Remote control healing: Next generation mechano-nano-therapeutics

Project Information

DYNACEUTICS

Grant agreement ID: 789119

DOI

10.3030/789119

Project closed

EC signature date 17 October 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 068,00

EU contribution

€ 2 499 068,00

Coordinated by

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Participation in the Open Research Data Pilot

Publications

Peer reviewed articles (35)

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model

Author(s): Hareklea Markides, Nicola C. Foster, Jane S. McLaren, Timothy Hopkins, Cameron Black, Richard O. C. Oreffo, Brigitte E. Scammell, Iria Echevarria, Lisa J. White, Alicia J. El Haj
Published in: Cells, Issue 10/7, 2021, Page(s) 1776, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10071776

Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells

Author(s): James R Henstock, Michael Rotherham, Alicia J El Haj
Published in: Journal of Tissue Engineering, Issue 9, 2025, ISSN 2041-7314
Publisher: Sage Journals
DOI: 10.1177/2041731418808695

Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces

Author(s): Maud Bongaerts, Koceila Aizel, Emilie Secret, Audric Jan, Tasmin Nahar, Fabian Raudzus, Sebastian Neumann, Neil Telling, Rolf Heumann, Jean-Michel Siaugue, Christine Ménager, Jérôme Fresnais, Catherine Villard, Alicia El Haj, Jacob Piehler, Monte A. Gates, Mathieu Coppey
Published in: International Journal of Molecular Sciences, Issue 21/18, 2020, Page(s) 6560, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21186560

Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing

Author(s): Richard Harrison, Hilda Anaid Lugo Leija, Stephanie Strohbuecker, James Crutchley, Sarah Marsh, Chris Denning, Alicia El Haj, Virginie Sottile
Published in: Stem Cell Research & Therapy, Issue 9, 2019, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-018-0968-0

The Grand Challenges of Medical Technology

Author(s): Alicia J. El Haj
Published in: Frontiers in Medical Technology, Issue 2, 2020, ISSN 2673-3129
Publisher: Frontiers
DOI: 10.3389/fmedt.2020.00001

Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside

Author(s): Candice Ashmore-Harris, Evangelia Antonopoulou, Simon M. Finney, Melissa R. Vieira, Matthew G. Hennessy, Andreas Muench, Wei-Yu Lu, Victoria L. Gadd, Alicia J. El Haj, Stuart J. Forbes, Sarah L. Waters
Published in: npj Regenerative Medicine, Issue 9, 2024, ISSN 2057-3995
Publisher: Springer Nature
DOI: 10.1038/s41536-024-00361-3

Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells

Author(s): Lu Luo, Nicola C. Foster, Kenny L. Man, Mathieu Brunet, David A. Hoey, Sophie C. Cox, Susan J. Kimber, Alicia J. El Haj
Published in: Biotechnology Journal, Issue 17, 2023, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.202100401

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model

Author(s): Joshua D. Kaggie, Hareklea Markides, Martin J. Graves, James MacKay, Gavin Houston, Alicia El Haj, Fiona Gilbert, Frances Henson
Published in: Scientific Reports, Issue 10, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-64423-4

Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties

Author(s): Jonathan H. Mason, Lu Luo, Yvonne Reinwald, Matteo Taffetani, Amelia Hallas-Potts, C. Simon Herrington, Vlastimil Srsen, Chih-Jen Lin, Inês A. Barroso, Zhihua Zhang, Zhibing Zhang, Anita K. Ghag, Ying Yang, Sarah Waters, Alicia J. El Haj, Pierre O. Bagnaninchi
Published in: Communications Biology, Issue 6, 2023, ISSN 2399-3642
Publisher: Communications Biology
DOI: 10.1038/s42003-023-04788-0

Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration

Author(s): Graziana Monaco, Alicia J. El Haj, Mauro Alini, Martin J. Stoddart
Published in: Journal of Functional Morphology and Kinesiology, Issue 6, 2024, Page(s) 6, ISSN 2411-5142
Publisher: MDPI
DOI: 10.3390/jfmk6010006

Roadmap on magnetic nanoparticles in nanomedicine

Author(s): Kai Wu, Jian-Ping Wang, Niranjan A Natekar, Stefano Ciannella, Cristina González-Fernández, Jenifer Gomez-Pastora, Yuping Bao, Jinming Liu, Shuang Liang, Xian Wu, Linh Nguyen T Tran, Karla Mercedes Paz González, Hyeon Choe, Jacob Strayer, Poornima Ramesh Iyer, Jeffrey Chalmers, Vinit Kumar Chugh, Bahareh Rezaei, Shahriar Mostufa, Zhi Wei Tay, Chinmoy Saayujya, Quincy Huynh, Jacob Bryan, Renesme
Published in: Nanotechnology, Issue 36, 2024, Page(s) 042003, ISSN 0957-4484
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6528/ad8626

Predicting Bone Formation in Mesenchymal Stromal Cell-Seeded Hydrogels Using Experiment-Based Mathematical Modeling

Author(s): Joshua C. Price, Andrew L. Krause, Sarah L. Waters, Alicia J. El Haj
Published in: Tissue Engineering Part A, Issue 26, 2024, Page(s) 1014-1023, ISSN 1937-3341
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2020.0027

Sodium hyaluronate supplemented culture medium combined with joint-simulating mechanical loading improves chondrogenic differentiation of human mesenchymal stem cells

Author(s): null null, G Monaco, AJ El Haj, M Alini, MJ Stoddart
Published in: European Cells and Materials, Issue 41, 2021, Page(s) 616-632, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v041a40

Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair

Author(s): Yoshihisa Okuchi, Joshua Reeves, Soon Seng Ng, Daniel H. Doro, Sergi Junyent, Karen J. Liu, Alicia J. El Haj, Shukry J. Habib
Published in: Nature Materials, Issue 20/1, 2021, Page(s) 108-118, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-020-0786-5

Regenerative medicine meets mathematical modelling: developing symbiotic relationships

Author(s): S. L. Waters, L. J. Schumacher, A. J. El Haj
Published in: npj Regenerative Medicine, Issue 6/1, 2021, ISSN 2057-3995
Publisher: Nature publishing Journals
DOI: 10.1038/s41536-021-00134-2

Magnetic Nanoparticle-Mediated Orientation of Collagen Hydrogels for Engineering of Tendon-Mimetic Constructs

Author(s): Abigail L. Wright, Lucrezia Righelli, T. J. Broomhall, Hannah C. Lamont, Alicia J. El Haj
Published in: Frontiers in Bioengineering and Biotechnology, Issue 10, 2022, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2022.797437

Translation of remote control regenerative technologies for bone repair

Author(s): Hareklea Markides, Jane S. McLaren, Neil D. Telling, Noura Alom, E’atelaf A. Al-Mutheffer, Richard O. C. Oreffo, Andrew Zannettino, Brigitte E. Scammell, Lisa J. White, Alicia J. El Haj
Published in: npj Regenerative Medicine, Issue 3, 2022, ISSN 2057-3995
Publisher: Springer Nature
DOI: 10.1038/s41536-018-0048-1

Regenerative Medicine: “Are We There Yet?”

Author(s): Alicia J. El Haj
Published in: Tissue Engineering Part A, Issue 25/15-16, 2019, Page(s) 1067-1071, ISSN 1937-3341
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2019.0134

Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation

Author(s): A.I. Gonçalves, M. Rotherham, H. Markides, M.T. Rodrigues, R.L. Reis, M.E. Gomes, A.J. El Haj
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, Issue 14, 2018, Page(s) 1149-1159, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2018.02.008

Long-range directional growth of neurites induced by magnetic forces

Author(s): Tasmin Nahar, Monte Gates, Emilie Secret, Jean-Michel Siaugue, Jérôme Fresnais, Michael Rotherham, Heidi R. Fuller, Sharon J. Brown, Alicia J. El Haj, Neil D. Telling
Published in: Acta Biomaterialia, Issue 193, 2025, Page(s) 215-230, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2024.12.057

Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis

Author(s): Hadi Hajiali, Michael Rotherham, Alicia J. El Haj
Published in: Pharmaceutics, Issue 16, 2023, Page(s) 21, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16010021

Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model

Author(s): Hareklea Markides, Karin J. Newell, Heike Rudorf, Lia Blokpoel Ferreras, James E. Dixon, Robert H. Morris, Martin Graves, Joshua Kaggie, Frances Henson, Alicia J. El Haj
Published in: Stem Cell Research & Therapy, Issue 10/1, 2019, Page(s) all, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-018-1123-7

Organ-on-a-chip for studying immune cell adhesion to liver sinusoidal endothelial cells: the potential for testing immunotherapies and cell therapy trafficking

Author(s): James I. Kennedy, Scott P. Davies, Peter W. Hewett, Alex L. Wilkinson, Ye H. Oo, Wei-Yu Lu, Alicia J. El Haj, Shishir Shetty
Published in: Frontiers in Cell and Developmental Biology, Issue 12, 2024, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2024.1359451

Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics

Author(s): Bin Hu, Michael Rotherham, Neil Farrow, Paul Roach, Jon Dobson, Alicia J. El Haj
Published in: International Journal of Molecular Sciences, Issue 23, 2025, Page(s) 10164, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231710164

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model

Author(s): Joshua D. Kaggie, Hareklea Markides, Martin J. Graves, James MacKay, Gavin Houston, Alicia El Haj, Fiona Gilbert, Frances Henson
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-64423-4

Experimental and mathematical modelling of magnetically labelled mesenchymal stromal cell delivery

Author(s): E. F. Yeo, H. Markides, A. T. Schade, A. J. Studd, J. M. Oliver, S. L. Waters, A. J. El Haj
Published in: Journal of The Royal Society Interface, Issue 18/175, 2021, ISSN 1742-5662
Publisher: Royal society
DOI: 10.1098/rsif.2020.0558

Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization

Author(s): Angela Imere, Nicola C. Foster, Hadi Hajiali, Kerime Ebrar Okur, Abigail L. Wright, Ines A. Barroso, Alicia J. El Haj
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-65970-w

Magnetic Mechanoactivation of Wnt Signaling Augments Dopaminergic Differentiation of Neuronal Cells

Author(s): Michael Rotherham, Tasmin Nahar, Timothy Goodman, Neil Telling, Monte Gates, Alicia El Haj
Published in: Advanced Biosystems, Issue 3/9, 2019, Page(s) 1900091, ISSN 2366-7478
Publisher: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/adbi.201900091

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model.

Author(s): Joshua D. Kaggie; Joshua D. Kaggie; Hareklea Markides; Hareklea Markides; Martin J. Graves; Martin J. Graves; James W. MacKay; James W. MacKay; Gavin C. Houston; Alicia J. El Haj; Alicia J. El Haj; Fiona J. Gilbert; Fiona J. Gilbert; Frances Henson
Published in: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020), Issue 20452322, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.17863/cam.54591

Magnetic Ion Channel Activation (MICA)-Enabled Screening Assay: A Dynamic Platform for Remote Activation of Mechanosensitive Ion Channels

Author(s): Afeesh Rajan Unnithan, Michael Rotherham, Hareklea Markides, Alicia J. El Haj
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 3364, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043364

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction

Author(s): Ana M. Matos, Ana I. Gonçalves, Alicia J. El Haj, Manuela E. Gomes
Published in: Nanoscale Advances, Issue 2/1, 2020, Page(s) 140-148, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9na00615j

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells

Author(s): Michael Rotherham, Yasamin Moradi, Tasmin Nahar, Dominic Mosses, Neil Telling, Alicia J. El Haj
Published in: Frontiers in Medical Technology, Issue 4, 2022, ISSN 2673-3129
Publisher: Frontiers in Medical Technology
DOI: 10.3389/fmedt.2022.981421

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients

Author(s): K. Dhillon, K. Aizel, T. J. Broomhall, E. Secret, T. Goodman, M. Rotherham, N. Telling, J. M. Siaugue, C. Ménager, J. Fresnais, M. Coppey, A. J. El Haj, M. A. Gates
Published in: Journal of The Royal Society Interface, Issue 19, 2022, ISSN 1742-5662
Publisher: The Royal Society
DOI: 10.1098/rsif.2022.0576

Tailoring Therapeutic Responses via Engineering Microenvironments with a Novel Synthetic Fluid Gel

Author(s): Nicola C. Foster, Piers Allen, Alicia J. El Haj, Liam M. Grover, Richard J. A. Moakes
Published in: Advanced Healthcare Materials, Issue 10, 2023, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202100622

Remote triggering of TGF-β/Smad2/3 signaling in human adipose stem cells laden on magnetic scaffolds synergistically promotes tenogenic commitment

Author(s): Ana M. Matos, Ana I. Gonçalves, Márcia T. Rodrigues, Margarida S. Miranda, Alicia J. El Haj, Rui L. Reis, Manuela E. Gomes
Published in: Acta Biomaterialia, Issue 113, 2020, Page(s) 488-500, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.07.009

Other (1)

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction

Author(s): Matos, Ana M.; Gonçalves, Ana I.; El Haj, Alicia J.; Gomes, Manuela E.
Published in: The Royal Society of Chemistry 2020, Issue 6, 2019, Page(s) 2
Publisher: Royal society of chemistry

Intellectual Property Rights

Patent (1)

T CELL ACTIVATION

Application/Publication number: 20 2318517633
Date: 2023-11-22
Applicant(s): THE UNIVERSITY OF BIRMINGHAM