Assessing transcriptional and nuclear pore aging in age-equivalent and rejuvenated induced neurons from Alzheimer patients

Project Information

iNtoPoreAge

Grant agreement ID: 797205

DOI 10.3030/797205

Project closed

EC signature date 17 April 2018

Start date 1 August 2019

End date 29 January 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 178 156,80

EU contribution € 178 156,80

Coordinated by

UNIVERSITAET INNSBRUCK
Austria

Publications

Peer reviewed articles (12)

Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy

Author(s): Cristina Marisol Castillo Bautista; Kristin Eismann; Marc Gentzel; Silvia Pelucchi; Jerome Mertens; Hannah E. Walters; Maximina H. Yun; Jared Sterneckert
Published in: Cells, Vol 12, Iss 18, Issue 1, 2023, Page(s) p 2247, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells12182247

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease

Author(s): Traxler, L., Herdy, J. R., Stefanoni, D., Eichhorner, S., Pelucchi, S., Szücs, A., Santagostino, A., Kim, Y., Agarwal, R. K., Schlachetzki, J. C. M., Glass, C. K., Lagerwall, J., Galasko, D., Gage, F. H., D'Alessandro, A., & Mertens, J.
Published in: Cell metabolism, 34(9), 2022, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.07.014

Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

Author(s): Herdy, Joseph; Traxler, Larissa; Agarwal, Ravi; Karbacher, Lukas; Schlachetzki, Johannes; Boehnke, Lena; Zangwill, Dina; Galasko, Doug; Glass, Christopher; Mertens, Jerome; Gage, Fred
Published in: Cell Stem Cell. 2022 December 01; 29(12), Issue 2, 2022, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2022.11.010

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients

Author(s): Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., Agarwal, R. K., Lucciola, R., Zhou-Yang, L., Karbacher, L., Edenhofer, F., Stern, S., Horvath, S., Paquola, A. C. M., Glass, C. K., Yuan, S. H., … Gage, F. H.
Published in: Cell stem cell, 28(9), 2021, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.04.004

Next-generation disease modeling with direct conversion: a new path to old neurons

Author(s): Larissa Traxler, Frank Edenhofer, Jerome Mertens
Published in: FEBS Letters, Volume 593, Issue23, 2019, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.13678

Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy

Author(s): Cristina Marisol Castillo Bautista; Kristin Eismann; Marc Gentzel; Silvia Pelucchi; Jerome Mertens; Hannah E. Walters; Maximina H. Yun; Jared Sterneckert
Published in: Cells, Vol 12, Iss 18, p 2247 (2023), Issue 1, 2023, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells12182247

When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron

Author(s): Schlachetzki, J. C. M., Toda, T., & Mertens, J.
Published in: Experimental gerontology, 133, 110876, 2020, ISSN 0531-5565
Publisher: Elsevier BV
DOI: 10.1016/j.exger.2020.110876

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Author(s): Simon Schafer; Abhinav Soni; Diana Klütsch; Hayder Amin; Jerome Mertens; Xin Hu; Judith Houtman
Published in: Cells 2021, 10(8), 1894, Issue 1, 2021, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells10081894

Novel therapeutic approaches to target neurodegeneration

Author(s): Alerie G. de la Fuente; Silvia Pelucchi; Jerome Mertens; Monica Di Luca; Daniela Mauceri; Elena Marcello
Published in: British journal of pharmacology, 180(13), 1651–1673, Issue 1, 2023, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.22541/au.167164898.84768756/v1

Metabolism navigates neural cell fate in development, aging and neurodegeneration.

Author(s): Traxler, Larissa; Lagerwall, Jessica; Eichhorner, Sophie; Stefanoni, Davide; D'Alessandro, Angelo; Mertens, Jerome
Published in: Dis Model Mech. 2021;14(8), Issue 1, 2021, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.048993

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Author(s): Simon Schafer; Abhinav Soni; Diana Klütsch; Hayder Amin; Jerome Mertens; Xin Hu; Judith Houtman
Published in: Cells 2021, 10(8), 1894, Issue 1, 2021, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells10081894

Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion

Author(s): Lena Böhnke, Lucia Zhou-Yang, Silvia Pelucchi, Flora Kogler, Daniela Frantal, Florian Schön, Stina Lagerström, Oliver Borgogno, Jennifer Baltazar, Joseph R. Herdy, Sarah Kittel-Schneider, Michaela Defrancesco, Jerome Mertens
Published in: Cellular Reprogramming, Vol. 24, No. 5 (2022), 2022, ISSN 2152-4971
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/cell.2021.0200