Remote control healing: Next generation mechano-nano-therapeutics

Información del proyecto

DYNACEUTICS

Identificador del acuerdo de subvención: 789119

DOI

10.3030/789119

Proyecto cerrado

Fecha de la firma de la CE 17 Octubre 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 068,00

Aportación de la UE

€ 2 499 068,00

Coordinado por

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

Participation in the Open Research Data Pilot

Publicaciones

Peer reviewed articles (35)

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model

Autores: Hareklea Markides, Nicola C. Foster, Jane S. McLaren, Timothy Hopkins, Cameron Black, Richard O. C. Oreffo, Brigitte E. Scammell, Iria Echevarria, Lisa J. White, Alicia J. El Haj
Publicado en: Cells, Edición 10/7, 2021, Página(s) 1776, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10071776

Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells

Autores: James R Henstock, Michael Rotherham, Alicia J El Haj
Publicado en: Journal of Tissue Engineering, Edición 9, 2025, ISSN 2041-7314
Editor: Sage Journals
DOI: 10.1177/2041731418808695

Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces

Autores: Maud Bongaerts, Koceila Aizel, Emilie Secret, Audric Jan, Tasmin Nahar, Fabian Raudzus, Sebastian Neumann, Neil Telling, Rolf Heumann, Jean-Michel Siaugue, Christine Ménager, Jérôme Fresnais, Catherine Villard, Alicia El Haj, Jacob Piehler, Monte A. Gates, Mathieu Coppey
Publicado en: International Journal of Molecular Sciences, Edición 21/18, 2020, Página(s) 6560, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21186560

Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing

Autores: Richard Harrison, Hilda Anaid Lugo Leija, Stephanie Strohbuecker, James Crutchley, Sarah Marsh, Chris Denning, Alicia El Haj, Virginie Sottile
Publicado en: Stem Cell Research & Therapy, Edición 9, 2019, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/s13287-018-0968-0

The Grand Challenges of Medical Technology

Autores: Alicia J. El Haj
Publicado en: Frontiers in Medical Technology, Edición 2, 2020, ISSN 2673-3129
Editor: Frontiers
DOI: 10.3389/fmedt.2020.00001

Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside

Autores: Candice Ashmore-Harris, Evangelia Antonopoulou, Simon M. Finney, Melissa R. Vieira, Matthew G. Hennessy, Andreas Muench, Wei-Yu Lu, Victoria L. Gadd, Alicia J. El Haj, Stuart J. Forbes, Sarah L. Waters
Publicado en: npj Regenerative Medicine, Edición 9, 2024, ISSN 2057-3995
Editor: Springer Nature
DOI: 10.1038/s41536-024-00361-3

Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells

Autores: Lu Luo, Nicola C. Foster, Kenny L. Man, Mathieu Brunet, David A. Hoey, Sophie C. Cox, Susan J. Kimber, Alicia J. El Haj
Publicado en: Biotechnology Journal, Edición 17, 2023, ISSN 1860-6768
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.202100401

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model

Autores: Joshua D. Kaggie, Hareklea Markides, Martin J. Graves, James MacKay, Gavin Houston, Alicia El Haj, Fiona Gilbert, Frances Henson
Publicado en: Scientific Reports, Edición 10, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-64423-4

Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties

Autores: Jonathan H. Mason, Lu Luo, Yvonne Reinwald, Matteo Taffetani, Amelia Hallas-Potts, C. Simon Herrington, Vlastimil Srsen, Chih-Jen Lin, Inês A. Barroso, Zhihua Zhang, Zhibing Zhang, Anita K. Ghag, Ying Yang, Sarah Waters, Alicia J. El Haj, Pierre O. Bagnaninchi
Publicado en: Communications Biology, Edición 6, 2023, ISSN 2399-3642
Editor: Communications Biology
DOI: 10.1038/s42003-023-04788-0

Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration

Autores: Graziana Monaco, Alicia J. El Haj, Mauro Alini, Martin J. Stoddart
Publicado en: Journal of Functional Morphology and Kinesiology, Edición 6, 2024, Página(s) 6, ISSN 2411-5142
Editor: MDPI
DOI: 10.3390/jfmk6010006

Roadmap on magnetic nanoparticles in nanomedicine

Autores: Kai Wu, Jian-Ping Wang, Niranjan A Natekar, Stefano Ciannella, Cristina González-Fernández, Jenifer Gomez-Pastora, Yuping Bao, Jinming Liu, Shuang Liang, Xian Wu, Linh Nguyen T Tran, Karla Mercedes Paz González, Hyeon Choe, Jacob Strayer, Poornima Ramesh Iyer, Jeffrey Chalmers, Vinit Kumar Chugh, Bahareh Rezaei, Shahriar Mostufa, Zhi Wei Tay, Chinmoy Saayujya, Quincy Huynh, Jacob Bryan, Renesme
Publicado en: Nanotechnology, Edición 36, 2024, Página(s) 042003, ISSN 0957-4484
Editor: Institute of Physics Publishing
DOI: 10.1088/1361-6528/ad8626

Predicting Bone Formation in Mesenchymal Stromal Cell-Seeded Hydrogels Using Experiment-Based Mathematical Modeling

Autores: Joshua C. Price, Andrew L. Krause, Sarah L. Waters, Alicia J. El Haj
Publicado en: Tissue Engineering Part A, Edición 26, 2024, Página(s) 1014-1023, ISSN 1937-3341
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2020.0027

Sodium hyaluronate supplemented culture medium combined with joint-simulating mechanical loading improves chondrogenic differentiation of human mesenchymal stem cells

Autores: null null, G Monaco, AJ El Haj, M Alini, MJ Stoddart
Publicado en: European Cells and Materials, Edición 41, 2021, Página(s) 616-632, ISSN 1473-2262
Editor: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v041a40

Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair

Autores: Yoshihisa Okuchi, Joshua Reeves, Soon Seng Ng, Daniel H. Doro, Sergi Junyent, Karen J. Liu, Alicia J. El Haj, Shukry J. Habib
Publicado en: Nature Materials, Edición 20/1, 2021, Página(s) 108-118, ISSN 1476-1122
Editor: Nature Publishing Group
DOI: 10.1038/s41563-020-0786-5

Regenerative medicine meets mathematical modelling: developing symbiotic relationships

Autores: S. L. Waters, L. J. Schumacher, A. J. El Haj
Publicado en: npj Regenerative Medicine, Edición 6/1, 2021, ISSN 2057-3995
Editor: Nature publishing Journals
DOI: 10.1038/s41536-021-00134-2

Magnetic Nanoparticle-Mediated Orientation of Collagen Hydrogels for Engineering of Tendon-Mimetic Constructs

Autores: Abigail L. Wright, Lucrezia Righelli, T. J. Broomhall, Hannah C. Lamont, Alicia J. El Haj
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 10, 2022, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2022.797437

Translation of remote control regenerative technologies for bone repair

Autores: Hareklea Markides, Jane S. McLaren, Neil D. Telling, Noura Alom, E’atelaf A. Al-Mutheffer, Richard O. C. Oreffo, Andrew Zannettino, Brigitte E. Scammell, Lisa J. White, Alicia J. El Haj
Publicado en: npj Regenerative Medicine, Edición 3, 2022, ISSN 2057-3995
Editor: Springer Nature
DOI: 10.1038/s41536-018-0048-1

Regenerative Medicine: “Are We There Yet?”

Autores: Alicia J. El Haj
Publicado en: Tissue Engineering Part A, Edición 25/15-16, 2019, Página(s) 1067-1071, ISSN 1937-3341
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2019.0134

Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation

Autores: A.I. Gonçalves, M. Rotherham, H. Markides, M.T. Rodrigues, R.L. Reis, M.E. Gomes, A.J. El Haj
Publicado en: Nanomedicine: Nanotechnology, Biology and Medicine, Edición 14, 2018, Página(s) 1149-1159, ISSN 1549-9634
Editor: Elsevier BV
DOI: 10.1016/j.nano.2018.02.008

Long-range directional growth of neurites induced by magnetic forces

Autores: Tasmin Nahar, Monte Gates, Emilie Secret, Jean-Michel Siaugue, Jérôme Fresnais, Michael Rotherham, Heidi R. Fuller, Sharon J. Brown, Alicia J. El Haj, Neil D. Telling
Publicado en: Acta Biomaterialia, Edición 193, 2025, Página(s) 215-230, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2024.12.057

Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis

Autores: Hadi Hajiali, Michael Rotherham, Alicia J. El Haj
Publicado en: Pharmaceutics, Edición 16, 2023, Página(s) 21, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16010021

Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model

Autores: Hareklea Markides, Karin J. Newell, Heike Rudorf, Lia Blokpoel Ferreras, James E. Dixon, Robert H. Morris, Martin Graves, Joshua Kaggie, Frances Henson, Alicia J. El Haj
Publicado en: Stem Cell Research & Therapy, Edición 10/1, 2019, Página(s) all, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/s13287-018-1123-7

Organ-on-a-chip for studying immune cell adhesion to liver sinusoidal endothelial cells: the potential for testing immunotherapies and cell therapy trafficking

Autores: James I. Kennedy, Scott P. Davies, Peter W. Hewett, Alex L. Wilkinson, Ye H. Oo, Wei-Yu Lu, Alicia J. El Haj, Shishir Shetty
Publicado en: Frontiers in Cell and Developmental Biology, Edición 12, 2024, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2024.1359451

Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics

Autores: Bin Hu, Michael Rotherham, Neil Farrow, Paul Roach, Jon Dobson, Alicia J. El Haj
Publicado en: International Journal of Molecular Sciences, Edición 23, 2025, Página(s) 10164, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231710164

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model

Autores: Joshua D. Kaggie, Hareklea Markides, Martin J. Graves, James MacKay, Gavin Houston, Alicia El Haj, Fiona Gilbert, Frances Henson
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-64423-4

Experimental and mathematical modelling of magnetically labelled mesenchymal stromal cell delivery

Autores: E. F. Yeo, H. Markides, A. T. Schade, A. J. Studd, J. M. Oliver, S. L. Waters, A. J. El Haj
Publicado en: Journal of The Royal Society Interface, Edición 18/175, 2021, ISSN 1742-5662
Editor: Royal society
DOI: 10.1098/rsif.2020.0558

Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization

Autores: Angela Imere, Nicola C. Foster, Hadi Hajiali, Kerime Ebrar Okur, Abigail L. Wright, Ines A. Barroso, Alicia J. El Haj
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-65970-w

Magnetic Mechanoactivation of Wnt Signaling Augments Dopaminergic Differentiation of Neuronal Cells

Autores: Michael Rotherham, Tasmin Nahar, Timothy Goodman, Neil Telling, Monte Gates, Alicia El Haj
Publicado en: Advanced Biosystems, Edición 3/9, 2019, Página(s) 1900091, ISSN 2366-7478
Editor: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/adbi.201900091

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model.

Autores: Joshua D. Kaggie; Joshua D. Kaggie; Hareklea Markides; Hareklea Markides; Martin J. Graves; Martin J. Graves; James W. MacKay; James W. MacKay; Gavin C. Houston; Alicia J. El Haj; Alicia J. El Haj; Fiona J. Gilbert; Fiona J. Gilbert; Frances Henson
Publicado en: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020), Edición 20452322, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.17863/cam.54591

Magnetic Ion Channel Activation (MICA)-Enabled Screening Assay: A Dynamic Platform for Remote Activation of Mechanosensitive Ion Channels

Autores: Afeesh Rajan Unnithan, Michael Rotherham, Hareklea Markides, Alicia J. El Haj
Publicado en: International Journal of Molecular Sciences, Edición 24, 2023, Página(s) 3364, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043364

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction

Autores: Ana M. Matos, Ana I. Gonçalves, Alicia J. El Haj, Manuela E. Gomes
Publicado en: Nanoscale Advances, Edición 2/1, 2020, Página(s) 140-148, ISSN 2516-0230
Editor: Royal Society of Chemistry
DOI: 10.1039/c9na00615j

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells

Autores: Michael Rotherham, Yasamin Moradi, Tasmin Nahar, Dominic Mosses, Neil Telling, Alicia J. El Haj
Publicado en: Frontiers in Medical Technology, Edición 4, 2022, ISSN 2673-3129
Editor: Frontiers in Medical Technology
DOI: 10.3389/fmedt.2022.981421

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients

Autores: K. Dhillon, K. Aizel, T. J. Broomhall, E. Secret, T. Goodman, M. Rotherham, N. Telling, J. M. Siaugue, C. Ménager, J. Fresnais, M. Coppey, A. J. El Haj, M. A. Gates
Publicado en: Journal of The Royal Society Interface, Edición 19, 2022, ISSN 1742-5662
Editor: The Royal Society
DOI: 10.1098/rsif.2022.0576

Tailoring Therapeutic Responses via Engineering Microenvironments with a Novel Synthetic Fluid Gel

Autores: Nicola C. Foster, Piers Allen, Alicia J. El Haj, Liam M. Grover, Richard J. A. Moakes
Publicado en: Advanced Healthcare Materials, Edición 10, 2023, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202100622

Remote triggering of TGF-β/Smad2/3 signaling in human adipose stem cells laden on magnetic scaffolds synergistically promotes tenogenic commitment

Autores: Ana M. Matos, Ana I. Gonçalves, Márcia T. Rodrigues, Margarida S. Miranda, Alicia J. El Haj, Rui L. Reis, Manuela E. Gomes
Publicado en: Acta Biomaterialia, Edición 113, 2020, Página(s) 488-500, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2020.07.009

Other (1)

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction

Autores: Matos, Ana M.; Gonçalves, Ana I.; El Haj, Alicia J.; Gomes, Manuela E.
Publicado en: The Royal Society of Chemistry 2020, Edición 6, 2019, Página(s) 2
Editor: Royal society of chemistry

Derechos de propiedad intelectual

Patent (1)

T CELL ACTIVATION

Número de solicitud/publicación: 20 2318517633
Fecha: 2023-11-22
Solicitante(s): THE UNIVERSITY OF BIRMINGHAM