Objective
The concept of a supergene, proposed nearly 80 years ago, has become a hot topic in biology. Supergenes are clusters of several loci, each affecting a different morphological or behavioural trait; tight physical linkage and chromosomal inversions suppress recombination so that multiple phenotypic characters are inherited as a single locus. Supergenes play a crucial role in the maintenance of highly discrete adaptive phenotypes, eventually leading to reproductive isolation and speciation. Despite the panoply of complex polymorphisms presumably controlled by supergenes, molecular evidence for their existence is scarce, and the emergence of such genetic architecture is surprisingly poorly understood. The proposed project helps to fill this scientific gap by investigating the supergene that controls shell colour polymorphism in a classical model for ecological genetics and climate-induced evolutionary change, the land snail Cepaea nemoralis. In particular, I will 1) sequence and assemble the genome of C. nemoralis, and 2) identify the individual components of its supergene by linkage mapping in laboratory crosses and association mapping in natural populations. I will do this by taking advantage of the most recent technical breakthroughs in DNA sequencing and bioinformatics. Combining my extensive knowledge of animal coloration with my host laboratory's track record in biodiversity research and genomics, this project offers a unique
window into the evolution of supergenes and polymorphisms and provides the European research community with a valuable genomic resource. By uncovering the molecular basis of C. nemoralis supergene I will establish this species as a prominent European model in evolutionary developmental biology. This fellowship will not only allow me to expand my technical and analytical skills, but also enhance my transferable skills, helping me to re-establish myself as a researcher and pave a path through which I will reach professional maturity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering colors
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences developmental biology
- natural sciences biological sciences ecology ecosystems
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2333 CR Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.