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Assessing transcriptional and nuclear pore aging in age-equivalent and rejuvenated induced neurons from Alzheimer patients

Publikacje

Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy

Autorzy: Cristina Marisol Castillo Bautista; Kristin Eismann; Marc Gentzel; Silvia Pelucchi; Jerome Mertens; Hannah E. Walters; Maximina H. Yun; Jared Sterneckert
Opublikowane w: Cells, Vol 12, Iss 18, Numer 1, 2023, Strona(/y) p 2247, ISSN 2073-4409
Wydawca: MDPI AG
DOI: 10.3390/cells12182247

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease

Autorzy: Traxler, L., Herdy, J. R., Stefanoni, D., Eichhorner, S., Pelucchi, S., Szücs, A., Santagostino, A., Kim, Y., Agarwal, R. K., Schlachetzki, J. C. M., Glass, C. K., Lagerwall, J., Galasko, D., Gage, F. H., D'Alessandro, A., & Mertens, J.
Opublikowane w: Cell metabolism, 34(9), 2022, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2022.07.014

Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

Autorzy: Herdy, Joseph; Traxler, Larissa; Agarwal, Ravi; Karbacher, Lukas; Schlachetzki, Johannes; Boehnke, Lena; Zangwill, Dina; Galasko, Doug; Glass, Christopher; Mertens, Jerome; Gage, Fred
Opublikowane w: Cell Stem Cell. 2022 December 01; 29(12), Numer 2, 2022, ISSN 1934-5909
Wydawca: Cell Press
DOI: 10.1016/j.stem.2022.11.010

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients

Autorzy: Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., Agarwal, R. K., Lucciola, R., Zhou-Yang, L., Karbacher, L., Edenhofer, F., Stern, S., Horvath, S., Paquola, A. C. M., Glass, C. K., Yuan, S. H., … Gage, F. H.
Opublikowane w: Cell stem cell, 28(9), 2021, ISSN 1934-5909
Wydawca: Cell Press
DOI: 10.1016/j.stem.2021.04.004

Next-generation disease modeling with direct conversion: a new path to old neurons

Autorzy: Larissa Traxler, Frank Edenhofer, Jerome Mertens
Opublikowane w: FEBS Letters, Volume 593, Numer23, 2019, ISSN 0014-5793
Wydawca: Elsevier BV
DOI: 10.1002/1873-3468.13678

Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy

Autorzy: Cristina Marisol Castillo Bautista; Kristin Eismann; Marc Gentzel; Silvia Pelucchi; Jerome Mertens; Hannah E. Walters; Maximina H. Yun; Jared Sterneckert
Opublikowane w: Cells, Vol 12, Iss 18, p 2247 (2023), Numer 1, 2023, ISSN 2073-4409
Wydawca: MDPI AG
DOI: 10.3390/cells12182247

When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron

Autorzy: Schlachetzki, J. C. M., Toda, T., & Mertens, J.
Opublikowane w: Experimental gerontology, 133, 110876, 2020, ISSN 0531-5565
Wydawca: Elsevier BV
DOI: 10.1016/j.exger.2020.110876

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Autorzy: Simon Schafer; Abhinav Soni; Diana Klütsch; Hayder Amin; Jerome Mertens; Xin Hu; Judith Houtman
Opublikowane w: Cells 2021, 10(8), 1894, Numer 1, 2021, ISSN 2073-4409
Wydawca: MDPI AG
DOI: 10.3390/cells10081894

Novel therapeutic approaches to target neurodegeneration

Autorzy: Alerie G. de la Fuente; Silvia Pelucchi; Jerome Mertens; Monica Di Luca; Daniela Mauceri; Elena Marcello
Opublikowane w: British journal of pharmacology, 180(13), 1651–1673, Numer 1, 2023, ISSN 0007-1188
Wydawca: Wiley-Blackwell
DOI: 10.22541/au.167164898.84768756/v1

Metabolism navigates neural cell fate in development, aging and neurodegeneration.

Autorzy: Traxler, Larissa; Lagerwall, Jessica; Eichhorner, Sophie; Stefanoni, Davide; D'Alessandro, Angelo; Mertens, Jerome
Opublikowane w: Dis Model Mech. 2021;14(8), Numer 1, 2021, ISSN 1754-8403
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/dmm.048993

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Autorzy: Simon Schafer; Abhinav Soni; Diana Klütsch; Hayder Amin; Jerome Mertens; Xin Hu; Judith Houtman
Opublikowane w: Cells 2021, 10(8), 1894, Numer 1, 2021, ISSN 2073-4409
Wydawca: MDPI AG
DOI: 10.3390/cells10081894

Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion

Autorzy: Lena Böhnke, Lucia Zhou-Yang, Silvia Pelucchi, Flora Kogler, Daniela Frantal, Florian Schön, Stina Lagerström, Oliver Borgogno, Jennifer Baltazar, Joseph R. Herdy, Sarah Kittel-Schneider, Michaela Defrancesco, Jerome Mertens
Opublikowane w: Cellular Reprogramming, Vol. 24, No. 5 (2022), 2022, ISSN 2152-4971
Wydawca: Mary Ann Liebert Inc.
DOI: 10.1089/cell.2021.0200

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