleh, Stephan Warnke, Thomas R. Rizzo
Published in: Analytical Chemistry, Issue 91/7, 2019, Page(s) 4876-4882, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.9b00659

Separation and Identification of Glycan Anomers Using Ultrahigh-Resolution Ion-Mobility Spectrometry and Cryogenic Ion Spectroscopy

Author(s): Stephan Warnke, Ahmed Ben Faleh, Valeriu Scutelnic, Thomas R. Rizzo
Published in: Journal of The American Society for Mass Spectrometry, Issue 30/11, 2019, Page(s) 2204-2211, ISSN 1044-0305
Publisher: Elsevier BV
DOI: 10.1007/s13361-019-02333-0

How General Is Anomeric Retention during Collision-Induced Dissociation of Glycans?

Author(s): Robert P. Pellegrinelli, Lei Yue, Eduardo Carrascosa, Stephan Warnke, Ahmed Ben Faleh, Thomas R. Rizzo
Published in: Journal of the American Chemical Society, Issue 142/13, 2020, Page(s) 5948-5951, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c00264

Combining ultra-high resolution ion mobility spectrometry with cryogenic IR spectroscopy for the study of biomolecular ions

Author(s): Stephan Warnke, Ahmed Ben Faleh, Robert P. Pellegrinelli, Natalia Yalovenko, Thomas R. Rizzo
Published in: Faraday Discussions, Issue 217, 2019, Page(s) 114-125, ISSN 1359-6640
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8fd00180d

Combining Cryogenic Infrared Spectroscopy with Selective Enzymatic Cleavage for Determining Glycan Primary Structure

Author(s): Irina Dyukova, Eduardo Carrascosa, Robert P. Pellegrinelli, Thomas R. Rizzo
Published in: Analytical Chemistry, Issue 92/2, 2020, Page(s) 1658-1662, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.9b04776

Unravelling the structures of sodiated β-cyclodextrin and its fragments

Author(s): Jordan M. Rabus, Robert P. Pellegrinelli, Ali Hassan Abi Khodr, Benjamin J. Bythell, Thomas R. Rizzo, Eduardo Carrascosa
Published in: Physical Chemistry Chemical Physics, Issue 23/24, 2021, Page(s) 13714-13723, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cp01058a

Identification of N-glycan positional isomers by combining IMS and vibrational fingerprinting of structurally determinant CID fragments

Author(s): Priyanka Bansal; Stephan Warnke; Thomas Rizzo; Ahmed Ben Faleh
Published in: Analyst, Issue 147, 2022, Page(s) 704-711, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1an01861b

Using SLIM-Based IMS-IMS Together with Cryogenic Infrared Spectroscopy for Glycan Analysis

Author(s): Priyanka Bansal, Vasyl Yatsyna, Ali H. AbiKhodr, Stephan Warnke, Ahmed Ben Faleh, Natalia Yalovenko, Vicki H. Wysocki, Thomas R. Rizzo
Published in: Analytical Chemistry, Issue 92/13, 2020, Page(s) 9079-9085, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c01265

Toward High-Throughput Cryogenic IR Fingerprinting of Mobility-Separated Glycan Isomers

Author(s): Stephan Warnke, Ahmed Ben Faleh, Thomas R. Rizzo
Published in: ACS Measurement Science Au, 2021, ISSN 2694-250X
Publisher: American Chemical Society
DOI: 10.1021/acsmeasuresciau.1c00018

Intellectual Property Rights

Patent (2)

A METHOD FOR CHARACTERIZING POLYSACCHARIDES

Application/Publication number: 17 787952
Date: 2017-08-29
Applicant(s): ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

HIGH-THROUGHPUT CRYOGENIC SPECTROSCOPY FOR GLYCAN ANALYSIS

Application/Publication number: 20 1816212875
Date: 2018-12-07
Applicant(s): ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE