Remote control healing: Next generation mechano-nano-therapeutics

Informazioni relative al progetto

DYNACEUTICS

ID dell’accordo di sovvenzione: 789119

DOI

10.3030/789119

Progetto chiuso

Data della firma CE 17 Ottobre 2018

Data di avvio 1 Gennaio 2019

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 068,00

Contributo UE

€ 2 499 068,00

Coordinato da

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Participation in the Open Research Data Pilot

Pubblicazioni

Peer reviewed articles (35)

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model

Autori: Hareklea Markides, Nicola C. Foster, Jane S. McLaren, Timothy Hopkins, Cameron Black, Richard O. C. Oreffo, Brigitte E. Scammell, Iria Echevarria, Lisa J. White, Alicia J. El Haj
Pubblicato in: Cells, Numero 10/7, 2021, Pagina/e 1776, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10071776

Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells

Autori: James R Henstock, Michael Rotherham, Alicia J El Haj
Pubblicato in: Journal of Tissue Engineering, Numero 9, 2025, ISSN 2041-7314
Editore: Sage Journals
DOI: 10.1177/2041731418808695

Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces

Autori: Maud Bongaerts, Koceila Aizel, Emilie Secret, Audric Jan, Tasmin Nahar, Fabian Raudzus, Sebastian Neumann, Neil Telling, Rolf Heumann, Jean-Michel Siaugue, Christine Ménager, Jérôme Fresnais, Catherine Villard, Alicia El Haj, Jacob Piehler, Monte A. Gates, Mathieu Coppey
Pubblicato in: International Journal of Molecular Sciences, Numero 21/18, 2020, Pagina/e 6560, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21186560

Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing

Autori: Richard Harrison, Hilda Anaid Lugo Leija, Stephanie Strohbuecker, James Crutchley, Sarah Marsh, Chris Denning, Alicia El Haj, Virginie Sottile
Pubblicato in: Stem Cell Research & Therapy, Numero 9, 2019, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-018-0968-0

The Grand Challenges of Medical Technology

Autori: Alicia J. El Haj
Pubblicato in: Frontiers in Medical Technology, Numero 2, 2020, ISSN 2673-3129
Editore: Frontiers
DOI: 10.3389/fmedt.2020.00001

Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside

Autori: Candice Ashmore-Harris, Evangelia Antonopoulou, Simon M. Finney, Melissa R. Vieira, Matthew G. Hennessy, Andreas Muench, Wei-Yu Lu, Victoria L. Gadd, Alicia J. El Haj, Stuart J. Forbes, Sarah L. Waters
Pubblicato in: npj Regenerative Medicine, Numero 9, 2024, ISSN 2057-3995
Editore: Springer Nature
DOI: 10.1038/s41536-024-00361-3

Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells

Autori: Lu Luo, Nicola C. Foster, Kenny L. Man, Mathieu Brunet, David A. Hoey, Sophie C. Cox, Susan J. Kimber, Alicia J. El Haj
Pubblicato in: Biotechnology Journal, Numero 17, 2023, ISSN 1860-6768
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.202100401

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model

Autori: Joshua D. Kaggie, Hareklea Markides, Martin J. Graves, James MacKay, Gavin Houston, Alicia El Haj, Fiona Gilbert, Frances Henson
Pubblicato in: Scientific Reports, Numero 10, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-64423-4

Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties

Autori: Jonathan H. Mason, Lu Luo, Yvonne Reinwald, Matteo Taffetani, Amelia Hallas-Potts, C. Simon Herrington, Vlastimil Srsen, Chih-Jen Lin, Inês A. Barroso, Zhihua Zhang, Zhibing Zhang, Anita K. Ghag, Ying Yang, Sarah Waters, Alicia J. El Haj, Pierre O. Bagnaninchi
Pubblicato in: Communications Biology, Numero 6, 2023, ISSN 2399-3642
Editore: Communications Biology
DOI: 10.1038/s42003-023-04788-0

Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration

Autori: Graziana Monaco, Alicia J. El Haj, Mauro Alini, Martin J. Stoddart
Pubblicato in: Journal of Functional Morphology and Kinesiology, Numero 6, 2024, Pagina/e 6, ISSN 2411-5142
Editore: MDPI
DOI: 10.3390/jfmk6010006

Roadmap on magnetic nanoparticles in nanomedicine

Autori: Kai Wu, Jian-Ping Wang, Niranjan A Natekar, Stefano Ciannella, Cristina González-Fernández, Jenifer Gomez-Pastora, Yuping Bao, Jinming Liu, Shuang Liang, Xian Wu, Linh Nguyen T Tran, Karla Mercedes Paz González, Hyeon Choe, Jacob Strayer, Poornima Ramesh Iyer, Jeffrey Chalmers, Vinit Kumar Chugh, Bahareh Rezaei, Shahriar Mostufa, Zhi Wei Tay, Chinmoy Saayujya, Quincy Huynh, Jacob Bryan, Renesme
Pubblicato in: Nanotechnology, Numero 36, 2024, Pagina/e 042003, ISSN 0957-4484
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6528/ad8626

Predicting Bone Formation in Mesenchymal Stromal Cell-Seeded Hydrogels Using Experiment-Based Mathematical Modeling

Autori: Joshua C. Price, Andrew L. Krause, Sarah L. Waters, Alicia J. El Haj
Pubblicato in: Tissue Engineering Part A, Numero 26, 2024, Pagina/e 1014-1023, ISSN 1937-3341
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2020.0027

Sodium hyaluronate supplemented culture medium combined with joint-simulating mechanical loading improves chondrogenic differentiation of human mesenchymal stem cells

Autori: null null, G Monaco, AJ El Haj, M Alini, MJ Stoddart
Pubblicato in: European Cells and Materials, Numero 41, 2021, Pagina/e 616-632, ISSN 1473-2262
Editore: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v041a40

Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair

Autori: Yoshihisa Okuchi, Joshua Reeves, Soon Seng Ng, Daniel H. Doro, Sergi Junyent, Karen J. Liu, Alicia J. El Haj, Shukry J. Habib
Pubblicato in: Nature Materials, Numero 20/1, 2021, Pagina/e 108-118, ISSN 1476-1122
Editore: Nature Publishing Group
DOI: 10.1038/s41563-020-0786-5

Regenerative medicine meets mathematical modelling: developing symbiotic relationships

Autori: S. L. Waters, L. J. Schumacher, A. J. El Haj
Pubblicato in: npj Regenerative Medicine, Numero 6/1, 2021, ISSN 2057-3995
Editore: Nature publishing Journals
DOI: 10.1038/s41536-021-00134-2

Magnetic Nanoparticle-Mediated Orientation of Collagen Hydrogels for Engineering of Tendon-Mimetic Constructs

Autori: Abigail L. Wright, Lucrezia Righelli, T. J. Broomhall, Hannah C. Lamont, Alicia J. El Haj
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 10, 2022, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2022.797437

Translation of remote control regenerative technologies for bone repair

Autori: Hareklea Markides, Jane S. McLaren, Neil D. Telling, Noura Alom, E’atelaf A. Al-Mutheffer, Richard O. C. Oreffo, Andrew Zannettino, Brigitte E. Scammell, Lisa J. White, Alicia J. El Haj
Pubblicato in: npj Regenerative Medicine, Numero 3, 2022, ISSN 2057-3995
Editore: Springer Nature
DOI: 10.1038/s41536-018-0048-1

Regenerative Medicine: “Are We There Yet?”

Autori: Alicia J. El Haj
Pubblicato in: Tissue Engineering Part A, Numero 25/15-16, 2019, Pagina/e 1067-1071, ISSN 1937-3341
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2019.0134

Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation

Autori: A.I. Gonçalves, M. Rotherham, H. Markides, M.T. Rodrigues, R.L. Reis, M.E. Gomes, A.J. El Haj
Pubblicato in: Nanomedicine: Nanotechnology, Biology and Medicine, Numero 14, 2018, Pagina/e 1149-1159, ISSN 1549-9634
Editore: Elsevier BV
DOI: 10.1016/j.nano.2018.02.008

Long-range directional growth of neurites induced by magnetic forces

Autori: Tasmin Nahar, Monte Gates, Emilie Secret, Jean-Michel Siaugue, Jérôme Fresnais, Michael Rotherham, Heidi R. Fuller, Sharon J. Brown, Alicia J. El Haj, Neil D. Telling
Pubblicato in: Acta Biomaterialia, Numero 193, 2025, Pagina/e 215-230, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2024.12.057

Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis

Autori: Hadi Hajiali, Michael Rotherham, Alicia J. El Haj
Pubblicato in: Pharmaceutics, Numero 16, 2023, Pagina/e 21, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16010021

Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model

Autori: Hareklea Markides, Karin J. Newell, Heike Rudorf, Lia Blokpoel Ferreras, James E. Dixon, Robert H. Morris, Martin Graves, Joshua Kaggie, Frances Henson, Alicia J. El Haj
Pubblicato in: Stem Cell Research & Therapy, Numero 10/1, 2019, Pagina/e all, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-018-1123-7

Organ-on-a-chip for studying immune cell adhesion to liver sinusoidal endothelial cells: the potential for testing immunotherapies and cell therapy trafficking

Autori: James I. Kennedy, Scott P. Davies, Peter W. Hewett, Alex L. Wilkinson, Ye H. Oo, Wei-Yu Lu, Alicia J. El Haj, Shishir Shetty
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 12, 2024, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2024.1359451

Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics

Autori: Bin Hu, Michael Rotherham, Neil Farrow, Paul Roach, Jon Dobson, Alicia J. El Haj
Pubblicato in: International Journal of Molecular Sciences, Numero 23, 2025, Pagina/e 10164, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231710164

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model

Autori: Joshua D. Kaggie, Hareklea Markides, Martin J. Graves, James MacKay, Gavin Houston, Alicia El Haj, Fiona Gilbert, Frances Henson
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-64423-4

Experimental and mathematical modelling of magnetically labelled mesenchymal stromal cell delivery

Autori: E. F. Yeo, H. Markides, A. T. Schade, A. J. Studd, J. M. Oliver, S. L. Waters, A. J. El Haj
Pubblicato in: Journal of The Royal Society Interface, Numero 18/175, 2021, ISSN 1742-5662
Editore: Royal society
DOI: 10.1098/rsif.2020.0558

Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization

Autori: Angela Imere, Nicola C. Foster, Hadi Hajiali, Kerime Ebrar Okur, Abigail L. Wright, Ines A. Barroso, Alicia J. El Haj
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-65970-w

Magnetic Mechanoactivation of Wnt Signaling Augments Dopaminergic Differentiation of Neuronal Cells

Autori: Michael Rotherham, Tasmin Nahar, Timothy Goodman, Neil Telling, Monte Gates, Alicia El Haj
Pubblicato in: Advanced Biosystems, Numero 3/9, 2019, Pagina/e 1900091, ISSN 2366-7478
Editore: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/adbi.201900091

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model.

Autori: Joshua D. Kaggie; Joshua D. Kaggie; Hareklea Markides; Hareklea Markides; Martin J. Graves; Martin J. Graves; James W. MacKay; James W. MacKay; Gavin C. Houston; Alicia J. El Haj; Alicia J. El Haj; Fiona J. Gilbert; Fiona J. Gilbert; Frances Henson
Pubblicato in: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020), Numero 20452322, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.17863/cam.54591

Magnetic Ion Channel Activation (MICA)-Enabled Screening Assay: A Dynamic Platform for Remote Activation of Mechanosensitive Ion Channels

Autori: Afeesh Rajan Unnithan, Michael Rotherham, Hareklea Markides, Alicia J. El Haj
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2023, Pagina/e 3364, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043364

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction

Autori: Ana M. Matos, Ana I. Gonçalves, Alicia J. El Haj, Manuela E. Gomes
Pubblicato in: Nanoscale Advances, Numero 2/1, 2020, Pagina/e 140-148, ISSN 2516-0230
Editore: Royal Society of Chemistry
DOI: 10.1039/c9na00615j

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells

Autori: Michael Rotherham, Yasamin Moradi, Tasmin Nahar, Dominic Mosses, Neil Telling, Alicia J. El Haj
Pubblicato in: Frontiers in Medical Technology, Numero 4, 2022, ISSN 2673-3129
Editore: Frontiers in Medical Technology
DOI: 10.3389/fmedt.2022.981421

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients

Autori: K. Dhillon, K. Aizel, T. J. Broomhall, E. Secret, T. Goodman, M. Rotherham, N. Telling, J. M. Siaugue, C. Ménager, J. Fresnais, M. Coppey, A. J. El Haj, M. A. Gates
Pubblicato in: Journal of The Royal Society Interface, Numero 19, 2022, ISSN 1742-5662
Editore: The Royal Society
DOI: 10.1098/rsif.2022.0576

Tailoring Therapeutic Responses via Engineering Microenvironments with a Novel Synthetic Fluid Gel

Autori: Nicola C. Foster, Piers Allen, Alicia J. El Haj, Liam M. Grover, Richard J. A. Moakes
Pubblicato in: Advanced Healthcare Materials, Numero 10, 2023, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202100622

Remote triggering of TGF-β/Smad2/3 signaling in human adipose stem cells laden on magnetic scaffolds synergistically promotes tenogenic commitment

Autori: Ana M. Matos, Ana I. Gonçalves, Márcia T. Rodrigues, Margarida S. Miranda, Alicia J. El Haj, Rui L. Reis, Manuela E. Gomes
Pubblicato in: Acta Biomaterialia, Numero 113, 2020, Pagina/e 488-500, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2020.07.009

Other (1)

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction

Autori: Matos, Ana M.; Gonçalves, Ana I.; El Haj, Alicia J.; Gomes, Manuela E.
Pubblicato in: The Royal Society of Chemistry 2020, Numero 6, 2019, Pagina/e 2
Editore: Royal society of chemistry

Diritti di proprietà intellettuale

Patent (1)

T CELL ACTIVATION

Numero candidatura/pubblicazione: 20 2318517633
Data: 2023-11-22
Candidato/i: THE UNIVERSITY OF BIRMINGHAM