Project description DEENESFRITPL Keeping crop plants and livestock protected against pathogens Bacterial disease control is a top priority for farmers who must keep their crop plants and livestock production safe from invading pathogens. This is one of the greatest challenges of the 21st century. While plants have developed multiple defence strategies for combating invading pathogens, antibiotic resistance in plant-pathogenic bacteria is an issue. The EU-funded T-REX project will build on recent studies on wheat that have revealed an unknown recognition mechanism of the effector translocator widely conserved in pathogenic bacteria. It will aim to characterise the recognised T3SS component, the membrane-bound receptor complex and the activated immunity. Overall, the findings will shed light on the complex plant-bacterial interactions and can potentially lead to the development of new phytopathogen control strategies. Show the project objective Hide the project objective Objective Among the greatest challenges of the 21st century are bacterial diseases that permanently threat plants and animals, including humans to whom they often are lethal. In plant and animal production, bacteria can cause severe yield reductions if not effectively controlled. However, the current control measures include use of environmentally problematic antibiotics, which in addition may lead to appearance of bacterial strains resistant to these antibiotics. Recent progress in the host laboratory using a Genome Wide Association Study (GWAS) of wheat reveals a hitherto unknown recognition mechanism of the effector translocator widely conserved in pathogenic bacteria. The associated receptor complex is predicted to have wide potential for exploitation in bacterial disease control, not only in crop plants but also in livestock production. In the T-REX project, number of parallel efforts will be taken to characterize the recognized T3SS component, the membrane bound receptor complex and the activated immunity. This will be undertaken using an integrated approach, which involves my background knowledge and experiences combined with the ones of the host institution within molecular genetics, biochemistry, molecular biology and bioinformatics. This study will shed light on the role of T3SS as a PAMP, which will help us to elucidate the complex plant-bacterial interactions and can potentially lead to the development of new phyto-pathogen control strategies. T3SS being conserved among plant and animal pathogen, the outcome of the T-REX project has potential for extrapolation into animal pathological systems, including humans, and may contribute to the world of medicine. Fields of science natural sciencesbiological sciencesmolecular biologymolecular geneticsnatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsagricultural sciencesagriculture, forestry, and fisheriesagricultureagricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2017 - Individual Fellowships Call for proposal H2020-MSCA-IF-2017 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator KOBENHAVNS UNIVERSITET Net EU contribution € 200 194,80 Address NORREGADE 10 1165 Kobenhavn Denmark See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 200 194,80
