Descripción del proyecto
Proteger cultivos y ganado frente a los patógenos
El control de enfermedades bacterianas es una de las principales prioridades para los agricultores, quienes deben proteger sus cultivos y su producción ganadera ante patógenos invasivos. De hecho, se trata de uno de los grandes desafíos del siglo XXI. Aunque las plantas han desarrollado muchas estrategias de defensa para luchar contra los patógenos invasivos, la resistencia a antibióticos en bacterias patógenas vegetales representa un problema. El proyecto T-REX, financiado con fondos europeos, se basará en estudios recientes sobre el trigo que han desvelado un mecanismo de reconocimiento desconocido del efector translocador conservado ampliamente en bacterias patógenas. Se centrará en caracterizar el componente T3SS identificado, el complejo receptor unido a la membrana y la inmunidad activada. En general, los descubrimientos aportarán información nueva sobre las complejas interacciones entre plantas y bacterias y podría conducir al desarrollo de nuevas estrategias para el control de fitopatógenos.
Objetivo
Among the greatest challenges of the 21st century are bacterial diseases that permanently threat plants and animals, including humans to whom they often are lethal. In plant and animal production, bacteria can cause severe yield reductions if not effectively controlled. However, the current control measures include use of environmentally problematic antibiotics, which in addition may lead to appearance of bacterial strains resistant to these antibiotics.
Recent progress in the host laboratory using a Genome Wide Association Study (GWAS) of wheat reveals a hitherto unknown recognition mechanism of the effector translocator widely conserved in pathogenic bacteria. The associated receptor complex is predicted to have wide potential for exploitation in bacterial disease control, not only in crop plants but also in livestock production. In the T-REX project, number of parallel efforts will be taken to characterize the recognized T3SS component, the membrane bound receptor complex and the activated immunity. This will be undertaken using an integrated approach, which involves my background knowledge and experiences combined with the ones of the host institution within molecular genetics, biochemistry, molecular biology and bioinformatics.
This study will shed light on the role of T3SS as a PAMP, which will help us to elucidate the complex plant-bacterial interactions and can potentially lead to the development of new phyto-pathogen control strategies. T3SS being conserved among plant and animal pathogen, the outcome of the T-REX project has potential for extrapolation into animal pathological systems, including humans, and may contribute to the world of medicine.
Ámbito científico
- natural sciencesbiological sciencesmolecular biologymolecular genetics
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- agricultural sciencesagriculture, forestry, and fisheriesagriculture
- agricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry
Programa(s)
Régimen de financiación
MSCA-IF-EF-ST - Standard EFCoordinador
1165 Kobenhavn
Dinamarca