Descrizione del progetto
Proteggere coltivazioni e bestiame dai patogeni
Il controllo delle malattie batteriche è una priorità assoluta per gli agricoltori che devono proteggere le proprie colture e il proprio bestiame dall’invasione di agenti patogeni. Si tratta di una delle più grandi sfide del XXI secolo. Anche se le piante hanno sviluppato molteplici strategie di difesa per combattere gli agenti patogeni invasori, la resistenza agli antibiotici nei batteri patogeni delle piante rappresenta un problema. Il progetto T-REX, finanziato dall’UE, si baserà su studi recenti sul grano che hanno rivelato un meccanismo di riconoscimento sconosciuto del traslocatore effettore ampiamente conservato nei batteri patogeni. Esso mirerà a caratterizzare il componente T3SS riconosciuto, il complesso recettoriale legato alla membrana e l’immunità attivata. Nel complesso, i risultati faranno luce sulle complesse interazioni tra piante e batteri, portando potenzialmente allo sviluppo di nuove strategie di controllo dei fitopatogeni.
Obiettivo
Among the greatest challenges of the 21st century are bacterial diseases that permanently threat plants and animals, including humans to whom they often are lethal. In plant and animal production, bacteria can cause severe yield reductions if not effectively controlled. However, the current control measures include use of environmentally problematic antibiotics, which in addition may lead to appearance of bacterial strains resistant to these antibiotics.
Recent progress in the host laboratory using a Genome Wide Association Study (GWAS) of wheat reveals a hitherto unknown recognition mechanism of the effector translocator widely conserved in pathogenic bacteria. The associated receptor complex is predicted to have wide potential for exploitation in bacterial disease control, not only in crop plants but also in livestock production. In the T-REX project, number of parallel efforts will be taken to characterize the recognized T3SS component, the membrane bound receptor complex and the activated immunity. This will be undertaken using an integrated approach, which involves my background knowledge and experiences combined with the ones of the host institution within molecular genetics, biochemistry, molecular biology and bioinformatics.
This study will shed light on the role of T3SS as a PAMP, which will help us to elucidate the complex plant-bacterial interactions and can potentially lead to the development of new phyto-pathogen control strategies. T3SS being conserved among plant and animal pathogen, the outcome of the T-REX project has potential for extrapolation into animal pathological systems, including humans, and may contribute to the world of medicine.
Campo scientifico
- natural sciencesbiological sciencesmolecular biologymolecular genetics
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- agricultural sciencesagriculture, forestry, and fisheriesagriculture
- agricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF-EF-ST - Standard EFCoordinatore
1165 Kobenhavn
Danimarca