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iFERMENTER - CONVERSION OF FORESTRY SUGAR RESIDUAL STREAMS TO ANTIMICROBIAL PROTEINS BY INTELLIGENT FERMENTATION

Deliverables

Initial Environmental impact assessment

Environmental impact assessment of the new strain, successfully demonstrating 20% reduction of CO2 in milliscales laboratory conditions

Developed (reduced) 3 models for the levels

Developed (reduced) 3 models for the levels: genome, metabolic and process. Model predictions have satisfactory error margins (25%) when compared to data (D3.2, D3.4, D3.6)

External website of iFermenter

External website of iFermenter open to the public, but also has secured login intranet pages to share secure internal information

Metabolic model, describing different physiological states of the cell factories

Metabolic model describing different physiological states of the cell factories

Genome network reduced dynamic mode

Genome network reduced dynamic mode

Process level reduced dynamic model

Process level reduced dynamic model

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Publications

Recombinant production of the lantibiotic nisin using <i>Corynebacterium glutamicum</i> in a two-step process

Author(s): Dominik Weixler; Max Berghoff; Kirill V. Ovchinnikov; Sebastian Reich; Oliver Goldbeck; Gerd M. Seibold; Christoph Wittmann; Nadav S. Bar; Bernhard J. Eikmanns; Dzung B. Diep; Christian U. Riedel
Published in: Microbial Cell Factories, 1, 2022, ISSN 1475-2859
Publisher: BioMed Central
DOI: 10.1186/s12934-022-01739-y

Sensor fusion based on Extended and Unscented Kalman Filter for bioprocess monitoring

Author(s): Andrea Tuveri; Fernando Pérez-García; Pedro A. Lira-Parada; Lars Imsland; Nadav Bar
Published in: Journal of Process Control, 2, 2021, ISSN 0959-1524
Publisher: Butterworth Scientific Ltd.
DOI: 10.1016/j.jprocont.2021.09.005

Waste biorefinery towards a sustainable biotechnological production of pediocin: Synergy between process simulation and environmental assessment

Author(s): Ana Arias, Daniel Barreiro, Gumersindo Feijoo, Maria Teresa Moreira
Published in: Environmental Technology & Innovation, 26, 2022, ISSN 2352-1864
Publisher: Elsevier BV
DOI: 10.1016/j.eti.2022.102306

Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum

Author(s): Oliver Goldbeck, Dominique N. Desef, Kirill V. Ovchinnikov, Fernando Perez-Garcia, Jens Christmann, Peter Sinner, Peter Crauwels, Dominik Weixler, Peng Cao, Judith Becker, Michael Kohlstedt, Julian Kager, Bernhard J. Eikmanns, Gerd M. Seibold, Christoph Herwig, Christoph Wittmann, Nadav S. Bar, Dzung B. Diep, Christian U. Riedel
Published in: Metabolic Engineering, 2021, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/j.ymben.2021.09.002

Inventory review and environmental evaluation of first- and second-generation sugars through life cycle assessment.

Author(s): Sara Bello; Iana Salim; Gumersindo Feijoo; Maria Teresa Moreira
Published in: Environmental Science and Pollution Research, 3, 2021, ISSN 0944-1344
Publisher: Springer Verlag
DOI: 10.1007/s11356-021-12405-y

Dynamic Co-Cultivation Process of Corynebacterium glutamicum Strains for the Fermentative Production of Riboflavin

Author(s): Fernando Pérez-García, Arthur Burgardt, Dina R. Kallman, Volker F. Wendisch, Nadav Bar
Published in: Fermentation, 7/1, 2021, Page(s) 11, ISSN 2311-5637
Publisher: MDPI
DOI: 10.3390/fermentation7010011

In Silico Prediction and Analysis of Unusual Lantibiotic Resistance Operons in the Genus Corynebacterium

Author(s): Oliver Goldbeck, Dominik Weixler, Bernhard J. Eikmanns, Christian U. Riedel
Published in: Microorganisms, 9/3, 2021, Page(s) 646, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms9030646

Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

Author(s): Sabrina Wolf, Judith Becker, Yota Tsuge, Hideo Kawaguchi, Akihiko Kondo, Jan Marienhagen, Michael Bott, Volker F. Wendisch, Christoph Wittmann
Published in: Essays in Biochemistry, 2021, ISSN 0071-1365
Publisher: Portland Press, Ltd.
DOI: 10.1042/ebc20200134

The use of maize stover and sugar beet pulp as feedstocks in industrial fermentation plants – An economic and environmental perspective

Author(s): Iana Câmara-Salim; Pablo Conde; Gumersindo Feijoo; Maria Teresa Moreira
Published in: Cleaner Environmental Systems, 3, 2021, ISSN 2666-7894
Publisher: Elsevier
DOI: 10.1016/j.cesys.2020.100005

Technological feasibility and environmental assessment of polylactic acid-nisin-based active packaging.

Author(s): Arias, A., Feijoo, G. & Moreira, M.T.
Published in: Sustainable Materials and Technologies, 2022, ISSN 2214-9937
Publisher: Elsevier
DOI: 10.1016/j.susmat.2022.e00460

Linking process and metabolic modelling for the estimation of carbon flux distribution in Corynebacterium glutamicum growth in spent sulfite liquor

Author(s): Pedro A.Lira-Parada, PeterSinner, MichaelKohlstedt, JulianKager, ChristophWittmann, ChristophHerwig, NadavBar
Published in: IFAC-PapersOnLine, 2022, ISSN 2405-8963
Publisher: Elsevier
DOI: 10.1016/j.ifacol.2022.07.449

BECCS based on bioethanol from wood residues: Potential towards a carbon-negative transport and side-effects

Author(s): Sara Bello, Ángel Galán-Martín, Gumersindo Feijoo, Maria Teresa Moreira, Gonzalo Guillén-Gosálbez
Published in: Applied Energy, 279, 2020, Page(s) 115884, ISSN 0306-2619
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.apenergy.2020.115884

Noninvasive online monitoring of Corynebacterium glutamicum fed-batch bioprocesses subject to spent sulfite liquor raw material uncertainty

Author(s): Peter Sinner, Marlene Stiegler, Christoph Herwig, Julian Kager
Published in: Bioresource Technology, 321, 2021, Page(s) 124395, ISSN 0960-8524
Publisher: Elsevier BV
DOI: 10.1016/j.biortech.2020.124395

The Increasing Issue of Vancomycin-Resistant Enterococci and the Bacteriocin Solution

Author(s): Ingvild S. Reinseth, Kirill V. Ovchinnikov, Hanne H. Tønnesen, Harald Carlsen, Dzung B. Diep
Published in: Probiotics and Antimicrobial Proteins, 2019, ISSN 1867-1306
Publisher: Springer Pub. Co.,
DOI: 10.1007/s12602-019-09618-6

Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste

Author(s): Peter Sinner, Julian Kager, Sven Daume, Christoph Herwig
Published in: IFAC-PapersOnLine, 2019, ISSN 2405-8963
Publisher: Elsevier

The Industrial Organism Corynebacterium glutamicum Requires Mycothiol as Antioxidant to Resist Against Oxidative Stress in Bioreactor Cultivations

Author(s): Fabian Stefan Franz Hartmann, Lina Clermont, Quach Ngoc Tung, Haike Antelmann, Gerd Michael Seibold
Published in: Antioxidants, 9/10, 2020, Page(s) 969, ISSN 2076-3921
Publisher: MDPI
DOI: 10.3390/antiox9100969

Establishing the multi-criteria roadmap and metrics for the evaluation of active films for food packaging

Author(s): Arias, A., Feijoo, G., & Moreira, M. T.
Published in: Current Research in Green and Sustainable Chemistry, 4, 2021, ISSN 2666-0865
Publisher: Elsevier
DOI: 10.1016/j.crgsc.2021.100160

Process and environmental simulation in the validation of the biotechnological production of nisin from waste

Author(s): Arias, A., Feijoo, G., & Moreira, M. T.
Published in: Biochemical Engineering Journal, 174, 2021, ISSN 1369-703X
Publisher: Elsevier BV
DOI: 10.1016/j.bej.2021.108105

Time Scale Analysis and Optimization of a Continuous Microbial Bioprocess

Author(s): Peter Sinner, Christoph Herwig, Julian Kager
Published in: 30th European Symposium on Computer Aided Process Engineering, 48, 2020, Page(s) 1603-1608, ISBN 9780128233771
Publisher: Elsevier
DOI: 10.1016/b978-0-12-823377-1.50268-8

Usage of Digital Twins Along a Typical Process Development Cycle

Author(s): Peter Sinner, Sven Daume, Christoph Herwig, Julian Kager
Published in: Digital Twins - Tools and Concepts for Smart Biomanufacturing, 176, 2021, Page(s) 71-96, ISBN 978-3-030-71659-2
Publisher: Springer International Publishing
DOI: 10.1007/10_2020_149

EXTENDED KALMAN FILTER FOR SUGAR ESTIMATION USING COMBINED FREQUENT AND INFREQUENT MEASUREMENTS

Author(s): Andrea Tuveri, Pedro LIra, Fernando Perez-Garcia, Nadav Bar
Published in: IFAC FOSBE 19, 17th October 2019, 2019
Publisher: Elsevier