Interaction of squalene-based anti-cancer and neuroprotective drugs with cell membranes: in silico study

Projektinformationen

SquaMem

ID Finanzhilfevereinbarung: 796245

DOI 10.3030/796245

Abgeschlossenes Projekt

EK-Unterschriftsdatum 3 April 2018

Startdatum 1 November 2018

Enddatum 19 September 2021

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 173 076,00

EU-Beitrag € 173 076,00

Koordiniert durch

UNIVERSITE DE FRANCHE-COMTE
France

Ziel

Squalene is a natural lipid precursor, which plays a crucial role in the biosynthesis of sterols in the cells . Squalene is 100% biocompatible, not toxic and is able to enter into the cells easily. This makes it very promising for creating highly efficient drugs and drug delivery systems. The so-called squalenoylation technology is based on fusing hydrophobic squalenic acid
with the molecules of water-soluble drugs. Resulting conjugated molecules spontaneously self-assemble into nanoparticles, which deliver the drugs into the target cells efficiently. Currently anticancer (gemcitabine , doxorubicin ), antiviral (dideoxycytidine ) and neuroprotective (adenosine ) drugs were used in this technology with great success.
This project is devoted to revealing mechanisms of interaction of novel and highly promising squalene-based anti-cancer and neuroprotective drugs with cell membranes by means of in silico ccomputer simulations. The main goals of the project are the following:
1. To reveal how squalene-based drugs incorporate into the cell membranes, interact with membrane components and are released from the membranes on atomistic level of details.
2. To propose the ways of improving translocation of squalene-based drugs through the membranes in order to increase their therapeutic efficacy.
The practical impact of the project is improving translocation of squalene-based drugs through the membranes and making it selective, which is of great interest for therapeutic applications of existing drugs and for creation of new compounds with desirable properties.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › lipids
• engineering and technology › nanotechnology › nano-materials

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2017 - Individual Fellowships

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2017

Finanzierungsplan

MSCA-IF-EF-ST - Standard EF

Koordinator

UNIVERSITE DE FRANCHE-COMTE

• Netto-EU-Beitrag: € 173 076,00
• Adresse: 1 RUE CLAUDE GOUDIMEL ; 25000 Besancon ; Frankreich
• Region: Bourgogne-Franche-Comté › Franche-Comté › Doubs
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 173 076,00