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Interaction of squalene-based anti-cancer and neuroprotective drugs with cell membranes: in silico study

Objective

Squalene is a natural lipid precursor, which plays a crucial role in the biosynthesis of sterols in the cells . Squalene is 100% biocompatible, not toxic and is able to enter into the cells easily. This makes it very promising for creating highly efficient drugs and drug delivery systems. The so-called squalenoylation technology is based on fusing hydrophobic squalenic acid
with the molecules of water-soluble drugs. Resulting conjugated molecules spontaneously self-assemble into nanoparticles, which deliver the drugs into the target cells efficiently. Currently anticancer (gemcitabine , doxorubicin ), antiviral (dideoxycytidine ) and neuroprotective (adenosine ) drugs were used in this technology with great success.
This project is devoted to revealing mechanisms of interaction of novel and highly promising squalene-based anti-cancer and neuroprotective drugs with cell membranes by means of in silico ccomputer simulations. The main goals of the project are the following:
1. To reveal how squalene-based drugs incorporate into the cell membranes, interact with membrane components and are released from the membranes on atomistic level of details.
2. To propose the ways of improving translocation of squalene-based drugs through the membranes in order to increase their therapeutic efficacy.
The practical impact of the project is improving translocation of squalene-based drugs through the membranes and making it selective, which is of great interest for therapeutic applications of existing drugs and for creation of new compounds with desirable properties.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF-EF-ST - Standard EF

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2017

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Coordinator

UNIVERSITE DE FRANCHE-COMTE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 173 076,00
Address
1 RUE CLAUDE GOUDIMEL
25000 Besancon
France

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Region
Bourgogne-Franche-Comté Franche-Comté Doubs
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 173 076,00
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