Assessing transcriptional and nuclear pore aging in age-equivalent and rejuvenated induced neurons from Alzheimer patients

Project Information

iNtoPoreAge

Grant agreement ID: 797205

DOI

10.3030/797205

Project closed

EC signature date 17 April 2018

Start date 1 August 2019

End date 29 January 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 178 156,80

EU contribution

€ 178 156,80

Coordinated by

UNIVERSITAET INNSBRUCK
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy

Author(s): Cristina Marisol Castillo Bautista; Kristin Eismann; Marc Gentzel; Silvia Pelucchi; Jerome Mertens; Hannah E. Walters; Maximina H. Yun; Jared Sterneckert
Published in: Cells, Vol 12, Iss 18, Issue 1, 2023, Page(s) p 2247, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells12182247

Neural cell state shifts and fate loss in ageing and age-related diseases

Author(s): Traxler, L., Lucciola, R., Herdy, J.R. et al.
Published in: Nat Rev Neurol 19, 434–443 (2023, 2023, ISSN 1759-4758
Publisher: Nature Publishing Group
DOI: 10.1038/s41582-023-00815-0

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease

Author(s): Traxler, L., Herdy, J. R., Stefanoni, D., Eichhorner, S., Pelucchi, S., Szücs, A., Santagostino, A., Kim, Y., Agarwal, R. K., Schlachetzki, J. C. M., Glass, C. K., Lagerwall, J., Galasko, D., Gage, F. H., D'Alessandro, A., & Mertens, J.
Published in: Cell metabolism, 34(9), 2022, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.07.014

Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

Author(s): Herdy, Joseph; Traxler, Larissa; Agarwal, Ravi; Karbacher, Lukas; Schlachetzki, Johannes; Boehnke, Lena; Zangwill, Dina; Galasko, Doug; Glass, Christopher; Mertens, Jerome; Gage, Fred
Published in: Cell Stem Cell. 2022 December 01; 29(12), Issue 2, 2022, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2022.11.010

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients

Author(s): Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., Agarwal, R. K., Lucciola, R., Zhou-Yang, L., Karbacher, L., Edenhofer, F., Stern, S., Horvath, S., Paquola, A. C. M., Glass, C. K., Yuan, S. H., … Gage, F. H.
Published in: Cell stem cell, 28(9), 2021, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.04.004

Next-generation disease modeling with direct conversion: a new path to old neurons

Author(s): Larissa Traxler, Frank Edenhofer, Jerome Mertens
Published in: FEBS Letters, Volume 593, Issue23, 2019, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.13678

When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron

Author(s): Schlachetzki, J. C. M., Toda, T., & Mertens, J.
Published in: Experimental gerontology, 133, 110876, 2020, ISSN 0531-5565
Publisher: Elsevier BV
DOI: 10.1016/j.exger.2020.110876

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Author(s): Simon Schafer; Abhinav Soni; Diana Klütsch; Hayder Amin; Jerome Mertens; Xin Hu; Judith Houtman
Published in: Cells 2021, 10(8), 1894, Issue 1, 2021, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells10081894

Novel therapeutic approaches to target neurodegeneration

Author(s): Alerie G. de la Fuente; Silvia Pelucchi; Jerome Mertens; Monica Di Luca; Daniela Mauceri; Elena Marcello
Published in: British journal of pharmacology, 180(13), 1651–1673, Issue 1, 2023, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.22541/au.167164898.84768756/v1

Metabolism navigates neural cell fate in development, aging and neurodegeneration.

Author(s): Traxler, Larissa; Lagerwall, Jessica; Eichhorner, Sophie; Stefanoni, Davide; D'Alessandro, Angelo; Mertens, Jerome
Published in: Dis Model Mech. 2021;14(8), Issue 1, 2021, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.048993

Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion

Author(s): Lena Böhnke, Lucia Zhou-Yang, Silvia Pelucchi, Flora Kogler, Daniela Frantal, Florian Schön, Stina Lagerström, Oliver Borgogno, Jennifer Baltazar, Joseph R. Herdy, Sarah Kittel-Schneider, Michaela Defrancesco, Jerome Mertens
Published in: Cellular Reprogramming, Vol. 24, No. 5 (2022), 2022, ISSN 2152-4971
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/cell.2021.0200