Structural and functional characterization of the ICOS/ICOSL immune complex

Project Information

SI

Grant agreement ID: 790012

DOI 10.3030/790012

Project closed

EC signature date 15 February 2018

Start date 1 August 2018

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 224 683,20

EU contribution € 224 683,20

Coordinated by

UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Spain

Publications

Peer reviewed articles (6)

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

Author(s): Moustafa T Mabrouk, Kevin Chiem, Edurne Rujas, Wei-Chiao Huang, Dushyant Jahagirdar, Breandan Quinn, Meera Surendran Nair, Ruth H Nissly, Victoria S Cavener, Nina R Boyle, Ty A Sornberger, Suresh V Kuchipudi, Joaquin Ortega, Jean-Philippe Julien, Luis Martinez-Sobrido, Jonathan Lovell
Published in: Science Advances, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abj1476

Engineering pan–HIV-1 neutralization potency through multispecific antibody avidity

Author(s): Edurne Rujas, Hong Cui, Jonathan Burnie, Clare Burn Aschner, Tiantian Zhao, Sara Insausti, Krithika Muthuraman, Anthony Semesi, Jasper Ophel, Jose L Nieva, Michael S Seaman, Christina Guzzo, Bebhinn Treanor, Jean-Philippe Julien
Published in: Proc Natl Acad Sci U S A, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2112887119

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

Author(s): Edurne Rujas, Iga Kucharska, Yong Zi Tan, Samir Benlekbir, Hong Cui, Tiantian Zhao, Gregory A. Wasney, Patrick Budylowski, Furkan Guvenc, Jocelyn C. Newton, Taylor Sicard, Anthony Semesi, Krithika Muthuraman, Amy Nouanesengsy, Clare Burn Aschner, Katherine Prieto, Stephanie A. Bueler, Sawsan Youssef, Sindy Liao-Chan, Jacob Glanville, Natasha Christie-Holmes, Samira Mubareka, Scott D. Gray-Owen, Jo
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23825-2

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

Author(s): Michael G Sugiyama, Haotian Cui, Dar'ya S Redka, Mehran Karimzadeh, Edurne Rujas, Hassaan Maan, Sikander Hayat, Kyle Cheung, Rahul Misra, Joseph B McPhee, Russell D Viirre, Andrew Haller, Roberto J Botelho, Raffi Karshafian, Sarah A Sabatinos, Gregory D Fairn, Seyed Ali Madani Tonekaboni, Andreas Windemuth, Jean-Philippe Julien, Vijay Shahani, Stephen S MacKinnon, Bo Wang, Costin N Antonescu
Published in: Scientific Reports, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-02432-7

Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile

Author(s): Edurne Rujas, Daniel P. Leaman, Sara Insausti, Pablo Carravilla, Miguel García-Porras, Eneko Largo, Izaskun Morillo, Rubén Sánchez-Eugenia, Lei Zhang, Hong Cui Ibon Iloro, Félix Elortza, Jean-Philippe Julien, Christian Eggeling, Michael B.Zwick, Jose M.M. Caaveiro, José L. Nieva
Published in: iScience, 2021, ISSN 2589-0042
Publisher: Elsevier Inc.
DOI: 10.1016/j.isci.2021.102987

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

Author(s): Edurne Rujas, Hong Cui, Taylor Sicard, Anthony Semesi, Jean-Philippe Julien
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18828-4