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iFERMENTER - CONVERSION OF FORESTRY SUGAR RESIDUAL STREAMS TO ANTIMICROBIAL PROTEINS BY INTELLIGENT FERMENTATION

Objective

Plant dry matter, so-called lignocellulosic biomass, is the largest renewable biomass feedstock on Earth. Europe has over 14 mill tons of sugar residuals from biorefineries, which could be converted to profitable products and contribute to a sustainable bioeconomy. Unfortunately, existing biorefineries struggle with technical issues and low profitability due to the lack of adequate fermentation processes. Therefore, these sugars are either incinerated to generate energy or at best converted to ethanol (€0.6 /kg) but not to higher value chemicals.
Current concepts that aim to establish fermentation processes to convert residual sugar streams to high value products face challenges including inefficient sugar utilization by microorganisms and inhibitors in the residual streams, leading to low productivity and yields.
Our project aims to recover high value compounds from sugar residuals, and to turn fermentation processes converting these residual to antimicrobials cost effective. We will recover the high value sugar galactose (€40-200 /kg) from residual streams as part of their treatment process. By genome editing technique, we will design cell factories that consume the remaining residuals and produce nisin (€50-150 /kg), an industrially important commercial food/feed preservative. Additionally, we will develop an affordable, online feedback add-on system that will allow to intelligently change residual mixture during fermentation of these cell factories to optimize production online during the process. In a 150 L industrial bioreactor, we will demonstrate that our add-on invention iFermenter
- increases the yields of nisin by over 2 fold
- increases the pediocin production by over 50% compared to what is possible today,
- and reduce at least 20% in CO2 footprint with this process compared to existing solutions.
Thus, iFermenter will render production of high value products with residual sugar stream highly efficient and cost-effective contributing to circular economy.

Coordinator

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Net EU contribution
€ 995 025,25
Address
Hogskoleringen 1
7491 Trondheim
Norway

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Region
Norge Trøndelag Trøndelag
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 350 874,75

Participants (11)

UNIVERSITAET ULM
Germany
Net EU contribution
€ 438 000,00
Address
Helmholtzstrasse 16
89081 Ulm

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Region
Baden-Württemberg Tübingen Ulm, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 42 890,00
UNIVERSITAT DES SAARLANDES
Germany
Net EU contribution
€ 613 875,00
Address
Campus
66123 Saarbrucken

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Region
Saarland Saarland Regionalverband Saarbrücken
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 134 123,75
TECHNISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 728 266,00
Address
Karlsplatz 13
1040 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 227 390,25
BIO BASE EUROPE PILOT PLANT VZW
Belgium
Net EU contribution
€ 438 473,75
Address
Rodenhuizekaai 1
9042 Desteldonk Gent

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Other
Non-EU contribution
€ 0,00
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain
Net EU contribution
€ 179 390,00
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela

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Region
Galicia A Coruña
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET
Norway
Net EU contribution
€ 146 500,00
Address
Universitetstunet 3
1433 As

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Region
Norge Oslo og Viken Viken
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 3 750,00
BORREGAARD AS
Norway
Net EU contribution
€ 0,00
Address
Hjalmar Wessels Vei 6
1721 Sarpsborg

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Region
Norge Oslo og Viken Viken
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 80 945,00
GALACTIC SA
Belgium
Net EU contribution
€ 0,00
Address
Place D'escanaffles 23
7760 Escanaffles

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Region
Région wallonne Prov. Hainaut Arr. Tournai-Mouscron
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MYBIOTECH GMBH
Germany
Net EU contribution
€ 128 025,00
Address
Industriestrasse 1b
66802 Uberherrn

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Saarland Saarland Saarlouis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 178 837,50
INFORS AG
Switzerland
Net EU contribution
€ 79 875,00
Address
Rittergasse 27
4103 Bottmingen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Landschaft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 286 762,50
DANMARKS TEKNISKE UNIVERSITET
Denmark
Net EU contribution
€ 250 395,00
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 17 496,25