Objective
T and B lymphocytes are effectors of adaptive immunity. Their dysregulation have dramatic health consequences, and can lead to autoimmunity and blood cancers. Recently, immune receptors involved in dictating the fate of B and T cells have expanded drastically. Once of these critical receptor/ligand immune pair is the inducible co-stimulator (ICOS) and its ligand ICOSL, which emerged as a novel T/B-cell co-signaling pathway. The multiple roles reported for this immune complex position ICOS/ICOSL at the center of attention for immunotherapy. Accordingly, several therapeutic antibodies targeting this immune complex are under clinical investigation. However, structure-function studies of ICOS/ICOSL interaction are critically lacking. This proposal aims to use integrative structural biology to provide molecular details into the function and targeting of the ICOS/ICOSL immune complex. These structural blueprints will contribute to the design of next-generation therapies against autoimmune diseases and cancer. This knowledge, will also serve as the basis to develop agonist antibodies that could act as adjuvants of B cell maturation for vaccine purposes. Therefore, this study will aim to apply fundamental mechanistic approaches to answer biomedical research questions and the outcome will result in advances to both molecular medicine and biology of disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology autoimmune diseases
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine immunology immunotherapy
- natural sciences biological sciences molecular biology structural biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-GF - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
48940 LEIOA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.