Objective
WHY: Although the impressive advances in the field of biosensing, most efforts are oriented in delivering lower limits of detection, whereas other aspects remain unattended. As consequence, the majority of novel assays for the detection of biomarkers still require: sophisticated equipment, washing intensive, reagent-intensive multi step processes. To effectively overcome the cited limitations and clear the way to the desired point-of-care tests (reagentless, single step, quick response, reusable, user friendly, robust and precise) it is mandatory to engineer the recognition elements (RE).
WHAT: The aim of the proposal, SBS, is to develop novel electrochemical biosensors by engineering the RE responsible of detection. I will achieve so by rationally applying mechanisms found in nature; First, I will explore the amazing single-step, reagentless signal transduction naturally occurring biological systems. Next, I will enhance precision of the recognition element (high output upon subtle variations of target concentration) through the insertion of cooperativity. Finally, I will deploy the engineered RE in biosensing approaches.
HOW: During the fellowship I will undertake a training program to develop skills and acquire expertise in biophysiscs, molecular biology and electrochemical biosensor. In a first out-going phase I will join Prof. K. Plaxco (UCSB) who is a world-wide expert in biomolecule folding and biophysics, there I will develop the engineered folding based RE. In the subsequent phase I will join Prof. F. Ricci group at University of Rome, Tor Vergata. Prof. Ricci leads a young and dynamic group specialized in the field nanotechnology, DNA engineering and electrochemical biosensors. Within his group I will work in the application of the RE into biosensors. The fellowship will grant the chance to build a robust, prestigious and attractive scientific record, while the knowledge and skills acquired will improve gratly my career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules
- natural sciences biological sciences biophysics
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-GF - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
00133 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.