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iFERMENTER - CONVERSION OF FORESTRY SUGAR RESIDUAL STREAMS TO ANTIMICROBIAL PROTEINS BY INTELLIGENT FERMENTATION

Deliverables

Initial Environmental impact assessment

Environmental impact assessment of the new strain, successfully demonstrating 20% reduction of CO2 in milliscales laboratory conditions

Developed (reduced) 3 models for the levels

Developed (reduced) 3 models for the levels: genome, metabolic and process. Model predictions have satisfactory error margins (25%) when compared to data (D3.2, D3.4, D3.6)

External website of iFermenter

External website of iFermenter open to the public, but also has secured login intranet pages to share secure internal information

Metabolic model, describing different physiological states of the cell factories

Metabolic model describing different physiological states of the cell factories

Genome network reduced dynamic mode

Genome network reduced dynamic mode

Process level reduced dynamic model

Process level reduced dynamic model

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Publications

Time Scale Analysis and Optimization of a Continuous Microbial Bioprocess

Author(s): Peter Sinner, Christoph Herwig, Julian Kager
Published in: 30th European Symposium on Computer Aided Process Engineering, Issue 48, 2020, Page(s) 1603-1608
DOI: 10.1016/b978-0-12-823377-1.50268-8

Usage of Digital Twins Along a Typical Process Development Cycle

Author(s): Peter Sinner, Sven Daume, Christoph Herwig, Julian Kager
Published in: Digital Twins - Tools and Concepts for Smart Biomanufacturing, Issue 176, 2021, Page(s) 71-96
DOI: 10.1007/10_2020_149

Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum

Author(s): Oliver Goldbeck, Dominique N. Desef, Kirill V. Ovchinnikov, Fernando Perez-Garcia, Jens Christmann, Peter Sinner, Peter Crauwels, Dominik Weixler, Peng Cao, Judith Becker, Michael Kohlstedt, Julian Kager, Bernhard J. Eikmanns, Gerd M. Seibold, Christoph Herwig, Christoph Wittmann, Nadav S. Bar, Dzung B. Diep, Christian U. Riedel
Published in: Metabolic Engineering, 2021, ISSN 1096-7176
DOI: 10.1016/j.ymben.2021.09.002

Inventory review and environmental evaluation of first- and second-generation sugars through life cycle assessment.

Author(s): Sara Bello; Iana Salim; Gumersindo Feijoo; Maria Teresa Moreira
Published in: Environmental Science and Pollution Research, Issue 3, 2021, ISSN 0944-1344
DOI: 10.1007/s11356-021-12405-y

Dynamic Co-Cultivation Process of Corynebacterium glutamicum Strains for the Fermentative Production of Riboflavin

Author(s): Fernando Pérez-García, Arthur Burgardt, Dina R. Kallman, Volker F. Wendisch, Nadav Bar
Published in: Fermentation, Issue 7/1, 2021, Page(s) 11, ISSN 2311-5637
DOI: 10.3390/fermentation7010011

In Silico Prediction and Analysis of Unusual Lantibiotic Resistance Operons in the Genus Corynebacterium

Author(s): Oliver Goldbeck, Dominik Weixler, Bernhard J. Eikmanns, Christian U. Riedel
Published in: Microorganisms, Issue 9/3, 2021, Page(s) 646, ISSN 2076-2607
DOI: 10.3390/microorganisms9030646

Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

Author(s): Sabrina Wolf, Judith Becker, Yota Tsuge, Hideo Kawaguchi, Akihiko Kondo, Jan Marienhagen, Michael Bott, Volker F. Wendisch, Christoph Wittmann
Published in: Essays in Biochemistry, 2021, ISSN 0071-1365
DOI: 10.1042/ebc20200134

BECCS based on bioethanol from wood residues: Potential towards a carbon-negative transport and side-effects

Author(s): Sara Bello, Ángel Galán-Martín, Gumersindo Feijoo, Maria Teresa Moreira, Gonzalo Guillén-Gosálbez
Published in: Applied Energy, Issue 279, 2020, Page(s) 115884, ISSN 0306-2619
DOI: 10.1016/j.apenergy.2020.115884

Noninvasive online monitoring of Corynebacterium glutamicum fed-batch bioprocesses subject to spent sulfite liquor raw material uncertainty

Author(s): Peter Sinner, Marlene Stiegler, Christoph Herwig, Julian Kager
Published in: Bioresource Technology, Issue 321, 2021, Page(s) 124395, ISSN 0960-8524
DOI: 10.1016/j.biortech.2020.124395

The Increasing Issue of Vancomycin-Resistant Enterococci and the Bacteriocin Solution

Author(s): Ingvild S. Reinseth, Kirill V. Ovchinnikov, Hanne H. Tønnesen, Harald Carlsen, Dzung B. Diep
Published in: Probiotics and Antimicrobial Proteins, 2019, ISSN 1867-1306
DOI: 10.1007/s12602-019-09618-6

Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste

Author(s): Peter Sinner, Julian Kager, Sven Daume, Christoph Herwig
Published in: IFAC-PapersOnLine, 2019, ISSN 2405-8963

The Industrial Organism Corynebacterium glutamicum Requires Mycothiol as Antioxidant to Resist Against Oxidative Stress in Bioreactor Cultivations

Author(s): Fabian Stefan Franz Hartmann, Lina Clermont, Quach Ngoc Tung, Haike Antelmann, Gerd Michael Seibold
Published in: Antioxidants, Issue 9/10, 2020, Page(s) 969, ISSN 2076-3921
DOI: 10.3390/antiox9100969

EXTENDED KALMAN FILTER FOR SUGAR ESTIMATION USING COMBINED FREQUENT AND INFREQUENT MEASUREMENTS

Author(s): Andrea Tuveri, Pedro LIra, Fernando Perez-Garcia, Nadav Bar
Published in: IFAC FOSBE 19, Issue 17th October 2019, 2019